LIVIVO - Search results -

Search results

Result 1 - 10 of total 5665

Search options

Article ; Online: The Impact of Vitamin D

Kotb Elmala, Moustafa / Suliman, Hany Abdelaziz / Al-Shokary, Ashraf Hamed / Ibrahim, Asmaa Obada / Kamal, Naglaa M / Elshorbagy, Hatem Hamed / Nasef, Khaled Amin / El Din Fathallah, Mohamed Gamal

Journal of child neurology

2022 Volume 37, Issue 10-11, Page(s) 833–839

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adolescent ; Anticonvulsants/therapeutic use ; Child ; Child, Preschool ; Cholecalciferol/adverse effects ; Dietary Supplements ; Double-Blind Method ; Fructose/adverse effects ; Humans ; Migraine Disorders/drug therapy ; Migraine Disorders/prevention & control ; Prospective Studies ; Topiramate/therapeutic use ; Treatment Outcome ; Vitamin D/therapeutic use
Chemical Substances	Anticonvulsants ; Topiramate (0H73WJJ391) ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; Fructose (30237-26-4)
Language	English
Publishing date	2022-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	639288-x
ISSN	1708-8283 ; 0883-0738
ISSN (online)	1708-8283
ISSN	0883-0738
DOI	10.1177/08830738221092882
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2301: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Enhancement in brain uptake of vitamin D

Kumar, Mukesh / Nishad, Dhruv Kumar / Kumar, Anoop / Bhatnagar, Aseem / Karwasra, Ritu / Khanna, Kushagra / S, Keerthana / Sharma, Deeksha / Dua, Kamal / Mudaliyar, Vijaybabu / Sharma, Nitin

Journal of microencapsulation

2020 Volume 37, Issue 7, Page(s) 492–501

Abstract: Aim: For the treatment of cerebral ischaemia, vitamin-D: Method: Tween 20 and ... characterised for various : Result: Vitamin D: Conclusion: This work demonstrated better permeation ...

Abstract	Aim: For the treatment of cerebral ischaemia, vitamin-D Method: Tween 20 and polyethylene glycol were chosen as surfactant/co-surfactant, while oleic acid as the oil phase. The formulation was characterised for various Result: Vitamin D Conclusion: This work demonstrated better permeation, deposition, and efficacy of vitaminD
MeSH term(s)	Administration, Intranasal ; Animals ; Brain/blood supply ; Brain/drug effects ; Brain/metabolism ; Cerebral Infarction/drug therapy ; Cerebral Infarction/metabolism ; Cholecalciferol/administration & dosage ; Cholecalciferol/pharmacokinetics ; Cholecalciferol/therapeutic use ; Drug Carriers/chemistry ; Emulsions/chemistry ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/metabolism ; Rats, Sprague-Dawley ; Vitamins/administration & dosage ; Vitamins/pharmacokinetics ; Vitamins/therapeutic use
Chemical Substances	Drug Carriers ; Emulsions ; Vitamins ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2020-08-06
Publishing country	England
Document type	Journal Article
ZDB-ID	843632-0
ISSN	1464-5246 ; 0265-2048
ISSN (online)	1464-5246
ISSN	0265-2048
DOI	10.1080/02652048.2020.1801870
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2267: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Vitamin D deficiency and the vitamin D receptor (VDR) gene polymorphism rs2228570 (FokI) are associated with an increased susceptibility to hypertension among the Bangladeshi population.

Nabil, Imrul Kayes / Mahmud, Zimam / Tamanna, Sonia / Rahman, Md Mostafijur / Rashid, Gowhar / Hossain, Md Sarowar / Asad, Humaira Binte / Kamal, Mohammad Amjad / Howlader, Md Zakir Hossain

PloS one

2024 Volume 19, Issue 3, Page(s) e0297138

Abstract: Vitamin D receptor (VDR) gene is implicated in hypertension vulnerability due to its role ... HPLC to measure 25-hydroxy vitamin D levels. Polymorphic variations in the VDR gene were detected and ... characterized using the PCR-RFLP method. At first, lower 25-hydroxy vitamin D levels were observed ...

Abstract	Vitamin D receptor (VDR) gene is implicated in hypertension vulnerability due to its role in regulating the renin-angiotensin system (RAS) and blood pressure. In this case-control study, a carefully selected cohort of 111 hypertensive individuals and 100 healthy controls underwent serum analysis using HPLC to measure 25-hydroxy vitamin D levels. Polymorphic variations in the VDR gene were detected and characterized using the PCR-RFLP method. At first, lower 25-hydroxy vitamin D levels were observed in hypertensive individuals compared to controls (p<0.001). The genotype frequency of the VDR gene TaqI showed no significant difference between cases and controls (p>0.05). Similarly, no significant difference was found in the VDR gene BsmI genotype frequency between hypertensive patients and controls (p>0.05). However, a statistically significant distinction was observed in the VDR gene FokI genotype frequency between cases and controls (p<0.01). The odds ratios for FokI genotypes (CC, CT, TT, and CT+TT) were 1.0, 0.590, 1.566, and 0.963, respectively. Furthermore, serum 25-hydroxy vitamin D levels were significantly higher in control subjects compared to hypertensive patients across all genotypes of VDR (p<0.001). Hypertensive patients, excluding those with the FokI VDR gene CC genotype, exhibited significantly higher systolic blood pressure levels compared to the control group (p<0.05). Similarly, hypertensive subjects displayed elevated diastolic blood pressure levels compared to the control group (p<0.001). Overall, the results suggest the presence of a potential inverse correlation between serum 25-hydroxy vitamin D levels and hypertension. The association analysis conducted indicated that there is no significant association between TaqI and bsmI genotypic variants and the risk of developing hypertension. However, it was observed that VDR gene polymorphisms do have a clear association with hypertension susceptibility, as evidenced by the significantly higher occurrence of FokI genotypic variants in hypertensive patients. Our study therefore introduces the possibility of utilizing 25-hydroxy vitamin D deficiency and VDR gene polymorphisms as a biomarker for hypertension.
MeSH term(s)	Humans ; Receptors, Calcitriol/genetics ; Case-Control Studies ; Genetic Predisposition to Disease ; Polymorphism, Genetic ; Vitamin D ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/genetics ; Genotype ; Hypertension/genetics ; Polymorphism, Single Nucleotide
Chemical Substances	Receptors, Calcitriol ; Vitamin D (1406-16-2) ; VDR protein, human
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297138
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Vitamin D, Calbindin, and calcium signaling: Unraveling the Alzheimer's connection.

Acharya, Manish / Singh, Nicky / Gupta, Gaurav / Tambuwala, Murtaza M / Aljabali, Alaa A A / Chellappan, Dinesh Kumar / Dua, Kamal / Goyal, Rohit

Cellular signalling

2024 Volume 116, Page(s) 111043

Abstract: ... and depolarizing signals. Vitamin D, an endogenous fat-soluble metabolite, is synthesized in the skin ... such as TRPV6. Vitamin D also modulates the activity of calcium-binding proteins, including CAM and calbindin ... by CAM. Low levels of both calbindin and vitamin D are attributed to the pathology of Alzheimer's disease ...

Abstract	Calcium is a ubiquitous second messenger that is indispensable in regulating neurotransmission and memory formation. A precise intracellular calcium level is achieved through the concerted action of calcium channels, and calcium exerts its effect by binding to an array of calcium-binding proteins, including calmodulin (CAM), calcium-calmodulin complex-dependent protein kinase-II (CAMK-II), calbindin (CAL), and calcineurin (CAN). Calbindin orchestrates a plethora of signaling events that regulate synaptic transmission and depolarizing signals. Vitamin D, an endogenous fat-soluble metabolite, is synthesized in the skin upon exposure to ultraviolet B radiation. It modulates calcium signaling by increasing the expression of the calcium-sensing receptor (CaSR), stimulating phospholipase C activity, and regulating the expression of calcium channels such as TRPV6. Vitamin D also modulates the activity of calcium-binding proteins, including CAM and calbindin, and increases their expression. Calbindin, a high-affinity calcium-binding protein, is involved in calcium buffering and transport in neurons. It has been shown to inhibit apoptosis and caspase-3 activity stimulated by presenilin 1 and 2 in AD. Whereas CAM, another calcium-binding protein, is implicated in regulating neurotransmitter release and memory formation by phosphorylating CAN, CAMK-II, and other calcium-regulated proteins. CAMK-II and CAN regulate actin-induced spine shape changes, which are further modulated by CAM. Low levels of both calbindin and vitamin D are attributed to the pathology of Alzheimer's disease. Further research on vitamin D via calbindin-CAMK-II signaling may provide newer insights, revealing novel therapeutic targets and strategies for treatment.
MeSH term(s)	Humans ; Vitamin D ; Calcium Signaling ; Calbindins ; Calmodulin ; Calcium ; Alzheimer Disease ; Calcium-Binding Proteins ; Calcium Channels ; Calcineurin ; Calcium-Calmodulin-Dependent Protein Kinase Type 2
Chemical Substances	Vitamin D (1406-16-2) ; Calbindins ; Calmodulin ; Calcium (SY7Q814VUP) ; Calcium-Binding Proteins ; Calcium Channels ; Calcineurin (EC 3.1.3.16) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17)
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2024.111043
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2579: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme:

Haque, Mst Farjanamul / El-Nashar, Heba A S / Akbor, Md Showkoth / Alfaifi, Mohammed / Bappi, Mehedi Hasan / Chowdhury, Afsana Kabir / Hossain, Muhammad Kamal / El-Shazly, Mohamed / Albayouk, Tala / Saleh, Na'il / Islam, Muhammad Torequl

Frontiers in chemistry

2024 Volume 12, Page(s) 1366844

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2024-04-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2024.1366844
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Therapeutic high-dose vitamin D for vitamin D-deficient severe COVID-19 disease: randomized, double-blind, placebo-controlled study (SHADE-S).

Singh, Ajay / Rastogi, Ashu / Puri, Goverdhan Dutt / Ganesh, Venkata / Naik, Naveen Bal / Kajal, Kamal / Kahlon, Shubhkarman / Soni, Shiv Lal / Kaloria, Narender / Saini, Kulbhushan / Hazarika, Amarjyoti / Mahajan, Varun / Singla, Karan / Bhadada, Sanjay / Soni, Vaishali

Journal of public health (Oxford, England)

2024

Abstract: ... ml (P = 0.06) at baseline; and 60 (55-65) ng/ml and 4 (1-7) ng/ml by Day 7 in vitamin D and placebo ... groups, respectively. The SOFA score on Day 7 was better in the vitamin D group [3 (95% CI, 2-5) versus 5 ... 28-day mortality [24% compared to 44% (P = 0.046)] was observed with vitamin D.: Conclusions ...

Abstract	Background: efficacy of therapeutic cholecalciferol supplementation for severe COVID-19 is sparingly studied. Objective: effect of single high-dose cholecalciferol supplementation on sequential organ failure assessment (SOFA) score in moderate-to-severe COVID-19. Methods: participants with moderate to severe COVID-19 with PaO2/FiO2 ratio < 200 were randomized to 0.6 million IU cholecalciferol oral (intervention) or placebo. Outcomes: primary outcome was change in Day 7 SOFA score and pre-specified secondary outcomes were SOFA and 28-day all-cause mortality. Results: in all, 90 patients (45 each group) were included for intention-to-treat analysis. 25(OH)D3 levels were 12 (10-16) and 13 (12-18) ng/ml (P = 0.06) at baseline; and 60 (55-65) ng/ml and 4 (1-7) ng/ml by Day 7 in vitamin D and placebo groups, respectively. The SOFA score on Day 7 was better in the vitamin D group [3 (95% CI, 2-5) versus 5 (95% CI, 3-7), P = 0.01, intergroup difference - 2 (95% CI, -4 to -0.01); r = 0.4]. A lower all-cause 28-day mortality [24% compared to 44% (P = 0.046)] was observed with vitamin D. Conclusions: single high-dose oral cholecalciferol supplementation on ICU admission can improve SOFA score at Day 7 and reduce in-hospital mortality in vitamin D-deficient COVID-19. ClinicalTrials.gov id: NCT04952857 registered dated 7 July 2021. What is already known on this topic-vitamin D has immunomodulatory role. Observational and isolated intervention studies show some benefit in COVID-19. Targeted therapeutic vitamin D supplementation improve outcomes in severe COVID-19 is not studied in RCTs. What this study adds-high-dose vitamin D supplementation (0.6 Million IU) to increase 25(OH)D > 50 ng/ml is safe and reduces sequential organ failure assessment score, in-hospital mortality in moderate to severe COVID-19. How this study might affect research, practice or policy-vitamin D supplementation in vitamin D-deficient patients with severe COVID-19 is useful may be practiced.
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2142082-8
ISSN	1741-3850 ; 1741-3842
ISSN (online)	1741-3850
ISSN	1741-3842
DOI	10.1093/pubmed/fdae007
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2186: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Online: D-DARTS

Heuillet, Alexandre / Tabia, Hedi / Arioui, Hichem / Youcef-Toumi, Kamal

Distributed Differentiable Architecture Search

2021

Abstract: ... we propose D-DARTS, a solution that addresses this problem by nesting neural networks at the cell level ... pretrained models can be accessed at https://github.com/aheuillet/D-DARTS. ... Comment: Submitted ...

Abstract	Differentiable ARchiTecture Search (DARTS) is one of the most trending Neural Architecture Search (NAS) methods. It drastically reduces search cost by resorting to weight-sharing. However, it also dramatically reduces the search space, thus excluding potential promising architectures. In this article, we propose D-DARTS, a solution that addresses this problem by nesting neural networks at the cell level instead of using weight-sharing to produce more diversified and specialized architectures. Moreover, we introduce a novel algorithm that can derive deeper architectures from a few trained cells, increasing performance and saving computation time. In addition, we also present an alternative search space (DARTOpti) in which we optimize existing handcrafted architectures (e.g., ResNet) rather than starting from scratch. This approach is accompanied by a novel metric that measures the distance between architectures inside our custom search space. Our solution reaches competitive performance on multiple computer vision tasks. Code and pretrained models can be accessed at https://github.com/aheuillet/D-DARTS. Comment: Submitted to Pattern Recognition Letters
Keywords	Computer Science - Machine Learning ; Computer Science - Computer Vision and Pattern Recognition
Publishing date	2021-08-20
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The Effects of Vitamin D Supplementation and 25-Hydroxyvitamin D Levels on the Risk of Myocardial Infarction and Mortality.

Acharya, Prakash / Dalia, Tarun / Ranka, Sagar / Sethi, Prince / Oni, Olurinde A / Safarova, Maya S / Parashara, Deepak / Gupta, Kamal / Barua, Rajat S

Journal of the Endocrine Society

2021 Volume 5, Issue 10, Page(s) bvab124

Abstract: Objective: The aim of the study was to examine the effects of the vitamin D (Vit-D) treatment and ... nontreatment on Vit-D-deficient patients without a prior history of myocardial infarction (MI).: Materials ... 025) with low 25-hydroxyvitamin D ([25-OH]D) levels (<20 ng/mL) who received care ...

Abstract	Objective: The aim of the study was to examine the effects of the vitamin D (Vit-D) treatment and nontreatment on Vit-D-deficient patients without a prior history of myocardial infarction (MI). Materials and methods: This was a retrospective, observational, nested case-control study of patients (N = 20 025) with low 25-hydroxyvitamin D ([25-OH]D) levels (<20 ng/mL) who received care at the Veterans Health Administration from 1999 to 2018. Patients were divided into 3 groups: Group A (untreated, levels ≤20 ng/mL), Group B (treated, levels 21-29 ng/mL), and Group C (treated, levels ≥30 ng/mL). The risk of MI and all-cause mortality were compared utilizing propensity score-weighted Cox proportional hazard models. Results: Among the cohort of 20 025 patients, the risk of MI was significantly lower in Group C than in Group B (hazard ratio [HR] 0.65, 95% CI 0.49-0.85, Conclusions: In patients with Vit-D deficiency and no prior history of MI, treatment to the (25-OH)D level of >20 ng/mL and >30 ng/mL was associated with a significantly lower risk of all-cause mortality. The lower risk of MI was observed only in individuals maintaining (25-OH)D levels ≥30 ng/mL.
Language	English
Publishing date	2021-07-15
Publishing country	United States
Document type	Journal Article
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvab124
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Steatosis regression assessed by cap after Vitamin 'D' supplementation in NAFLD patients with Vitamin 'D' deficiency.

Emam, Rabab Fouad / Soliman, Ahmed Fouad / Darweesh, Samar Kamal / AbdElmagid, Reham AbdElmoniem / Ibrahim, Ola Mohamed / Mohamed, Dina Mahmoud

European journal of gastroenterology & hepatology

2023 Volume 36, Issue 1, Page(s) 101–106

Abstract: ... liver disease, and previous studies suggested a relationship between vitamin D deficiency and NAFLD. It is ... suggested that vitamin D supplementation may have significant beneficial effect on liver biochemistry and ... controlled attenuation parameter (CAP) in NAFLD patients with vitamin D deficiency after vitamin D ...

Abstract	Background: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, and previous studies suggested a relationship between vitamin D deficiency and NAFLD. It is suggested that vitamin D supplementation may have significant beneficial effect on liver biochemistry and histology. Objective: This study aims to assess the degree of possible steatosis regression using controlled attenuation parameter (CAP) in NAFLD patients with vitamin D deficiency after vitamin D supplementation and evaluating its effect on lipid profile and transaminases. Patients and methods: This study was conducted on 100 NAFLD patients with vitamin D deficiency. They received 10000 IU/week of vitamin D orally for 3 months. CAP was used to assess hepatic steatosis and fibrosis before/after intervention. Transaminases, lipid profile, and vitamin D levels were evaluated before/after treatment. Results: Serum AST, ALT, cholesterol, TG, LDL and HDL showed a significant reduction posttreatment in patients with both normal and elevated baseline levels ( P < 0.001). The posttreatment mean CAP showed a significant reduction (300.44 ± 37.56 vs. 265 ± 36.19 dB/ml) ( P < 0.001), and there was a significant improvement in the mean fibrosis values by LSM (5.32 ± 1.53 vs. 4.86 ± 1.28 KPa) ( P = 0.001). After supplementation, serum vitamin D level was raised significantly in the majority of patients ( P < 0.001); however, only 13% of them reached sufficient levels (>30 ng/ml), insufficient levels (20-29 ng/ml) was reached in 83% and 5% showed vitamin D deficiency (<20 ng/ml). Conclusion: A significant improvement was detected in hepatic steatosis (by CAP); mean values of LSM, transaminases and lipid profile after three months of oral vitamin D supplementation.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/drug therapy ; Vitamin D/therapeutic use ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/drug therapy ; Vitamins/therapeutic use ; Fibrosis ; Cholesterol ; Transaminases ; Dietary Supplements ; Elasticity Imaging Techniques
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins ; Cholesterol (97C5T2UQ7J) ; Transaminases (EC 2.6.1.-)
Language	English
Publishing date	2023-11-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002653
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2932: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A prospective randomized comparative trial of pediatric C-MAC D-blade video laryngoscope with McCoy direct laryngoscope for intubation in children posted for elective surgical procedures under general anesthesia.

Kamal, Geeta / Agarwal, Divyamedha / Agarwal, Shilpa / Gupta, Anju / Gupta, Aikta / Kalra, Bhumika / Gupta, Nishkarsh

Paediatric anaesthesia

2024

Abstract: ... of the C-MAC D-blade compared to the McCoy direct laryngoscope.: Methods: After Ethics Committee ... to intubation using a C-MAC video laryngoscope size 2 D-blade (Group 1) and a McCoy laryngoscope size 2 blade ... 006) was lesser in the C-MAC D-blade group while the total duration of intubation was comparable (20 s ...

Abstract	Background: Pediatric airway management requires careful clinical evaluation and experienced execution due to anatomical, physiological, and developmental considerations. Video laryngoscopy in pediatric airways is a developing area of research, with recent data suggesting that video laryngoscopes are better than standard Macintosh blades. Specifically, there is a paucity of literature on the advantages of the C-MAC D-blade compared to the McCoy direct laryngoscope. Methods: After Ethics Committee approval, 70 American Society of Anesthesiologists physical status 1 and 2 children aged 4-12 years scheduled for elective surgery under general anesthesia were recruited. Patients were randomly allocated to intubation using a C-MAC video laryngoscope size 2 D-blade (Group 1) and a McCoy laryngoscope size 2 blade (Group 2). The Intubation Difficulty Scale (IDS) for ease of intubation was the primary outcome, while Cormack-Lehane grades, duration of laryngoscopy and intubation, hemodynamic responses, and incidence of any airway complications were secondary outcomes. Results: Both groups were comparable in terms of patient characteristics. The median (IQR) Intubation Difficulty Scale (IDS) score was better but was statistically nonsignificant with C-MAC (0 [0-0] vs. 0 [0-2], p = .055). The glottic views were superior (CL grade I in 32/35 vs. 23/35, p = .002), and the time to best glottic view (6 s [5-7] vs. 8.0 s [6-10], p = .006) was lesser in the C-MAC D-blade group while the total duration of intubation was comparable (20 s [16-22] vs. 18 s [15-22], p = .374). All the patients could be successfully intubated on the first attempt. None of the patients had any complications. Conclusion: The C-MAC video laryngoscope size 2 D-blade provided faster and better glottic visualization but similar intubation difficulty compared to McCoy size 2 laryngoscope in children. The shorter time to achieve glottic view demonstrated with the C-MAC failed to translate into a shorter total duration of intubation when compared to the McCoy laryngoscope attributable to a pronounced curvature of the D-blade.
Language	English
Publishing date	2024-04-29
Publishing country	France
Document type	Journal Article
ZDB-ID	1086049-6
ISSN	1460-9592 ; 1155-5645
ISSN (online)	1460-9592
ISSN	1155-5645
DOI	10.1111/pan.14911
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3306: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito