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  1. Article ; Online: Next-generation sequencing for the diagnosis of

    Yu, Lili / Zhang, Yu / Qi, Xuejiao / Bai, Kaixuan / Zhang, Zhenyuan / Bu, Hui

    Journal of medical microbiology

    2023  Volume 72, Issue 1

    Abstract: Introduction. ...

    Abstract Introduction.
    MeSH term(s) Humans ; Listeria monocytogenes/genetics ; Meningitis, Listeria/diagnosis ; Meningitis, Listeria/drug therapy ; Anti-Bacterial Agents/therapeutic use ; High-Throughput Nucleotide Sequencing/methods ; Meningoencephalitis/diagnosis ; Meningoencephalitis/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.001641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 634: Show issues Location:
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  2. Article: Heterochronous multiple primary prostate cancer and lymphoma: A case report.

    Liang, Jin-Long / Bu, Yu-Qing / Peng, Li-Li / Zhang, Hong-Zhen

    World journal of clinical cases

    2024  Volume 12, Issue 7, Page(s) 1333–1338

    Abstract: Background: Multiple primary malignant tumors (MPMTs) are rare type of cancer, especially when solid tumors are the first and lymphoma is the second primary malignancy. We report a patient with heterochronous MPMTs consisting of prostate cancer and ... ...

    Abstract Background: Multiple primary malignant tumors (MPMTs) are rare type of cancer, especially when solid tumors are the first and lymphoma is the second primary malignancy. We report a patient with heterochronous MPMTs consisting of prostate cancer and rectal diffuse large B-cell lymphoma (DLBCL).
    Case summary: We report a 77-year-old male patient diagnosed with prostate cancer who was treated with radiation therapy and one year of endocrine therapy with bicalutamide (50 mg per day) and an extended-release implant of goserelin (1/28 d). Seven years later, rectal DLBCL with lung metastases was found.
    Conclusion: Although rare, the possibility of prostate cancer combined with a double primary cancer of DLBCL can provide a deeper understanding.
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v12.i7.1333
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  3. Article ; Online: Engineering the Co(II)/Co(III) Redox Cycle and Co

    Bu, Yongguang / Yu, Wenjing / Zhang, Wenkai / Wang, Chao / Ding, Jie / Gao, Guandao

    Nano letters

    2024  Volume 24, Issue 9, Page(s) 2812–2820

    Abstract: Electroreduction of waste nitrate to valuable ammonia offers a green solution for environmental restoration and energy storage. However, the electrochemical self-reconstruction of catalysts remains a huge challenge in terms of maintaining their stability, ...

    Abstract Electroreduction of waste nitrate to valuable ammonia offers a green solution for environmental restoration and energy storage. However, the electrochemical self-reconstruction of catalysts remains a huge challenge in terms of maintaining their stability, achieving the desired active sites, and managing metal leaching. Herein, we present an electrical pulse-driven Co surface reconstruction-coupled Co
    Language English
    Publishing date 2024-02-24
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c04920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Advances in rapid point-of-care virus testing.

    Zhang, Yu-Peng / Bu, Jin-Wei / Shu, Ru-Xin / Liu, Shu-Lin

    The Analyst

    2024  Volume 149, Issue 9, Page(s) 2507–2525

    Abstract: Outbreaks of viral diseases seriously jeopardize people's health and cause huge economic losses. At the same time, virology provides a new perspective for biology, molecular biology and cancer research, and it is important to study the discovered viruses ...

    Abstract Outbreaks of viral diseases seriously jeopardize people's health and cause huge economic losses. At the same time, virology provides a new perspective for biology, molecular biology and cancer research, and it is important to study the discovered viruses with potential applications. Therefore, the development of immediate and rapid viral detection methods for the prevention and treatment of viral diseases as well as the study of viruses has attracted extensive attention from scientists. With the continuous progress of science and technology, especially in the field of bioanalysis, a series of new detection techniques have been applied to the on-site rapid detection of viruses, which has become a powerful approach for human beings to fight against viruses. In this paper, the latest research progress of rapid point-of-care detection of viral nucleic acids, antigens and antibodies is presented. In addition, the advantages and disadvantages of these technologies are discussed from the perspective of practical application requirements. Finally, the problems and challenges faced by rapid viral detection methods and their development prospects are discussed.
    MeSH term(s) Humans ; Point-of-Care Testing ; Viruses/isolation & purification ; Viruses/genetics ; Virus Diseases/diagnosis ; Antigens, Viral/analysis ; Antibodies, Viral/immunology ; Antibodies, Viral/analysis ; Biosensing Techniques/methods ; Point-of-Care Systems ; RNA, Viral/analysis ; RNA, Viral/genetics
    Chemical Substances Antigens, Viral ; Antibodies, Viral ; RNA, Viral
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d4an00238e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2423: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: Isolation and characterization of

    Bu, Zhang-Yu / Wu, Li-Min / Yu, Xiao-Hong / Zhong, Jian-Bo / Yang, Ping / Chen, Jian

    Experimental and therapeutic medicine

    2017  Volume 14, Issue 1, Page(s) 303–307

    Abstract: The present investigation explored ... ...

    Abstract The present investigation explored the
    Language English
    Publishing date 2017-05-16
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2017.4456
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  6. Article ; Online: Establishment and characterization of a highly metastatic hepatocellular carcinoma cell line.

    Huang, Jiacheng / Sun, Mengqing / Wang, Menglan / Yu, Anning / Zheng, Huilin / Bu, Chiwen / Zhou, Jie / Zhang, Yu / Qiao, Yiting / Hu, Zhenhua

    Bioengineered

    2024  Volume 15, Issue 1, Page(s) 2296775

    Abstract: The prevalence of alcohol-related hepatocellular carcinoma (HCC) has been increasing during the last decade. Cancer research requires cell lines suitable for ... ...

    Abstract The prevalence of alcohol-related hepatocellular carcinoma (HCC) has been increasing during the last decade. Cancer research requires cell lines suitable for both
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/genetics ; Cell Count ; Cell Line ; Liver Neoplasms/genetics ; Sorafenib
    Chemical Substances Sorafenib (9ZOQ3TZI87)
    Language English
    Publishing date 2024-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2023.2296775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Exploring the Potential of Hesperidin in Preventing Hypertrophic Scars: Insights from a Rabbit Ear Model.

    Yang, Ping / Zhong, JianBo / Zhao, XingYun / Ali, Kamran / Wu, Liming / Bu, ZhangYu

    Clinical, cosmetic and investigational dermatology

    2023  Volume 16, Page(s) 2957–2963

    Abstract: Background: Hypertrophic scars, commonly occurring after trauma or surgery in critical areas like the head and joints, pose significant challenges to both physical and mental health due to their impact on skin function and aesthetics. While the complex ... ...

    Abstract Background: Hypertrophic scars, commonly occurring after trauma or surgery in critical areas like the head and joints, pose significant challenges to both physical and mental health due to their impact on skin function and aesthetics. While the complex pathogenesis involves fibroblast activation and collagen deposition, effective treatments are lacking, underscoring the importance of exploring pathogenesis and targeted therapies. Hesperidin, a bioactive compound in citrus fruits with diverse health benefits, including anti-fibrotic and anti-angiogenic effects, is the focus of this study with the aim of investigating its impact on hypertrophic scar formation, given its potential to promote blood flow and improve skin microcirculation.
    Objective: This study aimed to observe the inhibitory effect of topical hesperidin on hypertrophic scars in rabbits.
    Methods: A total of 8 healthy adult New Zealand white rabbits were used to establish a rabbit hypertrophic scarring animal model. Five wounds were created on each rabbit's two ears, with three wounds on the left ear (groups A, B, and C) and two wounds on the right ear (groups D and E). After six days of wound drying postoperatively, the wounds were locally treated with medication as followed: group A, 0.1% hesperidin; group B, 1% hesperidin; group C, 1% triamcinolone acetonide; group D, Vaseline; and group E, blank control without any medication. After 28 days, the scar tissue samples were collected for histological examination.
    Results: The results showed that the scar texture of groups B and C was softer and lighter in color, and the number of fibroblasts, capillaries, and inflammatory cells in the tissue was significantly less than those in the other three groups. The hypertrophic scar indices of groups B and C were significantly smaller than those of groups A, D, and E, and the difference was statistically significant (P < 0.05). There were no significant difference between groups B and C.
    Conclusion: Topical application of hesperidin demonstrated promising potential for reducing hypertrophic scar formation in rabbits.
    Language English
    Publishing date 2023-10-19
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494852-4
    ISSN 1178-7015
    ISSN 1178-7015
    DOI 10.2147/CCID.S428587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Robust Decoding of Rich Dynamical Visual Scenes With Retinal Spikes.

    Yu, Zhaofei / Bu, Tong / Zhang, Yijun / Jia, Shanshan / Huang, Tiejun / Liu, Jian K

    IEEE transactions on neural networks and learning systems

    2024  Volume PP

    Abstract: Sensory information transmitted to the brain activates neurons to create a series of coping behaviors. Understanding the mechanisms of neural computation and reverse engineering the brain to build intelligent machines requires establishing a robust ... ...

    Abstract Sensory information transmitted to the brain activates neurons to create a series of coping behaviors. Understanding the mechanisms of neural computation and reverse engineering the brain to build intelligent machines requires establishing a robust relationship between stimuli and neural responses. Neural decoding aims to reconstruct the original stimuli that trigger neural responses. With the recent upsurge of artificial intelligence, neural decoding provides an insightful perspective for designing novel algorithms of brain-machine interface. For humans, vision is the dominant contributor to the interaction between the external environment and the brain. In this study, utilizing the retinal neural spike data collected over multi trials with visual stimuli of two movies with different levels of scene complexity, we used a neural network decoder to quantify the decoded visual stimuli with six different metrics for image quality assessment establishing comprehensive inspection of decoding. With the detailed and systematical study of the effect and single and multiple trials of data, different noise in spikes, and blurred images, our results provide an in-depth investigation of decoding dynamical visual scenes using retinal spikes. These results provide insights into the neural coding of visual scenes and services as a guideline for designing next-generation decoding algorithms of neuroprosthesis and other devices of brain-machine interface.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2024.3351120
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  9. Article ; Online: Batoclimab vs Placebo for Generalized Myasthenia Gravis: A Randomized Clinical Trial.

    Yan, Chong / Yue, Yaoxian / Guan, Yuzhou / Bu, Bitao / Ke, Qing / Duan, Ruisheng / Deng, Hui / Xue, Qun / Jiang, Haishan / Xiao, Fei / Yang, Huan / Chang, Ting / Zou, Zhangyu / Li, Haifeng / Tan, Song / Xiao, Haibing / Zhou, Hongyu / Zhang, Hua / Meng, Qiang /
    Li, Wenyu / Li, Wei / Guo, Junhong / Zhang, Yali / Li, Zunbo / Tu, Jianglong / Shi, Jianquan / Lee, Michael / Chen, Yu / Tao, Xiaolu / Zhao, Shuai / Li, Ping / Zhao, Chongbo

    JAMA neurology

    2024  

    Abstract: Importance: Myasthenia gravis (MG) is caused by autoantibodies that disrupt the neuromuscular junction. The neonatal fragment crystallizable receptor (FcRn) antagonists, efgartigimod and rozanolixizumab, reduce immunoglobulin G (IgG) level in the ... ...

    Abstract Importance: Myasthenia gravis (MG) is caused by autoantibodies that disrupt the neuromuscular junction. The neonatal fragment crystallizable receptor (FcRn) antagonists, efgartigimod and rozanolixizumab, reduce immunoglobulin G (IgG) level in the circulation and alleviate symptoms in patients with generalized MG.
    Objective: To examine the efficacy and safety profile of batoclimab, a monoclonal IgG1 antibody, in patients with generalized MG.
    Design, setting, and participants: This was a multicenter randomized clinical trial conducted from September 15, 2021, to June 29, 2022, at 27 centers in China. Adult patients 18 years or older with generalized MG were screened, and those who were antibody positive were enrolled.
    Intervention: Eligible patients received batoclimab or matching placebo in addition to standard of care. Each treatment cycle consisted of 6 weekly subcutaneous injections of batoclimab, 680 mg, or matching placebo followed by 4 weeks of observation. A second treatment cycle was conducted in patients who required continuing treatment.
    Main outcome and measure: The primary outcome was sustained improvement, as defined by a 3-point or greater reduction in the Myasthenia Gravis Activities of Daily Living (MG-ADL) score from baseline for 4 or more consecutive weeks in the first cycle in individuals who were positive for acetylcholine receptor or muscle-specific kinase antibodies.
    Results: A total of 178 adult patients with generalized MG were screened, 132 were randomly assigned, 131 tested positive for antibodies, and 1 tested negative for antibodies. A total of 132 patients (mean [SE] age, 43.8 [13.6] years; 88 women [67.2%]) were enrolled. The rate of sustained MG-ADL improvement in the first cycle in antibody-positive patients was 31.3% (20 of 64) in the placebo group vs 58.2% (39 of 67) in the batoclimab group (odds ratio, 3.45; 95% CI, 1.62-7.35; P = .001). The MG-ADL score diverged between the 2 groups as early as week 2. The mean (SE) maximum difference in MG-ADL score reduction occurred 1 week after the last dose (day 43, 1.7 [0.3] in the placebo group vs 3.6 [0.3] in the batoclimab group; group difference, -1.9; 95% CI, -2.8 to -1.0; nominal P < .001). The rates of treatment-related and severe treatment-emergent adverse events in patients were 36.9% (24 of 65) and 7.7% (5 of 65) in the placebo group vs 70.1% (47 of 67) and 3.0% (2 of 67) in the batoclimab group, respectively.
    Conclusions and relevance: Batoclimab increased the rate of sustained MG-ADL improvement and was well tolerated in adult patients with generalized MG. Clinical effects and the extent of IgG reduction were similar to those previously reported for efgartigimod and rozanolixizumab. Future studies of large sample size are needed to further understand the safety profile of batoclimab.
    Trial registration: ClinicalTrials.gov Identifier: NCT05039190.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2024.0044
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    Ui II Zs.191: Show issues Location:
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  10. Article ; Online: Correction to: Efficacy and safety of entecavir for hepatitis B virus-associated glomerulonephritis with renal insufficiency.

    Yu, Yani / Xu, Lingyu / Xu, Ting / Yang, Chengyu / Bu, Quandong / Zhang, Wei / Zhao, Long / Xu, Yan / Jiang, Wei

    Clinical and experimental nephrology

    2024  Volume 28, Issue 2, Page(s) 179

    Language English
    Publishing date 2024-01-25
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-023-02447-6
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