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Article ; Online: [No title information]

Lyngbakken, Magnus Nakrem

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

2017 Volume 137, Issue 19

Title translation	Kardialt troponin og kardiovaskulær risiko.
Language	Norwegian
Publishing date	2017-10-17
Publishing country	Norway
Document type	Journal Article
ZDB-ID	603504-8
ISSN	0807-7096 ; 0029-2001
ISSN (online)	0807-7096
ISSN	0029-2001
DOI	10.4045/tidsskr.17.0592
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Article ; Online: Systolic Blood Pressure, Diastolic Blood Pressure and Pulse Pressure and the Risk of Subclinical Myocardial Injury: The HUNT Study.

Young, Juliet / Lyngbakken, Magnus Nakrem / Hveem, Kristian / Røsjø, Helge / Omland, Torbjørn

Journal of the American Heart Association

2024 , Page(s) e031107

Abstract: Background: Subclinical myocardial injury expressed as higher cardiac troponin concentrations may represent an important intermediary between hypertension and the risk of cardiovascular disease. The study aimed to assess the relative strength of ... ...

Abstract	Background: Subclinical myocardial injury expressed as higher cardiac troponin concentrations may represent an important intermediary between hypertension and the risk of cardiovascular disease. The study aimed to assess the relative strength of associations between systolic blood pressure (BP), diastolic BP, and pulse pressure, and subclinical myocardial injury, and how change in BP variables over time associates with subclinical myocardial injury. Methods and results: cTnl (cardiac troponin I) was measured in 32 968 participants of the fourth wave of the population-based cohort HUNT4 (Trøndelag Health Study) without a history of cardiovascular disease. An additional longitudinal analysis included participants from HUNT4 with BP measurements from HUNT3 (n=18 681). Associations between BP variables and cTnI concentrations were assessed by linear and logistic regression analyses. The median cTnI concentration was 1.6 ng/L (25th-75th percentiles, 0.6-3.1 ng/L), median age was 52 years (39.1-65.6 years), and 57% were female subjects. Cross-sectionally, only systolic BP categories ≥130 mm Hg associated with higher cTnI concentrations, compared with a reference systolic BP of <110 mm Hg. All categories of diastolic BP and pulse pressure were positively associated with higher cTnI concentrations when diastolic BP 70 to 79 mm Hg and pulse pressure <40 mm Hg were used as references, respectively. When comparing systolic BP, diastolic BP, and pulse pressure as continuous variables, cross-sectionally, pulse pressure most strongly associated with cTnI concentrations ( Conclusions: Subjects with high pulse pressure and longitudinal increase in diastolic BP are at higher risk for subclinical myocardial injury.
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.031107
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Article ; Online: Subclinical Myocardial Injury and Risk of COVID-19 in the General Population: The Trøndelag Health Study.

Lyngbakken, Magnus Nakrem / Hveem, Kristian / Røsjø, Helge / Omland, Torbjørn

Clinical chemistry

2022 Volume 68, Issue 3, Page(s) 473–475

MeSH term(s)	Biomarkers ; COVID-19/epidemiology ; Heart Injuries/epidemiology ; Humans ; Norway/epidemiology ; SARS-CoV-2 ; Troponin I
Chemical Substances	Biomarkers ; Troponin I
Language	English
Publishing date	2022-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	80102-1
ISSN	1530-8561 ; 0009-9147
ISSN (online)	1530-8561
ISSN	0009-9147
DOI	10.1093/clinchem/hvab267
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Article ; Online: Mortality and length of hospital stay after bloodstream infections caused by ESBL-producing compared to non-ESBL-producing

Handal, Nina / Whitworth, Jimmy / Lyngbakken, Magnus Nakrem / Berdal, Jan Erik / Dalgard, Olav / Bakken Jørgensen, Silje

Infectious diseases (London, England)

2023 Volume 56, Issue 1, Page(s) 19–31

Abstract: Objective: To compare mortality and length of hospital stay between patients with ESBL-producing : Methods: A retrospective case-control study among adults admitted between 2014 and 2021 to a Norwegian University Hospital.: Results: A total of 468 ...

Abstract	Objective: To compare mortality and length of hospital stay between patients with ESBL-producing Methods: A retrospective case-control study among adults admitted between 2014 and 2021 to a Norwegian University Hospital. Results: A total of 468 Conclusion: There was no statistically significant difference in 30-day mortality in ESBL-producing
MeSH term(s)	Adult ; Humans ; Escherichia coli ; Length of Stay ; Escherichia coli Infections/drug therapy ; Retrospective Studies ; Case-Control Studies ; Bacteremia/drug therapy ; beta-Lactamases ; Risk Factors ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Sepsis/drug therapy
Chemical Substances	beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2839775-7
ISSN	2374-4243 ; 2374-4235
ISSN (online)	2374-4243
ISSN	2374-4235
DOI	10.1080/23744235.2023.2261538
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Article ; Online: Patterns of Cardiac Troponin I Concentrations as Risk Predictors of Cardiovascular Disease and Death: The Trøndelag Health Study.

Lyngbakken, Magnus Nakrem / Kimenai, Dorien M / Hveem, Kristian / Dalen, Håvard / Røsjø, Helge / Omland, Torbjørn

The American journal of medicine

2023 Volume 136, Issue 9, Page(s) 902–909.e4

Abstract: Background: Concentrations of cardiac troponin predict risk of cardiovascular disease and death in the general population. There is limited evidence on changing patterns of cardiac troponin in the years preceding cardiovascular events.: Methods: We ... ...

Abstract	Background: Concentrations of cardiac troponin predict risk of cardiovascular disease and death in the general population. There is limited evidence on changing patterns of cardiac troponin in the years preceding cardiovascular events. Methods: We analyzed cardiac troponin I (cTnI) with a high-sensitivity assay in 3272 participants in the Trøndelag Health (HUNT) Study at study visit 4 (2017-2019). Of these, 3198 had measurement of cTnI at study visit 2 (1995-1997), 2661 at study visit 3, and 2587 at all 3 study visits. We assessed the trajectories of cTnI concentrations in the years prior to cardiovascular events using a generalized linear mixed model, with adjustment for age, sex, cardiovascular risk factors, and comorbidities. Results: At HUNT4 baseline, median age was 64.8 (range 39.4-101.3) years, and 55% were women. Study participants who were admitted because of heart failure or died from cardiovascular cause on follow-up had a steeper increase in cTnI compared with study participants with no events (P < .001). The average yearly change in cTnI was 0.235 (95% confidence interval, 0.192-0.289) ng/L for study participants with heart failure or cardiovascular death, and -0.022 (95% confidence interval, -0.022 to -0.023) ng/L for study participants with no events. Study participants who experienced myocardial infarction, ischemic stroke, or noncardiovascular mortality exhibited similar cTnI patterns. Conclusions: Fatal and nonfatal cardiovascular events are preceded by slowly increasing concentrations of cardiac troponin, independently of established cardiovascular risk factors. Our results support the use of cTnI measurements to identify at-risk subjects who progress to subclinical and later overt cardiovascular disease.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Male ; Cardiovascular Diseases/epidemiology ; Troponin I ; Myocardial Infarction ; Heart Failure/epidemiology ; Ischemic Stroke ; Biomarkers
Chemical Substances	Troponin I ; Biomarkers
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2023.05.009
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Article ; Online: Tobacco Consumption and High-Sensitivity Cardiac Troponin I in the General Population: The HUNT Study.

Skranes, Julia Brox / Lyngbakken, Magnus Nakrem / Hveem, Kristian / Røsjø, Helge / Omland, Torbjørn

Journal of the American Heart Association

2022 Volume 11, Issue 2, Page(s) e021776

Abstract: Background Cardiac troponins represent a sensitive index of subclinical myocardial injury and are associated with increased risk of cardiovascular events in the general population. Despite positive associations with cardiovascular risk of both cardiac ... ...

Abstract	Background Cardiac troponins represent a sensitive index of subclinical myocardial injury and are associated with increased risk of cardiovascular events in the general population. Despite positive associations with cardiovascular risk of both cardiac troponins and cigarette smoking, concentrations of cardiac troponin I measured by high-sensitivity assays (hs-cTnI) are paradoxically lower in current smokers than in never-smokers. The impact of smoking intensity and time from smoking cessation on hs-cTnI remains unknown. Methods and Results hs-cTnI concentrations were measured in 32028 subjects free from cardiovascular disease enrolled in the prospective, population-based HUNT (Trøndelag Health Study). Tobacco habits were self-reported and classified as never (n=14 559), former (n=14 248), and current (n=3221) smokers. Current smokers exhibited significantly lower concentrations of hs-cTnI than never-smokers (
MeSH term(s)	Biomarkers ; Cardiovascular Diseases ; Humans ; Prospective Studies ; Tobacco Use ; Troponin I ; Troponin T
Chemical Substances	Biomarkers ; Troponin I ; Troponin T
Language	English
Publishing date	2022-01-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.021776
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Article ; Online: Pragmatic trials - what are they?

Lyngbakken, Magnus Nakrem / Paulsen, Aksel / Sethupathy, Ashwini / Hesselberg, Øyvind / Grimsgaard, Sameline / Hagen, Knut

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

2021 Volume 141, Issue 2021-14

Abstract: Pragmatic clinical trials are based on data from unselected patients recruited from common clinical practice. These trials therefore bridge the gap between evidence-based medicine and clinical practice. ...

Title translation	Pragmatiske studier – hva er det?
Abstract	Pragmatic clinical trials are based on data from unselected patients recruited from common clinical practice. These trials therefore bridge the gap between evidence-based medicine and clinical practice.
MeSH term(s)	Humans ; Research Design
Language	Norwegian
Publishing date	2021-10-11
Publishing country	Norway
Document type	Journal Article
ZDB-ID	603504-8
ISSN	0807-7096 ; 0029-2001
ISSN (online)	0807-7096
ISSN	0029-2001
DOI	10.4045/tidsskr.21.0490
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Article ; Online: Cardiac Troponin T and NT-proBNP for Prediction of 30-Day Readmission or Death in Patients with Acute Dyspnea: Data from the Akershus Cardiac Examination 2 Study.

Bhatnagar, Rahul / Berge, Kristian / Røysland, Ragnhild / Høiseth, Arne Didrik / Brynildsen, Jon / Christensen, Geir / Omland, Torbjørn / Røsjø, Helge / Lyngbakken, Magnus Nakrem

Cardiology

2023 Volume 148, Issue 6, Page(s) 506–516

Abstract: Introduction: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) measurements are recommended in patients with acute dyspnea. We aimed to assess the prognostic merit of cTnT compared to NT-proBNP for 30-day readmission ... ...

Abstract	Introduction: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) measurements are recommended in patients with acute dyspnea. We aimed to assess the prognostic merit of cTnT compared to NT-proBNP for 30-day readmission or death in patients hospitalized with acute dyspnea. Methods: We measured cTnT and NT-proBNP within 24 h in 314 patients hospitalized with acute dyspnea and adjudicated the cause of the index admission. Time to first event of readmission or death ≤30 days after hospital discharge was recorded, and cTnT and NT-proBNP measurements were compared head-to-head. Results: Patients who died (12/314) or were readmitted (71/314) within 30 days had higher cTnT concentrations (median: 32.6, Q1-Q3: 18.4-74.2 ng/L vs. median: 19.4, Q1-Q3: 8.4-36.1 ng/L; p for comparison <0.001) and NT-proBNP concentrations (median: 1,753.6, Q1-Q3: 464.2-6,862.0 ng/L vs. median 984, Q1-Q3 201-3,600 ng/L; for comparison p = 0.027) compared to patients who survived and were not readmitted. cTnT concentrations were associated with readmission or death within 30 days after discharge both in the total cohort (adjusted hazard ratio [aHR]: 1.64, 95% confidence interval [CI]: 1.30-2.05) and in patients with heart failure (HF) (aHR: 1.58, 95% CI: 1.14-2.18). In contrast, NT-proBNP concentrations were not associated with short-term events, neither in the total cohort (aHR: 1.10, 95% CI: 0.94-1.30) nor in patients with adjudicated HF (aHR: 1.06, 95% CI: 0.80-1.40). Conclusion: cTnT concentrations are associated with 30-day readmission or death in patients hospitalized with acute dyspnea, as well as in patients adjudicated HF.
MeSH term(s)	Troponin T/blood ; Troponin T/metabolism ; Natriuretic Peptide, Brain/blood ; Natriuretic Peptide, Brain/metabolism ; Patient Readmission/statistics & numerical data ; Dyspnea/blood ; Dyspnea/diagnosis ; Dyspnea/mortality ; Predictive Value of Tests ; Humans ; Male ; Female ; Middle Aged ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Biomarkers/metabolism ; Kaplan-Meier Estimate
Chemical Substances	TNNT2 protein, human ; Troponin T ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0) ; Biomarkers
Language	English
Publishing date	2023-08-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	80092-2
ISSN	1421-9751 ; 0008-6312
ISSN (online)	1421-9751
ISSN	0008-6312
DOI	10.1159/000533266
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Article: Treatable Traits in Misdiagnosed Chronic Obstructive Pulmonary Disease: Data from the Akershus Cardiac Examination 1950 Study.

Caspersen, Nina Faksvåg / Søyseth, Vidar / Lyngbakken, Magnus Nakrem / Berge, Trygve / Ariansen, Inger / Tveit, Arnljot / Røsjø, Helge / Einvik, Gunnar

Chronic obstructive pulmonary diseases (Miami, Fla.)

2022 Volume 9, Issue 2, Page(s) 165–180

Abstract: Background: Chronic obstructive pulmonary disease (COPD) is often misdiagnosed. We aimed to estimate the prevalence of misdiagnosed COPD in middle-aged Norwegians, and to assess potentially treatable clinical traits in over- and undiagnosed individuals.! ...

Abstract	Background: Chronic obstructive pulmonary disease (COPD) is often misdiagnosed. We aimed to estimate the prevalence of misdiagnosed COPD in middle-aged Norwegians, and to assess potentially treatable clinical traits in over- and undiagnosed individuals. Methods and findings: The Akershus Cardiac Examination (ACE) 1950 Study is a population-based study of the 1950 birth cohort of Akershus county including 3706 participants aged 62-65 years at baseline. COPD was defined as a forced expiratory volume in 1 second (FEV Conclusion: Both over- and underdiagnosis of COPD is frequent. Undiagnosed individuals have better lung function and less symptoms, but similar prevalence of comorbidities and systemic inflammation. Overdiagnosed individuals have treatable traits including asthma, eosinophilic inflammation, and sleep apnea. The main predictor of being overdiagnosed was being overweight.
Language	English
Publishing date	2022-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2771715-X
ISSN	2372-952X
ISSN	2372-952X
DOI	10.15326/jcopdf.2021.0265
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Article ; Online: Lifetime obesity trends are associated with subclinical myocardial injury: The Trøndelag health study.

Lyngbakken, Magnus Nakrem / de Lemos, James A / Hveem, Kristian / Røsjø, Helge / Omland, Torbjørn

Journal of internal medicine

2021 Volume 291, Issue 3, Page(s) 317–326

Abstract: Background: Obesity is associated with subclinical myocardial injury as quantified by concentrations of cardiac troponin T, but whether lifetime excess weight history is associated with increased concentrations of cardiac troponin I (cTnI) and how ... ...

Abstract	Background: Obesity is associated with subclinical myocardial injury as quantified by concentrations of cardiac troponin T, but whether lifetime excess weight history is associated with increased concentrations of cardiac troponin I (cTnI) and how indices of abdominal adiposity and glycemic dysregulation affect these associations remain unclear. Methods: We analyzed cTnI with a high-sensitivity assay in 9739 participants in the Trøndelag Health (HUNT) Study at study visit 4 (2017-2019). BMI was assessed at study Visit 1 (1984-1986), 2 (1995-1997), 3 (2006-2008), and 4. Results: Median age at visit 4 was 68.7 years and 59% were women. Concentrations of cTnI were detectable in 84.1% of study participants, with a median of 2.5 (1.5-4.5 ng/L). We identified three clusters of BMI trajectories from visit 1 to 4, (1) stable normal weight, (2) stable overweight, and (3) stable obesity. Participants in clusters 2 and 3 were at increased risk of elevated concentrations of cTnI at visit 4 (odds ratio 1.27, 95% CI 1.09-1.47, and odds ratio 1.70, 95% CI 1.33-2.17, p for trend <0.001). Participants in cluster 3 had 22.0 (95% CI 14.1-29.9) higher concentrations of cTnI compared to participants in cluster 1 (p for trend <0.001). Dysregulated glucose metabolism and abdominal obesity did not influence our results. Conclusions: Individuals with stable overweight or obesity are at increased risk of subclinical myocardial injury, independently of glycemic dysregulation and abdominal adiposity. Our data support a direct detrimental effect of long-standing obesity on cardiovascular health.
MeSH term(s)	Biomarkers/metabolism ; Female ; Heart Failure/complications ; Humans ; Obesity/complications ; Obesity/epidemiology ; Odds Ratio ; Troponin I ; Troponin T
Chemical Substances	Biomarkers ; Troponin I ; Troponin T
Language	English
Publishing date	2021-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13391
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