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Article ; Online: A Practical Review of the Presentation, Diagnosis, and Management of Cutaneous B-Cell Lymphomas.

Goyal, Nikhil / O'Leary, Daniel / Carter, Joi B / Comfere, Nneka / Sokumbi, Olayemi / Goyal, Amrita

2022 Volume 41, Issue 1, Page(s) 187–208

Abstract: This review of cutaneous B-cell lymphoma (CBCL) is focused on the clinical presentation, treatment ...

Abstract	This review of cutaneous B-cell lymphoma (CBCL) is focused on the clinical presentation, treatment, and workup of each type of lymphoma. Part 1 is an overview of each of the CBCLs, including clinical presentation, recent advances in the pathobiology, and evidence regarding treatment strategies. Part 2 is a detailed guide to the steps in diagnosis and workup of a newly diagnosed CBCL according to the International Society for Cutaneous Lymphoma/European Organization for Research and Treatment of Cancer and NCCN guidelines.
MeSH term(s)	Humans ; Female ; Skin Neoplasms/diagnosis ; Skin Neoplasms/therapy ; Breast Neoplasms ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/therapy
Language	English
Publishing date	2022-10-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	82798-8
ISSN	1558-0520 ; 0733-8635
ISSN (online)	1558-0520
ISSN	0733-8635
DOI	10.1016/j.det.2022.07.014
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Article ; Online: Cutaneous B-Cell Lymphoma.

Goyal, Amrita / LeBlanc, Robert E / Carter, Joi B

Hematology/oncology clinics of North America

2018 Volume 33, Issue 1, Page(s) 149–161

Abstract: Primary cutaneous B-cell lymphomas are non-Hodgkin lymphomas that present in the skin ... without evidence of extracutaneous involvement at diagnosis. There are 3 types of primary cutaneous B-cell ... cutaneous diffuse large B-cell lymphoma, leg-type. Because it is most frequently diagnosed on skin biopsy ...

Abstract	Primary cutaneous B-cell lymphomas are non-Hodgkin lymphomas that present in the skin without evidence of extracutaneous involvement at diagnosis. There are 3 types of primary cutaneous B-cell lymphomas: primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg-type. Because it is most frequently diagnosed on skin biopsy, intravascular large B-cell lymphoma is commonly included with pcBCL. A complicating factor in diagnosing primary cutaneous B-cell lymphomas is that they can appear histologically identical to their extracutaneous counterparts. This review summarizes the clinical presentation, histopathology, evaluation, treatment, and differential diagnosis of these lymphomas.
MeSH term(s)	Biopsy ; Diagnosis, Differential ; Disease Management ; Disease Susceptibility ; Humans ; Immunohistochemistry ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/etiology ; Lymphoma, B-Cell/therapy ; Neoplasm Staging ; Prognosis ; Skin/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/etiology ; Skin Neoplasms/therapy
Language	English
Publishing date	2018-11-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	93115-9
ISSN	1558-1977 ; 0889-8588
ISSN (online)	1558-1977
ISSN	0889-8588
DOI	10.1016/j.hoc.2018.08.006
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Article ; Online: Interview with a Retrovirologist: Sebla B. Kutluay in conversation with Carol Carter.

Carter, Carol / Kutluay, Sebla B

Retrovirology

2021 Volume 18, Issue 1, Page(s) 18

MeSH term(s)	Female ; Humans ; Interviews as Topic ; Laboratory Personnel ; Research ; Retroviridae
Language	English
Publishing date	2021-07-01
Publishing country	England
Document type	Interview
ISSN	1742-4690
ISSN (online)	1742-4690
DOI	10.1186/s12977-021-00562-4
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Article: Treatment of Relapsed B/T-cell Mixed Phenotype Acute Leukemia With Blinatumomab.

Abdo, Yasmeen / Gibson, Geoffrey D / Jain, Sarika P / Milner, Carter P / Hilal, Talal

Cureus

2023 Volume 15, Issue 6, Page(s) e40661

Abstract: Here, we describe the treatment of a patient with relapsed/refractory B/T mixed phenotype acute ... by the FDA for relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL). A 64-year-old man ... with a history of stage 3 chronic kidney disease and type 2 diabetes mellitus was discovered to have B/T MPAL ...

Abstract	Here, we describe the treatment of a patient with relapsed/refractory B/T mixed phenotype acute leukemia (MPAL) using blinatumomab monotherapy, the first bispecific T cell engager (BiTE) approved by the FDA for relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL). A 64-year-old man with a history of stage 3 chronic kidney disease and type 2 diabetes mellitus was discovered to have B/T MPAL on bone marrow biopsy during hospitalization for dyspnea due to pulmonary embolism. The patient achieved brief remission with blinatumomab treatment before succumbing to neutropenic sepsis. The lack of sufficient data to guide therapy in MPAL remains a challenge, highlighting the potential of new targeted approaches such as blinatumomab to improve outcomes in relapsed/refractory MPAL.
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.40661
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Article ; Online: Generation of recombinant hyperimmune globulins from diverse B-cell repertoires.

Keating, Sheila M / Mizrahi, Rena A / Adams, Matthew S / Asensio, Michael A / Benzie, Emily / Carter, Kyle P / Chiang, Yao / Edgar, Robert C / Gautam, Bishal K / Gras, Ashley / Leong, Jackson / Leong, Renee / Lim, Yoong Wearn / Manickam, Vishal A / Medina-Cucurella, Angelica V / Niedecken, Ariel R / Saini, Jasmeen / Simons, Jan Fredrik / Spindler, Matthew J /

Stadtmiller, Kacy / Tinsley, Brendan / Wagner, Ellen K / Wayham, Nicholas / Tracy, LaRee / Lundberg, Carina Vingsbo / Büscher, Dirk / Terencio, Jose Vicente / Roalfe, Lucy / Pearce, Emma / Richardson, Hayley / Goldblatt, David / Ramjag, Anushka T / Carrington, Christine V F / Simmons, Graham / Muench, Marcus O / Chamow, Steven M / Monroe, Bryan / Olson, Charles / Oguin, Thomas H / Lynch, Heather / Jeanfreau, Robert / Mosher, Rachel A / Walch, Matthew J / Bartley, Christopher R / Ross, Carl A / Meyer, Everett H / Adler, Adam S / Johnson, David S

Nature biotechnology

2021 Volume 39, Issue 8, Page(s) 989–999

Abstract: Plasma-derived polyclonal antibody therapeutics, such as intravenous immunoglobulin, have multiple drawbacks, including low potency, impurities, insufficient supply and batch-to-batch variation. Here we describe a microfluidics and molecular genomics ... ...

Abstract	Plasma-derived polyclonal antibody therapeutics, such as intravenous immunoglobulin, have multiple drawbacks, including low potency, impurities, insufficient supply and batch-to-batch variation. Here we describe a microfluidics and molecular genomics strategy for capturing diverse mammalian antibody repertoires to create recombinant multivalent hyperimmune globulins. Our method generates of diverse mixtures of thousands of recombinant antibodies, enriched for specificity and activity against therapeutic targets. Each hyperimmune globulin product comprised thousands to tens of thousands of antibodies derived from convalescent or vaccinated human donors or from immunized mice. Using this approach, we generated hyperimmune globulins with potent neutralizing activity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in under 3 months, Fc-engineered hyperimmune globulins specific for Zika virus that lacked antibody-dependent enhancement of disease, and hyperimmune globulins specific for lung pathogens present in patients with primary immune deficiency. To address the limitations of rabbit-derived anti-thymocyte globulin, we generated a recombinant human version and demonstrated its efficacy in mice against graft-versus-host disease.
MeSH term(s)	Animals ; Antibodies, Viral/immunology ; B-Lymphocytes/immunology ; CHO Cells ; COVID-19/therapy ; Cricetulus ; Enzyme-Linked Immunosorbent Assay ; Globulins/biosynthesis ; Globulins/immunology ; Humans ; Immunization, Passive ; Mice ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/immunology ; SARS-CoV-2/immunology ; Zika Virus/immunology
Chemical Substances	Antibodies, Viral ; Globulins ; Recombinant Proteins
Language	English
Publishing date	2021-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1311932-1
ISSN	1546-1696 ; 1087-0156
ISSN (online)	1546-1696
ISSN	1087-0156
DOI	10.1038/s41587-021-00894-8
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Article ; Online: CRISPR-Cas9 Targeting of Hepatitis B Virus Covalently Closed Circular DNA Generates Transcriptionally Active Episomal Variants.

Martinez, Maria Guadalupe / Combe, Emmanuel / Inchauspe, Aurore / Mangeot, Philippe Emmanuel / Delberghe, Elodie / Chapus, Fleur / Neveu, Gregory / Alam, Antoine / Carter, Kara / Testoni, Barbara / Zoulim, Fabien

mBio

2022 Volume 13, Issue 2, Page(s) e0288821

Abstract: Chronic hepatitis B virus (HBV) infection persists due to the lack of therapies that effectively ...

Abstract	Chronic hepatitis B virus (HBV) infection persists due to the lack of therapies that effectively target the HBV covalently closed circular DNA (cccDNA). We used HBV-specific guide RNAs (gRNAs) and CRISPR-Cas9 and determined the fate of cccDNA after gene editing. We set up a ribonucleoprotein (RNP) delivery system in HBV-infected HepG2-NTCP cells. HBV parameters after Cas9 editing were analyzed. Southern blot (SB) analysis and DNA/RNA sequencing (DNA/RNA-seq) were performed to determine the consequences of cccDNA editing and transcriptional activity of mutated cccDNA. Treatment of infected cells with HBV-specific gRNAs showed that CRISPR-Cas9 can efficiently affect HBV replication. The appearance of episomal HBV DNA variants after dual gRNA treatment was observed by PCR, SB analysis, and DNA/RNA-seq. These transcriptionally active variants are the products of simultaneous Cas9-induced double-strand breaks in two target sites, followed by repair and religation of both short and long fragments. Following suppression of HBV DNA replicative intermediates by nucleoside analogs, mutations and formation of smaller transcriptionally active HBV variants were still observed, suggesting that established cccDNA is accessible to CRISPR-Cas9 editing. Targeting HBV DNA with CRISPR-Cas9 leads to cleavage followed by appearance of episomal HBV DNA variants. Effects induced by Cas9 were sustainable after RNP degradation/loss of detection, suggesting permanent changes in the HBV genome instead of transient effects due to transcriptional interference.
MeSH term(s)	CRISPR-Cas Systems ; DNA, Circular/genetics ; DNA, Viral/genetics ; Hepatitis B virus/genetics ; Hepatitis B, Chronic/drug therapy ; Humans ; RNA, Guide, CRISPR-Cas Systems/genetics
Chemical Substances	DNA, Circular ; DNA, Viral ; RNA, Guide, CRISPR-Cas Systems
Language	English
Publishing date	2022-04-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.02888-21
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Article: B Cell Responses upon Human Papillomavirus (HPV) Infection and Vaccination.

Prabhu, Priya R / Carter, Joseph J / Galloway, Denise A

Vaccines

2022 Volume 10, Issue 6

Abstract: ... attained through generation and maintenance of a class of B cells named memory B cells (Bmem). Both LLPCs ... knowledge of B-cell responses following HPV vaccination and natural infection, including molecular ...

Abstract	Infection with human papillomavirus (HPV) is the necessary cause of cervical cancer. Availability of vaccines against HPV makes it a highly preventable disease. HPV vaccines act through type-specific neutralizing antibodies produced by antigen-specific plasma cells known as long-lived plasma cells (LLPC). However, just as any other vaccine, success of HPV vaccine is attributed to the immunologic memory that it builds, which is largely attained through generation and maintenance of a class of B cells named memory B cells (Bmem). Both LLPCs and Bmems are important in inducing and maintaining immune memory and it is therefore necessary to understand their role after HPV vaccination to better predict outcomes. This review summarizes current knowledge of B-cell responses following HPV vaccination and natural infection, including molecular signatures associated with these responses.
Language	English
Publishing date	2022-05-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10060837
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Article ; Online: Transcriptional analysis links B cells and TERT expression to favorable prognosis in head and neck cancer.

Xian, Su / Dosset, Magalie / Castro, Andrea / Carter, Hannah / Zanetti, Maurizio

PNAS nexus

2023 Volume 2, Issue 3, Page(s) pgad046

Abstract: ... and B and T cell infiltrate in the tumor microenvironment. We found a positive correlation between ... TERT expression, B and T cells in four cancer types with the strongest association in head and neck ... squamous cell carcinoma (HSNCC). In HNSCC a B ...

Abstract	Telomerase reverse transcriptase (TERT) is a conserved self-tumor antigen overexpressed in ∼85% of tumor cells and is immunogenic in cancer patients. The effect of TERT expression on the regulation of intratumor adaptive immunity has not yet been investigated. We used RNA sequencing data from The Cancer Genome Atlas (TCGA) in 11 solid tumor types to investigate potential interactions between TERT expression, and B and T cell infiltrate in the tumor microenvironment. We found a positive correlation between TERT expression, B and T cells in four cancer types with the strongest association in head and neck squamous cell carcinoma (HSNCC). In HNSCC a B
Language	English
Publishing date	2023-02-10
Publishing country	England
Document type	Journal Article
ISSN	2752-6542
ISSN (online)	2752-6542
DOI	10.1093/pnasnexus/pgad046
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Article ; Online: "Putting the power back into community": A mixed methods evaluation of a chronic hepatitis B training course for the Aboriginal health workforce of Australia's Northern Territory.

PloS one

2024 Volume 19, Issue 1, Page(s) e0288577

Abstract: Background: Chronic hepatitis B (CHB) is endemic in the Aboriginal and Torres Strait Islander ... living with CHB. We co-designed and delivered a culturally safe "Managing hepatitis B" training course ... hepatitis B" training course. 3. To enable participants to have the skills and confidence to be part ...

Abstract	Background: Chronic hepatitis B (CHB) is endemic in the Aboriginal and Torres Strait Islander population of Australia's Northern Territory. Progression to liver disease can be prevented if holistic care is provided. Low health literacy amongst health professionals is a known barrier to caring for people living with CHB. We co-designed and delivered a culturally safe "Managing hepatitis B" training course for the Aboriginal health workforce. Here, we present an evaluation of the course. Objectives: 1. To improve course participants CHB-related knowledge, attitudes, and clinical practice. 2. To evaluate the "Managing hepatitis B" training course. 3. To enable participants to have the skills and confidence to be part of the care team. Methods: We used participatory action research and culturally safe principles. We used purpose-built quantitative and qualitative evaluation tools to evaluate our "Managing hepatitis B" training course. We integrated the two forms of data, deductively analysing codes, grouped into categories, and assessed pedagogical outcomes against Kirkpatrick's training evaluation framework. Results: Eight courses were delivered between 2019 and 2023, with 130 participants from 32 communities. Pre- and post-course questionnaires demonstrated statistically significant improvements in all domains, p<0.001 on 93 matched pairs. Thematic network analysis demonstrated high levels of course acceptability and significant knowledge acquisition. Other themes identified include cultural safety, shame, previous misinformation, and misconceptions about transmission. Observations demonstrate improvements in post-course engagement, a deep understanding of CHB as well as increased participation in clinical care teams. Conclusions: The "Managing hepatitis B" training course led to a sustained improvement in the knowledge and attitudes of the Aboriginal health workforce, resulting in improved care and treatment uptake for people living with CHB. Important non-clinical outcomes included strengthening teaching and leadership skills, and empowerment.
MeSH term(s)	Humans ; Health Services, Indigenous ; Health Workforce ; Hepatitis B, Chronic ; Northern Territory ; Australian Aboriginal and Torres Strait Islander Peoples ; Education, Medical, Continuing
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0288577
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Article ; Online: Natural-Product-Inspired Compounds as Countermeasures against the Liver Carcinogen Aflatoxin B

Carter, Adam C / King, Jarrod B / Mattes, Allison O / Cai, Shengxin / Singh, Narender / Cichewicz, Robert H

Journal of natural products

2019 Volume 82, Issue 6, Page(s) 1694–1703

Abstract: Aflatoxin B ...

Abstract	Aflatoxin B
MeSH term(s)	Aflatoxin B1/chemistry ; Aflatoxin B1/pharmacology ; Aflatoxin B1/toxicity ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Biological Products/pharmacology ; Carcinogens/chemistry ; Carcinogens/toxicity ; Hepatocytes/chemistry ; Hepatocytes/drug effects ; Humans ; Liver/chemistry ; Liver/drug effects ; Molecular Structure ; Protective Agents/chemistry ; Protective Agents/pharmacology
Chemical Substances	Antineoplastic Agents, Phytogenic ; Biological Products ; Carcinogens ; Protective Agents ; Aflatoxin B1 (9N2N2Y55MH)
Language	English
Publishing date	2019-05-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.9b00290
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