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  1. Book ; Online ; E-Book: Pocket companion to Robbins and Cotran pathologic basis of disease

    Mitchell, Richard N. / Kumar, Vinay / Abbas, Abul K. / Aster, Jon C.

    (Robbins pathology series)

    2023  

    Author's details Richard N. Mitchell, Vinay Kumar, Abul K. Abbas, Jon C. Aster ; with illustrations by James A. Perkins
    Series title Robbins pathology series
    Keywords Pathology ; Electronic books
    Language English
    Size 1 Online-Ressource (xii, 1028 Seiten), Illustrationen, Diagramme
    Edition Tenth edition
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030639086
    ISBN 978-0-323-82563-4 ; 9780323653909 ; 0-323-82563-X ; 0323653901
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book: Robbins & Kumar basic pathology

    DAs, Abhijit / Robbins, Stanley L. / Kumar, Vinay / Abbas, Abul K. / Aster, Jon C. / Deyrup, Andrea T.

    2023  

    Title variant Basic pathology
    Author's details Vinay Kumar, Abul K. Abbas, Jon C. Aster, Andrea T. Deyrup, Abhijit Das
    Keywords Pathology
    Subject code 616.07
    Language English
    Size ix, 828 Seiten, Illustrationen, 29 cm
    Edition Eleventh edition
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    Note Zugang zur Online-Ausgabe über Code ; Includes bibliographical references and index
    HBZ-ID HT021732088
    ISBN 978-0-323-79018-5 ; 0-323-79018-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 A 281 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  3. Article ; Online: What is in a Name? Consequences of the Classification Schism in Hematopathology.

    Aster, Jon C

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 41, Issue 8, Page(s) 1523–1526

    Language English
    Publishing date 2022-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

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  4. Book ; Online ; E-Book: Pathophysiology of blood disorders

    Bunn, H. Franklin / Aster, Jon C.

    2017  

    Author's details Jon C. Aster, MD, PhD, Professor, Department of Pathology, Harvard Medical School, Staff Pathologist, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, H. Franklin Bunn, MD, Professor of Medicine, Harvard Medical School, Hematology Division, Brigham and Woman's Hospital, Boston, Massachusetts
    MeSH term(s) Hematologic Diseases/physiopathology. ; Blood Physiological Phenomena.
    Subject code 616.1/5
    Language English
    Edition 2nd edition
    Publisher McGraw-Hill Education
    Publishing place New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-1-25-964206-7 ; 1-259-64206-2 ; 1-25-964206-2 ; 978-1-259-64206-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  5. Article: NOTCH SIGNALING IN CONTEXT: BASIC AND TRANSLATIONAL IMPLICATIONS.

    Aster, Jon C

    Transactions of the American Clinical and Climatological Association

    2020  Volume 131, Page(s) 147–156

    Abstract: Notch receptors participate is a highly conserved signaling pathway that regulates numerous facets of cellular behavior, has protean roles during development and in adult tissue homeostasis, and is frequently dysregulated in human diseases, particularly ... ...

    Abstract Notch receptors participate is a highly conserved signaling pathway that regulates numerous facets of cellular behavior, has protean roles during development and in adult tissue homeostasis, and is frequently dysregulated in human diseases, particularly cancer. These relationships to disease and the ability to modulate Notch signaling at multiple levels have engendered attempts to target Notch therapeutically, but incomplete understanding of the outcomes of Notch activation and on-target toxicity have stymied efforts to date. Using well-controlled experimental systems, we have pursued studies that seek to understand how Notch influences the behavior of different types of cancer cells. Our work suggests that Notch effects are defined by epigenetic landscapes that are "laid out" by upstream pioneer transcription factors, which act to delineate the outcome of Notch activation. These insights define some of the "rules" that govern Notch functions and constitute one step toward bringing safe and effective targeting of Notch to fruition.
    Language English
    Publishing date 2020-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603823-2
    ISSN 0065-7778
    ISSN 0065-7778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 4: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: Robbins basic pathology

    Perkins, James A. / Robbins, Stanley L. / Kumar, Vinay / Abbas, Abul K. / Aster, Jon C.

    2018  

    Title variant Basic pathology
    Author's details Vinay Kumar (MBBS, MD FRCPath), Abul K. Abbas (MBBS), Jon C. Aster (MD, PhD) ; artist: James A. Perkins (MS, MFA)
    Keywords Pathologie
    Subject Allgemeine Pathologie ; Spezielle Pathologie ; Klinische Pathologie ; Allgemeine Krankheitslehre
    Language English
    Size xiv, 935 Seiten, Illustrationen, Diagramme
    Edition Tenth edition
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT019461959
    ISBN 978-0-323-35317-5 ; 978-0-323-48054-3 ; 0-323-35317-7 ; 0-323-48054-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 1871 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  7. Book: Hematopathology

    Aster, Jon C. / Pozdnyakova, Olga / Kutok, Jeffrey L.

    (High-yield pathology ; ExpertConsult.com)

    2013  

    Author's details Jon C. Aster ; Olga Pozdnyakova ; Jeffrey L. Kutok
    Series title High-yield pathology
    ExpertConsult.com
    Keywords Hematologic Diseases / pathology
    Language English
    Size XVII, 299 S. : zahlr. Ill.
    Publisher Elsevier Saunders
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    Note Includes index
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT017680722
    ISBN 978-1-4377-1758-7 ; 1-4377-1758-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 1446 available for loan (reading room) Lesesaal EG
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book: Pathophysiology of blood disorders

    Bunn, Howard Franklin / Aster, Jon C.

    (A Lange medical book)

    2011  

    Author's details H. Franklin Bunn ; Jon C. Aster
    Series title A Lange medical book
    Keywords Hematologic Diseases / physiopathology ; Blood Physiological Phenomena ; Blood--Diseases
    Subject code 616.1507
    Language English
    Size IX, 342 S. : zahlr. Ill., graph. Darst.
    Publisher McGraw-Hill Med
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016766494
    ISBN 978-0-07-171378-8 ; 0-07-171378-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 1209 order for loan Magazin

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  9. Article ; Online: Notch signaling in cancer: Complexity and challenges on the path to clinical translation.

    Ferreira, Antonio / Aster, Jon C

    Seminars in cancer biology

    2021  Volume 85, Page(s) 95–106

    Abstract: Notch receptors participate in a conserved pathway in which ligands expressed on neighboring cells trigger a series of proteolytic cleavages that allow the intracellular portion of the receptor to travel to the nucleus and form a short-lived ... ...

    Abstract Notch receptors participate in a conserved pathway in which ligands expressed on neighboring cells trigger a series of proteolytic cleavages that allow the intracellular portion of the receptor to travel to the nucleus and form a short-lived transcription complex that turns on target gene expression. The directness and seeming simplicity of this signaling mechanism belies the complexity of the outcomes of Notch signaling in normal cells, which are highly context and dosage dependent. This complexity is reflected in the diverse roles of Notch in cancers of various types, in which Notch may be oncogenic or tumor suppressive and may have a wide spectrum of effects on tumor cells and stromal elements. This review provides an overview of the roles of Notch in cancer and discusses challenges to clinical translation of Notch targeting agents as well as approaches that may overcome these hurdles.
    MeSH term(s) Humans ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Signal Transduction ; Neoplasms/genetics ; Neoplasms/metabolism ; Oncogenes ; Ligands
    Chemical Substances Receptors, Notch ; Ligands
    Language English
    Publishing date 2021-04-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2021.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2922: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Structural Requirements for Activity of Mind bomb1 in Notch Signaling.

    Cao, Ruili / Gozlan, Oren / Tveriakhina, Lena / Zhou, Haixia / Jiang, Hanjie / Cole, Philip A / Aster, Jon C / Sprinzak, David / Blacklow, Stephen C

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Mind bomb 1 (MIB1) is a RING E3 ligase that ubiquitinates Notch ligands, a necessary step for induction of Notch signaling. The structural basis for binding of the JAG1 ligand by the N-terminal region of MIB1 is known, yet how the ankyrin (ANK) and RING ... ...

    Abstract Mind bomb 1 (MIB1) is a RING E3 ligase that ubiquitinates Notch ligands, a necessary step for induction of Notch signaling. The structural basis for binding of the JAG1 ligand by the N-terminal region of MIB1 is known, yet how the ankyrin (ANK) and RING domains of MIB1 cooperate to catalyze ubiquitin transfer from E2~Ub to Notch ligands remains unclear. Here, we show that the third RING domain and adjacent coiled coil region of MIB1 (ccRING3) drives MIB1 dimerization and that ubiquitin transfer activity of MIB1 relies solely on RING3. We report x-ray crystal structures of a UbcH5B-ccRING3 complex as a fusion protein and of the ANK region. Directly tethering the N-terminal region to ccRING3 forms a minimal MIB1 protein, which is sufficient to induce a Notch response in receiver cells. Together, these studies define the functional elements of an E3 ligase needed for ligands to induce a Notch signaling response.
    Language English
    Publishing date 2024-03-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.01.582834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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