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Article ; Online: Notch and Wnt signaling, physiological stimuli and postnatal myogenesis.

Tsivitse, Susan

International journal of biological sciences

2010 Volume 6, Issue 3, Page(s) 268–281

Abstract: Adult skeletal muscle stem cells, termed satellite cells are imperative to muscle regeneration. Much work has been performed on satellite cell identification and the subsequent activation of the myogenic response but the regulation of satellite cells ... ...

Abstract	Adult skeletal muscle stem cells, termed satellite cells are imperative to muscle regeneration. Much work has been performed on satellite cell identification and the subsequent activation of the myogenic response but the regulation of satellite cells including its activation is not well elucidated. The purpose of this review article is to synthesize what the literature reveals in regards to the current understanding of satellite cells including their contribution to muscle repair and growth following physiological stimuli. In addition, this review article will describe the recent findings on the roles of the classic developmental signaling pathways, Notch and Wnt, to the myogenic response in various muscle injury models. This purpose of this summary is to bring awareness of the impact that muscle contraction models have on the local and systemic environment of adult muscle stem cells which will be beneficial for comprehending and treatment development for muscle -associated ailments and other organ diseases.
MeSH term(s)	Animals ; Humans ; Muscle Development/physiology ; Muscle, Skeletal/cytology ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiology ; Muscular Diseases/metabolism ; Muscular Diseases/therapy ; Myoblasts/metabolism ; Satellite Cells, Perineuronal/metabolism ; Signal Transduction/physiology
Language	English
Publishing date	2010-05-15
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.6.268
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Editorial

Yuji Ogura / Shuichi Sato / Yann S. Gallot / Susan Tsivitse Arthur

Frontiers in Cell and Developmental Biology, Vol

Emerging Mechanisms for Skeletal Muscle Mass Regulation

2021 Volume 9

Keywords	myocyte ; signaling ; cancer ; homeostasis ; myogenesis ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Editorial: Emerging Mechanisms for Skeletal Muscle Mass Regulation.

Ogura, Yuji / Sato, Shuichi / Gallot, Yann S / Arthur, Susan Tsivitse

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 764095

Language	English
Publishing date	2021-09-27
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.764095
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Article ; Online: Notch and Wnt Signaling, Physiological Stimuli and Postnatal Myogenesis

Susan Tsivitse

International Journal of Biological Sciences, Vol 6, Iss 3, Pp 268-

2010 Volume 281

Abstract	Adult skeletal muscle stem cells, termed satellite cells are imperative to muscle regeneration. Much work has been performed on satellite cell identification and the subsequent activation of the myogenic response but the regulation of satellite cells including its activation is not well elucidated. The purpose of this review article is to synthesize what the literature reveals in regards to the current understanding of satellite cells including their contribution to muscle repair and growth following physiological stimuli. In addition, this review article will describe the recent findings on the roles of the classic developmental signaling pathways, Notch and Wnt, to the myogenic response in various muscle injury models. This purpose of this summary is to bring awareness of the impact that muscle contraction models have on the local and systemic environment of adult muscle stem cells which will be beneficial for comprehending and treatment development for muscle -associated ailments and other organ diseases.
Keywords	Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2010-01-01T00:00:00Z
Publisher	Ivyspring International Publisher
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Effect of Physiological Stimuli on Sarcopenia; Impact of Notch and Wnt Signaling on Impaired Aged Skeletal Muscle Repair

Susan Tsivitse Arthur, Ian D. Cooley

International Journal of Biological Sciences, Vol 8, Iss 5, Pp 731-

2012 Volume 760

Abstract: The age-related loss of skeletal muscle mass and function that is associated with sarcopenia can result in ultimate consequences such as decreased quality of life. The causes of sarcopenia are multifactorial and include environmental and biological ... ...

Abstract	The age-related loss of skeletal muscle mass and function that is associated with sarcopenia can result in ultimate consequences such as decreased quality of life. The causes of sarcopenia are multifactorial and include environmental and biological factors. The purpose of this review is to synthesize what the literature reveals in regards to the cellular regulation of sarcopenia, including impaired muscle regenerative capacity in the aged, and to discuss if physiological stimuli have the potential to slow the loss of myogenic potential that is associated with sarcopenia. In addition, this review article will discuss the effect of aging on Notch and Wnt signaling, and whether physiological stimuli have the ability to restore Notch and Wnt signaling resulting in rejuvenated aged muscle repair. The intention of this summary is to bring awareness to the benefits of consistent physiological stimulus (exercise) to combating sarcopenia as well as proclaiming the usefulness of contraction-induced injury models to studying the effects of local and systemic influences on aged myogenic capability.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Ivyspring International Publisher
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair.

Arthur, Susan Tsivitse / Cooley, Ian D

International journal of biological sciences

2012 Volume 8, Issue 5, Page(s) 731–760

Abstract	The age-related loss of skeletal muscle mass and function that is associated with sarcopenia can result in ultimate consequences such as decreased quality of life. The causes of sarcopenia are multifactorial and include environmental and biological factors. The purpose of this review is to synthesize what the literature reveals in regards to the cellular regulation of sarcopenia, including impaired muscle regenerative capacity in the aged, and to discuss if physiological stimuli have the potential to slow the loss of myogenic potential that is associated with sarcopenia. In addition, this review article will discuss the effect of aging on Notch and Wnt signaling, and whether physiological stimuli have the ability to restore Notch and Wnt signaling resulting in rejuvenated aged muscle repair. The intention of this summary is to bring awareness to the benefits of consistent physiological stimulus (exercise) to combating sarcopenia as well as proclaiming the usefulness of contraction-induced injury models to studying the effects of local and systemic influences on aged myogenic capability.
MeSH term(s)	Adult ; Aged ; Aging/physiology ; Exercise/physiology ; Female ; Humans ; Male ; Muscle, Skeletal/metabolism ; Receptors, Notch/metabolism ; Sarcopenia/metabolism ; Sarcopenia/prevention & control ; Signal Transduction/physiology ; Wnt Signaling Pathway/physiology
Chemical Substances	Receptors, Notch
Language	English
Publishing date	2012-05-23
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.4262
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Article: One-year prevalence, comorbidities and cost of cachexia-related inpatient admissions in the USA.

Arthur, Susan Tsivitse / Noone, Joshua M / Van Doren, Bryce A / Roy, Debosoree / Blanchette, Christopher M

Drugs in context

2014 Volume 3, Page(s) 212265

Abstract: Background: Cachexia is a condition characterized as a loss in body mass or metabolic dysfunction and is associated with several prevalent chronic health conditions including many cancers, COPD, HIV, and kidney disease, with between 10 and 50% of ... ...

Abstract	Background: Cachexia is a condition characterized as a loss in body mass or metabolic dysfunction and is associated with several prevalent chronic health conditions including many cancers, COPD, HIV, and kidney disease, with between 10 and 50% of patients with these conditions having cachexia. Currently there is little research into cachexia and our objective is to characterize cachexia patients, their healthcare utilization, and associated hospitalization costs. Given the increasing prevalence of chronic diseases, it is important to better understand cachexia so that the condition can be better diagnosed and managed. Methods: We utilized one year (2009) of the Nationwide Inpatient Sample (NIS). The NIS represents all inpatient stays at a random 20% sample of all hospitals within the United States. We grouped cachexia individuals by primary or secondary discharge diagnosis and then compared those with cachexia to all others in terms of length of stay (LOS) and total cost. Finally we looked into factors predicting increased LOS using a negative binomial model. Results: We estimated US prevalence for cachexia-related inpatient admissions at 161,898 cases. Cachexia patients were older, with an average age of 67.95 versus 48.10 years in their non-cachexia peers. Hospitalizations associated with cachexia had an increased LOS compared to non-cachexia patients (6 versus 3 days), with average costs per stay $4641.30 greater. Differences were seen in loss of function (LOF) with cachexia patients, mostly in the major LOF category (52.60%), whereas non-cachexia patients were spread between minor, moderate, and major LOF (36.28%, 36.11%, and 21.26%, respectively). Significant positive predictors of increased LOS among cachexia patients included urban hospital (IRR=1.21, non-teaching urban; IRR=1.23, teaching urban), having either major (IRR=1.41) or extreme (IRR=2.64) LOF, and having a primary diagnosis of pneumonia (IRR=1.15). Conclusion: We have characterized cachexia and seen it associated with increased length of stay, increased cost, and more severe loss of function in patients compared to those without cachexia.
Language	English
Publishing date	2014-07-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2719560-0
ISSN	1740-4398 ; 1745-1981
ISSN (online)	1740-4398
ISSN	1745-1981
DOI	10.7573/dic.212265
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Article ; Online: The effect of downhill running on Notch signaling in regenerating skeletal muscle.

Tsivitse, Susan K / Peters, Michael G / Stoy, Angel L / Mundy, Jeffrey A / Bowen, Robert S

European journal of applied physiology

2009 Volume 106, Issue 5, Page(s) 759–767

Abstract: Notch signaling expression in regenerating muscle following injurious downhill running (DHR) was characterized in male C57BL/J6 mice (3 mo). Hindlimb muscles were harvested from control mice or at 24, 48, 72, 96 or 120 h post-DHR. Muscle injury was ... ...

Abstract	Notch signaling expression in regenerating muscle following injurious downhill running (DHR) was characterized in male C57BL/J6 mice (3 mo). Hindlimb muscles were harvested from control mice or at 24, 48, 72, 96 or 120 h post-DHR. Muscle injury was observed at 96 h (3.3-fold) and 120 h (3.7-fold) post-DHR (P < 0.01) and elevated MCadherin expression at 72 h (2.7-fold), 96 h (2.4-fold) post-DHR (P < 0.05) and 120 h (3.3-fold) post-DHR (P < 0.01). Desmin increased at 72 h (2.2-fold), 96 h (3-fold) and 120 h (1.8-fold) post-DHR (P < 0.05). Delta1 +/MCadherin + cells increased approximately 2-fold at 72, 96 (P < 0.01) and 120 h post-DHR (P < 0.05). Isolated muscle-associated cells increased Delta1 (2.6-fold) (P < 0.05) and Notch1 (fourfold) (P < 0.01) expression at 120 h post-DHR. The results of this novel study indicate that DHR up-regulates Notch components within myoblasts and regenerating muscle.
MeSH term(s)	Animals ; Cadherins/metabolism ; Cells, Cultured ; Desmin/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/injuries ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiology ; Physical Conditioning, Animal/physiology ; Receptors, Notch/metabolism ; Receptors, Notch/physiology ; Regeneration/physiology ; Running/physiology ; Signal Transduction/physiology ; Time Factors
Chemical Substances	Cadherins ; Desmin ; Receptors, Notch
Language	English
Publishing date	2009-05-21
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-009-1077-7
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Article ; Online: GSK3β inhibition and LEF1 upregulation in skeletal muscle following a bout of downhill running.

Amin, Hiral / Vachris, Judy / Hamilton, Alicia / Steuerwald, Nury / Howden, Reuben / Arthur, Susan Tsivitse

The journal of physiological sciences : JPS

2013 Volume 64, Issue 1, Page(s) 1–11

Abstract: Canonical Wnt signaling is important in skeletal muscle repair but has not been well characterized in response to physiological stimuli. The objective of this study was to assess the effect of downhill running (DHR) on components of Wnt signaling. Young, ...

Abstract	Canonical Wnt signaling is important in skeletal muscle repair but has not been well characterized in response to physiological stimuli. The objective of this study was to assess the effect of downhill running (DHR) on components of Wnt signaling. Young, male C57BL/J6 mice were exposed to DHR. Muscle injury and repair (MCadherin) were measured in soleus. Gene and protein expression of Wnt3a, active β-catenin, GSK3β, and LEF1 were measured in gastrocnemius. Muscle injury increased 6 days post-DHR and MCadherin protein increased 5 days post-DHR. Total and active GSK3β protein decreased 3 days (9-fold and 3.6-fold, respectively) post-DHR. LEF1 protein increased 6 days (5-fold) post-DHR. DHR decreased GSK3β and increased LEF1 protein expression, but did not affect other components of Wnt signaling. Due to their applicability, using models of physiological stimuli such as DHR will provide significant insight into cellular mechanisms within muscle.
MeSH term(s)	Animals ; Cadherins/metabolism ; Down-Regulation/physiology ; Glycogen Synthase Kinase 3/metabolism ; Glycogen Synthase Kinase 3 beta ; Lymphoid Enhancer-Binding Factor 1/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Muscle, Skeletal/metabolism ; Physical Conditioning, Animal/physiology ; Running/physiology ; Time Factors ; Up-Regulation/physiology ; Wnt Signaling Pathway/physiology ; Wnt3A Protein/metabolism ; beta Catenin/metabolism
Chemical Substances	Cadherins ; Lef1 protein, mouse ; Lymphoid Enhancer-Binding Factor 1 ; Wnt3A Protein ; Wnt3a protein, mouse ; beta Catenin ; M-cadherin (142845-03-2) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Gsk3b protein, mouse (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 (EC 2.7.11.26)
Language	English
Publishing date	2013-08-21
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2234472-X
ISSN	1880-6562 ; 1880-6546
ISSN (online)	1880-6562
ISSN	1880-6546
DOI	10.1007/s12576-013-0284-5
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Article: Mechanical loading and injury induce human myotubes to release neutrophil chemoattractants.

Tsivitse, Susan K / Mylona, Eleni / Peterson, Jennifer M / Gunning, William T / Pizza, Francis X

American journal of physiology. Cell physiology

2004 Volume 288, Issue 3, Page(s) C721–9

Abstract: The purpose of this study was to 1) test the hypothesis that skeletal muscle cells (myotubes) after mechanical loading and/or injury are a source of soluble factors that promote neutrophil chemotaxis and superoxide anion (O(2)(-).) production and 2) ... ...

Abstract	The purpose of this study was to 1) test the hypothesis that skeletal muscle cells (myotubes) after mechanical loading and/or injury are a source of soluble factors that promote neutrophil chemotaxis and superoxide anion (O(2)(-).) production and 2) determine whether mechanical loading and/or injury causes myotubes to release cytokines that are known to influence neutrophil responses [tumor necrosis factor-alpha (TNF-alpha), IL-8, and transforming growth factor-beta1 (TGF-beta1)]. Human myotubes were grown in culture and exposed to either a cyclic strain (0, 5, 10, 20, or 30% strain) or a scrape injury protocol. Protocols of 5, 10, and 20% strain did not cause injury, whereas 30% strain and scrape injury caused a modest and a high degree of injury, respectively. Conditioned media from strained myotubes promoted chemotaxis of human blood neutrophils and primed them for O(2)(-). production in a manner that was dependent on a threshold of strain and independent from injury. Neutrophil chemotaxis, but not priming, progressively increased with higher magnitudes of strain. Conditioned media only from scrape-injured myotubes increased O(2)(-). production from neutrophils. Concentrations of IL-8 and total TGF-beta1 in conditioned media were reduced by mechanical loading, whereas TNF-alpha and active TGF-beta1 concentrations were unaffected. In conclusion, skeletal muscle cells after mechanical loading and injury are an important source of soluble factors that differentially influence neutrophil chemotaxis and the stages of neutrophil-derived reactive oxygen species production. Neutrophil responses elicited by mechanical loading, however, did not parallel changes in the release of IL-8, TGF-beta1, or TNF-alpha from skeletal muscle cells.
MeSH term(s)	Adolescent ; Cells, Cultured ; Chemotactic Factors/metabolism ; Chemotaxis, Leukocyte/physiology ; Culture Media, Conditioned ; Female ; Humans ; Interleukin-8/metabolism ; Leukocytes/cytology ; Leukocytes/metabolism ; Muscle Fibers, Skeletal/metabolism ; Muscle Fibers, Skeletal/ultrastructure ; Muscle, Skeletal/cytology ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Stress, Mechanical ; Superoxides/metabolism ; Transforming Growth Factor beta/metabolism ; Transforming Growth Factor beta1 ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Chemotactic Factors ; Culture Media, Conditioned ; Interleukin-8 ; TGFB1 protein, human ; Transforming Growth Factor beta ; Transforming Growth Factor beta1 ; Tumor Necrosis Factor-alpha ; Superoxides (11062-77-4)
Language	English
Publishing date	2004-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	392098-7
ISSN	1522-1563 ; 0363-6143
ISSN (online)	1522-1563
ISSN	0363-6143
DOI	10.1152/ajpcell.00237.2004
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