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Article ; Online: Molecular Recognition of Aromatics in Spherical Nanocages.

Martí-Rujas, Javier / Elli, Stefano / Zanotti, Alessandro / Famulari, Antonino / Castiglione, Franca

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 29, Issue 57, Page(s) e202302025

Abstract: In general, due to the lack of efficient specific molecular interactions, achieving host-guest molecular recognition inside large and neutral metal-organic cages (MOCs) is challenging. Preferential molecular recognition of aromatics using the internal ... ...

Abstract	In general, due to the lack of efficient specific molecular interactions, achieving host-guest molecular recognition inside large and neutral metal-organic cages (MOCs) is challenging. Preferential molecular recognition of aromatics using the internal binding sites of interlocked icosahedral (i. e., spherical) M
Language	English
Publishing date	2023-09-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202302025
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: (±)-3-Deoxyradicinin Induces Stomata Opening and Chloroplast Oxidative Stress in Tomato (

Samperna, Simone / Zanotti, Clarissa / Scafato, Patrizia / Boari, Angela / Visconti, Sabina / Vurro, Maurizio / Superchi, Stefano / Evidente, Antonio / Marra, Mauro

International journal of molecular sciences

2023 Volume 24, Issue 10

Abstract: Radicinin is a phytotoxic dihydropyranopyran-4,5-dione isolated from the culture filtrates ... ...

Abstract	Radicinin is a phytotoxic dihydropyranopyran-4,5-dione isolated from the culture filtrates of
MeSH term(s)	Solanum lycopersicum ; Fungi ; Cenchrus ; Toxins, Biological ; Chloroplasts ; Reactive Oxygen Species ; Oxidative Stress
Chemical Substances	deoxyradicinin (S4H35K8SNS) ; Toxins, Biological ; Reactive Oxygen Species
Language	English
Publishing date	2023-05-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24108467
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Article ; Online: Activation of Notch3 in osteoblasts/osteocytes causes compartment-specific changes in bone remodeling.

Canalis, Ernesto / Zanotti, Stefano / Schilling, Lauren / Eller, Tabitha / Yu, Jungeun

The Journal of biological chemistry

2021 Volume 296, Page(s) 100583

Abstract: Notch receptors maintain skeletal homeostasis. NOTCH1 and 2 have been studied for their effects on bone remodeling. Although NOTCH3 plays a significant role in vascular physiology, knowledge about its function in other cellular environments, including ... ...

Abstract	Notch receptors maintain skeletal homeostasis. NOTCH1 and 2 have been studied for their effects on bone remodeling. Although NOTCH3 plays a significant role in vascular physiology, knowledge about its function in other cellular environments, including bone, is limited. The present study was conducted to establish the function of NOTCH3 in skeletal cells using models of Notch3 misexpression. Microcomputed tomography demonstrated that Notch3 null mice did not have appreciable bone phenotypes. To study the effects of the NOTCH3 activation in the osteoblast lineage, BGLAP-Cre or Dmp1-Cre transgenics were crossed with Rosa
MeSH term(s)	Animals ; Bone Remodeling ; Gene Expression Regulation ; Mice ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Osteocytes/cytology ; Osteocytes/metabolism ; Receptor, Notch3/metabolism
Chemical Substances	Receptor, Notch3
Language	English
Publishing date	2021-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2021.100583
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Article: The Role of New Morphological Parameters Provided by the BC 6800 Plus Analyzer in the Early Diagnosis of Sepsis.

Sacchetti, Sara / Vidali, Matteo / Esposito, Teresa / Zorzi, Stefano / Burgener, Alessia / Ciccarello, Lorenzo / Cammarota, Gianmaria / Zanotti, Valentina / Giacomini, Luca / Bellan, Mattia / Pirisi, Mario / Lopez, Ramon Simon / Dianzani, Umberto / Vaschetto, Rosanna / Rolla, Roberta

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 3

Abstract: Background: Late diagnosis of sepsis is associated with adverse consequences and high mortality rate. The aim of this study was to evaluate the diagnostic value of hematologic research parameters, that reflect the cell morphology of blood cells, ... ...

Abstract	Background: Late diagnosis of sepsis is associated with adverse consequences and high mortality rate. The aim of this study was to evaluate the diagnostic value of hematologic research parameters, that reflect the cell morphology of blood cells, available on the BC 6800 plus automated analyzer (Mindray) for the early detection of sepsis. Materials and methods: A complete blood count (CBC) was performed by Mindray BC 6800 Plus Analyzer in 327 patients (223 with a confirmed diagnosis of sepsis following sepsis-3 criteria, 104 without sepsis), admitted at the Intensive Care Unit of the Novara's Hospital (Italy) and in 56 patients with localized infection. Results: In univariate logistic regression, age, Hb, RDW, MO#, NMR, NeuX, NeuY, NeuZ, LymX, MonX, MonY, MonZ were associated with sepsis ( Conclusions: In addition to already established biomarkers and basic CBC parameters, new morphological cell parameters can be a valuable aid in the early diagnosis of sepsis at no additional cost.
Language	English
Publishing date	2024-02-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14030340
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Article ; Online: Dentin Particulate for Bone Regeneration: An In Vitro Study.

Brunello, Giulia / Zanotti, Federica / Scortecci, Gerard / Sapoznikov, Lari / Sivolella, Stefano / Zavan, Barbara

International journal of molecular sciences

2022 Volume 23, Issue 16

Abstract: The aim of this in vitro study was to investigate the commitment and behavior of dental pulp stem cells (DPSCs) seeded onto two different grafting materials, human dentin particulate (DP) and deproteinized bovine bone matrix (BG), with those cultured in ... ...

Abstract	The aim of this in vitro study was to investigate the commitment and behavior of dental pulp stem cells (DPSCs) seeded onto two different grafting materials, human dentin particulate (DP) and deproteinized bovine bone matrix (BG), with those cultured in the absence of supplements. Gene expression analyses along with epigenetic and morphological tests were carried out to examine odontogenic and osteogenic differentiation and cell proliferation. Compressive testing of the grafting materials seeded with DPSCs was performed as well. DPSC differentiation into odontoblast-like cells was identified from the upregulation of odontogenic markers (DSPP and MSX) and osteogenic markers (RUNX2, alkaline phosphatase, osteonectin, osteocalcin, collagen type I, bmp2, smad5/8). Epigenetic tests confirmed the presence of miRNAs involved in odontogenic or osteogenic commitment of DPSCs cultured for up to 21 days on DP. Compressive strength values obtained from extracellular matrix (ECM) synthesized by DPSCs showed a trend of being higher when seeded onto DP than onto BG. High expression of VEGF factor, which is related to angiogenesis, and of dentin sialoprotein was observed only in the presence of DP. Morphological analyses confirmed the typical phenotype of adult odontoblasts. In conclusion, the odontogenic and osteogenic commitment of DPSCs and their respective functions can be achieved on DP, which enables exceptional dentin and bone regeneration.
MeSH term(s)	Adult ; Animals ; Bone Regeneration ; Cattle ; Cell Differentiation/physiology ; Cell Proliferation ; Cells, Cultured ; Dental Pulp ; Dentin ; Humans ; Odontogenesis/physiology ; Osteogenesis/genetics ; Stem Cells/metabolism
Language	English
Publishing date	2022-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23169283
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Article ; Online: A pipeline for monitoring water pollution: The example of heavy metals in Lombardy waters

Zanchi, Marco / Zapperi, Stefano / Zanotti, Chiara / Rotiroti, Marco / Bonomi, Tullia / Gomarasca, Stefano / Bocchi, Stefano / La Porta, Caterina A.M.

Heliyon. 2022 Dec., v. 8, no. 12 p.e12435-

2022

Abstract: Time-dependent geolocalized analysis of pollution data allows to better understand their dynamics over time and could suggest strategies to restore a good ecological status of contaminated area. This research analyzes concentrations of pollutants in ... ...

Abstract	Time-dependent geolocalized analysis of pollution data allows to better understand their dynamics over time and could suggest strategies to restore a good ecological status of contaminated area. This research analyzes concentrations of pollutants in surface waters and groundwater monitored by the Regional Environment Protection Agency of Lombardy from 2017 to 2020. Lombardy is one of the richest and populous region of Europe, providing an interesting example of the impact of environmental pollutants due to anthropogenic and industrial activities, not only for Italy but also for all Europe. Results show that groundwater displays more sites with heavy metals above the legal limit with respect to surface waters, including As, Ni, Cr and Zn. Furthermore, the spatio-temporal analysis of the data clearly shows that the introduction of more restrictive laws is a proper policy to improve the ecological status of the water.
Keywords	environmental protection ; groundwater ; issues and policy ; water pollution ; Italy ; Pollutants ; Heavy metals ; Water ; Geolocalization
Language	English
Dates of publication	2022-12
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e12435
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Parathyroid hormone inhibits Notch signaling in osteoblasts and osteocytes.

Zanotti, Stefano / Canalis, Ernesto

Bone

2017 Volume 103, Page(s) 159–167

Abstract: Parathyroid hormone (PTH) and Notch receptors regulate bone formation by governing the function of osteoblastic cells. To determine whether PTH interacts with Notch signaling as a way to control osteoblast function, we tested the effects of PTH on Notch ... ...

Abstract	Parathyroid hormone (PTH) and Notch receptors regulate bone formation by governing the function of osteoblastic cells. To determine whether PTH interacts with Notch signaling as a way to control osteoblast function, we tested the effects of PTH on Notch activity in osteoblast- and osteocyte-enriched cultures. Notch signaling was activated in osteoblast-enriched cells from wild-type C57BL/6J mice following exposure to the Notch ligand Delta-like (Dll)1 or by the transient transfection of the Notch intracellular domain (NICD), the transcriptionally active fragment of Notch1. To induce Notch signaling in osteocyte-enriched cultures, a murine model of Notch2 gain-of-function was used. PTH opposed the stimulatory effects of Dll1 on Hey1, Hey2 and HeyL mRNA levels in osteoblast-enriched cells and suppressed the expression of selected Notch target genes in osteocyte-enriched cultures, either under basal conditions or in the context of Notch2 gain-of-function. Induction of Notch signaling in osteocytes did not alter the inhibitory effect of PTH on Sost expression, but reduced the stimulation of Tnfsf11 mRNA levels by PTH. In agreement with these in vitro observations, male mice administered with PTH displayed suppressed Hey1 and HeyL expression in parietal bones. Transactivation experiments with a Notch reporter construct and electrophoretic mobility shift assays in osteoblast-enriched cells suggest that PTH acts by decreasing the capacity of Rbpjκ to bind to DNA. In conclusion, downregulation of Notch in osteoblasts and osteocytes may represent a mechanism contributing to the anabolic effects of PTH in bone.
MeSH term(s)	Animals ; Male ; Mice ; Mice, Inbred C57BL ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteocytes/drug effects ; Osteocytes/metabolism ; Parathyroid Hormone/pharmacology ; Receptors, Notch/drug effects ; Receptors, Notch/metabolism ; Signal Transduction/drug effects
Chemical Substances	Parathyroid Hormone ; Receptors, Notch
Language	English
Publishing date	2017-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	632515-4
ISSN	1873-2763 ; 8756-3282
ISSN (online)	1873-2763
ISSN	8756-3282
DOI	10.1016/j.bone.2017.06.027
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Zs.A 1571: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Hairy and Enhancer of Split-Related With YRPW Motif-Like (HeyL) Is Dispensable for Bone Remodeling in Mice.

Canalis, Ernesto / Zanotti, Stefano

Journal of cellular biochemistry

2017 Volume 118, Issue 7, Page(s) 1819–1826

Abstract: Notch induces Hairy Enhancer of Split (Hes)1 and Hes-related with YRPW motif (Hey) Hey1, Hey2 and Hey-like (HeyL) expression in osteoblasts, but it is not known whether any of these target genes mediates the effect of Notch in the skeleton. We ... ...

Abstract	Notch induces Hairy Enhancer of Split (Hes)1 and Hes-related with YRPW motif (Hey) Hey1, Hey2 and Hey-like (HeyL) expression in osteoblasts, but it is not known whether any of these target genes mediates the effect of Notch in the skeleton. We demonstrated that Notch1 activation in osteoblasts/osteocytes induces Hes1, Hey1, Hey2, and HeyL, but HeyL was induced to a greater extent than other target genes. To characterize HeyL null mice for their skeletal phenotype, microcomputed tomography (µCT) and histomorphometric analysis of HeyL null and sex-matched littermate controls was performed. µCT demonstrated modest cancellous bone osteopenia in 1 month old male mice and normal microarchitecture in 3 month old male HeyL null mice. Female HeyL null mice were not different from controls at either 1 or 3 months of age. Bone histomorphometry did not demonstrate differences between HeyL null mice of either sex and littermate controls. In conclusion, HeyL null mice do not exhibit an obvious skeletal phenotype demonstrating that HeyL is dispensable for skeletal homeostasis. J. Cell. Biochem. 118: 1819-1826, 2017. © 2016 Wiley Periodicals, Inc.
MeSH term(s)	Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Bone Remodeling/genetics ; Bone Remodeling/physiology ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Osteoblasts/metabolism ; Osteocytes/metabolism ; Receptor, Notch1/genetics ; Receptor, Notch1/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Transcription Factor HES-1/genetics ; Transcription Factor HES-1/metabolism ; X-Ray Microtomography
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; Cell Cycle Proteins ; Hes1 protein, mouse ; Hey1 protein, mouse ; Hey2 protein, mouse ; Heyl protein, mouse ; Notch1 protein, mouse ; Receptor, Notch1 ; Repressor Proteins ; Transcription Factor HES-1
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.25859
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Article ; Online: Dentin Particulate for Bone Regeneration

Giulia Brunello / Federica Zanotti / Gerard Scortecci / Lari Sapoznikov / Stefano Sivolella / Barbara Zavan

International Journal of Molecular Sciences, Vol 23, Iss 16, p

An In Vitro Study

2022 Volume 9283

Abstract	The aim of this in vitro study was to investigate the commitment and behavior of dental pulp stem cells (DPSCs) seeded onto two different grafting materials, human dentin particulate (DP) and deproteinized bovine bone matrix (BG), with those cultured in the absence of supplements. Gene expression analyses along with epigenetic and morphological tests were carried out to examine odontogenic and osteogenic differentiation and cell proliferation. Compressive testing of the grafting materials seeded with DPSCs was performed as well. DPSC differentiation into odontoblast-like cells was identified from the upregulation of odontogenic markers (DSPP and MSX) and osteogenic markers (RUNX2, alkaline phosphatase, osteonectin, osteocalcin, collagen type I, bmp2, smad5/8). Epigenetic tests confirmed the presence of miRNAs involved in odontogenic or osteogenic commitment of DPSCs cultured for up to 21 days on DP. Compressive strength values obtained from extracellular matrix (ECM) synthesized by DPSCs showed a trend of being higher when seeded onto DP than onto BG. High expression of VEGF factor, which is related to angiogenesis, and of dentin sialoprotein was observed only in the presence of DP. Morphological analyses confirmed the typical phenotype of adult odontoblasts. In conclusion, the odontogenic and osteogenic commitment of DPSCs and their respective functions can be achieved on DP, which enables exceptional dentin and bone regeneration.
Keywords	odontogenesis ; dentin ; dentinogenesis ; embryonic ; ivory ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hajdu-Cheney Syndrome, a Disease Associated with NOTCH2 Mutations.

Canalis, Ernesto / Zanotti, Stefano

Current osteoporosis reports

2016 Volume 14, Issue 4, Page(s) 126–131

Abstract: Notch plays an important function in skeletal homeostasis, osteoblastogenesis, and osteoclastogenesis. Hajdu-Cheney syndrome (HCS) is a rare disease associated with mutations in NOTCH2 leading to the translation of a truncated NOTCH2 stable protein. As a ...

Abstract	Notch plays an important function in skeletal homeostasis, osteoblastogenesis, and osteoclastogenesis. Hajdu-Cheney syndrome (HCS) is a rare disease associated with mutations in NOTCH2 leading to the translation of a truncated NOTCH2 stable protein. As a consequence, a gain-of-NOTCH2 function is manifested. HCS is inherited as an autosomal dominant disease although sporadic cases exist. HCS is characterized by craniofacial developmental defects, including platybasia and wormian bones, osteoporosis with fractures, and acro-osteolysis. Subjects may suffer severe neurological complications, and HCS presents with cardiovascular defects and polycystic kidneys. An experimental mouse model harboring a HCSNotch2 mutation exhibits osteopenia secondary to enhanced bone resorption suggesting this as a possible mechanism for the skeletal disease. If the same mechanisms were operational in humans, anti-resorptive therapy could correct the bone loss, but not necessarily the acro-osteolysis. In conclusion, HCS is a devastating disease associated with a gain-of-NOTCH2 function resulting in diverse clinical manifestations.
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2186581-4
ISSN	1544-2241 ; 1544-1873
ISSN (online)	1544-2241
ISSN	1544-1873
DOI	10.1007/s11914-016-0311-6
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