Article ; Online: Plasma ammonia concentration after L-asparaginase therapy in 27 dogs with high-grade lymphoma or leukemia.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
2018 Volume 28, Issue 2, Page(s) 130–139
Abstract: Objectives: To establish the occurrence of increased plasma ammonia concentration after L ... asparaginase (L-asp) administration in dogs with high-grade lymphoma or leukemia; to identify risk factors ... for the development of hyperammonemia after L-asp administration; and to determine occurrence of adverse events ...
| Abstract | Objectives: To establish the occurrence of increased plasma ammonia concentration after L-asparaginase (L-asp) administration in dogs with high-grade lymphoma or leukemia; to identify risk factors for the development of hyperammonemia after L-asp administration; and to determine occurrence of adverse events related to hyperammonemia. Design: Prospective case controlled study of sequentially enrolled dogs between May 2011 and March 2012. Setting: A university veterinary teaching hospital. Animals: Twenty-seven dogs with high-grade lymphoma or leukemia. Interventions: All dogs received L-asp intramuscularly at a median dose of 400 IU/kg. Measurements and main results: Plasma ammonia concentrations were measured at baseline, 16 hours, and 48 hours after L-asp therapy. Clinicopathological abnormalities were assessed to determine risk factors for the development of hyperammonemia. Adverse events following L-asp were recorded. Median plasma ammonia concentrations at baseline, 16 hours, and 48 hours were 26 μmol/L (44 μg/dL), 98 μmol/L (166.9 μg/dL), and 67 μmol/L (114 μg/dL), respectively. Median plasma ammonia concentrations at 16 and 48 hours after administration were significantly increased compared to baseline. Six dogs had adverse events following L-asp administration. No significant clinical signs were noted that could clearly be attributed to hyperammonemia. No risk factors for developing hyperammonemia were identified; however, there was a positive correlation between the development of hyperammonemia at 16- and 48-hour time points. Conclusions: Subclinical hyperammonemia in dogs with lymphoma or leukemia after L-asp administration appears to be common. No risk factors were identified for the development of hyperammonemia after L-asp treatment, and severe adverse events were rare. |
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| MeSH term(s) | Ammonia/blood ; Animals ; Antineoplastic Agents/therapeutic use ; Asparaginase/adverse effects ; Asparaginase/therapeutic use ; Case-Control Studies ; Dogs ; Female ; Humans ; Hyperammonemia ; Leukemia/drug therapy ; Leukemia/veterinary ; Lymphoma, Non-Hodgkin/drug therapy ; Lymphoma, Non-Hodgkin/veterinary ; Male ; Prospective Studies ; Risk Factors |
| Chemical Substances | Antineoplastic Agents ; Ammonia (7664-41-7) ; Asparaginase (EC 3.5.1.1) |
| Language | English |
| Publishing date | 2018-02-22 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2077212-9 |
| ISSN | 1476-4431 ; 1479-3261 |
| ISSN (online) | 1476-4431 |
| ISSN | 1479-3261 |
| DOI | 10.1111/vec.12695 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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