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Article ; Online: Multilevel BCR signals toward CLL.

Herling, Marco / Vasyutina, Elena

2015 Volume 125, Issue 10, Page(s) 1510–1512

Abstract: In this issue of Blood, Iacovelli et al provide the first in vivo experimental evidence on the proleukemogenic relevance of autonomous (exo-antigen–independent) B-cell receptor (BCR) stimulation in conjunction with ligand (autoantigen)- mediated BCR ... ...

Abstract	In this issue of Blood, Iacovelli et al provide the first in vivo experimental evidence on the proleukemogenic relevance of autonomous (exo-antigen–independent) B-cell receptor (BCR) stimulation in conjunction with ligand (autoantigen)- mediated BCR signaling in chronic lymphocytic leukemia (CLL).
MeSH term(s)	Animals ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/etiology ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Receptors, Antigen, B-Cell/metabolism
Chemical Substances	Receptors, Antigen, B-Cell
Language	English
Publishing date	2015-03-05
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2015-01-621227
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Article ; Online: Vesicular Release and Uptake of Circular LSD1-RNAs from Non-Cancer and Cancer Lung Cells.

Galang, Joelle Noriko / Shen, Yefeng / Koitzsch, Ulrike / Yu, Xiaojie / Eischeid-Scholz, Hannah / Bachurski, Daniel / Rau, Tilman T / Neppl, Christina / Herling, Marco / Bulimaga, Bianca / Vasyutina, Elena / Schweiger, Michal R / Büttner, Reinhard / Odenthal, Margarete / Anokhina, Maria M

International journal of molecular sciences

2023 Volume 24, Issue 18

Abstract: Lysine-specific demethylase 1 (LSD1) is highly expressed in many cancer types and strongly associated with cancer progression and metastasis. Circular RNAs (circRNAs) are produced by back-splicing and influence the interactive RNA network by microRNA and ...

Abstract	Lysine-specific demethylase 1 (LSD1) is highly expressed in many cancer types and strongly associated with cancer progression and metastasis. Circular RNAs (circRNAs) are produced by back-splicing and influence the interactive RNA network by microRNA and protein sponging. In the present study, we aimedto identify circRNAs that derive from the LSD1-encoding
Language	English
Publishing date	2023-09-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241813981
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Article ; Online: Molecular mechanisms in renal degenerative disease.

Vasyutina, Elena / Treier, Mathias

Seminars in cell & developmental biology

2010 Volume 21, Issue 8, Page(s) 831–837

Abstract: Chronic kidney disease (CKD) has become a major public health problem worldwide. Therefore, a considerable effort is currently directed to understand the molecular mechanisms of renal degenerative processes. Regardless of their initiating cause, all ... ...

Abstract	Chronic kidney disease (CKD) has become a major public health problem worldwide. Therefore, a considerable effort is currently directed to understand the molecular mechanisms of renal degenerative processes. Regardless of their initiating cause, all chronic kidney diseases (CKD) develop at some level organ fibrosis that interferes with kidney function. This is also true for the two most common inherited CKD syndromes, nephronophthitis and polycystic kidney disease, whose primary defects reside within the cilium of kidney epithelial cells. A cohort of elegant recent studies has elicited the role of the primary cilium as a versatile mechanosensory organelle that also might coordinate cross-talk between multiple signaling pathways. In addition, epigenetic mechanisms are now realized to be essential in the maintenance of adult renal architecture. In this review, we will discuss recent advances in our understanding of the signaling systems implicated in kidney homeostasis and repair.
MeSH term(s)	Fibrosis ; Humans ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/genetics ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Kidney Diseases, Cystic/genetics ; Kidney Diseases, Cystic/metabolism ; Kidney Diseases, Cystic/pathology ; Renal Insufficiency/metabolism ; Renal Insufficiency/pathology ; Signal Transduction
Language	English
Publishing date	2010-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2010.08.010
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Book ; Online ; Thesis: Role of CXCR4 and Gab1 in the development of muscle precursor cells

Vasyutina, Elena [Verfasser]

2006

Author's details	vorgelegt von Elena Vasyutina
Keywords	Biowissenschaften, Biologie ; Life Science, Biology
Subject code	sg570
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Biological Safety and Biodistribution of Chitosan Nanoparticles.

Sonin, Dmitry / Pochkaeva, Evgeniia / Zhuravskii, Sergei / Postnov, Viktor / Korolev, Dmitry / Vasina, Lyubov / Kostina, Daria / Mukhametdinova, Daria / Zelinskaya, Irina / Skorik, Yury / Naumysheva, Elena / Malashicheva, Anna / Somov, Pavel / Istomina, Maria / Rubanova, Natalia / Aleksandrov, Ilia / Vasyutina, Marina / Galagudza, Michael

Nanomaterials (Basel, Switzerland)

2020 Volume 10, Issue 4

Abstract: ...

Abstract	:
Language	English
Publishing date	2020-04-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano10040810
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Article ; Online: Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.

Jiang, Qu / Stachelscheid, Johanna / Bloehdorn, Johannes / Pacholewska, Alicja / Aszyk, Christoph / Grotenhuijs, Francien / Müller, Tony / Onder, Ozlem / Wagle, Prerana / Herling, Carmen D / Kleppe, Maria / Wang, Zhefang / Coombes, Kevin R / Robrecht, Sandra / Dalvi, Priya S / Plosnita, Bianca / Mayer, Petra / Abruzzo, Lynne V / Altmüller, Janine /

Gathof, Birgit / Persigehl, Thorsten / Fischer, Kirsten / Jebaraj, Billy / Rienhoff, Hugh Y / Ecker, Rupert / Zhao, Yue / Bruns, Christiane J / Stilgenbauer, Stephan / Elenitoba-Johnson, Kojo / Hallek, Michael / Schweiger, Michal R / Odenthal, Margarete / Vasyutina, Elena / Herling, Marco

Blood

2023 Volume 142, Issue 1, Page(s) 44–61

Abstract: In chronic lymphocytic leukemia (CLL), epigenetic alterations are considered to centrally shape the transcriptional signatures that drive disease evolution and underlie its biological and clinical subsets. Characterizations of epigenetic regulators, ... ...

Abstract	In chronic lymphocytic leukemia (CLL), epigenetic alterations are considered to centrally shape the transcriptional signatures that drive disease evolution and underlie its biological and clinical subsets. Characterizations of epigenetic regulators, particularly histone-modifying enzymes, are very rudimentary in CLL. In efforts to establish effectors of the CLL-associated oncogene T-cell leukemia 1A (TCL1A), we identified here the lysine-specific histone demethylase KDM1A to interact with the TCL1A protein in B cells in conjunction with an increased catalytic activity of KDM1A. We demonstrate that KDM1A is upregulated in malignant B cells. Elevated KDM1A and associated gene expression signatures correlated with aggressive disease features and adverse clinical outcomes in a large prospective CLL trial cohort. Genetic Kdm1a knockdown in Eμ-TCL1A mice reduced leukemic burden and prolonged animal survival, accompanied by upregulated p53 and proapoptotic pathways. Genetic KDM1A depletion also affected milieu components (T, stromal, and monocytic cells), resulting in significant reductions in their capacity to support CLL-cell survival and proliferation. Integrated analyses of differential global transcriptomes (RNA sequencing) and H3K4me3 marks (chromatin immunoprecipitation sequencing) in Eμ-TCL1A vs iKdm1aKD;Eμ-TCL1A mice (confirmed in human CLL) implicate KDM1A as an oncogenic transcriptional repressor in CLL which alters histone methylation patterns with pronounced effects on defined cell death and motility pathways. Finally, pharmacologic KDM1A inhibition altered H3K4/9 target methylation and revealed marked anti-B-cell leukemic synergisms. Overall, we established the pathogenic role and effector networks of KDM1A in CLL via tumor-cell intrinsic mechanisms and its impacts in cells of the microenvironment. Our data also provide rationales to further investigate therapeutic KDM1A targeting in CLL.
MeSH term(s)	Humans ; Mice ; Animals ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Histones/metabolism ; Lysine ; Prospective Studies ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Tumor Microenvironment
Chemical Substances	Histones ; Lysine (K3Z4F929H6) ; Histone Demethylases (EC 1.14.11.-) ; KDM1A protein, human (EC 1.5.-)
Language	English
Publishing date	2023-04-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2022017230
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Article: The development of migrating muscle precursor cells.

Vasyutina, Elena / Birchmeier, Carmen

Anatomy and embryology

2006 Volume 211 Suppl 1, Page(s) 37–41

Abstract: A major subclass of hypaxial muscle groups is derived from long-range migrating precursor cells that delaminate from the dermomyotome. Migrating precursors are generated on particular axial levels only, i.e. occipitally, cervically, and on the levels of ... ...

Abstract	A major subclass of hypaxial muscle groups is derived from long-range migrating precursor cells that delaminate from the dermomyotome. Migrating precursors are generated on particular axial levels only, i.e. occipitally, cervically, and on the levels of the fore and hind limbs. They express the homeobox gene Lbx1, which provides a useful marker for their visualization. In the mouse, migrating precursor cells give rise to muscles of the extremities, the hypoglossal chord, and the diaphragm. We discuss here the development of this migrating lineage, which critically depends on the correct specification of the precursors in the dermomyotome, their delamination and correct migration. Finally, proliferation at the targets is essential to ensure a correct size of the precursor pool and of the muscle that derives thereof.
MeSH term(s)	Animals ; Body Patterning/physiology ; Cell Lineage/physiology ; Cell Movement/physiology ; Mice ; Muscle Proteins/metabolism ; Muscles/embryology ; Signal Transduction/physiology ; Somites/physiology
Chemical Substances	Lbx1h protein, mouse ; Muscle Proteins
Language	English
Publishing date	2006-12
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	7488-3
ISSN	0340-2061 ; 0044-2232
ISSN	0340-2061 ; 0044-2232
DOI	10.1007/s00429-006-0118-9
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Article ; Online: Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNA to bystander cells.

Reiners, Katrin S / Shatnyeva, Olga / Vasyutina, Elena / Bösl, Teresa / Hansen, Hinrich P / Hallek, Michael / Herling, Marco / von Strandmann, Elke Pogge

Haematologica

2017 Volume 102, Issue 3, Page(s) e100–e103

MeSH term(s)	Antigens, CD/genetics ; Antigens, CD/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; B-Lymphocytes/secretion ; Bystander Effect/genetics ; Bystander Effect/immunology ; Extracellular Vesicles/chemistry ; Extracellular Vesicles/immunology ; Extracellular Vesicles/pathology ; Gene Expression Profiling ; Gene Expression Regulation ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Neoplasm Proteins/genetics ; Neoplasm Proteins/immunology ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/immunology ; RNA Splicing Factors/genetics ; RNA Splicing Factors/immunology ; RNA Transport ; RNA, Messenger/genetics ; RNA, Messenger/immunology ; Signal Transduction ; Syk Kinase/genetics ; Syk Kinase/immunology ; Toll-Like Receptor 9/genetics ; Toll-Like Receptor 9/immunology ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology ; src-Family Kinases/genetics ; src-Family Kinases/immunology
Chemical Substances	Antigens, CD ; Neoplasm Proteins ; Proto-Oncogene Proteins ; RNA Splicing Factors ; RNA, Messenger ; TCL1A protein, human ; TLR9 protein, human ; Toll-Like Receptor 9 ; Tumor Necrosis Factor-alpha ; SYK protein, human (EC 2.7.10.2) ; Syk Kinase (EC 2.7.10.2) ; lyn protein-tyrosine kinase (EC 2.7.10.2) ; src-Family Kinases (EC 2.7.10.2)
Language	English
Publishing date	2017
Publishing country	Italy
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2016.153197
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Article ; Online: Activity of the CD40 antagonistic antibody lucatumumab - insights from CLL-niche mimicking xenografts and fludarabine combinations.

Stiefelhagen, Marius / Gigel, Carola / Vasyutina, Elena / Möllmann, Michael / Breuer, Alexandra / Mayer, Petra / Dürig, Jan / Herling, Marco

Leukemia & lymphoma

2016 Volume 57, Issue 9, Page(s) 2235–2238

MeSH term(s)	Antibodies, Monoclonal, Humanized ; CD40 Antigens ; Heterografts ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell ; Vidarabine/analogs & derivatives
Chemical Substances	Antibodies, Monoclonal, Humanized ; CD40 Antigens ; Vidarabine (FA2DM6879K) ; lucatumumab (P0EP9VFC4R) ; fludarabine (P2K93U8740)
Language	English
Publishing date	2016-01-12
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.3109/10428194.2015.1135433
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Article ; Online: Silicon-containing nanocarriers for targeted drug delivery: synthesis, physicochemical properties and acute toxicity.

Sonin, Dmitry L / Korolev, Dmitry V / Postnov, Viktor N / Naumysheva, Elena B / Pochkaeva, Evgenia I / Vasyutina, Marina L / Galagudza, Michael M

Drug delivery

2016 Volume 23, Issue 5, Page(s) 1747–1756

Abstract: Silicon-containing nanoparticles (NPs) are considered promising drug carriers for targeted drug delivery. In this study, we investigated the physical and chemical properties of silicon-containing NPs, including silica and organomodified silica NPs ( ... ...

Abstract	Silicon-containing nanoparticles (NPs) are considered promising drug carriers for targeted drug delivery. In this study, we investigated the physical and chemical properties of silicon-containing NPs, including silica and organomodified silica NPs (SiO2NPs and OrSiO2NPs, respectively), with different surface modifications, with the aim of increasing drug-loading efficiency. In addition, we described the original synthesis methods of different sizes of OrSiO2NPs, as well as new hybrid OrSiO2NPs with a silica core (SiO2 + OrSiO2NPs). Animal experiments revealed that the silicon-containing NPs investigated were non-toxic, as evidenced by a lack of hemodynamic response after intravenous administration. Bioelimination studies showed rapid renal excretion of OrSiO2NPs. In drug release kinetics studies, adenosine was immobilized on SiO2NPs using three different approaches: physical adsorption, ionic, and covalent bonding. We observed that the rate of adenosine desorption critically depended on the type of immobilization; therefore, adenosine release kinetics can be adjusted by SiO2NP surface modification technique. Adsorption of adenosine on SiO2 + OrSiO2NPs resulted in a significant attenuation of adenosine-induced hypotension and bradycardia.
MeSH term(s)	Adsorption ; Drug Carriers/chemistry ; Drug Delivery Systems/methods ; Drug Liberation ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Silicon/chemistry ; Silicon Dioxide/chemical synthesis ; Silicon Dioxide/chemistry ; Silicon Dioxide/metabolism ; Silicon Dioxide/toxicity
Chemical Substances	Drug Carriers ; Silicon Dioxide (7631-86-9) ; Silicon (Z4152N8IUI)
Language	English
Publishing date	2016-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1213261-5
ISSN	1521-0464 ; 1071-7544
ISSN (online)	1521-0464
ISSN	1071-7544
DOI	10.3109/10717544.2015.1069421
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