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  1. AU=Torres Victor J.
  2. AU="Manning, Nyla"
  3. AU="Sindkar, Anushka"
  4. AU=Rodieux Frdrique
  5. AU="Tote, Sachin"

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  1. Artikel ; Online: SarS and Rot are necessary for the repression of

    Anderson, Exene E / Ilmain, Juliana K / Torres, Victor J

    Microbiology spectrum

    2023  Band 11, Heft 6, Seite(n) e0165623

    Abstract: Importance: The leukocidins play an important role in disarming the host immune system and promoting infection. While both SarS and Rot have been established as repressors of leukocidins, the importance of each repressor in infection is unclear. Here, ... ...

    Abstract Importance: The leukocidins play an important role in disarming the host immune system and promoting infection. While both SarS and Rot have been established as repressors of leukocidins, the importance of each repressor in infection is unclear. Here, we demonstrate that repression by SarS and Rot is not additive and show that in addition to upregulating expression of each other, they are also able to bind concurrently to the leukocidin promoters. These findings suggest that both repressors are necessary for maximal repression of
    Mesh-Begriff(e) Humans ; Staphylococcus aureus/metabolism ; Leukocidins/genetics ; Bacterial Toxins/genetics ; Bacterial Toxins/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Staphylococcal Infections ; Exotoxins/genetics ; Exotoxins/metabolism ; Methicillin-Resistant Staphylococcus aureus/metabolism
    Chemische Substanzen Leukocidins ; Bacterial Toxins ; Bacterial Proteins ; Exotoxins
    Sprache Englisch
    Erscheinungsdatum 2023-10-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01656-23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Note from a Concerned American Citizen, an

    Torres, Victor J

    Infection and immunity

    2017  Band 85, Heft 12

    Sprache Englisch
    Erscheinungsdatum 2017-12
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00702-17
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Staphylococcus aureus

    Savin, Avital / Anderson, Exene E / Dyzenhaus, Sophie / Podkowik, Magdalena / Shopsin, Bo / Pironti, Alejandro / Torres, Victor J

    Infection and immunity

    2024  Band 92, Heft 2, Seite(n) e0052623

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    Mesh-Begriff(e) Humans ; Staphylococcus aureus ; Neutrophils ; Hydrogen Peroxide/toxicity ; Hydrogen Peroxide/metabolism ; Virulence Factors/genetics ; Virulence Factors/metabolism ; Bacterial Proteins/metabolism ; Leukocidins ; Staphylococcal Infections/microbiology
    Chemische Substanzen Hydrogen Peroxide (BBX060AN9V) ; Virulence Factors ; Bacterial Proteins ; Leukocidins
    Sprache Englisch
    Erscheinungsdatum 2024-01-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00526-23
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  4. Artikel ; Online: Oral infectivity through carnivorism in murine model of

    Torres, Víctor / Contreras, Víctor / Gutiérrez, Bessy / San Francisco, Juan / Catalán, Alejandro / Vega, José Luis / Moon, Kyung-Mee / Foster, Leonard J / de Almeida, Rafael F / Kalergis, Alexis M / González, Jorge

    Frontiers in cellular and infection microbiology

    2024  Band 14, Seite(n) 1297099

    Abstract: Introduction: Oral transmission of : Methods: Cell infectivity assays were performed on AGS cells in the presence or absence of mucin, and the roles of pepsin and acidic pH were determined. Moreover, groups of five female Balb/c mice were fed with ... ...

    Abstract Introduction: Oral transmission of
    Methods: Cell infectivity assays were performed on AGS cells in the presence or absence of mucin, and the roles of pepsin and acidic pH were determined. Moreover, groups of five female Balb/c mice were fed with muscle tissue obtained from mice in the acute phase of infection by the clone H510 C8C3
    Results: Trypomastigote migration in the presence of mucin was reduced by approximately 30%, whereas in the presence of mucin and pepsin at pH 3.5, only a small proportion of parasites were able to migrate (∼6%). Similarly, the ability of TCTs to infect AGS cells in the presence of mucin is reduced by approximately 20%. In all cases, 60-100% of the animals were fed meat from mice infected in the acute phase or infected with trypomastigotes or amastigotes developed high parasitemia, and 80% died around day 40 post-infection. The adhesion assay showed that cruzipain is a molecule of trypomastigotes and amastigotes that binds to AGS cells. LC-MS/MS and bioinformatics analysis, also confirmed that transialidase, cysteine proteinases, and gp63 may be involved in TCTs attachment or invasion of human stomach cells because they can potentially interact with different proteins in the human stomach mucosa. In addition, several human gastric mucins have cysteine protease cleavage sites.
    Discussion: Then, under our experimental conditions, consuming meat from infected animals in the acute phase allows the
    Mesh-Begriff(e) Female ; Animals ; Mice ; Humans ; Trypanosoma cruzi/metabolism ; Pepsin A/metabolism ; Parasitemia ; Disease Models, Animal ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Chagas Disease/parasitology ; Mucins ; Communicable Diseases
    Chemische Substanzen Pepsin A (EC 3.4.23.1) ; Mucins
    Sprache Englisch
    Erscheinungsdatum 2024-02-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2024.1297099
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Defensosomes: a new role for autophagy proteins in innate immune defense.

    Ching, Krystal L / Torres, Victor J / Cadwell, Ken

    Autophagy

    2022  Band 19, Heft 6, Seite(n) 1887–1889

    Abstract: In recent years, the contribution of exosomes to immunity, inflammation and host-pathogen interaction have been appreciated. Exosomes are small secreted extracellular vesicles from endosomal origin that contain a myriad of cellular molecules (protein, ... ...

    Abstract In recent years, the contribution of exosomes to immunity, inflammation and host-pathogen interaction have been appreciated. Exosomes are small secreted extracellular vesicles from endosomal origin that contain a myriad of cellular molecules (protein, nucleic acids), including surface receptors. We have reported a pathogen-induced and macroautophagy/autophagy-dependent class of exosomes coined as "defensosomes", which protect the host from membrane-targeting toxins. In a recent study, we found that defensosomes decorated with ACE2, the SARS-CoV-2 cellular receptor, are produced in the lungs of patients with COVID-19, and that increased concentration of ACE2-loaded defensosomes is associated with decreased hospitalization length. Mechanistically, SARS-CoV-2 induces the production of ACE2-coated defensosomes, a process requiring the autophagy machinery, which in turn binds and neutralizes the virus. We propose that defensosomes represent a new form of autophagy-mediated innate immunity that contributes to the host's armamentarium against pathogens.
    Mesh-Begriff(e) Humans ; COVID-19 ; Autophagy ; SARS-CoV-2 ; Angiotensin-Converting Enzyme 2/metabolism ; Immunity, Innate ; Carrier Proteins/metabolism
    Chemische Substanzen Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Carrier Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-11-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2022.2146894
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Characterization of tigurilysin, a novel human CD59-specific cholesterol-dependent cytolysin, reveals a role for host specificity in augmenting toxin activity.

    Shahi, Ifrah / Dongas, Sophia A / Ilmain, Juliana K / Torres, Victor J / Ratner, Adam J

    Microbiology (Reading, England)

    2023  Band 169, Heft 9

    Abstract: Cholesterol-dependent cytolysins (CDCs) are a large family of pore-forming toxins, produced by numerous Gram-positive pathogens. CDCs depend on host membrane cholesterol for pore formation; some CDCs also require surface-associated human CD59 (hCD59) for ...

    Abstract Cholesterol-dependent cytolysins (CDCs) are a large family of pore-forming toxins, produced by numerous Gram-positive pathogens. CDCs depend on host membrane cholesterol for pore formation; some CDCs also require surface-associated human CD59 (hCD59) for binding, conferring specificity for human cells. We purified a recombinant version of a putative CDC encoded in the genome of
    Mesh-Begriff(e) Humans ; Host Specificity ; Cell Line, Tumor ; Cytotoxins/genetics ; Cholesterol ; Amino Acids ; CD59 Antigens/genetics
    Chemische Substanzen Cytotoxins ; Cholesterol (97C5T2UQ7J) ; Amino Acids ; CD59 protein, human (101754-01-2) ; CD59 Antigens
    Sprache Englisch
    Erscheinungsdatum 2023-09-13
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/mic.0.001393
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Regulation of Bacterial Two-Component Systems by Cardiolipin.

    Yeo, Won-Sik / Dyzenhaus, Sophie / Torres, Victor J / Brinsmade, Shaun R / Bae, Taeok

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The composition of phospholipid membranes is critical to regulating the activity of membrane proteins for cellular functions. Cardiolipin is a unique phospholipid present within the bacterial membrane and mitochondria of eukaryotes and plays a role in ... ...

    Abstract The composition of phospholipid membranes is critical to regulating the activity of membrane proteins for cellular functions. Cardiolipin is a unique phospholipid present within the bacterial membrane and mitochondria of eukaryotes and plays a role in maintaining the function and stabilization of membrane proteins. Here, we report that, in the human pathogen Staphylococcus aureus, cardiolipin is required for full activity of the SaeRS two-component system (TCS). Deletion of the cardiolipin synthase genes,
    Sprache Englisch
    Erscheinungsdatum 2023-02-02
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.02.01.526740
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Characterization of Tigurilysin, a Novel Human CD59-Specific Cholesterol-Dependent Cytolysin, Reveals a Role for Host Specificity in Augmenting Toxin Activity.

    Shahi, Ifrah / Dongas, Sophia A / Ilmain, Juliana K / Torres, Victor J / Ratner, Adam J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Cholesterol dependent cytolysins (CDCs) are a large family of pore forming toxins, produced by numerous gram-positive pathogens. CDCs depend on host membrane cholesterol for pore formation; some CDCs also require surface associated human CD59 (hCD59) for ...

    Abstract Cholesterol dependent cytolysins (CDCs) are a large family of pore forming toxins, produced by numerous gram-positive pathogens. CDCs depend on host membrane cholesterol for pore formation; some CDCs also require surface associated human CD59 (hCD59) for binding, conferring specificity for human cells. We purified a recombinant version of a putative CDC encoded in the genome of
    Importance: Cholesterol dependent cytolysins (CDCs) are produced by a variety of disease-causing bacteria, and may play a significant role in pathogenesis. Understanding CDC mechanisms of action provides useful information for developing anti-virulence strategies against bacteria that utilize CDCs and other pore-forming toxins in pathogenesis. This study describes for the first time a novel human-specific CDC with an atypical pore forming mechanism compared to known CDCs. In addition, this study demonstrates that human-specificity potentially confers increased lytic efficiency to CDCs. These data provide a possible explanation for the selective advantage of developing hCD59-dependency in CDCs and the consequent host restriction.
    Sprache Englisch
    Erscheinungsdatum 2023-07-25
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.06.21.545930
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Irrigation and Crop Load Management Lessen Rain-Induced Cherry Cracking.

    Blanco, Victor / Blaya-Ros, Pedro J / Torres-Sánchez, Roque / Domingo, Rafael

    Plants (Basel, Switzerland)

    2022  Band 11, Heft 23

    Abstract: The combined effects of deficit irrigation and crop load level on sweet cherry ( ...

    Abstract The combined effects of deficit irrigation and crop load level on sweet cherry (
    Sprache Englisch
    Erscheinungsdatum 2022-11-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11233249
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  10. Artikel ; Online: Staphylococcus aureus

    Tam, Kayan / Torres, Victor J

    Microbiology spectrum

    2019  Band 7, Heft 2

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    Mesh-Begriff(e) Animals ; Bacterial Toxins/classification ; Bacterial Toxins/immunology ; Bacterial Toxins/metabolism ; Humans ; Staphylococcal Infections/immunology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/enzymology ; Staphylococcus aureus/immunology ; Staphylococcus aureus/metabolism
    Chemische Substanzen Bacterial Toxins
    Sprache Englisch
    Erscheinungsdatum 2019-03-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/microbiolspec.GPP3-0039-2018
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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