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  1. Article ; Online: X

    Billmyre, Katherine Kretovich / Cahoon, Cori K / Heenan, G Matthew / Wesley, Emily R / Yu, Zulin / Unruh, Jay R / Takeo, Satomi / Hawley, R Scott

    Proceedings of the National Academy of Sciences of the United States of America

    2019  Volume 116, Issue 43, Page(s) 21641–21650

    Abstract: The synaptonemal complex (SC) is a conserved meiotic structure that regulates the repair of double-strand breaks (DSBs) into crossovers or gene conversions. The removal of any central-region SC component, such as ... ...

    Abstract The synaptonemal complex (SC) is a conserved meiotic structure that regulates the repair of double-strand breaks (DSBs) into crossovers or gene conversions. The removal of any central-region SC component, such as the
    MeSH term(s) Animals ; DNA Breaks, Double-Stranded ; DNA Repair/genetics ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Pachytene Stage/genetics ; Recombination, Genetic/genetics ; Sequence Deletion/genetics ; Synaptonemal Complex/genetics ; X Chromosome/genetics
    Chemical Substances C3G protein, Drosophila ; Drosophila Proteins
    Language English
    Publishing date 2019-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1910840116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Nematic Spin Correlations Pervading the Phase Diagram of FeSe_{1-x}S_{x}.

    Liu, Ruixian / Zhang, Wenliang / Wei, Yuan / Tao, Zhen / Asmara, Teguh C / Li, Yi / Strocov, Vladimir N / Yu, Rong / Si, Qimiao / Schmitt, Thorsten / Lu, Xingye

    Physical review letters

    2024  Volume 132, Issue 1, Page(s) 16501

    Abstract: We use resonant inelastic x-ray scattering (RIXS) at the Fe-L_{3} edge to study the spin ... excitations of uniaxial-strained and unstrained FeSe_{1-x}S_{x} (0≤x≤0.21) samples. The measurements ... 0x}S_{x}. The spin-excitation anisotropy persists to a high temperature up to T ...

    Abstract We use resonant inelastic x-ray scattering (RIXS) at the Fe-L_{3} edge to study the spin excitations of uniaxial-strained and unstrained FeSe_{1-x}S_{x} (0≤x≤0.21) samples. The measurements on unstrained samples reveal dispersive spin excitations in all doping levels, which show only minor doping dependence in energy dispersion, lifetime, and intensity, indicating that high-energy spin excitations are only marginally affected by sulfur doping. RIXS measurements on uniaxial-strained samples reveal that the high-energy spin-excitation anisotropy observed previously in FeSe is also present in the doping range 0<x≤0.21 of FeSe_{1-<mark>x}S_{x}. The spin-excitation anisotropy persists to a high temperature up to T>200  K in x=0.18 and reaches a maximum around the nematic quantum critical doping (x_{c}≈0.17). Since the spin-excitation anisotropy directly reflects the existence of nematic spin correlations, our results indicate that high-energy nematic spin correlations pervade the regime of nematicity in the phase diagram and are enhanced by the nematic quantum criticality. These results emphasize the essential role of spin fluctuations in driving electronic nematicity and highlight the capability of uniaxial strain in tuning spin excitations in quantum materials hosting strong magnetoelastic coupling and electronic nematicity.
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.132.016501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 58/153: Show issues

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  3. Article ; Online: Probing Energy-Funneling Kinetics in Nanocrystal Sublattices for Superior X-ray Imaging.

    Wu, Qinxia / Xu, Xinqi / Li, Xiaokun / Jiang, Hao / Qin, Xian / Hong, Zhongzhu / Chen, Xiaofeng / Yang, Zhijian / Ou, Xiangyu / Xie, Lili / He, Yu / Han, Sanyang / Chen, Qiushui / Yang, Huanghao

    Angewandte Chemie (International ed. in English)

    2024  , Page(s) e202404177

    Abstract: ... storing X-ray energy. However, determination of energy-conversion kinetics in these nanocrystals remaines ... in X-ray sensitivity, 22 lp/mm high-resolution X-ray imaging, and a 30-day-long optical memory ...

    Abstract Long-lasting radioluminescence scintillators have recently attracted substantial attention from both research and industrial communities, primarily due to their distinctive capabilities of converting and storing X-ray energy. However, determination of energy-conversion kinetics in these nanocrystals remaines unexplored. Here we investigate energy funneling kinetics in NaLuF4:Mn2+/Gd3+ nanocrystal sublattices via Gd3+-driven microenvironment engineering and Mn2+-mediated radioluminescence profiling. Our photophysical studies reveal effective control of energy-funneling kinetics and demonstrate the tunability of electron trap depth ranging from 0.66 to 0.96 eV, with the corresponding trap density varying between 2.38 × 105 and 1.34 × 107 cm-3. This enables controlled release of captured electrons over durations spanning from seconds to 30 days. Furthermore, it allows tailorable radioluminescence emission within the range of 520-580 nm and fine-tuning of thermally-stimulated temperature between 313-403 K. We further utilize these scintillators to fabricate high-density, large-area scintillation screens that exhibit a 6-fold improvement in X-ray sensitivity, 22 lp/mm high-resolution X-ray imaging, and a 30-day-long optical memory. This enables high-contrast imaging of injured mice through fast thermally-stimulated radioluminescence readout. These findings offer new insights into the correlation of radioluminescence dynamics with energy funneling kinetics, thereby contributing to the advancement of high-energy nanophotonic applications.
    Language English
    Publishing date 2024-04-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202404177
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  4. Book ; Online: Dense X Retrieval

    Chen, Tong / Wang, Hongwei / Chen, Sihao / Yu, Wenhao / Ma, Kaixin / Zhao, Xinran / Zhang, Hongming / Yu, Dong

    What Retrieval Granularity Should We Use?

    2023  

    Abstract: Dense retrieval has become a prominent method to obtain relevant context or world knowledge in open-domain NLP tasks. When we use a learned dense retriever on a retrieval corpus at inference time, an often-overlooked design choice is the retrieval unit ... ...

    Abstract Dense retrieval has become a prominent method to obtain relevant context or world knowledge in open-domain NLP tasks. When we use a learned dense retriever on a retrieval corpus at inference time, an often-overlooked design choice is the retrieval unit in which the corpus is indexed, e.g. document, passage, or sentence. We discover that the retrieval unit choice significantly impacts the performance of both retrieval and downstream tasks. Distinct from the typical approach of using passages or sentences, we introduce a novel retrieval unit, proposition, for dense retrieval. Propositions are defined as atomic expressions within text, each encapsulating a distinct factoid and presented in a concise, self-contained natural language format. We conduct an empirical comparison of different retrieval granularity. Our results reveal that proposition-based retrieval significantly outperforms traditional passage or sentence-based methods in dense retrieval. Moreover, retrieval by proposition also enhances the performance of downstream QA tasks, since the retrieved texts are more condensed with question-relevant information, reducing the need for lengthy input tokens and minimizing the inclusion of extraneous, irrelevant information.
    Keywords Computer Science - Computation and Language ; Computer Science - Artificial Intelligence ; Computer Science - Information Retrieval
    Subject code 004
    Publishing date 2023-12-11
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Dynamic X-ray imaging with screen-printed perovskite CMOS array.

    Liu, Yanliang / Gao, Chaosong / Li, Dong / Zhang, Xin / Zhu, Jiongtao / Wu, Meng / Liu, Wenjun / Shi, Tongyu / He, Xingchen / Wang, Jiahong / Huang, Hao / Sheng, Zonghai / Liang, Dong / Yu, Xue-Feng / Zheng, Hairong / Sun, Xiangming / Ge, Yongshuai

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1588

    Abstract: High performance X-ray detector with ultra-high spatial and temporal resolution are crucial ... for biomedical imaging. This study reports a dynamic direct-conversion CMOS X-ray detector assembled with screen ...

    Abstract High performance X-ray detector with ultra-high spatial and temporal resolution are crucial for biomedical imaging. This study reports a dynamic direct-conversion CMOS X-ray detector assembled with screen-printed CsPbBr
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45871-2
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  6. Article: System X

    Li, Feng-Jiao / Long, Hui-Zhi / Zhou, Zi-Wei / Luo, Hong-Yu / Xu, Shuo-Guo / Gao, Li-Chen

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 910292

    Abstract: ... have been discovered to regulate ferroptosis. In particular, the cystine/glutamate antiporter (System X ...

    Abstract The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors. Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid peroxides. The intracellular imbalance between oxidant and antioxidant due to the abnormal expression of multiple redox active enzymes will promote the produce of reactive oxygen species (ROS). So far, a few pathways and regulators have been discovered to regulate ferroptosis. In particular, the cystine/glutamate antiporter (System X
    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.910292
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  7. Article ; Online: Visualized X-ray Dosimetry for Multienvironment Applications.

    Lu, Lan / Peng, Songcheng / Zhao, Lei / Zhang, Meiguang / Xiao, Jianqiang / Wen, Hongyu / Zhang, Peng / Yakovlev, Alexey Nikolaevich / Qiu, Jianbei / Yu, Xue / Wang, Ting / Xu, Xuhui

    Nano letters

    2023  Volume 23, Issue 18, Page(s) 8753–8760

    Abstract: X-ray dose detection plays a critical role in various scientific fields, including chemistry ... in both immediate and delayed radiation detections. Here, we present a visual X-ray dosimetry method ...

    Abstract X-ray dose detection plays a critical role in various scientific fields, including chemistry, materials, and medicine. However, the current materials used for this purpose face challenges in both immediate and delayed radiation detections. Here, we present a visual X-ray dosimetry method for multienvironment applications, utilizing NaLuF
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c02826
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  8. Article ; Online: Breast cancer cells have an increased ferroptosis risk induced by system x

    Xue, Wenwen / Yu, Ying / Yao, Yongzhong / Zhou, Lin / Huang, Ying / Wang, Yixuan / Chen, Zhixiu / Wang, Liwei / Li, Xinran / Wang, Xiaoning / Du, Ronghui / Shen, Yan / Xu, Qiang

    Redox biology

    2024  Volume 70, Page(s) 103034

    Abstract: ... expression showed hypersensitivity to system x ...

    Abstract Cytokine-like protein 1 (CYTL1) expression is deliberately downregulated during the progression of multiple types of cancers, especially breast cancer. However, the metabolic characteristics of cancer progression remain unclear. Here, we uncovered a risk of breast cancer cells harboring low CYTL1 expression, which is metabolically controlled during malignant progression. We performed metabolism comparison and revealed that breast cancer cells with low CYTL1 expression have highly suppressed transsulfuration activity that is driven by cystathionine β-synthase (CBS) and contributes to de novo cysteine synthesis. Mechanistically, CYTL1 activated Nrf2 by promoting autophagic Keap1 degradation, and Nrf2 subsequently transactivated CBS expression. Due to the lack of cellular cysteine synthesis, breast cancer cells with low CYTL1 expression showed hypersensitivity to system x
    MeSH term(s) Humans ; Female ; Kelch-Like ECH-Associated Protein 1/metabolism ; Breast Neoplasms/genetics ; Ferroptosis ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Cysteine ; Cystathionine beta-Synthase/metabolism ; Blood Proteins/metabolism ; Cytokines/metabolism
    Chemical Substances Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Cysteine (K848JZ4886) ; Cystathionine beta-Synthase (EC 4.2.1.22) ; CYTL1 protein, human ; Blood Proteins ; Cytokines
    Language English
    Publishing date 2024-01-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2024.103034
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  9. Article ; Online: Size characterization of x-ray tube source with sphere encoded imaging method.

    Yu, Jian / Li, Dikai / Dai, Yanmeng / Zhang, Chunhui / Chen, Wei / Zhong, Jian / Wang, Xue / Xia, Runxiang / Cao, Leifeng / Zhou, Cangtao / Ruan, Shuangchen

    The Review of scientific instruments

    2024  Volume 95, Issue 1

    Abstract: In x-ray imaging, the size of the x-ray tube light source significantly impacts image quality ... However, existing methods for characterizing the size of the x-ray tube light source do not meet measurement ... a novel method for accurately characterizing the size of the x-ray tube light source using spherical ...

    Abstract In x-ray imaging, the size of the x-ray tube light source significantly impacts image quality. However, existing methods for characterizing the size of the x-ray tube light source do not meet measurement requirements due to limitations in processing accuracy and mechanical precision. In this study, we introduce a novel method for accurately characterizing the size of the x-ray tube light source using spherical encoded imaging technology. This method effectively mitigates blurring caused by system tilting, making system alignment and assembly more manageable. We employ the Richardson-Lucy algorithm to iteratively deconvolve the image and recover spatial information about the x-ray tube source. Unlike traditional coded imaging methods, spherical coded imaging employs high-Z material spheres as coding elements, replacing the coded holes used in traditional approaches. This innovation effectively mitigates blurring caused by system tilting, making system alignment and assembly more manageable. In addition, the mean square error is reduced to 0.008. Our results demonstrate that spherical encoded imaging technology accurately characterizes the size of the x-ray tube light source. This method holds significant promise for enhancing image quality in x-ray imaging.
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/5.0180056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Giant X-Ray Circular Dichroism in a Time-Reversal Invariant Antiferromagnet.

    Okamoto, Jun / Wang, Ru-Pan / Chu, Yen-Yi / Shiu, Hung-Wei / Singh, Amol / Huang, Hsiao-Yu / Mou, Chung-Yu / Teh, Sukhito / Jeng, Horng-Tay / Du, Kai / Xu, Xianghan / Cheong, Sang-Wook / Du, Chao-Hung / Chen, Chien-Te / Fujimori, Atsushi / Huang, Di-Jing

    Advanced materials (Deerfield Beach, Fla.)

    2024  , Page(s) e2309172

    Abstract: X-ray circular dichroism, arising from the contrast in X-ray absorption between opposite photon ... X-ray magnetic circular dichroism because of time-reversal symmetry, yet exhibit weak X-ray natural ...

    Abstract X-ray circular dichroism, arising from the contrast in X-ray absorption between opposite photon helicities, serves as a spectroscopic tool to measure the magnetization of ferromagnetic materials and identify the handedness of chiral crystals. Antiferromagnets with crystallographic chirality typically lack X-ray magnetic circular dichroism because of time-reversal symmetry, yet exhibit weak X-ray natural circular dichroism. Here, the observation of giant natural circular dichroism in the Ni L
    Language English
    Publishing date 2024-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202309172
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