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  1. Article ; Online: Low dose naloxone for pruritus in systemic sclerosis: Case series and literature review.

    Meridor, Katya / Berookhim, Joshua / Levy, Yair

    Medicine

    2022  Volume 101, Issue 4, Page(s) e28653

    Abstract: Rationale: Pruritus is a common symptom in patients with systemic sclerosis and has a tremendous effect on the quality of life. Nevertheless, current therapeutic options are limited. The pathogenesis of pruritus in systemic sclerosis is not completely ... ...

    Abstract Rationale: Pruritus is a common symptom in patients with systemic sclerosis and has a tremendous effect on the quality of life. Nevertheless, current therapeutic options are limited. The pathogenesis of pruritus in systemic sclerosis is not completely understood; however, opiate-mediated neurotransmission has been postulated to be involved.
    Patient concerns and diagnosis: We describe 4 female patients with systemic sclerosis suffering from severe pruritus, with an average 5D-itch score of 22.75.
    Intervention and outcomes: Low-dose oral naloxone was initiated, followed by a significant improvement in the level of pruritus, reaching an average 5D-itch score of 7.5, after 6 and 12 months of treatment. None of the patients experienced side effects.
    Lessons: Low-dose naloxone plays an important role in the management of pruritus in systemic sclerosis.
    MeSH term(s) Adult ; Aged ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/therapeutic use ; Female ; Humans ; Middle Aged ; Naloxone/administration & dosage ; Naloxone/therapeutic use ; Pruritus/drug therapy ; Pruritus/etiology ; Quality of Life ; Scleroderma, Systemic/complications
    Chemical Substances Analgesics, Opioid ; Naloxone (36B82AMQ7N)
    Language English
    Publishing date 2022-01-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000028653
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  2. Article ; Online: Notes From the Eye of the Storm: Trainees at the Frontlines of the COVID-19 Pandemic.

    Berookhim, Joshua / Correa, Ashish / Tamis-Holland, Jacqueline E

    Journal of the American College of Cardiology

    2020  Volume 76, Issue 2, Page(s) 218–220

    MeSH term(s) COVID-19 ; Coronavirus Infections ; Hospital Administration ; Humans ; Internship and Residency ; New York City ; Pandemics ; Patient Care ; Pneumonia, Viral
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.05.021
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  3. Article ; Online: Safety of exercise for adults with thoracic aortic aneurysms and dissections.

    Li, Jesse / Boyd, Alexandra / Huang, Michael / Berookhim, Joshua / Prakash, Siddharth K

    Frontiers in sports and active living

    2022  Volume 4, Page(s) 888534

    Abstract: Background: Current guidelines for patients with thoracic aortic aneurysms or dissections (TAD) restrict vigorous exertion with the intention to prevent acute aortic dissections. However, a safe threshold for exercise intensity has not been established ... ...

    Abstract Background: Current guidelines for patients with thoracic aortic aneurysms or dissections (TAD) restrict vigorous exertion with the intention to prevent acute aortic dissections. However, a safe threshold for exercise intensity has not been established for TAD patients. In this study, we measured exertional changes in systolic and diastolic blood pressure during isometric and dynamic exercises in a cohort of TAD patients to determine safety of moderate intensity exercise.
    Methods: Thirty-one adults with TAD and 14 controls were recruited from UTHealth outpatient clinics. All participants completed an exercise protocol consisting of two circuits of five moderate intensity exercises: hand grips, leg raises, bicep curls, stationary cycling, and wall sits. Blood pressure values were recorded during exercise using Spacelabs OnTrak Ambulatory Blood Pressure monitors. Perceived exertion during each exercise was measured using the Borg CR-10 scale.
    Results: No significant differences in the maximum exertional systolic pressure, diastolic pressure, or change from baseline was found between the TAD and control groups. Higher amounts of self-reported weekly moderate activity level (MAL) in TAD correlated with lower exertional SBP during exercise. Higher Borg scores were associated with a greater change in systolic pressure.
    Conclusion: Moderate intensity exercise is safe and feasible for many TAD patients. Our data confirms that the Borg score may be a useful proxy for exercise intensity. In this study, we establish a reproducible exercise protocol that can be adapted to create individualized exercise regimens for TAD patients as part of a care plan to improve long-term cardiovascular health.
    Language English
    Publishing date 2022-08-22
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2624-9367
    ISSN (online) 2624-9367
    DOI 10.3389/fspor.2022.888534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Delayed Presentation of a Large Pseudoaneurysm in the Common Femoral Artery After an Electrophysiology Study.

    Ratcliffe, Justin / Berookhim, Joshua / Khullar, Pankaj / Rajper, Naveed / Puma, Joseph

    JACC. Case reports

    2020  Volume 2, Issue 3, Page(s) 454–455

    Abstract: We describe a rare case of an exceptionally large pseudoaneurysm that developed in the right common femoral artery 6 months after an electrophysiological study. Surgical and other conventional methods to treat his pseudoaneurysm were not feasible. ... ...

    Abstract We describe a rare case of an exceptionally large pseudoaneurysm that developed in the right common femoral artery 6 months after an electrophysiological study. Surgical and other conventional methods to treat his pseudoaneurysm were not feasible. Therefore, the pseudoaneurysm was successfully treated via an endovascular approach with a covered stent. (
    Language English
    Publishing date 2020-03-18
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2019.12.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: MELD-Na score, Acute Physiologic and Chronic Health Evaluation II score, and SOFA score and their association with mortality in critically ill COVID-19 patients with liver injury: A retrospective single-center study.

    Gomez-Paz, Sandra / Lam, Eric / Gonzalez-Mosquera, Luis / Berookhim, Brian / Mustacchia, Paul / Fogel, Joshua / Rubinstein, Sofia

    International journal of critical illness and injury science

    2022  Volume 12, Issue 4, Page(s) 222–228

    Abstract: Background: The Acute Physiologic and Chronic Health Evaluation II (APACHE-II), Sequential Organ Failure Assessment (SOFA), and Model for End-Stage Liver Disease modified for Sodium concentration (MELD-Na) scores are validated to predict disease ... ...

    Abstract Background: The Acute Physiologic and Chronic Health Evaluation II (APACHE-II), Sequential Organ Failure Assessment (SOFA), and Model for End-Stage Liver Disease modified for Sodium concentration (MELD-Na) scores are validated to predict disease mortality. We studied the prognostic utility of these scoring systems in critically ill coronavirus disease 2019 (COVID-19) patients with liver injury.
    Methods: This was a retrospective study of 291 confirmed COVID-19 and liver injury patients requiring intensive care unit level of care. These patients required supplemental oxygen requirement with fraction of inspired oxygen >55% and/or the use of vasopressor. MELD-Na, SOFA, and APACHE-II scores were adjusted. Outcomes were mortality and length of stay (LOS).
    Results: SOFA (odds ratio: 0.78, 95% confidence interval: 0.63-0.98,
    Conclusions: We suggest that the novel nature of COVID-19 necessitates new scoring systems to predict outcomes in critically ill COVID-19 patients with liver injury.
    Language English
    Publishing date 2022-12-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2638865-0
    ISSN 2231-5004 ; 2229-5151
    ISSN (online) 2231-5004
    ISSN 2229-5151
    DOI 10.4103/ijciis.ijciis_29_22
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  7. Article ; Online: Development and treatment of two distinct pseudoaneurysms following transradial coronary catheterization in a patient with high bleeding risk: a case report.

    Wu, Lingling / Haddadin, Faris / Berookhim, Joshua / Ratcliffe, Justin / Puma, Joseph

    Journal of medical case reports

    2019  Volume 13, Issue 1, Page(s) 282

    Abstract: Background: A pseudoaneurysm is a rare but serious complication after transradial coronary catheterization. Although different treatment modalities have been proposed to treat post-catheterization pseudoaneurysm, only limited data are available to guide ...

    Abstract Background: A pseudoaneurysm is a rare but serious complication after transradial coronary catheterization. Although different treatment modalities have been proposed to treat post-catheterization pseudoaneurysm, only limited data are available to guide the treatment approach.
    Case presentation: We report a rare case of two distinct pseudoaneurysms complicating transradial percutaneous coronary intervention in a 75-year-old Hispanic woman being treated with dual antiplatelet agents for myocardial infarction and warfarin for atrial fibrillation. The pseudoaneurysms were diagnosed with ultrasound and were successfully treated with a series of Terumo Corporation (TR) band compressions.
    Conclusions: This case demonstrates the efficacy of compression therapy in managing post-catheterization radial artery pseudoaneurysm in patients with high bleeding risk.
    MeSH term(s) Aged ; Aneurysm, False/diagnostic imaging ; Atrial Fibrillation/drug therapy ; Cardiac Catheterization/adverse effects ; Dual Anti-Platelet Therapy ; Female ; Humans ; Myocardial Infarction/drug therapy ; Percutaneous Coronary Intervention ; Radial Artery/diagnostic imaging ; Ultrasonography, Doppler, Duplex
    Language English
    Publishing date 2019-09-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-019-2205-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Development and treatment of two distinct pseudoaneurysms following transradial coronary catheterization in a patient with high bleeding risk

    Lingling Wu / Faris Haddadin / Joshua Berookhim / Justin Ratcliffe / Joseph Puma

    Journal of Medical Case Reports, Vol 13, Iss 1, Pp 1-

    a case report

    2019  Volume 5

    Abstract: Abstract Background A pseudoaneurysm is a rare but serious complication after transradial coronary catheterization. Although different treatment modalities have been proposed to treat post-catheterization pseudoaneurysm, only limited data are available ... ...

    Abstract Abstract Background A pseudoaneurysm is a rare but serious complication after transradial coronary catheterization. Although different treatment modalities have been proposed to treat post-catheterization pseudoaneurysm, only limited data are available to guide the treatment approach. Case presentation We report a rare case of two distinct pseudoaneurysms complicating transradial percutaneous coronary intervention in a 75-year-old Hispanic woman being treated with dual antiplatelet agents for myocardial infarction and warfarin for atrial fibrillation. The pseudoaneurysms were diagnosed with ultrasound and were successfully treated with a series of Terumo Corporation (TR) band compressions. Conclusions This case demonstrates the efficacy of compression therapy in managing post-catheterization radial artery pseudoaneurysm in patients with high bleeding risk.
    Keywords Pseudoaneurysm ; Coronary artery disease ; Intervention ; Complication ; Compression ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Abstract 10613: Symptomatic Human Immunodeficiency Virus Infected Patients Receive Less Aggressive Revascularization Management After Acute Coronary Syndrome, a 5-year Nationwide Analysis.

    Huang Lucas, Claire / Wu, Lingling / Yue, Bing / Bachoo, Nikhil / Abed, Robert / Berookhim, Joshua / Wei, Xin / Herzog, Eyal

    Circulation

    2019  Volume 140, Issue Suppl_1, Page(s) A10613

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2019-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/circ.140.suppl_1.10613
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    Ui IV Zs.60: Show issues Location:
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  10. Article: Detection of Antibodies against Human and Plant Aquaporins in Patients with Multiple Sclerosis.

    Vojdani, Aristo / Mukherjee, Partha Sarathi / Berookhim, Joshua / Kharrazian, Datis

    Autoimmune diseases

    2015  Volume 2015, Page(s) 905208

    Abstract: Multiple sclerosis (MS) is an autoimmune disease that affects the body's central nervous system. Around 90% of MS sufferers are diagnosed with relapsing-remitting MS (RRMS). We used ELISA to measure IgG, IgA, and IgM antibodies against linear epitopes of ...

    Abstract Multiple sclerosis (MS) is an autoimmune disease that affects the body's central nervous system. Around 90% of MS sufferers are diagnosed with relapsing-remitting MS (RRMS). We used ELISA to measure IgG, IgA, and IgM antibodies against linear epitopes of human and plant aquaporins (AQP4) as well as neural antigens in RRMS patients and controls to determine whether patients suffering from RRMS have simultaneous elevations in antibodies against these peptides and antigens. In comparison to controls, significant elevations in isotype-specific antibodies against human and plant AQP4 and neural antigens such as MBP, MOG, and S100B were detected in RRMS patients, indicating a high correlation in antibody reaction between plant aquaporins and brain antigens. This correlation between the reactivities of RRMS patients with various tested antigens was the most significant for the IgM isotype. We conclude that a subclass of patients with RRMS reacts to both plant and human AQP4 peptides. This immune reaction against different plant aquaporins may help in the development of dietary modifications for patients with MS and other neuroimmune disorders.
    Language English
    Publishing date 2015-07-26
    Publishing country United States
    Document type Journal Article
    ISSN 2090-0422
    ISSN 2090-0422
    DOI 10.1155/2015/905208
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