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  1. Book ; Online: Rare Kidney Diseases : New Translational Research Approach to Improve Diagnosis and Therapy

    Zaza, Gianluigi / Gambaro, Giovanni

    2020  

    Keywords Medicine
    Size 1 electronic resource (168 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044247
    ISBN 9783039367832 ; 3039367838
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: In memory of professor Giuseppe Maschio.

    Gambaro, Giovanni

    Journal of nephrology

    2024  Volume 37, Issue 2, Page(s) 265–266

    MeSH term(s) History, 20th Century ; History, 21st Century ; Nephrology/history ; Humans ; Italy
    Language English
    Publishing date 2024-01-27
    Publishing country Italy
    Document type Historical Article ; Biography ; Portrait ; Editorial
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01871-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3369: Show issues Location:
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  3. Article ; Online: Discovering predictive temporal patterns for Acute Kidney Injury from critical care data.

    Amico, Beatrice / Combi, Carlo / Gambaro, Giovanni

    AMIA ... Annual Symposium proceedings. AMIA Symposium

    2024  Volume 2023, Page(s) 261–269

    Abstract: Acute Kidney Injury is a severe clinical condition with a high risk of multi-organs complications and mortality. For this reason, early recognition is crucial. Our proposal based on a 3-window framework discovers all hidden regularities, called ... ...

    Abstract Acute Kidney Injury is a severe clinical condition with a high risk of multi-organs complications and mortality. For this reason, early recognition is crucial. Our proposal based on a 3-window framework discovers all hidden regularities, called Approximate Predictive Functional Dependencies, with the aim to enable early recognition of high-risk patients during hospitalization in the Intensive Care Unit (ICU). We evaluated the different severity stages according to the Kidney Disease Improving Global Outcomes (KDIGO) guidelines, building different pathological state patterns, from admission to the discharge from ICU. According to the clinical practice, for each patient, we examined various characteristics expressed as a temporal history of events that may predict a pathological state pattern. We evaluated our proposal exploiting the MIMIC-IV dataset, a collection of Electronic Medical Records from ICU. The obtained results showed promising possibilities to use this type of dependency to support clinical practice.
    MeSH term(s) Humans ; Critical Care ; Intensive Care Units ; Acute Kidney Injury/diagnosis ; Hospitalization ; Kidney ; Retrospective Studies
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 1942-597X
    ISSN (online) 1942-597X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Optimal Length of Pharmacological Prophylaxis in Calcium Kidney Stone Formers.

    Lombardi, Gianmarco / Ferraro, Pietro Manuel / Gambaro, Giovanni

    Kidney360

    2023  Volume 4, Issue 9, Page(s) e1318–e1321

    MeSH term(s) Humans ; Kidney Calculi/drug therapy ; Kidney Calculi/prevention & control
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Empirical therapy or precision medicine for kidney stone formers in the '-omics' era?

    Gambaro, Giovanni

    Urolithiasis

    2018  Volume 47, Issue 1, Page(s) 1–3

    MeSH term(s) Genetic Predisposition to Disease ; Genetic Testing/economics ; Genetic Testing/methods ; Genomics ; Genotyping Techniques/economics ; Genotyping Techniques/methods ; Humans ; Kidney Calculi/diagnosis ; Kidney Calculi/epidemiology ; Kidney Calculi/genetics ; Kidney Calculi/therapy ; Precision Medicine/methods ; Prevalence ; Time Factors
    Language English
    Publishing date 2018-11-29
    Publishing country Germany
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2703553-0
    ISSN 2194-7236 ; 2194-7228
    ISSN (online) 2194-7236
    ISSN 2194-7228
    DOI 10.1007/s00240-018-1099-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 928: Show issues Location:
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  6. Article ; Online: What has vaccination against COVID-19 in CKD patients taught us?

    Rossi, Mattia / Pessolano, Giuseppina / Gambaro, Giovanni

    Journal of nephrology

    2023  Volume 36, Issue 5, Page(s) 1257–1266

    Abstract: Effective vaccination strategies are of crucial importance to protecting patients who are vulnerable to infections, such as patients with chronic kidney disease. This is because the decreased efficiency of the immune system in chronic kidney disease ... ...

    Abstract Effective vaccination strategies are of crucial importance to protecting patients who are vulnerable to infections, such as patients with chronic kidney disease. This is because the decreased efficiency of the immune system in chronic kidney disease impairs vaccine-induced immunisation. COVID-19 has prompted investigation of the immune response to SARS-CoV-2 vaccines in chronic kidney disease and in kidney transplant recipients in an effort to improve efficacy. The seroconversion rate after two vaccine doses is reduced, especially in kidney transplant recipients. Furthermore, although the seroconversion rate in chronic kidney disease patients is as high as in healthy subjects, anti-spike antibody titres are lower than in healthy vaccinated individuals, and these titres decrease rapidly. Although the vaccine-induced anti-spike antibody titre correlates with neutralising antibody levels and with protection against COVID-19, the protective prognostic significance of their titre is decreased due to the emergence of SARS-CoV-2 variants other than the Wuhan index virus against which the original vaccines were produced. Cellular immunity is also relevant, and because of cross-reactivity to the spike protein, epitopes of different viral variants confer protection against newly emerging variants of SARS-CoV-2. A multi-dose vaccination strategy is the most effective way to obtain a sufficient serological response. In kidney transplant recipients, a 5-week discontinuation period from antimetabolite drugs in concomitance with vaccine administration may also increase the vaccine's efficacy. The newly acquired knowledge obtained from COVID-19 vaccination is of general interest for the success of other vaccinations in chronic kidney disease patients.
    MeSH term(s) Humans ; COVID-19/prevention & control ; SARS-CoV-2 ; COVID-19 Vaccines ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-05-04
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01640-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Impact of the new, race-free CKD-EPI equation on prevalence and clinical outcomes of CKD in northeastern Italy: the INCIPE study.

    Ferraro, Pietro Manuel / Lombardi, Gianmarco / Gambaro, Giovanni

    Journal of nephrology

    2022  Volume 35, Issue 6, Page(s) 1767–1769

    MeSH term(s) Creatinine ; Glomerular Filtration Rate ; Humans ; Italy/epidemiology ; Prevalence ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2022-02-17
    Publishing country Italy
    Document type Letter
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-022-01284-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3369: Show issues Location:
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  8. Article ; Online: Sex differences in chronic kidney disease-related complications and mortality across levels of glomerular filtration rate.

    Lombardi, Gianmarco / Ferraro, Pietro Manuel / De Tomi, Elisa / Bargagli, Matteo / Spasiano, Andrea / Gambaro, Giovanni

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2024  

    Abstract: Background and hypothesis: Chronic kidney disease (CKD) is a growing global health concern. Recent research has indicated sex disparities in CKD-related complications, yet the impact of sex differences on critical kidney function levels that trigger ... ...

    Abstract Background and hypothesis: Chronic kidney disease (CKD) is a growing global health concern. Recent research has indicated sex disparities in CKD-related complications, yet the impact of sex differences on critical kidney function levels that trigger these complications and mortality remains inadequately documented.
    Methods: We investigated sex-specific disparities in CKD-related complications and mortality according to eGFR levels. We analyzed NHANES data spanning from 1999 to 2018, including adult participants with an eGFR of 15-150 ml/min per 1.73m². The outcomes were CKD-related complications (hypertension, anaemia, CV diseases, acidosis, hyperphosphatemia, hyperparathyroidism) and all-cause and cause-specific mortality (CV mortality and non-CV mortality). Sex-stratified multivariable logistic and Cox regression models yielded odds ratios (ORs) and hazard ratios (HRs) for the relationship between eGFR categories and outcomes. Sex-stratified natural splines were used to explore the relationship between continuous eGFR and outcomes and identified eGFR thresholds of statistical significance.
    Results: The study included 49 558 participants (50.3% women, 49.7% men). Multivariable logistic regression demonstrated a significant eGFR association with all CKD-related complications, exhibiting a linear trend across eGFR categories. Modelling eGFR as a natural spline revealed varied significance thresholds between sexes for anaemia and hyperparathyroidism. Additionally, the eGFR-hyperphosphatemia association was more pronounced in men. We observed substantial but not statistically significant differences between men and women in the thresholds of statistical significance for CV (significance appeared at a higher eGFR in men) and non-CV mortality (significance appeared at a higher eGFR in women).
    Conclusions: Research shows sex disparities in most CKD-related complications. Men develop anaemia and hyperparathyroidism earlier, women show steeper anaemia increase. Men have higher CV mortality risk. As eGFR decreased, men faced a higher risk of CV mortality at a higher eGFR threshold than women.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfae087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  9. Article ; Online: Nothing will ever be as before. Reflections on the COVID-19 epidemics by nephrologists in eleven countries.

    Gambaro, Giovanni / Piccoli, Giorgina B

    Journal of nephrology

    2020  Volume 33, Issue 4, Page(s) 633–637

    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Middle Aged ; Nephrologists ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-25
    Publishing country Italy
    Document type Editorial
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-020-00756-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Research, friendship, the joy of writing and the editorship of Journal of Nephrology.

    Gambaro, Giovanni / Piccoli, Giorgina Barbara

    Journal of nephrology

    2020  Volume 33, Issue 4, Page(s) 621–624

    MeSH term(s) Editorial Policies ; Friends ; Humans ; Nephrology ; Periodicals as Topic ; Publications ; SARS-CoV-2 ; Writing
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country Italy
    Document type Editorial
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-020-00791-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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