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  1. Book ; Thesis: Präanalytische Beeinflussung des Immunmodulators "Löslicher CD40 Ligand" in diagnostischen Proben und dessen therapeutische Alteration im peripheren Blut unter spezieller Berücksichtigung von Patienten mit Chemotherapie-induzierter Thrombozytopenie

    Wenzel, Folker

    2011  

    Author's details vorgelegt von Folker Wenzel
    Language German
    Size Getr. Zählung
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Düsseldorf, Univ., Habil., 2011
    HBZ-ID HT017316158
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 E 1615 order for loan Magazin

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  2. Article ; Online: Notions of "coronavirus" from the perspective of a clinical immunologist and medical historian.

    Wenzel, Folker

    Clinical hemorheology and microcirculation

    2020  Volume 74, Issue 4, Page(s) 349–352

    Keywords covid19
    Language English
    Publishing date 2020-04-25
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1381750-4
    ISSN 1875-8622 ; 1386-0291
    ISSN (online) 1875-8622
    ISSN 1386-0291
    DOI 10.3233/CH-209002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1623: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Defibrillation data analysis of prehospital resuscitation scenarios having different impulse durations

    Fischer Jonas / Wenzel Folker

    Current Directions in Biomedical Engineering, Vol 9, Iss 1, Pp 431-

    2023  Volume 434

    Abstract: The objective of this study was to assess and present technical data related to resuscitation procedures that involved the application of a defibrillator for at least one shock. Specifically, we sought to distinguish two rectangular defibrillation ... ...

    Abstract The objective of this study was to assess and present technical data related to resuscitation procedures that involved the application of a defibrillator for at least one shock. Specifically, we sought to distinguish two rectangular defibrillation impulses in terms of varying phase durations. The evaluation encompassed a range of defibrillation metrics and metadata, including transthoracic impedance, mean and peak currents. The results of this analysis provide valuable insights into the technical aspects of defibrillation.
    Keywords defibrillation ; impulse duration ; prehospital data ; Medicine ; R
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Thesis: Bildgesteuert lokalisierte 31 P-NMR-Spektroskopie der Transplantatniere des Menschen in vivo

    Wenzel, Folker

    1998  

    Author's details vorgelegt von Folker Wenzel
    Language German
    Size V, 106 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 1998
    HBZ-ID HT008259101
    Database Catalogue ZB MED Medicine, Health

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  6. Article: Longitudinal analysis of external quality assessment of immunoassay-based steroid hormone measurement indicates potential for improvement in standardization.

    Vierbaum, Laura / Weiss, Nathalie / Kaiser, Patricia / Kremser, Marcel / Wenzel, Folker / Thevis, Mario / Schellenberg, Ingo / Luppa, Peter B

    Frontiers in molecular biosciences

    2024  Volume 11, Page(s) 1345356

    Abstract: As hormonal disorders are linked to several diseases, the accurate quantitation of steroid hormone levels in serum is crucial in order to provide patients with a reliable diagnosis. Mass spectrometry-based methods are regarded as having the highest level ...

    Abstract As hormonal disorders are linked to several diseases, the accurate quantitation of steroid hormone levels in serum is crucial in order to provide patients with a reliable diagnosis. Mass spectrometry-based methods are regarded as having the highest level of specificity and sensitivity. However, immunoassays are more commonly used in routine diagnostics to measure steroid levels as they are more cost effective and straightforward to conduct. This study analyzes the external quality assessment results for the measurement of testosterone, progesterone and 17β-estradiol in serum using immunoassays between early 2020 and May 2022. As reference measurement procedures are available for the three steroid hormones, the manufacturer-specific biases were normalized to the reference measurement values. The manufacturer-specific coefficients of variation were predominantly inconspicuous, below 20% for the three hormones when outliers are disregarded, however there were large differences between the various manufacturer collectives. For some collectives, the median bias to the respective reference measurement value was repeatedly greater than ±35%, which is the acceptance limit defined by the German Medical Association. In the case of testosterone and progesterone determination, some collectives tended to consistently over- or underestimate analyte concentrations compared to the reference measurement value, however, for 17β-estradiol determination, both positive and negative biases were observed. This insufficient level of accuracy suggests that cross-reactivity continues to be a fundamental challenge when antibody detection is used to quantify steroids with a high structural similarity. Distinct improvements in standardization are required to provide accurate analysis and thus, reliable clinical interpretations. The increased accuracy of the AX immunoassay for testosterone measurement, as observed in the INSTAND EQAs between 2020 and 2022, could be the result of a recalibration of the assay and raises hope for further improvement of standardization of immunoassay-based steroid hormone analyses in the coming years.
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2024.1345356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Role of Lp(a) in patients with erectile dysfunction undergoing angioplasty for symptomatic pelvic artery disease.

    Kalka, Christoph / Lippik, Lisa / Wenzel, Folker / Hoppe, Hanno / Keo, Hak-Hong / Heiss, Christian / Diehm, Nicolas

    VASA. Zeitschrift fur Gefasskrankheiten

    2023  Volume 52, Issue 4, Page(s) 230–238

    MeSH term(s) Male ; Humans ; Middle Aged ; Aged ; Erectile Dysfunction/diagnosis ; Erectile Dysfunction/therapy ; Retrospective Studies ; Impotence, Vasculogenic/diagnosis ; Impotence, Vasculogenic/therapy ; Angioplasty/adverse effects ; Atherosclerosis ; Arteries
    Language English
    Publishing date 2023-05-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 120977-2
    ISSN 1664-2872 ; 0301-1526
    ISSN (online) 1664-2872
    ISSN 0301-1526
    DOI 10.1024/0301-1526/a001072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 808: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Comparative analysis of alignment tools for application on Nanopore sequencing data

    Becht Chiara / Schmidt Jonas / Blessing Frithjof / Wenzel Folker

    Current Directions in Biomedical Engineering, Vol 7, Iss 2, Pp 831-

    2021  Volume 834

    Abstract: INTRODUCTION: Long-read sequencing techniques such as Oxford Nanopore sequencing, are representing a promising novel approach in molecular-biological methodology, enabling potential facilitation in mapping and de novo assembly. In comparison to ... ...

    Abstract INTRODUCTION: Long-read sequencing techniques such as Oxford Nanopore sequencing, are representing a promising novel approach in molecular-biological methodology, enabling potential facilitation in mapping and de novo assembly. In comparison to conventional sequencing methods, novel alignment tools are mandated to compensate differing data structures (especially high error rate) to achieve acceptably accurate analysis results. METHODS: In this study, benchmarking for long read aligners BLASR, GraphMap, LAST, minimap2, NGMLR and the short-read aligner BWA MEM on three experimental datasets was conducted. Obtained alignment results were compared for various quality and performance criteria, such as match rate, mismatch rate, error rate, working memory usage and computational time. RESULTS: The comparison yielded differences in alignment quality and performance of tools under test. Tool LAST showed the largest differences among all tools. Minimap2 achieved constant quality with good performance. BLASR, GraphMap, BWA MEM and NGMLR showed slight differences only. CONCLUSION: Differences among the tools could be reasoned with dataset characteristics and algorithm approaches of individual tools. All tools except BLASR seem applicable for Nanopore sequencing data. Therefore, selection of the tool should be done under consideration of the experimental design and the further downstream analysis
    Keywords alignment tools ; nanopore sequencing ; benchmarking ; comparative analysis ; Medicine ; R
    Subject code 670
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online ; Thesis: Untersuchung der abweichenden Laborparameter bei gesunden Blutstammzellspendern unter besonderer Berücksichtigung des metabolischen Syndroms

    Becker, Ruth Marie [Verfasser] / Wenzel, Folker [Gutachter] / Boege, Fritz [Gutachter]

    2021  

    Author's details Ruth Marie Becker ; Gutachter: Folker Wenzel, Fritz Boege
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Article ; Online: Cutaneous microcirculation during operations with a cardiopulmonary bypass.

    Saemann, Lars / Wenzel, Folker

    Clinical hemorheology and microcirculation

    2018  Volume 69, Issue 1-2, Page(s) 13–21

    Abstract: Background: Cutaneous microcirculation (cMC) is influenced by many factors. In cardiac surgery, most operations are performed with a cardiopulmonary bypass (CPB) and cardiac arrest induced by cardioplegic solutions.: Objectives: Aim of this study was ...

    Abstract Background: Cutaneous microcirculation (cMC) is influenced by many factors. In cardiac surgery, most operations are performed with a cardiopulmonary bypass (CPB) and cardiac arrest induced by cardioplegic solutions.
    Objectives: Aim of this study was to examine a correlation between cMC and hemodynamic parameters in patients undergoing heart surgery with two different cardioplegic solutions.
    Methods: 20 patients were included and divided into Histidine-Tryptophane-α-Ketoglutarate solution- (HTK, n = 10) and blood cardioplegia- (BCP, n = 10) groups. With initiation of CPB, cMC was continuously monitored with Laser-Doppler-Perfusion (LDP) until termination of CPB. Additionally, we measured hemoglobin-concentration (HbC) with a Blood-Parameter-Monitoring-System.
    Results: LDP pulsation was almost equal before and after CPB and decreased during aortic cross clamping. The following factors influenced LDP: central venous pressure (CVP), mean arterial pressure (MAP), total peripheral resistance (TPR) and flow of the heart-lung machine. We measured relative LDP and HbC (RLDP; RHbC). Five and 25 min after administration of cardioplegia, RLDP (1.22±0.8; 1.17±0.94) and RHbC (0.92±0.06; 0.96±0.09) in the HTK-group were lower than in the BCP-group: RLDP (1.58±1.11; 1.58±2.2) and RHbC (1.00±0.05; 0.99±0.13). HTK-patients with a body surface area (BSA) <2 m2 showed a lower RLDP (0.75±0.50), than patients over 2 m2 (RLDP = 1.64±0.97).
    Conclusions: The cMC is influenced by CPB. Cutaneous LDP monitoring is a non-invasive method, for estimating hemodynamics intraoperatively.
    MeSH term(s) Cardiac Surgical Procedures/methods ; Cardiopulmonary Bypass/methods ; Female ; Heart Arrest, Induced/methods ; Hemodynamics/drug effects ; Humans ; Male ; Microcirculation/physiology ; Middle Aged ; Prospective Studies
    Language English
    Publishing date 2018
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1381750-4
    ISSN 1875-8622 ; 1386-0291
    ISSN (online) 1875-8622
    ISSN 1386-0291
    DOI 10.3233/CH-189102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1623: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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