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Article ; Online: COVID arm and PET/FDG imaging.

Barriere, Jérôme / Bondouy, Michaël

2021 Volume 108, Issue 6, Page(s) 668–669

MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Axilla ; BNT162 Vaccine/administration & dosage ; BNT162 Vaccine/adverse effects ; Deltoid Muscle/diagnostic imaging ; Deltoid Muscle/metabolism ; Female ; Fluorodeoxyglucose F18 ; Humans ; Immunization, Secondary/adverse effects ; Incidental Findings ; Lymphadenopathy/diagnostic imaging ; Lymphadenopathy/metabolism ; Neoplasm Recurrence, Local/drug therapy ; Ovarian Neoplasms/drug therapy ; Positron Emission Tomography Computed Tomography ; Radiopharmaceuticals
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-05-07
Publishing country	France
Document type	Case Reports ; Letter
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2021.04.002
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Article ; Online: Current perspectives for SARS-CoV-2 vaccination efficacy improvement in patients with active treatment against cancer.

Barrière, Jérôme / Re, Daniel / Peyrade, Frédéric / Carles, Michel

European journal of cancer (Oxford, England : 1990)

2021 Volume 154, Page(s) 66–72

Abstract: A higher risk of death from coronavirus disease 19 has been shown for patients with solid cancers or haematological malignancies (HM). Thanks to the accelerated development of anti-SARS-SoV-2 vaccines in less than a year since the start of the global ... ...

Abstract	A higher risk of death from coronavirus disease 19 has been shown for patients with solid cancers or haematological malignancies (HM). Thanks to the accelerated development of anti-SARS-SoV-2 vaccines in less than a year since the start of the global pandemic, patients with cancer were quickly prioritised in early 2021 for vaccination, however dependent on the very unequal availability at the global level. Impaired immunogenicity of SARS-CoV-2 mRNA vaccines in immunocompromised patients was rapidly reported as early as April 2021, although the vaccination fortunately appears to be generally effective without increasing the spacing. Worryingly, the humoral response of the SARS-CoV-2 vaccination is, however, considered insufficient in patients followed for HM, in particular when they are on anti-CD20 treatment. Thus, improving vaccination coverage by strengthening immune stimulation should be evaluated in patients under active treatment against cancer. Here, we discuss three different approaches: a third dose of early vaccine (repeated immune stimulation), heterologous prime-boost vaccination (multimodal immune stimulation) and a double-dose strategy (maximisation of immune response). Dedicated therapeutic trials, currently almost non-existent, seem rapidly necessary.
MeSH term(s)	Antibodies, Viral/blood ; COVID-19/immunology ; COVID-19/mortality ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/adverse effects ; Cause of Death ; Hospitalization ; Humans ; Immunity, Humoral ; Immunogenicity, Vaccine ; Neoplasms/diagnosis ; Neoplasms/immunology ; Neoplasms/therapy ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome ; Vaccination/adverse effects ; Vaccination/mortality
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines
Language	English
Publishing date	2021-06-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2021.06.008
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Préconisations pour protéger les patients de la filière oncologique face au variant Omicron.

Barrière, Jérôme / Zalcman, Gérard / Fignon, Laurent / Peiffer-Smadja, Nathan / Audigier-Valette, Clarisse / Carles, Michel

Bulletin du cancer

2022 Volume 109, Issue 2, Page(s) 115–118

Title translation	Recommendations to protect patients with cancer against the Omicron variant.
MeSH term(s)	COVID-19/complications ; COVID-19/prevention & control ; Humans ; Neoplasms/complications ; Practice Guidelines as Topic ; SARS-CoV-2
Language	French
Publishing date	2022-01-11
Publishing country	France
Document type	Editorial
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2021.12.007
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Article: Les arbres et les forêts peuvent-ils contribuer à l’amélioration de l’environnement sonore ?

Defrance, Jérôme / Jean, Philippe / Barrière, Nicolas

Sante publique (Vandoeuvre-les-Nancy, France)

2019 Volume S1, Issue HS, Page(s) 187–195

Abstract: In this article, we focus on ground transportation noise abatement and more precisely road traffic noise control. From literature as well as our own experience in this field we aim at determining in which planting schemes are trees or forest strips ... ...

Title translation	Can trees and forests help in improving environmental noise quality?
Abstract	In this article, we focus on ground transportation noise abatement and more precisely road traffic noise control. From literature as well as our own experience in this field we aim at determining in which planting schemes are trees or forest strips beneficial to environmental noise abatement, for which expected noise attenuation and with which good practices.We start by a brief point on French regulation on road noise management and we present a synthetic review of main attenuation processes observed when sounds propagates through areas with trees: ground, diffusion and refraction effects. Then we consider some typical landscape configurations studied in the scientific literature and we provide with expected acoustic impact: a forest strip along a road infrastructure, a row of trees along a noise protection and trees in the city. We finally give a set of recommendations of correct use of trees and forest strips as an element to the improvement of outdoor sound environment. Our advice is to plant broadleaved evergreens or a mixture of broadleaved evergreens and coniferous, with a minimum density of 0.25 tree/m2. We also advise to cultivate the ground before trees planting and to use well-rotted organic matter. On the other hand we do not recommend planting trees at the top of earth berms.
MeSH term(s)	Forests ; Humans ; Noise ; Trees
Language	French
Publishing date	2019-06-17
Publishing country	France
Document type	Journal Article
ZDB-ID	1465524-x
ISSN	2104-3841 ; 0995-3914
ISSN (online)	2104-3841
ISSN	0995-3914
DOI	10.3917/spub.190.0187
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Article ; Online: La lutte contre la fraude scientifique : une tâche ingrate mais nécessaire.

Barrière, Jérôme / Frank, Fabrice / Besancon, Lonni / Samuel, Alexander / Saada, Véronique / Billy, Eric / Seitz-Polski, Barbara / Robert, Jacques

Bulletin du cancer

2022 Volume 109, Issue 10, Page(s) 996–998

Title translation	The fight against scientific fraud: A thankless but necessary task.
MeSH term(s)	Fraud/prevention & control ; Humans ; Scientific Misconduct
Language	French
Publishing date	2022-08-31
Publishing country	France
Document type	Editorial
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2022.06.013
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Article ; Online: Scientific Integrity Requires Publishing Rebuttals and Retracting Problematic Papers.

Barrière, Jérôme / Frank, Fabrice / Besançon, Lonni / Samuel, Alexander / Saada, Véronique / Billy, Eric / Al-Ahmad, Abraham / Seitz-Polski, Barbara / Robert, Jacques

Stem cell reviews and reports

2022 Volume 19, Issue 2, Page(s) 568–572

Abstract: Recently, an article by Seneff et al. entitled "Innate immunosuppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs" was published in Food and Chemical Toxicology (FCT). Here, we describe why this article, which ... ...

Abstract	Recently, an article by Seneff et al. entitled "Innate immunosuppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs" was published in Food and Chemical Toxicology (FCT). Here, we describe why this article, which contains unsubstantiated claims and misunderstandings such as "billions of lives are potentially at risk" with COVID-19 mRNA vaccines, is problematic and should be retracted. We report here our request to the editor of FCT to have our rebuttal published, unfortunately rejected after three rounds of reviewing. Fighting the spread of false information requires enormous effort while receiving little or no credit for this necessary work, which often even ends up being threatened. This need for more scientific integrity is at the heart of our advocacy, and we call for large support, especially from editors and publishers, to fight more effectively against deadly disinformation.
MeSH term(s)	Humans ; COVID-19 ; Publishing ; SARS-CoV-2/genetics ; Retraction of Publication as Topic
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-022-10465-2
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Article ; Online: Does Bariatric Surgery Reduce the Risk of Colorectal Cancer in Individuals with Morbid Obesity? A Systematic Review and Meta-Analysis.

Chierici, Andrea / Amoretti, Paolo / Drai, Céline / De Fatico, Serena / Barriere, Jérôme / Schiavo, Luigi / Iannelli, Antonio

Nutrients

2023 Volume 15, Issue 2

Abstract: Bariatric surgery has shown to be effective in producing sustained weight loss and the resolution of obesity related medical problems. Recent research focused on the role of obesity and adipose tissue in tumorigenesis, finding a strong crosslink through ... ...

Abstract	Bariatric surgery has shown to be effective in producing sustained weight loss and the resolution of obesity related medical problems. Recent research focused on the role of obesity and adipose tissue in tumorigenesis, finding a strong crosslink through different mechanisms and highlighting an increase in cancer incidence in individuals with obesity. The aim of this meta-analysis is to find if bariatric surgery reduces the incidence of colorectal cancer in patients with obesity. We performed a meta-analysis including 18 studies (PROSPERO ID: CRD4202235931). Bariatric surgery was found to be significantly protective toward colorectal cancer incidence in individuals with obesity (HR: 0.81,
MeSH term(s)	Male ; Humans ; Female ; Obesity, Morbid/complications ; Obesity, Morbid/epidemiology ; Obesity, Morbid/surgery ; Prospective Studies ; Gastric Bypass/methods ; Bariatric Surgery/methods ; Metabolism, Inborn Errors ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/prevention & control ; Laparoscopy/methods ; Treatment Outcome
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15020467
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Article ; Online: Raising concerns on questionable ethics approvals - a case study of 456 trials from the Institut Hospitalo-Universitaire Méditerranée Infection.

Frank, Fabrice / Florens, Nans / Meyerowitz-Katz, Gideon / Barriere, Jérôme / Billy, Éric / Saada, Véronique / Samuel, Alexander / Robert, Jacques / Besançon, Lonni

Research integrity and peer review

2023 Volume 8, Issue 1, Page(s) 9

Abstract: Background: The practice of clinical research is strictly regulated by law. During submission and review processes, compliance of such research with the laws enforced in the country where it was conducted is not always correctly filled in by the authors ...

Abstract	Background: The practice of clinical research is strictly regulated by law. During submission and review processes, compliance of such research with the laws enforced in the country where it was conducted is not always correctly filled in by the authors or verified by the editors. Here, we report a case of a single institution for which one may find hundreds of publications with seemingly relevant ethical concerns, along with 10 months of follow-up through contacts with the editors of these articles. We thus argue for a stricter control of ethical authorization by scientific editors and we call on publishers to cooperate to this end. Methods: We present an investigation of the ethics and legal aspects of 456 studies published by the IHU-MI (Institut Hospitalo-Universitaire Méditerranée Infection) in Marseille, France. Results: We identified a wide range of issues with the stated research authorization and ethics of the published studies with respect to the Institutional Review Board and the approval presented. Among the studies investigated, 248 were conducted with the same ethics approval number, even though the subjects, samples, and countries of investigation were different. Thirty-nine (39) did not even contain a reference to the ethics approval number while they present research on human beings. We thus contacted the journals that published these articles and provide their responses to our concerns. It should be noted that, since our investigation and reporting to journals, PLOS has issued expressions of concerns for several publications we analyze here. Conclusion: This case presents an investigation of the veracity of ethical approval, and more than 10 months of follow-up by independent researchers. We call for stricter control and cooperation in handling of these cases, including editorial requirement to upload ethical approval documents, guidelines from COPE to address such ethical concerns, and transparent editorial policies and timelines to answer such concerns. All supplementary materials are available.
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Letter
ISSN	2058-8615
ISSN (online)	2058-8615
DOI	10.1186/s41073-023-00134-4
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Article ; Online: Letter to Editor "Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs": Important concerns on the validity of this article.

Barrière, Jérôme / Frank, Fabrice / Besancon, Lonni / Samuel, Alexander / Saada, Véronique / Billy, Eric / Al-Ahmad, Abraham / Florens, Nans / Seitz-Polski, Barbara / Robert, Jacques

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2023 Volume 178, Page(s) 113897

MeSH term(s)	Humans ; Exosomes ; G-Quadruplexes ; MicroRNAs ; SARS-CoV-2 ; COVID-19/prevention & control ; Immunity, Innate ; Vaccination ; RNA, Messenger/genetics
Chemical Substances	MicroRNAs ; RNA, Messenger
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2023.113897
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Article ; Online: Breakthrough infections due to SARS-CoV-2 Delta variant: relation to humoral and cellular vaccine responses.

Buscot, Matthieu / Cremoni, Marion / Graça, Daisy / Brglez, Vesna / Courjon, Johan / Allouche, Jonathan / Teisseyre, Maxime / Boyer, Laurent / Barrière, Jérôme / Chamorey, Emmanuel / Carles, Michel / Seitz-Polski, Barbara

Frontiers in immunology

2023 Volume 14, Page(s) 1145652

Abstract: Introduction: COVID-19 vaccines are expected to provide effective protection. However, emerging strains can cause breakthrough infection in vaccinated individuals. The immune response of vaccinated individuals who have experienced breakthrough infection ...

Abstract	Introduction: COVID-19 vaccines are expected to provide effective protection. However, emerging strains can cause breakthrough infection in vaccinated individuals. The immune response of vaccinated individuals who have experienced breakthrough infection is still poorly understood. Methods: Here, we studied the humoral and cellular immune responses of fully vaccinated individuals who subsequently experienced breakthrough infection due to the Delta variant of SARS-CoV-2 and correlated them with the severity of the disease. Results: In this study, an effective humoral response alone was not sufficient to induce effective immune protection against severe breakthrough infection, which also required effective cell-mediated immunity to SARS-CoV-2. Patients who did not require oxygen had significantly higher specific (p=0.021) and nonspecific (p=0.004) cellular responses to SARS-CoV-2 at the onset of infection than those who progressed to a severe form. Discussion: Knowing both humoral and cellular immune response could allow to adapt preventive strategy, by better selecting patients who would benefit from additional vaccine boosters. Trial registration numbers: https://clinicaltrials.gov, identifier NCT04355351; https://clinicaltrials.gov, identifier NCT04429594.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 Vaccines ; Breakthrough Infections ; COVID-19/prevention & control ; Vaccines
Chemical Substances	COVID-19 Vaccines ; Vaccines
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1145652
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