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Article ; Online: Kaempferol therapy improved MC903 induced-atopic dermatitis in a mouse by suppressing TSLP, oxidative stress, and type 2 inflammation.

Nasanbat, Bolor / Uchiyama, Akihiko / Amalia, Syahla Nisaa / Inoue, Yuta / Yokoyama, Yoko / Ogino, Sachiko / Torii, Ryoko / Hosoi, Mari / Motegi, Sei-Ichiro

Journal of dermatological science

2023 Volume 111, Issue 3, Page(s) 93–100

Abstract: Background: Atopic dermatitis is a common skin disease caused by genetic susceptibility, environmental factors, immune response, and skin barrier dysfunction. Kaempferol is a natural flavonoid widely found in tea, vegetables, and fruits and has been ... ...

Abstract	Background: Atopic dermatitis is a common skin disease caused by genetic susceptibility, environmental factors, immune response, and skin barrier dysfunction. Kaempferol is a natural flavonoid widely found in tea, vegetables, and fruits and has been reported to have excellent anti-inflammation activity. However, the therapeutic effect of kaempferol on atopic dermatitis is unclear. Objective: This study aimed to elucidate the effect of kaempferol on skin inflammation in atopic dermatitis. Methods: The suppressive effect of kaempferol administration on skin inflammation was examined using MC903-induced atopic dermatitis-like skin inflammation mouse model. Quantification of skin dermatitis and transepidermal water loss was performed. A histopathological study was performed to examine thymic stromal lymphopoietin expression, cornified envelope proteins such as filaggrin, loricrin, and involucrin, and the numbers of infiltrating inflammatory cells, including lymphocytes, macrophages, and mast cells in the dermatitis area. The expressions of IL-4 and IL-13 were investigated by qPCR and flow cytometry analysis using skin tissues. The expression of HO-1 was investigated by western blot and qPCR. Results: Kaempferol therapy significantly suppressed MC903-induced dermatitis, TEWL, TSLP, and HO-1 expression, and infiltration of inflammatory cells. Kaempferol therapy improved the decreased expressions of filaggrin, loricrin, and involucrin in MC903-induced dermatitis skin site. The expressions of IL-4, and IL-13 were partially decreased in kaempferol-treated mice. Conclusion: Kaempferol might improve MC903-induced dermatitis via suppression of type 2 inflammation and improvement of barrier dysfunction by inhibition of TSLP expression and oxidative stress. Kaempferol might have the potential to be a new treatment for atopic dermatitis.
MeSH term(s)	Mice ; Animals ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/drug therapy ; Filaggrin Proteins ; Interleukin-13/metabolism ; Interleukin-4/metabolism ; Kaempferols/pharmacology ; Kaempferols/therapeutic use ; Cytokines/metabolism ; Skin/pathology ; Inflammation/metabolism ; Oxidative Stress
Chemical Substances	Filaggrin Proteins ; Interleukin-13 ; Interleukin-4 (207137-56-2) ; Kaempferols ; Cytokines
Language	English
Publishing date	2023-06-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1024446-3
ISSN	1873-569X ; 0923-1811
ISSN (online)	1873-569X
ISSN	0923-1811
DOI	10.1016/j.jdermsci.2023.06.008
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Zs.A 2870: Show issues

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Article ; Online: Two-Team Transanal Total Mesorectal Excision and En Bloc Resection of the Lateral Pelvic Lymph Nodes, Main Iliac Vessels, and Pelvic Plexus for Locally Advanced Rectal Cancer With Lateral Lymph Node Metastasis.

Shioi, Ikuma / Ogawa, Hiroomi / Hosoi, Nobuhiro / Yamaguchi, Arisa / Watanabe, Takayoshi / Nakazawa, Nobuhiro / Shibasaki, Yuta / Shiraishi, Takuya / Osone, Katsuya / Okada, Takuhisa / Sano, Akihiko / Sakai, Makoto / Sohda, Makoto / Shirabe, Ken / Saeki, Hiroshi

Surgical laparoscopy, endoscopy & percutaneous techniques

2024 Volume 34, Issue 2, Page(s) 237–241

Abstract: Background: Here, we describe the precise surgical technique for a novel procedure involving 2-team transanal total mesorectal excision with en bloc lateral pelvic lymph node (LPLN) dissection combined with resection of the involved main internal iliac ... ...

Abstract	Background: Here, we describe the precise surgical technique for a novel procedure involving 2-team transanal total mesorectal excision with en bloc lateral pelvic lymph node (LPLN) dissection combined with resection of the involved main internal iliac vessels and pelvic plexus. Methods: From September 2020 to May 2023, 4 patients underwent the procedure at our hospital. Results: The operation time and blood loss were 272 to 412 minutes and 10 to 124 mL, respectively. No patients required conversion to open surgery or exhibited Clavien-Dindo grade III or worse postoperative complications, although 2 developed grade II urinary dysfunction. All surgical margins were negative. Conclusions: Our novel 2-team method can facilitate safe and satisfactory surgery, even for highly advanced rectal cancer. The transanal approach offers excellent visibility and operability, even during LPLN and adjacent structure dissection. Furthermore, initial dissection of the distal branches of the iliac vessels prevents excessive lymphatic tissue congestion, facilitating easier, and clearer dissection.
MeSH term(s)	Humans ; Lymphatic Metastasis/pathology ; Hypogastric Plexus/pathology ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Lymph Node Excision/methods ; Rectal Neoplasms/surgery ; Rectal Neoplasms/pathology ; Retrospective Studies
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1475108-2
ISSN	1534-4908 ; 1530-4515 ; 1051-7200
ISSN (online)	1534-4908
ISSN	1530-4515 ; 1051-7200
DOI	10.1097/SLE.0000000000001268
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Zs.A 3200: Show issues

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Article ; Online: A Novel Method for Thoracoscopic Overlap Esophagogastric Reconstruction With Pleural Closure following Minimally Invasive Ivor-Lewis Esophagectomy for Esophagogastric Junction Cancer.

Sano, Akihiko / Sohda, Makoto / Hosoi, Nobuhiro / Tateno, Kohei / Watanabe, Takayoshi / Nakazawa, Nobuhiro / Shioi, Ikuma / Shibasaki, Yuta / Okada, Takuhisa / Osone, Katsuya / Shiraishi, Takuya / Sakai, Makoto / Ogawa, Hiroomi / Okabe, Hiroshi / Shirabe, Ken / Saeki, Hiroshi

Surgical laparoscopy, endoscopy & percutaneous techniques

2024 Volume 34, Issue 1, Page(s) 108–112

Abstract: Background: Intrathoracic esophagogastric anastomosis following minimally invasive Ivor-Lewis esophagectomy is a technically demanding surgical technique that can result in serious intrathoracic infections when anastomotic leakage occurs. Herein, we ... ...

Abstract	Background: Intrathoracic esophagogastric anastomosis following minimally invasive Ivor-Lewis esophagectomy is a technically demanding surgical technique that can result in serious intrathoracic infections when anastomotic leakage occurs. Herein, we report a novel side-overlap esophagogastric anastomosis with pleural closure for esophagogastric junction cancer. Methods: The 3 key points of our novel technique were the following: (1) overlap esophagogastric anastomosis and closure of the entry hole were all performed using a linear stapler; (2) the pleura was closed to separate the anastomotic site from the thoracic cavity; and (3) the mediastinal drain was inserted transhiatally from the abdominal cavity. Results: This modified anastomosis procedure was performed on 8 consecutive patients at our institution. The median overall/thoracoscopic operating time and estimated blood loss were 652.5/241.5 min and 89 mL, respectively. No mortality or serious postoperative complications occurred, and the median postoperative hospital stay was 22 days (range, 17 to 37 d). Conclusion: This novel thoracoscopic overlap esophagogastric reconstruction procedure with pleural closure is safe and feasible.
MeSH term(s)	Humans ; Esophagectomy/methods ; Pleura/surgery ; Esophageal Neoplasms/surgery ; Esophagogastric Junction/surgery ; Anastomotic Leak/surgery ; Anastomosis, Surgical/methods ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Retrospective Studies
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1475108-2
ISSN	1534-4908 ; 1530-4515 ; 1051-7200
ISSN (online)	1534-4908
ISSN	1530-4515 ; 1051-7200
DOI	10.1097/SLE.0000000000001250
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Article: Squamous cell carcinoma of the anus successfully treated with multidisciplinary therapy for metachronous metastatic and local recurrences after DCF chemotherapy: a case report.

Naito, Ryozan / Shiraishi, Takuya / Hosoi, Nobuhiro / Watanabe, Takayoshi / Shioi, Ikuma / Shibasaki, Yuta / Nakazawa, Nobuhiro / Osone, Katsuya / Okada, Takuhisa / Sano, Akihiko / Sakai, Makoto / Ogawa, Hiroomi / Sohda, Makoto / Shirabe, Ken / Saeki, Hiroshi

Surgical case reports

2024 Volume 10, Issue 1, Page(s) 71

Abstract: Background: Docetaxel, cisplatin, and 5-fluorouracil (DCF) chemotherapy is reportedly an effective treatment strategy for squamous cell carcinoma of the anus (SCCA). However, studies regarding its use in Japanese patients remain scarce.: Case ... ...

Abstract	Background: Docetaxel, cisplatin, and 5-fluorouracil (DCF) chemotherapy is reportedly an effective treatment strategy for squamous cell carcinoma of the anus (SCCA). However, studies regarding its use in Japanese patients remain scarce. Case presentation: Here, we present the case of an 82-year-old woman with SCCA, cStage IIIB. Chemoradiotherapy was initiated after colostomy of the anorectal mass; however, para-aortic lymph node recurrence was observed 3 months after treatment completion. Five courses of DCF chemotherapy were subsequently administered, resulting in a complete response (CR). Two years and 1 month later, the aortic lymph node was enlarged again, and the patient achieved CR again after radiotherapy. Nine months later, local recurrence was detected in the anal canal, and laparoscopic perineal rectal amputation was performed. The patient remains progression-free 5 years and 10 months after the initial treatment and 1 year and 7 months after the final treatment. Conclusions: Our findings suggest that complementary treatment after DCF chemotherapy may be efficacious in Japanese patients with SCCA and help achieve CR. Despite occasional local recurrences, this approach may help achieve long-term progression-free survival.
Language	English
Publishing date	2024-03-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2809613-7
ISSN	2198-7793
ISSN	2198-7793
DOI	10.1186/s40792-024-01873-2
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Article: Retrograde drainage for duodenal stump leakage using ileal decompression tube guided by double-balloon endoscopy: a novel case report.

Naito, Ryozan / Nakazawa, Nobuhiro / Zennyoji, Dan / Shimizu, Takehiro / Hosoi, Nobuhiro / Watanabe, Takayoshi / Shioi, Ikuma / Shibasaki, Yuta / Osone, Katsuya / Okada, Takuhisa / Shiraishi, Takuya / Sano, Akihiko / Sakai, Makoto / Ogawa, Hiroomi / Sohda, Makoto / Uraoka, Toshio / Shirabe, Ken / Saeki, Hiroshi

Surgical case reports

2024 Volume 10, Issue 1, Page(s) 44

Abstract: Background: Duodenal stump leakage is a serious post-gastrectomy complication, and there have been no reports on endoscopic drainage.: Case presentation: We report a case of duodenal stump leakage after laparoscopic gastrectomy with Roux-en-Y ... ...

Abstract	Background: Duodenal stump leakage is a serious post-gastrectomy complication, and there have been no reports on endoscopic drainage. Case presentation: We report a case of duodenal stump leakage after laparoscopic gastrectomy with Roux-en-Y reconstruction in a 68-year-old man. First-line conservative management was ineffective. Reoperation was performed because of severe abdominal pain and increased ascites. After reoperation, duodenal stump leakage recurred with bleeding from the anterior superior pancreaticoduodenal artery. Coil embolization and pigtail catheter insertion were performed. Furthermore, we retrogradely inserted an ileal tube for tube decompression near the duodenal stump using double-balloon endoscopy for effective drainage. After tube insertion, duodenal stump leakage decreased; on the 47th primary postoperative day, the patient was discharged. The primary postoperative course was uneventful after 1 year and 9 months of follow-up. Conclusions: This is the first successful case of duodenal stump leakage treated with retrograde decompression tube insertion near the duodenal stump using double-balloon endoscopy.
Language	English
Publishing date	2024-02-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2809613-7
ISSN	2198-7793
ISSN	2198-7793
DOI	10.1186/s40792-024-01842-9
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Article ; Online: TRPV4 Regulates the Development of Psoriasis by Controlling Adenosine Triphosphate Expression in Keratinocytes and the Neuroimmune System.

Amalia, Syahla Nisaa / Baral, Hritu / Fujiwara, Chisako / Uchiyama, Akihiko / Inoue, Yuta / Yamazaki, Sahori / Ishikawa, Mai / Kosaka, Keiji / Sekiguchi, Akiko / Yokoyama, Yoko / Ogino, Sachiko / Torii, Ryoko / Hosoi, Mari / Shibasaki, Koji / Motegi, Sei-Ichiro

The Journal of investigative dermatology

2023 Volume 143, Issue 12, Page(s) 2356–2365.e5

Abstract: TRPV4 is a calcium ion channel that is widely expressed in various cells. It is also involved in physiological and pathological processes. However, the role of TRPV4 in psoriasis remains unknown. We aimed to investigate the role of TRPV4 in psoriasis ... ...

Abstract	TRPV4 is a calcium ion channel that is widely expressed in various cells. It is also involved in physiological and pathological processes. However, the role of TRPV4 in psoriasis remains unknown. We aimed to investigate the role of TRPV4 in psoriasis using human psoriasis skin samples and an imiquimod-induced psoriasis-like mouse model. Keratinocytes in human psoriasis skin had high TRPV4 expression. Trpv4-knockout mice had less severe dermatitis than wild-type mice in the imiquimod-induced mouse model. Knockout mice had significantly reduced epidermal thickness and a low number of infiltrated CD3
MeSH term(s)	Humans ; Animals ; Mice ; Imiquimod/pharmacology ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism ; Adenosine Triphosphate/metabolism ; Mice, Knockout ; Keratinocytes/metabolism ; Psoriasis/chemically induced ; Psoriasis/genetics ; Psoriasis/drug therapy ; Skin/metabolism ; Dermatitis/pathology ; Neuropeptides/metabolism ; Disease Models, Animal ; Mice, Inbred BALB C
Chemical Substances	Imiquimod (P1QW714R7M) ; TRPV Cation Channels ; Adenosine Triphosphate (8L70Q75FXE) ; Neuropeptides ; TRPV4 protein, human ; Trpv4 protein, mouse
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2023.05.009
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Article ; Online: Keratinocyte-Specific SOX2 Overexpression Suppressed Pressure Ulcer Formation after Cutaneous Ischemia-Reperfusion Injury via Enhancement of Amphiregulin Production.

Inoue, Yuta / Uchiyama, Akihiko / Amalia, Syahla Nisaa / Ishikawa, Mai / Kosaka, Keiji / Sekiguchi, Akiko / Ogino, Sachiko / Yokoyama, Yoko / Torii, Ryoko / Hosoi, Mari / Akai, Ryoko / Iwawaki, Takao / Morasso, Maria I / Motegi, Sei-Ichiro

The Journal of investigative dermatology

2023 Volume 144, Issue 1, Page(s) 142–151.e5

Abstract: Ischemia-reperfusion (I/R) injury is a key player in the pathogeneses of pressure ulcer formation. Our previous work demonstrated that inducing the transcription factor SOX2 promotes cutaneous wound healing through EGFR signaling pathway enhancement. ... ...

Abstract	Ischemia-reperfusion (I/R) injury is a key player in the pathogeneses of pressure ulcer formation. Our previous work demonstrated that inducing the transcription factor SOX2 promotes cutaneous wound healing through EGFR signaling pathway enhancement. However, its protective effect on cutaneous I/R injury was not well-characterized. We aimed to assess the role of SOX2 in cutaneous I/R injury and the tissue-protective effect of SOX2 induction in keratinocytes (KCs) in cutaneous I/R injury. SOX2 was transiently expressed in KCs after cutaneous I/R injury. Ulcer formation was significantly suppressed in KC-specific SOX2-overexpressing mice. SOX2 in skin KCs significantly suppressed the infiltrating inflammatory cells, apoptotic cells, vascular damage, and hypoxic areas in cutaneous I/R injury. Oxidative stress-induced mRNA levels of inflammatory cytokine expression were suppressed, and antioxidant stress factors and amphiregulin were elevated by SOX2 induction in skin KCs. Recombinant amphiregulin administration suppressed pressure ulcer development after cutaneous I/R injury in mice and suppressed oxidative stress-induced ROS production and apoptosis in vitro. These findings support that SOX2 in KCs might regulate cutaneous I/R injury through amphiregulin production, resulting in oxidative stress suppression. Recombinant amphiregulin can be a potential therapeutic agent for cutaneous I/R injury.
MeSH term(s)	Animals ; Mice ; Amphiregulin/genetics ; Amphiregulin/metabolism ; Apoptosis ; Keratinocytes/metabolism ; Pressure Ulcer ; Reperfusion Injury/complications ; Reperfusion Injury/genetics ; Reperfusion Injury/metabolism ; Skin/metabolism
Chemical Substances	Amphiregulin ; Sox2 protein, mouse ; Areg protein, mouse
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2023.06.202
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Article ; Online: Significance of Lipopolysaccharides in Gastric Cancer and Their Potential as a Biomarker for Nivolumab Sensitivity.

Nakazawa, Nobuhiro / Yokobori, Takehiko / Sohda, Makoto / Hosoi, Nobuhiro / Watanabe, Takayoshi / Shimoda, Yuki / Ide, Munenori / Sano, Akihiko / Sakai, Makoto / Erkhem-Ochir, Bilguun / Ogawa, Hiroomi / Shirabe, Ken / Saeki, Hiroshi

International journal of molecular sciences

2023 Volume 24, Issue 14

Abstract: Lipopolysaccharides are a type of polysaccharide mainly present in the bacterial outer membrane of Gram-negative bacteria. Recent studies have revealed that lipopolysaccharides contribute to the immune response of the host by functioning as a cancer ... ...

Abstract	Lipopolysaccharides are a type of polysaccharide mainly present in the bacterial outer membrane of Gram-negative bacteria. Recent studies have revealed that lipopolysaccharides contribute to the immune response of the host by functioning as a cancer antigen. We retrospectively recruited 198 patients with gastric cancer who underwent surgery. The presence of lipopolysaccharides was determined using immunohistochemical staining, with the intensity score indicating positivity. The relationship between lipopolysaccharides and CD8, PD-L1, TGFBI (a representative downstream gene of TGF-β signaling), wnt3a, and E-cadherin (epithelial-mesenchymal transition marker) was also investigated. Thereafter, we identified 20 patients with advanced gastric cancer receiving nivolumab and investigated the relationship between lipopolysaccharides and nivolumab sensitivity. After staining for lipopolysaccharides in the nucleus of cancer cells, 150 negative (75.8%) and 48 positive cases (24.2%) were found. The lipopolysaccharide-positive group showed increased cancer stromal TGFBI expression (
MeSH term(s)	Humans ; Lipopolysaccharides ; Nivolumab/therapeutic use ; B7-H1 Antigen/genetics ; Stomach Neoplasms/drug therapy ; Retrospective Studies ; Biomarkers ; Cadherins/metabolism ; Transforming Growth Factor beta ; Epithelial-Mesenchymal Transition/genetics
Chemical Substances	Lipopolysaccharides ; Nivolumab (31YO63LBSN) ; B7-H1 Antigen ; Biomarkers ; Cadherins ; Transforming Growth Factor beta
Language	English
Publishing date	2023-07-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241411790
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Article ; Online: Concentration of folic acid (FA) in serum of Japanese pregnant women.

Mise, Nathan / Ohtsu, Mayumi / Ikegami, Akihiko / Hosoi, Yoko / Nakagi, Yoshihiko / Yoshida, Takahiko / Kayama, Fujio

Reviews on environmental health

2020 Volume 35, Issue 3, Page(s) 277–280

Abstract: Objectives Exposure to inorganic arsenic (iAs) is a world-wide health concern. We reported that Japanese children and pregnant women are exposed to moderate levels of iAs through food. Reducing iAs contamination from foods of high iAs is an important ... ...

Abstract	Objectives Exposure to inorganic arsenic (iAs) is a world-wide health concern. We reported that Japanese children and pregnant women are exposed to moderate levels of iAs through food. Reducing iAs contamination from foods of high iAs is an important issue unique in Japan. Integrated iAs is methylated to less toxic organic forms, and S-adenosyl-L-methyonine (SAM), a common methyl-donor of DNA and histones, is utilized in this process. Chronic consumption of SAM by iAs metabolism due to exposure to iAs might alter the epigenetic modification of genome. The SAM biosynthesis pathway is dependent on folate cycle, and it is possible that ingestion of sufficient folic acid (FA) is protective to iAs induced toxicity. Methods In the course of our cross-sectional body burden analyses of Pb and iAs in Japanese children and pregnant women, termed "PbAs study", FA concentration in serum of 104 pregnant women was measured. Results Mean (±SEM) of serum FA concentration was 15.8 ± 1.3 (ng/mL). There are significant number of people showing very high FA (>30 ng/ mL), and large fraction of them were taking supplements daily. Conclusions These results suggested that level of FA ingestion of Japanese pregnant women is high for supporting normal fetal development.
MeSH term(s)	Adult ; Arsenic/metabolism ; Female ; Folic Acid/blood ; Humans ; Japan ; Lead/metabolism ; Pregnancy ; Young Adult
Chemical Substances	Lead (2P299V784P) ; Folic Acid (935E97BOY8) ; Arsenic (N712M78A8G)
Language	English
Publishing date	2020-07-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	184450-7
ISSN	2191-0308 ; 0048-7562 ; 0048-7554
ISSN (online)	2191-0308
ISSN	0048-7562 ; 0048-7554
DOI	10.1515/reveh-2020-0014
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Article ; Online: Importance of Progression-free Survival in Second-line Chemotherapy in Patients With Advanced or Recurrent Gastric Cancer.

Sano, Akihiko / Sohda, Makoto / Hosoi, Nobuhiro / Tateno, Kohei / Watanabe, Takayoshi / Uchida, Shintaro / Nakazawa, Nobuhiro / Osone, Katsuya / Okada, Takuhisa / Shiraishi, Takuya / Sakai, Makoto / Ogawa, Hiroomi / Shirabe, Ken / Saeki, Hiroshi

Anticancer research

2023 Volume 43, Issue 11, Page(s) 5205–5213

Abstract: Background/aim: Impact of second-line chemotherapy in unresectable advanced/recurrent gastric/esophagogastric junction cancer (AGC) remains unclear. This retrospective analysis aimed to identify factors affecting prognosis in chemotherapy for patients ... ...

Abstract	Background/aim: Impact of second-line chemotherapy in unresectable advanced/recurrent gastric/esophagogastric junction cancer (AGC) remains unclear. This retrospective analysis aimed to identify factors affecting prognosis in chemotherapy for patients with AGC, including the importance of progression-free survival in second-line chemotherapy (PFS-2). Patients and methods: Data from a total of 109 patients with AGC that received second-line treatment were analyzed with the aim of clarifying prognostic factors. Furthermore, the correlation between PFS-2 and clinical characteristics and the association between PFS-2 and inflammation-based and/or nutritional markers were investigated. Results: Multivariate analysis identified the following prognostic factors: ECOG PS ≥1, presence of peritoneal dissemination, metastasis in two or more organs, and taxane use on second-line chemotherapy. Short PFS-2 was strongly associated with prognosis in the univariate analysis [hazard ratio (HR)=3.107, 95% confidence interval (CI)=1.969-4.904, p<0.001]. The duration of PFS-2 was significantly correlated with ECOG PS (p=0.019), liver metastasis rates (p=0.035) and taxane use on second-line chemotherapy (p=0.001). In addition, weight loss rate during first-line treatment (p=0.042), white blood cell count (p=0.008), C-reactive protein (p=0.032), c-reactive protein to albumin ratio (p=0.039), prognostic index (p=0.028), and modified Glasgow prognostic score (p=0.027) were significantly associated with the duration of PFS-2. Conclusion: The duration of PFS-2 significantly correlated with ECOG PS, liver metastasis, and taxane use on second-line treatment, and strongly affected OS. It was suggested that the presence of malnutrition and inflammation at the start of second-line therapy had a negative impact on PFS-2 and OS.
MeSH term(s)	Humans ; Progression-Free Survival ; C-Reactive Protein ; Retrospective Studies ; Stomach Neoplasms/drug therapy ; Inflammation ; Liver Neoplasms ; Taxoids
Chemical Substances	C-Reactive Protein (9007-41-4) ; taxane (1605-68-1) ; Taxoids
Language	English
Publishing date	2023-11-01
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16722
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