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Book ; Online: Cholesterol Lowering Therapies and Drugs

Huang, Chunfa / Freter, Carl

2016

Keywords	Cardiovascular medicine ; hypercholesterolemia, cancer, antioxidants, atherosclerosis, cardiovascular diseases, dyslipidemia
Language	English
Size	1 electronic resource (186 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English
HBZ-ID	HT030645189
ISBN	9789535141662 ; 953514166X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Impact of the severity of brain injury on secondary adrenal insufficiency in traumatic brain injury patients and the influence of HPA axis dysfunction on prognosis.

Li, Dongping / Chen, Jianhui / Weng, Chunfa / Huang, Xiaohai

The International journal of neuroscience

2023 , Page(s) 1–10

Abstract: Objective: To investigate secondary adrenal insufficiency post varying traumatic brain injuries' and its impact on prognosis.: Methods: 120 traumatic brain injury patients were categorized into mild, moderate and severe groups based on Glasgow Coma ... ...

Abstract	Objective: To investigate secondary adrenal insufficiency post varying traumatic brain injuries' and its impact on prognosis. Methods: 120 traumatic brain injury patients were categorized into mild, moderate and severe groups based on Glasgow Coma Scale. Adrenal function was evaluated through testing. Results: Secondary adrenal insufficiency rates were 0% (mild), 22.85% (moderate) and 44.82% (severe). Hypothalamus-pituitary-adrenal axis dysfunction rates were 14.81% (mild), 42.85% (moderate) and 63.79% (severe). Differences among groups were significant ( Conclusion: As traumatic brain injury severity increases, secondary adrenal insufficiency incidence rises. The low-dose adrenocorticotropic hormone test is promising for hypothalamus-pituitary-adrenal axis evaluation. Patients with hypothalamus-pituitary-adrenal dysfunction experience prolonged hospitalization and worse prognosis.
Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Journal Article
ZDB-ID	3061-2
ISSN	1563-5279 ; 1543-5245 ; 0020-7454
ISSN (online)	1563-5279 ; 1543-5245
ISSN	0020-7454
DOI	10.1080/00207454.2023.2280450
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Article ; Online: Lesion segmentation using 3D scan and deep learning for the evaluation of facial portwine stain birthmarks.

Ke, Cheng / Huang, Yuanbo / Yang, Jun / Zhang, Yunjie / Zhan, Huiqi / Wu, Chunfa / Bi, Mingye / Huang, Zheng

Photodiagnosis and photodynamic therapy

2024 Volume 46, Page(s) 104030

Abstract: Background: Portwine stain (PWS) birthmarks are congenital vascular malformations. The quantification of PWS area is an important step in lesion classification and treatment evaluation.: Aims: The aim of this study was to evaluate the combination of ... ...

Abstract	Background: Portwine stain (PWS) birthmarks are congenital vascular malformations. The quantification of PWS area is an important step in lesion classification and treatment evaluation. Aims: The aim of this study was to evaluate the combination of 3D scan with deep learning for automated PWS area quantization. Materials and methods: PWS color was measured using a portable spectrophotometer. PWS patches (29.26-45.82 cm Results: IDeepLabV3+ (Xception) showed the best results in PWS lesion extraction and area quantification. Its mean Intersection over Union (MIou) was 0.9797, Mean Pixel Accuracy (MPA) 0.9908, Accuracy 0.9989, Recall 0.9886 and F1-score 0.9897, respectively. In PWS area quantization, the mean value of the area error rate of this scheme was 2.61 ± 2.33. Conclusions: The new 3D method developed in this study was able to achieve accurate quantification of PWS lesion area and has potentials for clinical applications.
Language	English
Publishing date	2024-02-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2024.104030
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Influence of Alloying Element Mg on Na and Sr Modifying Al-7Si Hypoeutectic Alloy.

Huang, Chunfa / Liu, Zhiguo / Li, Jianguo

Materials (Basel, Switzerland)

2022 Volume 15, Issue 4

Abstract: The influence of alloying element Mg on Na and Sr modifying Al-7Si hypoeutectic alloys was investigated. The residual content of Na and the morphology of modified eutectic silicon were characterized. It was found that the alloying element Mg had an ... ...

Abstract	The influence of alloying element Mg on Na and Sr modifying Al-7Si hypoeutectic alloys was investigated. The residual content of Na and the morphology of modified eutectic silicon were characterized. It was found that the alloying element Mg had an enhanced effect on the uptake of sodium in the Al-7Si hypoeutectic alloy modified by the Na-contained modifier. Moreover, the morphology of eutectic silicon of the modified Al-7Si alloys was significantly different from that of Al-7Si-0.4Mg alloys in the present research. When the addition of the modifier is enough, both modifiers could entirely modify the eutectic silicon phase of Al-7Si alloys, while incompletely modified eutectic silicon was observed in both Na-modified and Sr-modified Al-7Si-0.4Mg alloy. It was observed that there was an adhering relationship between the partially modified eutectic silicon with Mg-rich phases. According to the results, it can be proposed that the addition of Mg will affect the solidification behavior of alloys, thereby, leading to the incomplete modification of eutectic silicon phases.
Language	English
Publishing date	2022-02-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15041537
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: NMR used to study the side-reactions between peroxides and antioxidants during the reactive extrusion process of the impact polypropylene

Chunfa Li / Ting Huang / Yubin Bao / Zhe Chen / Guangxin Lin

Magnetic Resonance Letters, Vol 2, Iss 2, Pp 91-

2022 Volume 106

Abstract: Side reaction pathways are observed to occur between antioxidants and peroxide during the processing of multiple resin grades mediated by controlled peroxide-induced degradation of impact polypropylene. In the present work, the reaction mechanism and ... ...

Abstract	Side reaction pathways are observed to occur between antioxidants and peroxide during the processing of multiple resin grades mediated by controlled peroxide-induced degradation of impact polypropylene. In the present work, the reaction mechanism and main by-products between antioxidants and peroxides were investigated. The results demonstrate that peroxides greatly accelerate the decomposition reactions, and the free radicals formed from peroxide decomposition react with, for example, the antioxidant AO1010 to produce dehydrogenation of phenyl propionic unit(s) at the α position (cinnamic acid ester moiety), which generates a conjugated system leading to the increased color of the product. It is the first time to confirm the cinnamic acid moiety's existence and report its NMR data. Further, this work confirms the dehydrogenation mechanism by comparison with different sterically hindered phenolic antioxidants. It also systematically summarizes the oxidation and degradation mechanism of AO168 and AO1010 under air and peroxide environments, respectively. Based on present study, clear guidelines are obtained to improve the quality of polymeric products, especially the appearance and stability, during product development.
Keywords	Peroxide ; Antioxidant ; Free radical ; Cinnamic acid ester ; Polypropylene ; Physical and theoretical chemistry ; QD450-801 ; Analytical chemistry ; QD71-142
Subject code	540
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	KeAi Communications Co. Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Integration of traditional Chinese medicine and nibble debridement and dressing method reduces thrombosis and inflammatory response in the treatment of thromboangiitis obliterans.

Li, Jianhua / Zhong, Jingfeng / Huang, Chunfa / Guo, Jiewen / Wang, Bingyu

Annals of translational medicine

2021 Volume 9, Issue 18, Page(s) 1413

Abstract: Background: Thromboangiitis obliterans (TAO), also known as Buerger's disease, is an occlusive arterial disease; however, the pathogenesis of TAO is still unclear. Research has shown that traditional Chinese medicine (TCM) has significant advantages in ... ...

Abstract	Background: Thromboangiitis obliterans (TAO), also known as Buerger's disease, is an occlusive arterial disease; however, the pathogenesis of TAO is still unclear. Research has shown that traditional Chinese medicine (TCM) has significant advantages in the treatment of TAO. Our purpose was to explore the underlying roles of TCM in combination with nibble debridement and dressing method (NDDM) in a TAO rat model. Methods: We administered rats with 10 mg/mL sodium laurate to establish a TAO model, and then the TAO model rats were treated with notoginseng powder (NP), maifusheng (MFS), or the combination of NP or MFS and NDDM. Gangrene classification and blood rheology were evaluated; the pathological characteristics of rat limbs were examined by hematoxylin and eosin (H&E) staining and Masson staining; and cluster of differentiation 3+ (CD3+) and cluster of differentiation 20+ (CD20+) levels were measured by immunohistochemistry (IHC) and flow cytometry. In addition, inflammation-associated cytokines were analyzed by quantitative reverse transcription polymerase chain reaction (RT-qPCR), western blot, and enzyme-linked immunosorbent assay (ELISA). Results: Integration of NP or MFS and NDDM dramatically reduced the gangrene classification and affected blood rheology parameters of TAO model rats compared with NP and MFS alone. Meanwhile, NP or MFS in combination with NDDM decreased CD3+CD20+ T cells, reduced thrombosis and inflammatory cell infiltration, and dramatically decreased the levels of inflammation-associated cytokines. Conclusions: Our results suggested that integration of NP or MFS and NDDM could relieve the symptoms of TAO model rats induced by sodium laurate, which might provide a new management strategy for TAO.
Language	English
Publishing date	2021-10-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-21-3752
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prognostic implication of novel immune-related signature in breast cancer.

Chen, Bingfeng / Wu, Haoming / Fang, Yutong / Huang, Guangsheng / Guo, Cuiping / Chen, Chunfa / He, Lifang / Chen, Zexiao / Hou, Xiangling / Li, Cheukfai / Wu, Jundong

Medicine

2024 Volume 103, Issue 6, Page(s) e37065

Abstract: Checkpoint inhibitor therapy has become increasingly important and has been endorsed as a treatment regimen in breast cancer. But benefits were limited to a small proportion of patients. We aimed to develop an improved signature on the basis of immune ... ...

Abstract	Checkpoint inhibitor therapy has become increasingly important and has been endorsed as a treatment regimen in breast cancer. But benefits were limited to a small proportion of patients. We aimed to develop an improved signature on the basis of immune genes for detection of potential benefit from immunotherapy. Gene expression data of patients with breast cancer initially extracted from The Cancer Genome Atlas were analyzed. Ten genes were selected from the interaction of differentially expressed genes as well as immune-related genes to develop a survival signature. We compared the high-risk and low-risk groups by gene set enrichment analysis, immune infiltration, checkpoint molecule expression and immunophenoscore. Ten genes were extracted from interactions of differentially expressed and immune-related genes. The immune risk score was determined on the basis of the Cox regression coefficient of hub genes and validated with the GSE96058 dataset. Immune cell infiltrates, including CD8 + T cells, plasma cells, follicular helper T cells, CD4 + memory T cells, M1 macrophages, regulatory T cells and resting NK cells, were more highly infiltrated in the high-risk group as compared to the low-risk group. Checkpoint molecules, including CTLA-4, PD-L1, TIM-3, VISTA, ICOS, PD-1, and PD-L2, were expressed at markedly lower levels in the high-risk group as compared to the low-risk group. Immunophenoscores, as a surrogate of response to immune checkpoint therapy, was observed significant lower in the high-risk group. The 10-gene prognostic signature could identify patients' survival and was correlated with the biomarkers of immune checkpoint inhibitor therapy, which may guide precise therapeutic decisions in clinical practice.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/genetics ; Prognosis ; Risk Factors ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037065
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Article ; Online: Intratracheal administration of programmable DNA nanostructures combats acute lung injury by targeting microRNA-155.

Huang, Chaowang / Liu, Qian / Xu, Jing / Chen, Chunfa / You, Qianyi / Wang, Dan / Qian, Hang / Hu, Mingdong

International journal of pharmaceutics

2023 Volume 651, Page(s) 123750

Abstract: Acute lung injury (ALI) is an acute inflammatory process that can result in life-threatening consequences. Programmable DNA nanostructures have emerged as excellent nanoplatforms for microRNA-based therapeutics, offering potential nanomedicines for ALI ... ...

Abstract	Acute lung injury (ALI) is an acute inflammatory process that can result in life-threatening consequences. Programmable DNA nanostructures have emerged as excellent nanoplatforms for microRNA-based therapeutics, offering potential nanomedicines for ALI treatment. Nonetheless, the traditional systematic administration of nanomedicines is constrained by low delivery efficiency, poor pharmacokinetics, and nonspecific side effects. Here, we identify macrophage microRNA-155 as a novel therapeutic target using the magnetic bead sorting technique. We further construct a DNA nanotubular nucleic acid drug antagonizing microRNA-155 (NT-155) for ALI treatment through intratracheal administration. Flow cytometry results demonstrate that NT-155, when inhaled, is taken up much more effectively by macrophages and dendritic cells in the bronchoalveolar lavage fluid of ALI mice. Furthermore, NT-155 effectively silences the overexpressed microRNA-155 in macrophages and exerts excellent inflammation inhibition effects in vitro and ALI mouse models. Mechanistically, NT-155 suppresses microRNA-155 expression and activates its target gene SOCS1, inhibiting the p-P65 signaling pathway and suppressing proinflammatory cytokine secretion. The current study suggests that deliberately designed nucleic acid drugs are promising nanomedicines for ALI treatment and the local administration may open up new practical applications of DNA in the future.
MeSH term(s)	Mice ; Animals ; Acute Lung Injury/drug therapy ; Inflammation/metabolism ; Signal Transduction ; MicroRNAs/genetics ; DNA/metabolism ; Lipopolysaccharides/pharmacology ; Lung/metabolism
Chemical Substances	MicroRNAs ; DNA (9007-49-2) ; Lipopolysaccharides ; Mirn155 microRNA, mouse
Language	English
Publishing date	2023-12-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2023.123750
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Article: O-6-methylguanine DNA methyltransferase is a favorable biomarker with proliferation suppressive potential in Breast Cancer.

Lin, Danxia / Xiao, Yingsheng / Huang, Binliang / Wu, Xiao / Chen, Chunfa / Liang, Yuanke / Zeng, De

Journal of Cancer

2020 Volume 11, Issue 21, Page(s) 6326–6336

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-09-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.46466
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Article ; Online: Transcription factor Nrf2 binds to circRNAPIBF1 to regulate SOD2 in lung adenocarcinoma progression.

Zhang, Zuxiong / Chen, Qianshun / Huang, Chen / Rao, Dingyu / Sang, Chengpeng / Zhu, Shenyu / Gu, Liang / Xie, Chunfa / Tang, Zhixian / Xu, Xunyu

Molecular carcinogenesis

2022 Volume 61, Issue 12, Page(s) 1161–1176

Abstract: Emerging evidence indicates that circular RNAs (circRNAs) play important roles in disease development, especially in cancers. Analysis of circRNA expression microarrays from the Gene Expression Omnibus database revealed that circPIBF1 was highly ... ...

Abstract	Emerging evidence indicates that circular RNAs (circRNAs) play important roles in disease development, especially in cancers. Analysis of circRNA expression microarrays from the Gene Expression Omnibus database revealed that circPIBF1 was highly upregulated in lung adenocarcinoma (LUAD). The main aim of this study was to probe the function of circPIBF1 in pyroptosis of LUAD cells and the signal transduction pathways involved. CircPIBF1 was significantly overexpressed in LUAD and was related to the dismal prognosis of patients with LUAD. CircPIBF1 could bind to nuclear factor erythroid 2-related factor 2 (Nrf2), which further promoted the expression of superoxide dismutase 2 (SOD2). In addition, Nrf2 was also observed to recruit histone acetyltransferase E1A binding protein p300 (EP300) to enhance H3K27ac modification of SOD2, thus modulating the Nrf2-Keap1 signaling pathway. Moreover, we found that knockdown of circPIBF1 significantly suppressed the expression of SOD2 in cells and LUAD cell growth, while enhanced the expression of pyroptosis-related factors, which were further reversed by overexpression of SOD2 or EP300. Collectively, our findings suggest a direct involvement of circPIBF1 in pyroptosis-related LUAD carcinogenesis and implicate a role of Nrf2/EP300/SOD2 signaling in this process.
MeSH term(s)	Humans ; Kelch-Like ECH-Associated Protein 1/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Lung Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/pathology ; Adenocarcinoma/pathology ; RNA, Circular/genetics ; Cell Proliferation/genetics
Chemical Substances	superoxide dismutase 2 (EC 1.15.1.1) ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; RNA, Circular
Language	English
Publishing date	2022-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004029-8
ISSN	1098-2744 ; 0899-1987
ISSN (online)	1098-2744
ISSN	0899-1987
DOI	10.1002/mc.23468
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