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  1. Article ; Online: Impact of Arterial Input Function and Pharmacokinetic Models on DCE-MRI Biomarkers for Detection of Vascular Effect Induced by Stroma-Directed Drug in an Orthotopic Mouse Model of Pancreatic Cancer.

    Cao, Jianbo / Pickup, Stephen / Rosen, Mark / Zhou, Rong

    Molecular imaging and biology

    2023  Volume 25, Issue 4, Page(s) 638–647

    Abstract: ... Results: Individual AIF exhibit a marked difference in peak gadolinium concentration. However, across ...

    Abstract Purpose: We demonstrated earlier in mouse models of pancreatic ductal adenocarcinoma (PDA) that K
    Procedures: Retrospective analyses of the DCE-MRI of the orthotopic PDA model are performed to examine the impact of individual versus group AIF combined with Tofts model (TM), extended-Tofts model (ETM), or shutter-speed model (SSM) on the ability to detect the microvascular changes induced by PEGPH20 treatment.
    Results: Individual AIF exhibit a marked difference in peak gadolinium concentration. However, across all three PK models, k
    Conclusion: Our results suggest that k
    MeSH term(s) Animals ; Mice ; Contrast Media/pharmacokinetics ; Retrospective Studies ; Image Enhancement/methods ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/drug therapy ; Disease Models, Animal ; Carcinoma, Pancreatic Ductal/diagnostic imaging ; Carcinoma, Pancreatic Ductal/drug therapy ; Magnetic Resonance Imaging/methods ; Reproducibility of Results ; Pancreatic Neoplasms
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-023-01824-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Social Media, Cognitive Reflection, and Conspiracy Beliefs

    Dominik A. Stecula / Mark Pickup

    Frontiers in Political Science, Vol

    2021  Volume 3

    Abstract: A growing number of Americans stay informed about current events through social media. But using social media as a source of news is associated with increased likelihood of being misinformed about important topics, such as COVID-19. The two most popular ... ...

    Abstract A growing number of Americans stay informed about current events through social media. But using social media as a source of news is associated with increased likelihood of being misinformed about important topics, such as COVID-19. The two most popular platforms—Facebook and YouTube—remain relatively understudied in comparison to Twitter, which tends to be used by elites, but less than a quarter of the American public. In this brief research report, we investigate how cognitive reflection can mitigate the potential effects of using Facebook, YouTube and Twitter for news on subsequent conspiracy theory endorsement. To do that, we rely on an original dataset of 1,009 survey responses collected during the first wave of the coronavirus pandemic in the United States, on March 31, 2020. We find that using Facebook and YouTube for news increases conspiracy belief (both general and COVID-19 specific), controlling for cognitive reflection, traditional news media use, use of web-based news media, partisanship, education, age, and income. We also find that the impact of Facebook use on conspiracy belief is moderated by cognitive reflection. Facebook use increases conspiracy belief among those with low cognitive reflection but has no effect among those with moderate levels of cognitive reflection. It might even decrease conspiracy belief among those with the highest levels of cognitive reflection.
    Keywords social media ; cognitive reflection ; conspiracy theories ; COVID-19 ; misinformation ; Political science ; J
    Subject code 070
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book: Introduction to time series analysis

    Pickup, Mark

    (Quantitative applications in the social sciences ; 174)

    2015  

    Author's details Mark Pickup
    Series title Quantitative applications in the social sciences ; 174
    Language English
    Size XVII, 208 S., graph. Darst.
    Publisher Sage
    Publishing place Los Angeles, Calif. u.a.
    Document type Book
    Note Includes bibliographical references and index
    ISBN 9781452282015 ; 1452282013
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Book: Introduction to time series analysis

    Pickup, Mark

    (Quantitative applications in the social sciences ; 174)

    2015  

    Author's details Mark Pickup
    Series title Quantitative applications in the social sciences ; 174
    Language English
    Size XVIII, 208 S., graph. Darst.
    Publisher Sage
    Publishing place Los Angeles, Calif. u.a.
    Document type Book
    Note Literaturverz. S. 197 - 202
    ISBN 9781452282015 ; 1452282013
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article ; Online: Erratum: Variation in activity levels amongst dogs of different breeds: results of a large online survey of dog owners from the UK - CORRIGENDUM.

    Pickup, Emily / German, Alexander J / Blackwell, Emily / Evans, Mark / Westgarth, Carri

    Journal of nutritional science

    2021  Volume 10, Page(s) e93

    Abstract: This corrects the article DOI: 10.1017/jns.2017.7.]. ...

    Abstract [This corrects the article DOI: 10.1017/jns.2017.7.].
    Language English
    Publishing date 2021-10-21
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2656288-1
    ISSN 2048-6790 ; 2048-6790
    ISSN (online) 2048-6790
    ISSN 2048-6790
    DOI 10.1017/jns.2021.29
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  6. Article: The contribution of human factors and ergonomics to the design and delivery of safe future healthcare.

    Sujan, Mark / Pickup, Laura / Bowie, Paul / Hignett, Sue / Ives, Fran / Vosper, Helen / Rashid, Noorzaman

    Future healthcare journal

    2021  Volume 8, Issue 3, Page(s) e574–e579

    Abstract: Human factors and ergonomics (HF/E) is concerned with the design of work and work systems. There is an increasing appreciation of the value that HF/E can bring to enhancing the quality and safety of care, but the professionalisation of HF/E in healthcare ...

    Abstract Human factors and ergonomics (HF/E) is concerned with the design of work and work systems. There is an increasing appreciation of the value that HF/E can bring to enhancing the quality and safety of care, but the professionalisation of HF/E in healthcare is still in its infancy. In this paper, we set out a vision for HF/E in healthcare based on the work of the Chartered Institute of Ergonomics and Human Factors (CIEHF), which is the professional body for HF/E in the UK. We consider the contribution of HF/E in design, in digital transformation, in organisational learning and during COVID-19.
    Language English
    Publishing date 2021-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 3016427-8
    ISSN 2514-6653 ; 2514-6645
    ISSN (online) 2514-6653
    ISSN 2514-6645
    DOI 10.7861/fhj.2021-0112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Brexit, COVID-19, and attitudes toward immigration in Britain.

    Pickup, Mark / de Rooij, Eline A / van der Linden, Clifton / Goodwin, Matthew J

    Social science quarterly

    2021  Volume 102, Issue 5, Page(s) 2184–2193

    Abstract: Objective: A key issue in Britain's referendum on European Union membership was the free movement of labor into Britain, with Brexit "Leavers" having more negative attitudes toward immigrants than "Remainers." Such anti-immigrant attitudes are driven by ...

    Abstract Objective: A key issue in Britain's referendum on European Union membership was the free movement of labor into Britain, with Brexit "Leavers" having more negative attitudes toward immigrants than "Remainers." Such anti-immigrant attitudes are driven by feelings of threat. The coronavirus pandemic presented a new threat in the context of ongoing Brexit negotiations. This paper examines how the COVID-19 pandemic affected anti-immigrant attitudes and how these effects differ between Leavers and Remainers.
    Methods: Using an online survey in Spring 2020 of 3,708 individuals residing in the UK, we experimentally test the effect of priming COVID-19 thoughts on anti-immigrant attitudes, and examine whether this effect varies by Brexit identity.
    Results: We show that COVID-19 may exacerbate anti-immigrant attitudes among Leavers while having little effect on Remainers.
    Conclusion: These findings support the idea that the coronavirus pandemic might have presented a new, viral, threat that heightened anti-immigrant attitudes among certain political identities.
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2130790-8
    ISSN 1540-6237 ; 0038-4941
    ISSN (online) 1540-6237
    ISSN 0038-4941
    DOI 10.1111/ssqu.13010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: MicroRNA-148a Controls Epidermal and Hair Follicle Stem/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5.

    Pickup, Maximilian E / Hu, Anhua / Patel, Hetal J / Ahmed, Mohammed I

    The Journal of investigative dermatology

    2022  Volume 143, Issue 3, Page(s) 480–491.e5

    Abstract: ... of miR-148a markedly increases during telogen (bulge and hair germ stem cell compartments ...

    Abstract Skin and hair development is regulated by complex programs of gene activation and silencing and microRNA-dependent modulation of gene expression to maintain normal skin and hair follicle development, homeostasis, and cycling. In this study, we show that miR-148a, through its gene targets, plays an important role in regulating skin homeostasis and hair follicle cycling. RNA and protein analysis of miR-148a and its gene targets were analyzed using a combination of in vitro and in vivo experiments. We show that the expression of miR-148a markedly increases during telogen (bulge and hair germ stem cell compartments). Administration of antisense miR-148a inhibitor into mouse skin during the telogen phases of the postnatal hair cycle results in accelerated anagen development and altered stem cell activity in the skin. We also show that miR-148a can regulate colony-forming abilities of hair follicle bulge stem cells as well as control keratinocyte proliferation/differentiation processes. RNA and protein analysis revealed that miR-148a may control these processes by regulating the expression of Rock1 and Elf5 in vitro and in vivo. These data provide an important foundation for further analyses of miR-148a as a crucial regulator of these genes target in the skin and hair follicles and its importance in maintaining stem/progenitor cell functions during normal tissue homeostasis and regeneration.
    MeSH term(s) Mice ; Animals ; Hair Follicle/metabolism ; Epidermis/metabolism ; Hair/metabolism ; MicroRNAs/genetics ; Stem Cells
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2022-09-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.06.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Novel Coronavirus, Old Partisanship: COVID-19 Attitudes and Behaviours in the United States and Canada

    Pickup, Mark / Stecula, Dominik / van der Linden, Clifton

    Canadian Journal of Political Science

    Abstract: The novel coronavirus reached the United States and Canada almost at the same time. The first reported American case was January 20, 2020, and in Canada it was January 15, 2020 (Canada, 2020; Holshue et al., 2020). Yet, the response to this crisis has ... ...

    Abstract The novel coronavirus reached the United States and Canada almost at the same time. The first reported American case was January 20, 2020, and in Canada it was January 15, 2020 (Canada, 2020; Holshue et al., 2020). Yet, the response to this crisis has been different in the two countries. In the US, President Donald Trump, prominent Republicans, and conservative media initially dismissed the dangers of COVID-19 (Stecula, 2020). The pandemic became politicized from the early days, and even though Trump and Republicans have walked back many of their initial claims, there continue to be media reports of partisan differences in public opinion shaped by that early response. At the same time, the response in Canada has been mostly characterized by across-the-board partisan consensus among political elites (Merkley et al., 2020).
    Keywords covid19
    Publisher PMC; WHO
    Document type Article ; Online
    Note WHO #Covidence: #244846
    DOI 10.1017/s0008423920000463
    Database COVID19

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  10. Article: Novel coronavirus, old partisanship: COVID-19 attitudes and behaviors in the United States and Canada

    Pickup, Mark / Stecula, Dominik / Van Der Linden, Clifton

    Can. J. Polit. Sci.

    Abstract: We utilize nationally representative surveys from the United States and Canada to examine the partisan divide in COVID-19 attitudes and behaviours in both countries. The first cases of COVID-19 in both the US and Canada occurred around the same time, but ...

    Abstract We utilize nationally representative surveys from the United States and Canada to examine the partisan divide in COVID-19 attitudes and behaviours in both countries. The first cases of COVID-19 in both the US and Canada occurred around the same time, but government responses were starkly different. We explore politically salient assessments of governmental performance in both countries, as well as general concern regarding COVID-19 and declarations of changes to daily routines undertaken in response to the pandemic. We find strong partisan differences in evaluations of the government's response to COVID-19 and confidence in its ability to handle the crisis. We also find partisan differences in concern and behavioural responses to the pandemic in both countries. However, the behavioural differences are small, suggesting that while overtly political assessments are strongly partisan this polarization is dampened down when it comes to actual behavioural responses to the pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #244846
    Database COVID19

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