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  1. Article: N

    Lamb, Jessica R / Brown, Christopher M / Johnson, Jeremiah A

    Chemical science

    2021  Volume 12, Issue 8, Page(s) 2699–2715

    Abstract: ... ...

    Abstract N
    Language English
    Publishing date 2021-01-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d0sc06465c
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  2. Article ; Online: Integrating Clinical and Air Quality Data to Improve Prediction of COPD Exacerbations.

    Ratcliff, Grace E / Matheny, Michael E / Brown, Jeremiah R / Sullivan, Iben / Richmond, Bradley W / Paulin, Laura M / Conger, Adrienne K / Davis, Sharon E

    AMIA ... Annual Symposium proceedings. AMIA Symposium

    2024  Volume 2023, Page(s) 1209–1217

    Abstract: Several studies have found associations between air pollution and respiratory disease outcomes. However, there is minimal prognostic research exploring whether integrating air quality into clinical prediction models can improve accuracy and utility. In ... ...

    Abstract Several studies have found associations between air pollution and respiratory disease outcomes. However, there is minimal prognostic research exploring whether integrating air quality into clinical prediction models can improve accuracy and utility. In this study, we built models using both logistic regression and random forests to determine the benefits of including air quality data with meteorological and clinical data in prediction of COPD exacerbations requiring medical care. Logistic models were not improved by inclusion of air quality. However, the net benefit curves of random forest models showed greater clinical utility with the addition of air quality data. These models demonstrate a practical and relatively low-cost way to include environmental information into clinical prediction tools to improve the clinical utility of COPD prediction. Findings could be used to provide population level health warnings as well as individual-patient risk assessments.
    MeSH term(s) Humans ; Disease Progression ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Air Pollution/adverse effects ; Risk Assessment ; Data Accuracy
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 1942-597X
    ISSN (online) 1942-597X
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  3. Article ; Online: Modifying the Risk of Contrast-Associated Acute Kidney Injury in Percutaneous Coronary Interventions and Transcatheter Aortic Valve Implantations.

    Carhart, Briggs S / Stabler, Meagan E / Brown, Jeremiah R

    Journal of the American Heart Association

    2021  Volume 10, Issue 15, Page(s) e022099

    MeSH term(s) Acute Kidney Injury/chemically induced ; Acute Kidney Injury/epidemiology ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Humans ; Percutaneous Coronary Intervention/adverse effects ; Transcatheter Aortic Valve Replacement/adverse effects
    Language English
    Publishing date 2021-07-26
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.121.022099
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  4. Article ; Online: Biomarkers for the prediction of cardiac readmission.

    Parker, Devin M / Brown, Jeremiah R

    Biomarkers in medicine

    2019  Volume 13, Issue 2, Page(s) 55–58

    MeSH term(s) Biomarkers/analysis ; Cardiac Surgical Procedures/adverse effects ; Heart Diseases/surgery ; Humans ; Patient Readmission/statistics & numerical data ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Postoperative Complications/metabolism ; Predictive Value of Tests ; Risk Assessment/methods
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-01-23
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm-2018-0381
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6985: Show issues Location:
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  5. Article ; Online: Inconsistent Inferences.

    Ramkumar, Niveditta / Brown, Jeremiah R

    Circulation. Cardiovascular quality and outcomes

    2018  Volume 11, Issue 12, Page(s) e005235

    MeSH term(s) Cardiac Resynchronization Therapy ; Cardiac Resynchronization Therapy Devices ; Defibrillators, Implantable ; Heart Failure ; Humans
    Language English
    Publishing date 2018-12-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.118.005235
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6744: Show issues Location:
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  6. Article ; Online: The impact of exercise on blood-based biomarkers of Alzheimer's disease in cognitively unimpaired older adults.

    Sewell, Kelsey R / Rainey-Smith, Stephanie R / Pedrini, Steve / Peiffer, Jeremiah J / Sohrabi, Hamid R / Taddei, Kevin / Markovic, Shaun J / Martins, Ralph N / Brown, Belinda M

    GeroScience

    2024  

    Abstract: Physical activity is a promising preventative strategy for Alzheimer's disease: it is associated with lower dementia risk, better cognition, greater brain volume and lower brain beta-amyloid. Blood-based biomarkers have emerged as a low-cost, non- ... ...

    Abstract Physical activity is a promising preventative strategy for Alzheimer's disease: it is associated with lower dementia risk, better cognition, greater brain volume and lower brain beta-amyloid. Blood-based biomarkers have emerged as a low-cost, non-invasive strategy for detecting preclinical Alzheimer's disease, however, there is limited literature examining the effect of exercise (a structured form of physical activity) on blood-based biomarkers. The current study investigated the influence of a 6-month exercise intervention on levels of plasma beta-amyloid (Aβ42
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2886586-8
    ISSN 2509-2723 ; 2509-2715
    ISSN (online) 2509-2723
    ISSN 2509-2715
    DOI 10.1007/s11357-024-01130-2
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    Zs.A 1502: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The efficacy of multifaceted versus single anesthesia work area infection control measures and the importance of surgical site infection follow-up duration.

    Dexter, Franklin / Brown, Jeremiah R / Wall, Russell T / Loftus, Randy W

    Journal of clinical anesthesia

    2022  Volume 85, Page(s) 111043

    Abstract: Background: Earlier a randomized trial showed efficacy of a multifaceted intervention approach for reducing surgical site infection: hand hygiene, vascular care, environmental cleaning, patient decolonization (nasal povidone iodine, chlorhexidine wipes), ...

    Abstract Background: Earlier a randomized trial showed efficacy of a multifaceted intervention approach for reducing surgical site infection: hand hygiene, vascular care, environmental cleaning, patient decolonization (nasal povidone iodine, chlorhexidine wipes), with feedback on pathogen transmission. The follow-up prospective observational study showed effectiveness when applied to all operating rooms of an inpatient surgical suite. In practice, many organizations will at baseline not be using conditions equivalent to the control groups but instead functionally have had ongoing a single intervention for infection control (e.g., encouraging better hand hygiene). Organizations also differ in how well and long they survey every surgical patient for postoperative surgical site infection. Thus, estimation of the expected net cost savings from implementing multifaceted intervention depends on the relative efficacy of multifaceted approach versus single intervention approaches and on the incidence of surgical site infection, the latter depending itself on the monitoring period for infection development.
    Methods: The retrospective cohort analysis included 4865 patients from two single intervention and two multifaceted studies, each of the four studies with matched control groups. We used Poisson regression with robust variance to estimate the relative risk reduction in surgical site infections for the multifaceted approach versus single interventions and, with 30-day follow-up versus ≥60-day follow-up for infection.
    Results: The multifaceted approach was associated with an estimated 68% reduction in postoperative surgical site infections relative to single interventions (risk ratio 0.32, 97.5% confidence interval 0.15-0.70, P = 0.001). There were approximately 2.61-fold more surgical site infections detected with follow-up for at least 60 days of medical records relative to 30 days of records reviewed (97.5% CI 1.62 to 4.21, P < 0.001).
    Conclusions: An evidence-based, multifaceted approach to anesthesia work area infection control can generate substantial reductions in surgical site infections. A follow-up period of at least 60-days is indicated for infection detection.
    MeSH term(s) Humans ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/prevention & control ; Retrospective Studies ; Follow-Up Studies ; Chlorhexidine ; Infection Control ; Anesthesia ; Anti-Infective Agents, Local/therapeutic use
    Chemical Substances Chlorhexidine (R4KO0DY52L) ; Anti-Infective Agents, Local
    Language English
    Publishing date 2022-12-23
    Publishing country United States
    Document type Observational Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1011618-7
    ISSN 1873-4529 ; 0952-8180
    ISSN (online) 1873-4529
    ISSN 0952-8180
    DOI 10.1016/j.jclinane.2022.111043
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2622: Show issues Location:
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  8. Article ; Online: Death, coronary revascularization choices, and chronic kidney disease.

    Solomon, Richard J / Brown, Jeremiah R

    Coronary artery disease

    2017  Volume 29, Issue 1, Page(s) 4–5

    MeSH term(s) Coronary Artery Bypass ; Humans ; Myocardial Revascularization ; Renal Insufficiency, Chronic
    Language English
    Publishing date 2017-12-08
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1047268-x
    ISSN 1473-5830 ; 0954-6928
    ISSN (online) 1473-5830
    ISSN 0954-6928
    DOI 10.1097/MCA.0000000000000580
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    Zs.A 3039: Show issues Location:
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  9. Article ; Online: Healthcare spending in the State of Louisiana.

    Kruger, Blake P / Brown, Jeremiah R

    BMC health services research

    2019  Volume 19, Issue 1, Page(s) 471

    Abstract: Background: The State of Louisiana spends the most on Medicare beneficiaries per capita, but reports greater disparities in health status and death rates than other states. This project sought to investigate the associations between healthcare intensity, ...

    Abstract Background: The State of Louisiana spends the most on Medicare beneficiaries per capita, but reports greater disparities in health status and death rates than other states. This project sought to investigate the associations between healthcare intensity, healthcare spending, and mortality in Louisiana.
    Methods: We used a 100% sample of 2014 Medicare claims data with beneficiaries assigned to hospital referral regions in Louisiana using small area analysis. We used simple and multivariable linear regression modelling to evaluate associations between healthcare intensity, healthcare spending rates, and mortality rates. We adjusted for age, sex, race, and population health risk factors.
    Results: We found no statistically significant associations between our measured variables when adjusted for age, sex, and race. These results were consistent after further adjusting mortality for population health risk factors.
    Conclusions: To our knowledge, no prior studies have investigated the associations between healthcare intensity, healthcare spending, and mortality in Louisiana. Our findings suggest that increased healthcare spending in Louisiana may not improve survival. Identifying more granular aspects of healthcare contributing to spending patterns in Louisiana may provide targets for future quality improvement work.
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Health Expenditures/statistics & numerical data ; Health Services Research ; Health Status ; Humans ; Linear Models ; Louisiana ; Male ; Medicare/economics ; Medicare/statistics & numerical data ; Risk Factors ; United States/epidemiology
    Language English
    Publishing date 2019-07-09
    Publishing country England
    Document type Journal Article
    ISSN 1472-6963
    ISSN (online) 1472-6963
    DOI 10.1186/s12913-019-4275-y
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  10. Article: The effect of acute exercise on objectively measured sleep and cognition in older adults.

    Sewell, Kelsey R / Smith, Nathan D W / Rainey-Smith, Stephanie R / Peiffer, Jeremiah / Sohrabi, Hamid R / Erickson, Kirk I / Brown, Belinda M

    Frontiers in psychology

    2023  Volume 14, Page(s) 1207199

    Abstract: Background: Exercise can improve cognition in aging, however it is unclear : Methods: Participants were 30 cognitively unimpaired, physically active older adults (69.2 ± 4.3 years) with poor sleep (determined via self-report). After a triple baseline ...

    Abstract Background: Exercise can improve cognition in aging, however it is unclear
    Methods: Participants were 30 cognitively unimpaired, physically active older adults (69.2 ± 4.3 years) with poor sleep (determined via self-report). After a triple baseline cognitive assessment to account for any natural fluctuation in cognitive performance, participants completed either a single bout of 20-minutes of high intensity exercise on a cycle ergometer, or a control condition, in a cross-over trial design. Cognition was measured immediately post-intervention and the following day, and sleep (total sleep time, sleep onset latency, sleep efficiency, % of rapid eye movement sleep, light sleep and deep sleep) was characterized using WatchPAT
    Results: Results showed no effect of the exercise intervention on cognition immediately post-intervention, nor an effect of acute exercise on any sleep variable. There was no mediating effect of sleep on associations between exercise and cognition. However, a change from baseline to post-intervention in light sleep and deep sleep did predict change in episodic memory at the ~24 h post-intervention cognitive assessment, regardless of intervention condition.
    Discussion: There was no effect of acute high intensity exercise on sleep or cognition in the current study. However, results suggest that associations between sleep and cognition may exist independently of exercise in our sample. Further research is required, and such studies may aid in informing the most effective lifestyle interventions for cognitive health.
    Language English
    Publishing date 2023-10-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1207199
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