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Article ; Online: Jia-Wei-Si-Miao-Yong-An Fang stimulates the healing of acute radiation-induced cutaneous wounds through MAPK/ERK pathway.

Wang, Yin / Gao, Junfeng / Sun, Liqiao / Li, Qi / Kang, Ning / Gao, Chen / Li, Tong

2023 Volume 306, Page(s) 116180

Abstract: ... to add herbs and improve them into an external dosage form, called Jia-Wei-Si-Miao-Yong-An Fang (JWSMYA ...

Abstract	Ethnopharmacological relevance: A famous traditional oral Chinese medicine formula, Si-Miao-Yong-An decoction, has been used to treat thromboangiitis obliterans from the Qing Dynasty. Because its therapeutic principles including clearing away heat, detoxification, accelerating blood circulation and relieving pains are consistent with acute radiation-induced cutaneous wounds in traditional Chinese medicine, we tried to add herbs and improve them into an external dosage form, called Jia-Wei-Si-Miao-Yong-An Fang (JWSMYA). However, its mechanism on radiation-induced cutaneous wounds is still unknown. Aim of the study: This study evaluated the therapeutic effect of JWSMYA and investigated the mechanism of repair and anti-fibrosis on acute radiation-induced cutaneous wounds with JWSMYA. Materials and methods: Firstly, we prepared JWSMYA, and determined the composition through UHPLC LC-MS/MS. Then we used ionizing radiation to make a cutaneous wound model of rats, and observed wound healing through their skin injury score, wound contraction percentage and histological staining. In addition, immunohistochemical staining, Western blot analysis, qRT-PCR and Elisa were used to explore wound rehabilitation and anti-fibrosis mechanisms. Results: An in vivo assay revealed that JWSMYA promoted the repairment of acute radiation-induced cutaneous wounds, facilitated MAPK/ERK phosphorylation, inhibited PI3K/AKT activation, reduced the level of alpha-smooth muscle actin (a-sma), collagen type-I alpha 2 (Col1a2) and transforming growth factor-beta 1 (TGF-β1) in cutaneous tissues. However, no statistical difference was found in vascular endothelial growth factor (VEGF). Conclusion: JWSMYA accelerated the repair of acute radiation-induced cutaneous wounds, which might be associated with the MAPK/ERK pathway. In addition, PI3K/AKT might be associated with the inhibition of fibrosis and the promotion of high-quality wound healing.
MeSH term(s)	Rats ; Animals ; MAP Kinase Signaling System ; Proto-Oncogene Proteins c-akt/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Fibrosis
Chemical Substances	Collagen Type I, alpha2 Subunit ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Vascular Endothelial Growth Factor A ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2023-01-21
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116180
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Article: Jia-Wei-Si-Miao-Yong-An decoction modulates intestinal flora and metabolites in acute coronary syndrome model.

Zhao, Ning / Wang, Ying / Ma, Yan / Liang, Xiaoxue / Zhang, Xi / Gao, Yuan / Dong, Yingying / Bai, Dong / Hu, Jingqing

Frontiers in cardiovascular medicine

2023 Volume 9, Page(s) 1038273

Abstract: Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao ...

Abstract	Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao-Yong-An decoction (HJ11) in the treatment of acute coronary syndrome and evaluated its impact on the intestinal microbiota and their metabolites. Methods: An acute coronary syndrome model was established in rats, which were randomly assigned to the model, HJ11 treatment, and atorvastatin treatment groups. Rats were then administered saline solution (model and sham operation control groups) or drugs by oral gavage for 28 d. Echocardiography was performed and serum creatine kinase-MB and cardiac troponin I levels were monitored to examine the cardiac function. Inflammation was evaluated using hematoxylin and eosin staining of heart tissue, and serum interleukin-2, interleukin-6, tumor necrosis factor alpha, and high-sensitivity C-reactive protein measurements. Gut microbiota composition was analyzed Results: HJ11 improved cardiac function and attenuated inflammation in rats with acute coronary syndrome. Relative to the untreated model group, the HJ11-treated group presented normalized Firmicutes/Bacteroidetes ratio and reduced abundances of the bacterial genera Conclusion: This work demonstrated that HJ11 effectively treats acute coronary syndrome. HJ11 seems to increase the abundance of beneficial bacterial taxa (
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1038273
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Article ; Online: Retraction: He-Wei granules (HWKL) combat cisplatin-induced nephrotoxicity and myelosuppression in rats by inhibiting oxidative stress, inflammatory cytokines and apoptosis.

Song, Zehai / Chang, Hang / Han, Na / Liu, Zhihui / Liu, Ye / Wang, Hui / Shao, Jingxuan / Wang, Zhonglin / Gao, Hao / Yin, Jun

RSC advances

2023 Volume 13, Issue 18, Page(s) 12276

Abstract: This retracts the article DOI: 10.1039/C7RA02830J.]. ...

Abstract	[This retracts the article DOI: 10.1039/C7RA02830J.].
Language	English
Publishing date	2023-04-19
Publishing country	England
Document type	Retraction of Publication
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra90036c
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Article: A Comprehensive Review of the Main Lignan Components of Schisandra chinensis (North Wu Wei Zi) and Schisandra sphenanthera (South Wu Wei Zi) and the Lignan-Induced Drug-Drug Interactions Based on the Inhibition of Cytochrome P450 and P-Glycoprotein Activities.

Zhang, Feng / Zhai, Jianxiu / Weng, Nan / Gao, Jie / Yin, Jun / Chen, Wansheng

Frontiers in pharmacology

2022 Volume 13, Page(s) 816036

Abstract: Wu Wei Zi is the dried fruit of ...

Abstract	Wu Wei Zi is the dried fruit of
Language	English
Publishing date	2022-03-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.816036
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Article: Integrated analyses of miRNA and mRNA profiles in leukocytes and serums in traditional Chinese medicine (TCM)-defined Pi-qi-deficiency syndrome and Pi-wei damp-heat syndrome resulting from chronic atrophic gastritis.

You, Leiming / Zhang, Shen / Li, Ting'an / Sang, Xiaopu / Li, Kunyu / Wang, Wei / Gao, Xinhui / Wu, Jiarui / Huang, Guangrui / Wang, Ting / Xu, Anlong

Chinese medicine

2021 Volume 16, Issue 1, Page(s) 4

Abstract: ... in the traditional Chinese medicine (TCM)-defined Pi-qi-deficiency syndrome (PQDS) and Pi-wei damp-heat syndrome (PDHS) resulting ...

Abstract	Background: To investigate the microRNA (miRNA)-gene interactions underlying leukocyte functions and characteristics, especially the potential serum biomarkers, implicated in the traditional Chinese medicine (TCM)-defined Pi-qi-deficiency syndrome (PQDS) and Pi-wei damp-heat syndrome (PDHS) resulting from chronic atrophic gastritis (CAG). Methods: Using RNA/miRNA-sequencing approach, compared with healthy control population, we identified the PDHS- or PQDS-specific miRNAs and genes in leukocytes or serums, especially the Zheng (syndrome)-specific miRNA-gene interactions, and further decoded their functions and pathways. Results: Despite being the TCM-defined Zhengs resulting from the same disease of CAG, the Zheng-specific genes and miRNAs were not same. The PDHS-specific leukocyte genes were mainly involved in defense and immune responses, including NOD-like receptor signaling and several synapses-related pathways. The expression upregulation of PDHS-specific genes enriched in the neutrophil degranulation pathway, indicated the enhanced leukocyte degranulation activation. The PQDS-specific genes in leukocytes were implicated in inflammatory response, extracellular matrix (ECM) organization and collagen catabolism. They could be enriched in MAPK and IL17 signaling and helper T cell differentiation pathways, especially the pathways associated with cell-to-cell adhesion/junction and communication such as cell adhesion molecules, ECM organization and ECM-receptor interaction, probably contributing to the characteristics and functions of leukocytes. Also, the experimentally-supported miRNA-gene interactions, concerned with COL4A2, COL26A1, SPP1 and PROCR, were implicated in the regulation of pathways related to cell-to-cell adhesion/junction and communication, suggesting the potential roles of the PQDS-specific miRNA-gene interactions for the characteristic and functional changes of leukocytes. Interestingly, the PQDS-specific miRNAs in the serums and the corresponding leukocytes, seemed to have the common roles in contributing to the characteristics and functions of leukocytes. Importantly, the hsa-miR-122-5p could be a potential biomarker, capable of being contained and carried in plasma exosomes and much higher expression in both the leukocytes and corresponding serums in the CAG patients with PQDS rather than PDHS. Conclusions: These results may provide new insights into the characteristic and functional changes of leukocytes in the two Zhengs, PDHS and PQDS, especially the miRNA-mediated gene regulation underlying leukocyte characteristics and functions, with potential leukocyte and serum biomarkers for future application in integrative medicine. Trial registration ClinicalTrials.gov, NCT02915393. Registered on September 17, 2016.
Language	English
Publishing date	2021-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-020-00416-9
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Article: Changes in extreme precipitation in the Wei River Basin of China during 1957–2019 and potential driving factors

Qiu, Dexun / Wu, Changxue / Mu, Xingmin / Zhao, Guangju / Gao, Peng

Theoretical and applied climatology. 2022 Aug., v. 149, no. 3-4

2022

Abstract: ... we analyzed the changes in nine extreme precipitation indices (EPIs) over the Wei River Basin (WRB) during ...

Abstract	Extreme precipitation poses a severe threat to the natural ecosystem, socioeconomic development, and human life. Investigating the spatiotemporal variations in extreme precipitation and exploring the potential drivers have implications for disaster risk reduction and water resource management. In this study, we analyzed the changes in nine extreme precipitation indices (EPIs) over the Wei River Basin (WRB) during 1957–2019. Furthermore, we assessed the effect of geographic factors (latitude, longitude, and altitude) on the spatial distribution of EPIs and the potential impact of ocean–atmosphere circulation on the temporal variability of EPIs. The results indicate that six EPIs present a downward trend and three EPIs show an upward trend, but all the trends are not significant. In the seasonal scale, max 1-day precipitation amount (RX1day) increases significantly in summer (P < 0.05), while the trends in max 5-day precipitation amount (RX5day) are not significant in all seasons. The period of about 8 years and less than 3 years were observed in most EPIs. The mean values of EPIs except consecutive dry days (CDD) gradually increase from northwest to southeast of the WRB. Latitude, longitude, and altitude are important factors affecting the spatial distribution of the extreme precipitation. Southern Oscillation Index (SOI) and Atlantic Multidecadal Oscillation (AMO) contribute the most to EPIs variation. Interdecadal and interannual oscillations occur between most EPIs and ocean-atmospheric circulation factors, but their phase relationships are different. Our findings highlight the importance of examining global and local driving factors of trend in regional extreme precipitation by a systematic approach, and help to further understand the precipitation changes in the WRB.
Keywords	altitude ; climatology ; ecosystems ; humans ; latitude ; longitude ; risk reduction ; socioeconomic development ; summer ; temporal variation ; water management ; watersheds ; China
Language	English
Dates of publication	2022-08
Size	p. 915-929.
Publishing place	Springer Vienna
Document type	Article
ZDB-ID	1463177-5
ISSN	1434-4483 ; 0177-798X
ISSN (online)	1434-4483
ISSN	0177-798X
DOI	10.1007/s00704-022-04101-9
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comprehensive chemical profiling of Jia-Wei-Qi-Fu-Yin and its network pharmacology-based analysis on Alzheimer's disease.

An, Hai-Ming / Huang, Da-Rong / Yang, Hua / Liu, Xin-Guang / Du, Jing / Li, Yi / Li, Chao-Ran / Pang, Han-Qing / Liu, Run-Zhou / Peng, Chao / Li, Ping / Gao, Wen

Journal of pharmaceutical and biomedical analysis

2020 Volume 189, Page(s) 113467

Abstract: Jia-Wei-Qi-Fu-Yin (JWQFY) is a newly developed anti-Alzheimer's disease (AD) prescription modified ...

Abstract	Jia-Wei-Qi-Fu-Yin (JWQFY) is a newly developed anti-Alzheimer's disease (AD) prescription modified from a classical traditional Chinese medicine formula, Qi-Fu-Yin (QFY). However, a systematic understanding of its chemical constituents and molecular mechanisms is still elusive. To address this problem, comprehensive chemical profiling followed by network pharmacology-based analysis of JWQFY was performed. Firstly, a total of 136 compounds were characterized by high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (HPLC-QTOF MS), 17 of them were specifically identified in JWQFY comparing with QFY. Seventy compounds were further quantified via a validated HPLC coupled with triple quadrupole tandem mass spectrometry (QQQ MS) method. Then the protein targets of the seventy compounds were gathered from public databases for network construction. As a result, fifty-seven compounds were filtered, which interacted with 655 targets. Thirty-four of them were mapped into the KEGG pathway of AD, indicating JWQFY might exert anti-AD effects by anti-inflammation, neuronal apoptosis intervening, Aβ production inhibition and phosphorylating tau protein moderating. Furthermore, in the compound-target-AD network, a list of hub compounds and hub targets was identified based on their topological features, including the degree, node betweenness and closeness. Four of the hub compounds were specifically originated from JWQFY, supporting the modification rationality of this formula. This study provided a scientific basis for understanding the bioactive compounds and the multi-target mechanism of JWQFY.
MeSH term(s)	Alzheimer Disease/drug therapy ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal ; Humans ; Tandem Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal ; qi-fu-yin
Language	English
Publishing date	2020-07-08
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2020.113467
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Zs.A 1850: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Integrated analyses of miRNA and mRNA profiles in leukocytes and serums in traditional Chinese medicine (TCM)-defined Pi-qi-deficiency syndrome and Pi-wei damp-heat syndrome resulting from chronic atrophic gastritis

Leiming You / Shen Zhang / Ting’an Li / Xiaopu Sang / Kunyu Li / Wei Wang / Xinhui Gao / Jiarui Wu / Guangrui Huang / Ting Wang / Anlong Xu

Chinese Medicine, Vol 16, Iss 1, Pp 1-

2021 Volume 15

Abstract: ... in the traditional Chinese medicine (TCM)-defined Pi-qi-deficiency syndrome (PQDS) and Pi-wei damp-heat syndrome (PDHS) resulting ...

Abstract	Abstract Background To investigate the microRNA (miRNA)-gene interactions underlying leukocyte functions and characteristics, especially the potential serum biomarkers, implicated in the traditional Chinese medicine (TCM)-defined Pi-qi-deficiency syndrome (PQDS) and Pi-wei damp-heat syndrome (PDHS) resulting from chronic atrophic gastritis (CAG). Methods Using RNA/miRNA-sequencing approach, compared with healthy control population, we identified the PDHS- or PQDS-specific miRNAs and genes in leukocytes or serums, especially the Zheng (syndrome)-specific miRNA-gene interactions, and further decoded their functions and pathways. Results Despite being the TCM-defined Zhengs resulting from the same disease of CAG, the Zheng-specific genes and miRNAs were not same. The PDHS-specific leukocyte genes were mainly involved in defense and immune responses, including NOD-like receptor signaling and several synapses-related pathways. The expression upregulation of PDHS-specific genes enriched in the neutrophil degranulation pathway, indicated the enhanced leukocyte degranulation activation. The PQDS-specific genes in leukocytes were implicated in inflammatory response, extracellular matrix (ECM) organization and collagen catabolism. They could be enriched in MAPK and IL17 signaling and helper T cell differentiation pathways, especially the pathways associated with cell-to-cell adhesion/junction and communication such as cell adhesion molecules, ECM organization and ECM-receptor interaction, probably contributing to the characteristics and functions of leukocytes. Also, the experimentally-supported miRNA-gene interactions, concerned with COL4A2, COL26A1, SPP1 and PROCR, were implicated in the regulation of pathways related to cell-to-cell adhesion/junction and communication, suggesting the potential roles of the PQDS-specific miRNA-gene interactions for the characteristic and functional changes of leukocytes. Interestingly, the PQDS-specific miRNAs in the serums and the corresponding leukocytes, seemed to have the common ...
Keywords	Chronic atrophic gastritis ; Pi-qi-deficiency syndrome ; Pi-wei damp-heat syndrome ; Leukocyte ; Serum ; miRNA biomarker ; Other systems of medicine ; RZ201-999
Subject code	572
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: iTRAQ-Based Proteomics Analysis of Plasma of Myasthenia Gravis Patients Treated with Jia Wei Bu Zhong Yi Qi Decoction.

Zhang, Yunke / Yang, Junhong / Chen, Yingzhe / Lv, Jie / Zhang, Jing / Zhang, Yingna / Zhao, Xue / Fang, Hua / Liu, Chongchong / Zhang, Qingyong / Cui, Xinzheng / Wang, Xiaohan / Gao, Feng

Evidence-based complementary and alternative medicine : eCAM

2019 Volume 2019, Page(s) 9147072

Abstract: ... satisfactory results after treatment with pyridostigmine and prednisone. Jia Wei Bu Zhong Yi Qi (Jia Wei BZYQ ... with routine western medical treatment (T2), and MG patients with combined treatments of Jia Wei BZYQ decoction ...

Abstract	Myasthenia gravis (MG) is an autoimmune disease. A proportion of MG patients did not get satisfactory results after treatment with pyridostigmine and prednisone. Jia Wei Bu Zhong Yi Qi (Jia Wei BZYQ) decoction, a water extract from multiple herbs, has been demonstrated to be effective in the treatment of multiple "Qi deficiency type" diseases including MG in China. In this text, we investigated protein alterations in the plasma from healthy volunteers (C), MG patients without any treatment (T1), MG patients with routine western medical treatment (T2), and MG patients with combined treatments of Jia Wei BZYQ decoction and routine western medicines (T3) and identified some potential proteins involved in the pathogenesis and treatment of MG. iTRAQ (isobaric tags for relative and absolute quantitation) and 2D-LC-MS/MS (two-dimensional liquid chromatography-tandem mass spectrometry technologies) were employed to screen differentially expressed proteins. The identification, quantification, functional annotation, and interaction of proteins were analyzed by matching software and databases. In our project, 618 proteins were identified, among which 447 proteins had quantitative data. The number of differentially expressed proteins was 110, 117, 143, 115, 86, and 158 in T1 vs. C, T2 vs. C, T2 vs. T1, T3 vs. C, T3 vs. T1, and T3 vs. T2 groups, respectively. Functional annotation results showed that many differentially expressed proteins were closely associated with immune responses. For instance, some key proteins such as C-reactive protein, apolipoprotein C-III, apolipoprotein A-II, alpha-actinin-1, and thrombospondin-1 have been found to be abnormally expressed in T3 group compared to T1 group or T2 group. Interaction network analyses also provided some potential biomarkers or targets for MG management.
Language	English
Publishing date	2019-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2019/9147072
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Zs.A 5995: Show issues

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Book ; Online: Spatiotemporal variability and assessment of drought in the Wei River basin of China

Cai, Siyang / Zuo, Depeng / Xu, Zongxue / Han, Xianming / Gao, Xiaoxi

eISSN: 2199-899X

2019

Abstract: The temporal and spatial variations of drought in the Wei River basin (WRB) were investigated ... agricultural drought conditions than temperature in the Wei River basin. ...

Abstract	The temporal and spatial variations of drought in the Wei River basin (WRB) were investigated by calculating the meteorological drought Index (Standardized Precipitation Index, SPI) and the agricultural drought index (Vegetation Health Index, VHI). Monthly precipitation and air temperature were from 22 meteorological stations over the region from 1960 to 2015. Monthly Normalized Difference Vegetation Index (NDVI) and 8-days Land Surface Temperature (LST) were provided from the National Aeronautics and Space Administration (NASA) for the period 2000–2015 were also adopted. The results showed that the drought initially increased and then decreased, reaching at the maximum value in 1990s. The spatial pattern of meteorological drought showed that the drought in northern WRB was heavier than that in southern WRB before 1990s, after that, the situation had the opposite. By comparing the agricultural drought index (VHI) with crop yield, it was proved that VHI was applicable in the WRB and could well reflect the fluctuation of agricultural drought. The WRB suffered from serious agricultural drought in 2000, 2001, 2007 and 2008. Through analysis of the historical precipitation and temperature data, it was found that precipitation had a greater contribution to creating agricultural drought conditions than temperature in the Wei River basin.
Subject code	333 ; 910
Language	English
Publishing date	2019-02-08
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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