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Article ; Online: High perceived stress is associated with decreased sensory-specific satiety in humans.

Yan, Yuqing / Yu, Haiyang / Han, Pengfei

2024 Volume 277, Page(s) 114482

Abstract: ... sample of participants, MAIA total score was positively associated with the magnitude of SSS (r = 0.29, p ...

Abstract	Previous studies have shown that chronic stress increases food intake. One possible mechanism may be due to altered sensory-specific satiety (SSS) among people with high level of chronic stress. In the current study, seventy-six participants were divided into either high-stress or low-stress groups according to their Perceived Stress Scale (PSS) scores. Participants were assigned to consume one of two foods (banana milk and corn soup) ad libitum until they felt comfortably satiated. Before and after eating, participants rated their liking and wanting for the flavor and the odor (via retronasal and orthonasal routes) of the eaten and uneaten foods. Individual interoceptive sensibility and eating behavior were measured using the Multidimensional Assessment of Interoceptive Awareness (MAIA) and Reasons Individuals Stop Eating Questionnaire (RISE-Q-15), respectively. Compared to the low-stress group, the high-stress group demonstrated blunted SSS to the whole food flavor. No significant difference was found for olfactory-specific satiety (retronasal or orthonasal) between the two groups. In addition, across the whole sample of participants, MAIA total score was positively associated with the magnitude of SSS (r = 0.29, p = 0.01). These results indicate that chronic perceived stress may play a role in the experience of reward during eating.
MeSH term(s)	Humans ; Food Preferences ; Taste ; Eating ; Stress, Psychological ; Psychological Tests ; Self Report
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2024.114482
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Article ; Online: Single Transverse Spin Asymmetry as a New Probe of Standard-Model-Effective-Field-Theory Dipole Operators.

Wen, Xin-Kai / Yan, Bin / Yu, Zhite / Yuan, C-P

Physical review letters

2024 Volume 131, Issue 24, Page(s) 241801

Abstract: Electroweak dipole operators in the standard-model-effective-field theory (SMEFT) are important indirect probes of quantum effects of new physics beyond the standard model (SM), yet they remain poorly constrained by current experimental analyses for lack ...

Abstract	Electroweak dipole operators in the standard-model-effective-field theory (SMEFT) are important indirect probes of quantum effects of new physics beyond the standard model (SM), yet they remain poorly constrained by current experimental analyses for lack of interference with the SM amplitudes in constructing cross section observables. In this Letter, we point out that dipole operators flip fermion helicities and so are ideally studied through single transverse spin asymmetries. We illustrate this at a future electron-positron collider with transversely polarized beams, where such an effect exhibits as azimuthal cosϕ and sinϕ distributions which originate from the interference of the electron dipole operators with the SM and are linearly dependent on their Wilson coefficients. This new method can improve the current constraints on the electron dipole couplings by 1-2 orders of magnitude, without depending on other new physics operators, and can also simultaneously constrain both their real and imaginary parts, offering a new opportunity for probing potential CP-violating effects.
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.241801
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Article: Comparing [18F]FET PET and [18F]FDOPA PET for glioma recurrence diagnosis: a systematic review and meta-analysis.

Yu, Pengbo / Wang, Yinan / Su, Fengbo / Chen, Yan

Frontiers in oncology

2024 Volume 13, Page(s) 1346951

Abstract: ... through the Cochrane Q and I² statistics. If substantial heterogeneity among the studies was observed (P < 0.10 or I² ... for assessing heterogeneity (P < 0.10), statistical significance was determined when the two-tailed P value fell ... in sensitivity existed between these two radiotracers (P=0.04), while no significant difference was observed ...

Abstract	Purpose: The purpose of our meta-analysis and systematic review was to evaluate and compare the diagnostic effectiveness of [18F]FET PET and [18F]FDOPA PET in detecting glioma recurrence. Methods: Sensitivities and specificities were assessed using the DerSimonian and Laird methodology, and subsequently transformed using the Freeman-Tukey double inverse sine transformation. Confidence intervals were computed employing the Jackson method, while heterogeneity within and between groups was evaluated through the Cochrane Q and I² statistics. If substantial heterogeneity among the studies was observed (P < 0.10 or I² > 50%), we conducted meta-regression and sensitivity analyses. Publication bias was assessed through the test of a funnel plot and the application of Egger's test. For all statistical tests, except for assessing heterogeneity (P < 0.10), statistical significance was determined when the two-tailed P value fell below 0.05. Results: Initially, 579 publications were identified, and ultimately, 22 studies, involving 1514 patients(1226 patients for [18F]FET PET and 288 patients for [18F]FDOPA PET), were included in the analysis. The sensitivity and specificity of [18F]FET PET were 0.84 (95% CI, 0.75-0.90) and 0.86 (95% CI, 0.80-0.91), respectively, while for [18F]FDOPA PET, the values were 0.95 (95% CI, 0.86-1.00) for sensitivity and 0.90 (95% CI, 0.77-0.98) for specificity. A statistically significant difference in sensitivity existed between these two radiotracers (P=0.04), while no significant difference was observed in specificity (P=0.58). Conclusion: It seems that [18F]FDOPA PET demonstrates superior sensitivity and similar specificity to [18F] FET PET. Nevertheless, it's crucial to emphasize that [18F]FDOPA PET results were obtained from studies with limited sample sizes. Further larger prospective studies, especially head-to-head comparisons, are needed in this issue. Systematic review registration: identifier CRD42023463476.
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1346951
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Article ; Online: Relationship between human epididymal protein 4 and depth of tumor invasion, postoperative recurrence, and metastasis of epithelial epithelial ovarian cancer.

Li, Yan / Yu, Chunxiang / Li, Hui / Feng, Yan / Fan, Panhong / Chen, Xiaohui

Asia-Pacific journal of clinical oncology

2024

Abstract: ... in adjacent tissues (p < 0.01). The International Federation of Gynecology and Obstetrics stage, infiltration ... protective factor for the prognosis of patients with epithelial OVCA (p < 0.05). The area under the curve ... while these were 31.4 and 35.6 months in HE4-negative epithelial OVCA patients (p < 0.05). In conclusion, HE4 was ...

Abstract	This study aimed to analyze the relationship between human epididymal protein 4 (HE4) and infiltration depth, postoperative recurrence, and metastasis of epithelial ovarian cancer (OVCA). Immunohistochemistry was used to detect the expression level of HE4 in cancer tissues and adjacent tissues of 90 patients with epithelial OVCA admitted to our hospital from May 2017 to January 2018. Cox regression was used to analyze the factors affecting the prognosis of epithelial OVCA. The relationship between HE4 and the prognosis of epithelial OVCA was analyzed by the receiver operating characteristic curve and Kaplan-Meier survival curve. The positive expression rate of HE4 in epithelial OVCA was 85.56%, which was higher than 34.44% in adjacent tissues (p < 0.01). The International Federation of Gynecology and Obstetrics stage, infiltration depth, lymph node metastasis, postoperative recurrence and metastasis, and HE4 positivity were independent risk factors for the prognosis, and platinum-based chemotherapy sensitivity was an independent protective factor for the prognosis of patients with epithelial OVCA (p < 0.05). The area under the curve of HE4 in diagnosing epithelial OVCA and predicting recurrence was 0.863 and 0.700, the sensitivity was 91.60% and 85.60%, and the specificity was 90.20% and 65.60%. The median progression-free survival and overall survival were 26.1 and 30.2 months in HE4-positive epithelial OVCA patients, while these were 31.4 and 35.6 months in HE4-negative epithelial OVCA patients (p < 0.05). In conclusion, HE4 was highly expressed in epithelial OVCA tissues. Its expression level was related to the depth of tumor invasion, postoperative recurrence and metastasis, and other clinicopathological characteristics of patients with epithelial OVCA.
Language	English
Publishing date	2024-04-14
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2187409-8
ISSN	1743-7563 ; 1743-7555
ISSN (online)	1743-7563
ISSN	1743-7555
DOI	10.1111/ajco.14062
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Article: Effectiveness of oncology nurse navigator on the incidence of postoperative pulmonary complications in gastric cancer patients undergoing radical gastrectomy.

Yan, Yamin / Jin, Peili / Yu, Zhenghong / Tang, Zhaoqing / Lu, Jingjing / Hu, Yan / Zhang, Yuxia

BMC nursing

2023 Volume 22, Issue 1, Page(s) 208

Abstract: ... 378, P = 0.045)), but there was no significant difference in the components of PPCs including ... higher in the non-ONN group (p = 0.020). No significant statistical difference was observed for the major ... pulmonary complications ([Formula: see text] 3) between the two groups (p = 0.286).: Conclusions: Role ...

Abstract	Background: Management of postoperative pulmonary complications (PPCs) can be challenging in gastric cancer patients undergoing radical gastrectomy and is always associated with poor prognosis. Even though oncology nurse navigator (ONN) provide effective and critical individualized care to patients, little is known about their impact on the occurrence of PPCs in gastric cancer patients. This study aimed to determine whether ONN decreases the incidence of PPCs in gastric cancer patients. Methods: This was a retrospective review in which data for gastric cancer patients at one centre was evaluated before and after an ONN hired. An ONN was introduced to patients at their initial visit to manage pulmonary complications throughout treatment. The research was conducted from 1 August 2020 to 31 January 2022. The study participants were divided into the non-ONN group (from 1 August 2020 to 31 January 2021) and the ONN group (from 1 August 2021 to 31 January 2022). The incidence and severity of PPCs between the groups were then compared. Results: ONN significantly decreased the incidence of PPCs (15.0% vs. 9.8%) (OR = 2.532(95% CI: 1.087-3.378, P = 0.045)), but there was no significant difference in the components of PPCs including pleural effusion, atelectasis, respiratory infection, and pneumothorax. The severity of PPCs was also significantly higher in the non-ONN group (p = 0.020). No significant statistical difference was observed for the major pulmonary complications ([Formula: see text] 3) between the two groups (p = 0.286). Conclusions: Role of ONN significantly decrease the incidence of PPCs in gastric cancer patients undergoing radical gastrectomy.
Language	English
Publishing date	2023-06-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2091496-9
ISSN	1472-6955
ISSN	1472-6955
DOI	10.1186/s12912-023-01291-z
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Article ; Online: Facet-specific NiCo

Liang, Yan / Xiang, Zhongke / Zhao, Xiaojian / Yan, Peipei / Xue, Li / Gu, Lisheng / Long, Yongdong / Yu, Ting / Yang, Yong

Journal of colloid and interface science

2023 Volume 653, Issue Pt B, Page(s) 1539–1547

Abstract: ... The research on crystal facets designing of semiconductor p-n heterojunction is still highly challenging ...

Abstract	Semiconductor gas sensing materials with specific crystal facets exposure have attracted researchers' attention recently. However, related research mainly focuses on single metal oxide semiconductor. The research on crystal facets designing of semiconductor p-n heterojunction is still highly challenging. Herein, based on NiCo
Language	English
Publishing date	2023-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.09.187
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Article ; Online: Effect of microplastics on oxytetracycline trophic transfer: Immune, gut microbiota and antibiotic resistance gene responses.

Zhang, Peng / Lu, Guanghua / Sun, Yu / Yan, Zhenhua / Zhang, Leibo / Liu, Jianchao

Journal of hazardous materials

2024 Volume 470, Page(s) 134147

Abstract: ... complement C3 levels in shrimp and fish, and hepatic immunoglobulin M levels in fish (p < 0.05). Co-exposure ...

Abstract	Microplastics and antibiotics are prevalent and emerging pollutants in aquatic ecosystems, but their interactions in aquatic food chains remain largely unexplored. This study investigated the impact of polypropylene microplastics (PP-MPs) on oxytetracycline (OTC) trophic transfer from the shrimp (Neocaridina denticulate) to crucian carp (Carassius auratus) by metagenomic sequencing. The carrier effects of PP-MPs promoted OTC bioaccumulation and trophic transfer, which exacerbated enterocyte vacuolation and hepatocyte eosinophilic necrosis. PP-MPs enhanced the inhibitory effect of OTC on intestinal lysozyme activities and complement C3 levels in shrimp and fish, and hepatic immunoglobulin M levels in fish (p < 0.05). Co-exposure of MPs and OTC markedly increased the abundance of Actinobacteria in shrimp and Firmicutes in fish, which caused disturbances in carbohydrate, amino acid, and energy metabolism. Moreover, OTC exacerbated the enrichment of antibiotic resistance genes (ARGs) in aquatic animals, and PP-MPs significantly increased the diversity and abundance of ARGs and facilitated the trophic transfer of teta and tetm. Our findings disclosed the impacts of PP-MPs on the mechanism of antibiotic toxicity in aquatic food chains and emphasized the importance of gut microbiota for ARGs trophic transfer, which contributed to a deeper understanding of potential risks posed by complex pollutants on aquatic ecosystems.
MeSH term(s)	Animals ; Oxytetracycline/toxicity ; Microplastics/toxicity ; Gastrointestinal Microbiome/drug effects ; Water Pollutants, Chemical/toxicity ; Food Chain ; Anti-Bacterial Agents/toxicity ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Microbial/genetics ; Polypropylenes ; Goldfish/genetics ; Goldfish/metabolism ; Penaeidae/microbiology ; Penaeidae/drug effects ; Muramidase/metabolism
Chemical Substances	Oxytetracycline (X20I9EN955) ; Microplastics ; Water Pollutants, Chemical ; Anti-Bacterial Agents ; Polypropylenes ; Muramidase (EC 3.2.1.17)
Language	English
Publishing date	2024-03-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.134147
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Article ; Online: The potential effect of salvianolic acid B against rat ischemic brain injury in combination with mesenchymal stem cells.

Yan, Minli / Li, Zheming / Dai, Shijie / Li, Shouye / Yu, Pingping

Journal of chemical neuroanatomy

2023 Volume 133, Page(s) 102338

Abstract: ... of TLR4, MYD88, p-NF-κB p65, TRAF6-and action of SIRT1 in brain tissues.: Conclusion: The present study ...

Abstract	Background: Mesenchymal stem cells (MSCs) and Salvianolic acid B (SAB) are known to exert potent anti-inflammatory and anti-oxidative properties. But the effect of SAB and MSCs combination treatment on the cerebral ischemia/reperfusion injury (CI/RI) is not clear. Methods: After the CI/RI animal model established, rats were administered with MSCs and SAB individually or combination treatment. To evaluate the therapeutic potential, behavioral tests, TTC staining, Hematoxylin-eosin (HE) staining, and immunofluorescence assays were performed to evaluate the neuroprotection and endogenous neurogenesis. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining and enzyme linked immunosorbent assay (ELISA) were performed to evaluate the anti-apoptosis and anti-inflammatory effect. Meanwhile, the expression of the TLR4/NF-ĸB/MYD88 signal pathway-related proteins was evaluated by Western blot. Results: MSCs and SAB individually or combination treatment have protective effect in CI/RI rats. More importantly, the rats with the combination treatment showed a better behavioral recovery, neurogenesis and smaller infarct size compared with the rats administered with MSCs or SAB individually. Further research showed that the combination treatment decreased CI/RI induced inflammatory cytokines and oxidative stress, including inhibiting the production of IL-1β, IL-6, TNF-α, decreasing the levels of malondialdehyde (MDA), and increased the activity of superoxide dismutase (SOD). In addition, the neuroprotection effect of SAB and MSCs combination was achieved through the regulation of TLR4/NF-κB/MyD88 signaling pathway related proteins, including inhibition the protein levels of TLR4, MYD88, p-NF-κB p65, TRAF6-and action of SIRT1 in brain tissues. Conclusion: The present study indicated that the MSCs and SAB combination treatment had better protective effect against rat ischemic brain injury. The combination of SAB and MSCs may provide a potent and promising strategy for the treatment of ischemic stroke and is worthy for further development.
MeSH term(s)	Rats ; Animals ; NF-kappa B/metabolism ; Rats, Sprague-Dawley ; Toll-Like Receptor 4/metabolism ; Myeloid Differentiation Factor 88/metabolism ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Anti-Inflammatory Agents/therapeutic use ; Brain Ischemia/drug therapy ; Brain Ischemia/prevention & control ; Brain Injuries ; Mesenchymal Stem Cells/metabolism
Chemical Substances	NF-kappa B ; salvianolic acid B (C1GQ844199) ; Toll-Like Receptor 4 ; Myeloid Differentiation Factor 88 ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-09-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	639443-7
ISSN	1873-6300 ; 0891-0618
ISSN (online)	1873-6300
ISSN	0891-0618
DOI	10.1016/j.jchemneu.2023.102338
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Article: [Alterations in erythrocytic oligomeric alpha-synuclein in patients with Parkinson's disease and multiple system atrophy].

Yan, X M / Li, P J / Li, W / Wang, X M / Yu, S

Zhonghua yi xue za zhi

2023 Volume 103, Issue 37, Page(s) 2933–2939

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Female ; Male ; Middle Aged ; Aged ; alpha-Synuclein ; Parkinson Disease ; Multiple System Atrophy ; Longitudinal Studies ; REM Sleep Behavior Disorder ; Erythrocytes
Chemical Substances	alpha-Synuclein
Language	Chinese
Publishing date	2023-09-26
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.cn112137-20230607-00957
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Article ; Online: Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis.

Liu, Ruiyan / Shang, Xin / Fu, Yu / Wang, Ying / Wang, Ping / Yan, Shuxun

Molecular immunology

2024 Volume 168, Page(s) 17–24

Abstract: ... a significant genetic correlation between hypothyroidism and RA(LDSC:rg=0.3803,p=7.23e-11;HDL:rg=0.3849,p=1.02e ...

Abstract	Background: In recent years, mounting evidence has indicated a co-morbid relationship between hypothyroidism and rheumatoid arthritis (RA), however, the shared genetic factors underlying this association remain unclear. This study aims to investigate the common genetic architecture between hypothyroidism and RA. Methods: Genome-wide association study (GWAS) summary statistics from recently published studies were utilized to examine the genetic correlation, shared genetic loci, and potential causal relationship between hypothyroidism and RA. Statistical methods included linkage disequilibrium score regression (LDSC), high-definition likelihood (HDL), cross-trait meta-analyses, colocalization analysis, multi-marker analysis of genomic annotation (MAGMA), tissue-specific enrichment analysis (TSEA), functional enrichment analysis, and latent causal variable method (LCV). Results: Our study demonstrated a significant genetic correlation between hypothyroidism and RA(LDSC:rg=0.3803,p=7.23e-11;HDL:rg=0.3849,p=1.02e-21). Through cross-trait meta-analysis, we identified 1035 loci, including 43 novel genetic loci. By integrating colocalization analysis and the MAGMA algorithm, we found a substantial number of genes, such as PTPN22, TYK2, and CTLA-4, shared between the two diseases, which showed significant enrichment across 14 tissues. These genes were primarily associated with the regulation of alpha-beta T cell proliferation, positive regulation of T cell activation, positive regulation of leukocyte cell-cell adhesion, T cell receptor signaling pathway, and JAK-STAT signaling pathway. However, our study did not reveal a significant causal association between the two diseases using the LCV approach. Conclusion: Based on these findings, there is a significant genetic correlation between hypothyroidism and RA, suggesting a shared genetic basis for these conditions.
MeSH term(s)	Humans ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/metabolism ; Genetic Loci ; Hypothyroidism/genetics ; Polymorphism, Single Nucleotide ; Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics
Chemical Substances	PTPN22 protein, human (EC 3.1.3.48) ; Protein Tyrosine Phosphatase, Non-Receptor Type 22 (EC 3.1.3.48)
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2024.02.002
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