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Article: Percutaneous aspiration of aortic valve vegetation in a patient with aortic valve endocarditis.

Cioci, Anthony Louis / Hutton, Anneka / Yi, Slee / Khoriaty, George / Gottlieb, Gary / Cartledge, Richard / Rubenstein, Mark

Clinical case reports

2024 Volume 12, Issue 4, Page(s) e8724

Abstract: Key clinical message: Percutaneous aspiration for debulking of vegetations in right-sided infective endocarditis has been well-described, however, this technique can be employed successfully for left-sided vegetations in select high-risk patients.: ... ...

Abstract	Key clinical message: Percutaneous aspiration for debulking of vegetations in right-sided infective endocarditis has been well-described, however, this technique can be employed successfully for left-sided vegetations in select high-risk patients. Abstract: We report a case of percutaneous aspiration of an aortic valve vegetation in a patient with prosthetic valve endocarditis. This novel approach was selected after patient declined surgical intervention for an enlarging vegetation despite antibiotic therapy. The procedure was successful, resulting in the complete removal of solid vegetation without complications.
Language	English
Publishing date	2024-03-29
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.8724
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Proteomic analysis of prion diseases: creating clarity or causing confusion?

Rubenstein, Richard

Electrophoresis

2012 Volume 33, Issue 24, Page(s) 3631–3643

Abstract: Prion diseases, or transmissible spongiform encephalopathies, are progressive, fatal neurodegenerative diseases. There are both human and animal forms of the disease and all are associated with the conversion of a normal host-coded cellular prion protein ...

Abstract	Prion diseases, or transmissible spongiform encephalopathies, are progressive, fatal neurodegenerative diseases. There are both human and animal forms of the disease and all are associated with the conversion of a normal host-coded cellular prion protein (PrP(C) ) into an abnormal protease-resistant isoform (PrP(Sc) ). Although methodologies are sensitive and specific for postmortem disease diagnosis, the use of PrP(Sc) as a preclinical or general biomarker for surveillance is difficult, due to the fact that it is present in extremely small amounts in accessible tissues or body fluids such as blood, urine, saliva, and cerebrospinal fluid. Recently, amplification techniques have been developed, which have enabled increased sensitivity for PrP(Sc) detection. However, it has recently been reported that proteinase K sensitive, pathological isoforms of PrP may have a significant role in the pathogenesis of some prion diseases. Accordingly, the development of new diagnostic tests that do not rely on PrP(Sc) and proteinase K digestion is desirable. The search for biomarkers (other than PrP(Sc) ) as tools for diagnosis of prion diseases has a long history. Ideally biomarkers able to detect all transmissible spongiform encephalopathies, even at preclinical stages of infection are desirable but not yet possible due to the heterogeneity of the disease and lengthy disease progression. Recent advances in neuroproteomics have led to an overwhelming amount of information, which may offer insight on protein-protein interactions. While the amount of data obtained is impressive, the ability to relate it to the disease and validating its usefulness in diagnostic biomarker development remains a formidable challenge.
MeSH term(s)	Animals ; Biomarkers/analysis ; Humans ; Prion Diseases/metabolism ; Prions/analysis ; Prions/metabolism ; Proteomics/methods
Chemical Substances	Biomarkers ; Prions
Language	English
Publishing date	2012-12
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	619001-7
ISSN	1522-2683 ; 0173-0835
ISSN (online)	1522-2683
ISSN	0173-0835
DOI	10.1002/elps.201200310
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Article ; Online: Parallel CSF and serum temporal profile assessment of axonal injury biomarkers NF-L and pNF-H: Associations with patient outcome in moderate-severe traumatic brain injury.

Wang, Kevin K W / Barton, David J / McQuillan, Leah / Kobeissy, Firas / Cai, Guangzheng / Xu, Haiyan / Yang, Zhihui / Trifilio, Erin / Williamson, John B / Rubenstein, Richard / Robertson, Claudia S / Wagner, Amy K

Journal of neurotrauma

2024

Abstract: Neurofilament-light chain (NF-L) and phosphorylated neurofilament-heavy chain (pNF-H) are axonal proteins that have been reported as potential diagnostic and prognostic biomarkers in traumatic brain injury (TBI). However, detailed temporal profiles for ... ...

Abstract	Neurofilament-light chain (NF-L) and phosphorylated neurofilament-heavy chain (pNF-H) are axonal proteins that have been reported as potential diagnostic and prognostic biomarkers in traumatic brain injury (TBI). However, detailed temporal profiles for these proteins in blood, and interrelationships in the acute and chronic time periods post-TBI have not been established. Our objectives were 1) to characterize acute-to-chronic serum NF-L and pNF-H profiles after moderate-severe TBI, as well as acute cerebrospinal fluid (CSF) levels, 2) to evaluate CSF and serum NF-L and pNF-H associations with each other, and 3) to assess biomarker associations with global patient outcome using both the Glasgow Outcome Scale-Extended (GOS-E) and Disability Rating Scale (DRS). In this multi-cohort study, we measured serum and CSF NF-L and pNF-H levels in samples collected from two clinical cohorts (University of Pittsburgh [UPITT] and Baylor College of Medicine [BCM]) of individuals with moderate-to-severe TBI. The UPITT cohort includes 279 subjects from an observational cohort study; we obtained serum (n=277 unique subjects) and CSF (n=95 unique subjects) daily for one week, and serum every two weeks for six months. The BCM cohort included 103 subjects from a previous randomized clinical trial of erythropoietin and blood transfusion threshold after severe TBI, which showed no effect on neurological outcome between treatment arms; serum (n=99 unique subjects) and CSF (n=54 unique subjects) NF-L and pNF-H levels were measured at least daily during days (D) 0-10 post-injury. GOS-E and DRS were assessed at 6 months (both cohorts) and 12 months (UPITT cohort only). Results show serum NF-L and pNF-H gradually rise during the first 10 days and peak at D20-30 post-injury. In the UPITT cohort, acute (D0-6) NF-L and pNF-H levels correlate within CSF and serum (Spearman r=0.44-0.48; p<0.05). In the UPITT cohort, acute NF-L CSF and serum levels, as well as chronic (M2-6) serum NF-L levels, were higher among individuals with unfavorable GOS-E and worse DRS at 12 months (p<0.05, all comparisons). In the BCM cohort, higher acute serum NF-L levels were also associated with unfavorable GOS-E. Higher pNF-H serum concentrations (D0-6 and M2-6), but not CSF pNF-H, were associated with unfavorable GOS-E and worse DRS (p<0.05, all comparisons) in the UPITT cohort. Relationships between biomarker levels and favorable outcome persisted after controlling for age, sex, and GCS. This study shows for the first time that serum levels of NF-L and pNF-H peak at D20-30 post-TBI. Serum NF-L levels, and to a lesser extent pNF-H levels, are robustly associated with global patient outcomes and disability after moderate-to-severe TBI. Further studies on clinical utility as prognosis and treatment-response indicators are needed.
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2023.0449
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Article ; Online: Endoplasmic reticulum stress-regulated degradation of a translocon-associated protein is independent of integrated stress response transcription factor Gcn4p.

Richards, Kyle A / Rubenstein, Eric M

microPublication biology

2020 Volume 2020

Language	English
Publishing date	2020-04-09
Publishing country	United States
Document type	Journal Article
ISSN	2578-9430
ISSN (online)	2578-9430
DOI	10.17912/micropub.biology.000239
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Article ; Online: Characterization and standardization of multiassay platforms for four commonly studied traumatic brain injury protein biomarkers: a TBI Endpoints Development Study.

Sarkis, George Anis / Zhu, Tian / Yang, Zhihui / Li, Xue / Shi, Yuan / Rubenstein, Richard / Yost, Richard A / Manley, Geoffrey T / Wang, Kevin K

Biomarkers in medicine

2021 Volume 15, Issue 18, Page(s) 1721–1732

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Antigens/metabolism ; Biological Assay/standards ; Biomarkers/cerebrospinal fluid ; Brain Injuries, Traumatic/cerebrospinal fluid ; Brain Injuries, Traumatic/diagnosis ; Case-Control Studies ; Endpoint Determination ; Glial Fibrillary Acidic Protein/cerebrospinal fluid ; Humans ; Recombinant Proteins/metabolism ; Reference Standards ; S100 Calcium Binding Protein beta Subunit/cerebrospinal fluid ; Ubiquitin Thiolesterase/cerebrospinal fluid ; tau Proteins/cerebrospinal fluid
Chemical Substances	Antigens ; Biomarkers ; Glial Fibrillary Acidic Protein ; Recombinant Proteins ; S100 Calcium Binding Protein beta Subunit ; S100B protein, human ; UCHL1 protein, human ; tau Proteins ; Ubiquitin Thiolesterase (EC 3.4.19.12)
Language	English
Publishing date	2021-10-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2481014-9
ISSN	1752-0371 ; 1752-0363
ISSN (online)	1752-0371
ISSN	1752-0363
DOI	10.2217/bmm-2021-0284
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Book ; Online: When Jesus Became God

Rubenstein, Richard E

The Epic Fight over Christ's Divinity in the Last Days of Rome

2013

Abstract: Richard E. Rubenstein takes the reader to the streets of the Roman Empire during the fourth century ...

Abstract	Richard E. Rubenstein takes the reader to the streets of the Roman Empire during the fourth century, when a fateful debate over the divinity of Jesus Christ is being fought
Language	English
Size	Online-Ressource (368 p)
Publisher	Houghton Mifflin Harcourt
Publishing place	Boston
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9780156013154 ; 0156013150
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Temporal Profiles of P-Tau, T-Tau, and P-Tau:Tau Ratios in Cerebrospinal Fluid and Blood from Moderate-Severe Traumatic Brain Injury Patients and Relationship to 6-12 Month Global Outcomes.

Rubenstein, Richard / McQuillan, Leah / Wang, Kevin K W / Robertson, Claudia / Chang, Binggong / Yang, Zhihui / Xu, Haiyan / Williamson, John / Wagner, Amy K

Journal of neurotrauma

2023 Volume 41, Issue 3-4, Page(s) 369–392

Abstract: Traumatic brain injury (TBI) can initiate progressive injury responses, which are linked to increased risk of neurodegenerative diseases known as "tauopathies." Increased post-TBI tau hyperphosphorylation has been reported in brain tissue and biofluids. ... ...

Abstract	Traumatic brain injury (TBI) can initiate progressive injury responses, which are linked to increased risk of neurodegenerative diseases known as "tauopathies." Increased post-TBI tau hyperphosphorylation has been reported in brain tissue and biofluids. Acute-to-chronic TBI total (T)-tau and phosphorylated (P)-tau temporal profiles in the cerebrospinal fluid (CSF) and serum and their relationship to global outcome is unknown. Our multi-site longitudinal study examines these concurrent profiles acutely (CSF and serum) and also characterizes the acute- to-chronic serum patterns. Serial serum and CSF samples from individuals with moderate-to-severe TBI were obtained from two cohorts (acute, subacute, and chronic samples from University of Pittsburgh [UPitt] [
MeSH term(s)	Humans ; Biomarkers ; Brain Injuries ; Brain Injuries, Traumatic ; Glasgow Outcome Scale ; Longitudinal Studies
Chemical Substances	Biomarkers ; MAPT protein, human
Language	English
Publishing date	2023-11-16
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2022.0479
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Article ; Online: Serial Measurements of Serum Glial Fibrillary Acidic Protein in Moderate-Severe Traumatic Brain Injury: Potential Utility in Providing Insights into Secondary Insults and Long-Term Outcome.

Robertson, Claudia S / Martinez, Felipe Salinas / McQuillan, Leah E / Williamson, John / Lamb, Damon G / Wang, Kevin K W / Rubenstein, Richard / Wagner, Amy K

Journal of neurotrauma

2023 Volume 41, Issue 1-2, Page(s) 73–90

Abstract: In patients with traumatic brain injury (TBI), serum biomarkers may have utility in assessing the evolution of secondary brain injury. A panel of nine brain-injury- associated biomarkers was measured in archived serum samples over 10 days post-injury ... ...

Abstract	In patients with traumatic brain injury (TBI), serum biomarkers may have utility in assessing the evolution of secondary brain injury. A panel of nine brain-injury- associated biomarkers was measured in archived serum samples over 10 days post-injury from 100 patients with moderate-severe TBI. Among the biomarkers evaluated, serum glial fibrillary acidic protein (GFAP) had the strongest associations with summary measures of acute pathophysiology, including intracranial pressure (ICP), cerebral perfusion pressure (CPP), and brain tissue pO
MeSH term(s)	Humans ; Glial Fibrillary Acidic Protein ; Brain Injuries, Traumatic ; Brain Injuries ; Biomarkers ; Intracranial Pressure/physiology
Chemical Substances	Glial Fibrillary Acidic Protein ; Biomarkers
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2023.0111
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Book ; Online: Zero-Rating and Net Neutrality

Bayat, Niloofar / Ma, Richard / Misra, Vishal / Rubenstein, Dan

Who Wins, Who Loses?

2020

Abstract: An objective of network neutrality is that the design of regulations for the Internet will ensure that it remains a public, open platform where innovations can thrive. While there is broad agreement that preserving the content quality of service falls ... ...

Abstract	An objective of network neutrality is that the design of regulations for the Internet will ensure that it remains a public, open platform where innovations can thrive. While there is broad agreement that preserving the content quality of service falls under the purview of net neutrality, the role of differential pricing, especially the practice of \emph {zero-rating} remains controversial. Even though some countries (India, Canada) have banned zero-rating, others have either taken no stance or explicitly allowed it (South Africa, Kenya, U.S.). In this paper, we model zero-rating options available between Internet service providers (ISPs) and content providers (CPs) and use these models to better understand the conditions under which offering zero-rated services are preferred, and who specifically gains in utility. We develop a formulation in which providers' incomes vary, from low-income startups to high-income incumbents, and where their decisions to zero-rate are a variation of the traditional prisoner's dilemma game. We find that if zero-rating is permitted, low-income CPs often lose utility, whereas high-income CPs often gain utility. We also study the competitiveness of the CP markets via the \emph{Herfindahl Index}. Our findings suggest that in most cases the introduction of zero-rating \emph{reduces} competitiveness.
Keywords	Computer Science - Computer Science and Game Theory
Subject code	303
Publishing date	2020-02-13
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Early Complications in Prepectoral Breast Reconstructions with and without Acellular Dermal Matrix: A Preliminary Analysis of Outcomes.

Plotsker, Ethan L / Graziano, Francis D / Rubenstein, Robyn N / Haglich, Kathryn / Allen, Robert J / Coriddi, Michelle R / Dayan, Joseph H / Poulton, Richard / McKernan, Cayla / Mehrara, Babak J / Matros, Evan / Disa, Joseph J / Nelson, Jonas A

Plastic and reconstructive surgery

2023 Volume 153, Issue 4, Page(s) 786–793

Abstract: Background: Prepectoral tissue expander (TE) placement for two-stage postmastectomy reconstruction is usually performed in conjunction with insertion of acellular dermal matrix (ADM). However, the effects of ADM use on TE loss or other early ... ...

Abstract	Background: Prepectoral tissue expander (TE) placement for two-stage postmastectomy reconstruction is usually performed in conjunction with insertion of acellular dermal matrix (ADM). However, the effects of ADM use on TE loss or other early complications remain unknown. Therefore, the aim of this study was to compare early postoperative complications in patients who underwent prepectoral breast implant reconstruction with or without ADM use. Methods: The authors performed a retrospective cohort study of all patients at their institution who underwent prepectoral breast reconstruction from January of 2018 to June of 2021. The primary outcome was TE loss within 90 days of surgery; secondary outcomes included other complications such as infection, TE exposure, mastectomy skin flap necrosis requiring revision, and seroma. Results: Data on 714 patients with 1225 TEs (1060 with ADM and 165 without) were analyzed. Baseline demographics did not differ by ADM use, although mastectomy breast tissue weight was higher in patients without ADM (750.3 g versus 540.8 g; P < 0.001). Rates of TE loss were similar in reconstructions with (3.8%) ADM and without (6.7%; P = 0.09). We also did not find differences in the rates of secondary outcomes between cohorts. Conclusions: ADM use had no statistically significant effect on early complication rates among patients undergoing breast reconstruction with prepectoral TEs. Still, this study was underpowered, and data trended toward statistical significance; thus, larger studies are required in the future. Additional research and randomized studies should focus on larger cohorts and examine long-term complications such as capsular contracture and implant malposition. Clinical question/level of evidence: Therapeutic, III.
MeSH term(s)	Humans ; Female ; Mastectomy/adverse effects ; Breast Neoplasms/surgery ; Breast Neoplasms/complications ; Retrospective Studies ; Acellular Dermis ; Mammaplasty/adverse effects ; Breast Implantation/adverse effects ; Breast Implants/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000010712
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