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  1. Book ; Thesis: Die Interaktion des Pilzes Chaetomium globosum mit der Gerste (Hordeum vulgare) und dem Echten Gerstenmehltau (Erysiphe graminis f. sp. hordei)

    Reissinger, Annette

    2001  

    Author's details vorgelegt von Annette Reissinger
    Language German
    Size 95 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 2000
    Note Zsfassung in engl. Sprache
    HBZ-ID HT012922531
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    008/2650 available for loan (reading room) Freihandmagazin (U1)

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  2. Book ; Thesis: Die Interaktion des Pilzes Chaetomium globosum mit der Gerste (Hordeum vulgare) und dem Echten Gerstenmehltau (Erysiphe graminis f. sp. hordei)

    Reissinger, Annette

    2000  

    Author's details vorgelegt von Annette Reissinger
    Keywords Wechselwirkung ; Gerstenmehltau ; Mehltaupilze ; Gerste ; Chaetomium globosum
    Language Undetermined
    Size 95 S, Ill., graph. Darst, 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @Bonn, Univ., Diss, 2001 (Nicht für den Austausch)
    Database Julius Kühn-Institute

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  3. Book ; Online ; Thesis: Die Interaktion des Pilzes Chaetomium globosum mit der Gerste (Hordeum vulgare) und dem Echten Gerstenmehltau (Erysiphe graminis f. sp. hordei)

    Reissinger, Annette

    2000  

    Author's details von Annette Reissinger
    Keywords Wechselwirkung ; Gerstenmehltau ; Gerste ; Chaetomium globosum
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Bonn, 2002
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book ; Online ; Thesis: Die Interaktion des Pilzes Chaetomium globosum mit der Gerste (Hordeum vulgare) und dem Echten Gerstenmehltau (Erysiphe graminis f. sp. hordei)

    Reissinger, Annette [Verfasser]

    2000  

    Author's details von Annette Reissinger
    Keywords Landwirtschaft, Veterinärmedizin ; Agriculture, Veterinary Science
    Subject code sg630
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  5. Article: Downregulation of mitogen-activated protein kinases by the Bordetella bronchiseptica Type III secretion system leads to attenuated nonclassical macrophage activation.

    Reissinger, Annette / Skinner, Jason A / Yuk, Ming H

    Infection and immunity

    2005  Volume 73, Issue 1, Page(s) 308–316

    Abstract: Bordetella bronchiseptica utilizes a type III secretion system (TTSS) to establish a persistent infection of the murine respiratory tract. Previous studies have shown that the Bordetella TTSS mediated cytotoxicity in different cell types, inhibition of ... ...

    Abstract Bordetella bronchiseptica utilizes a type III secretion system (TTSS) to establish a persistent infection of the murine respiratory tract. Previous studies have shown that the Bordetella TTSS mediated cytotoxicity in different cell types, inhibition of NF-kappaB in epithelial cells, and differentiation of dendritic cells into a semimature state. Here we demonstrate modulation of mitogen-activated protein kinase (MAPK) signaling pathways and altered cytokine production in macrophages and dendritic cells by the Bordetella TTSS. In macrophages, the MAPKs ERK and p38 were downregulated. This resulted in attenuated production of interleukin- (IL-)6 and IL-10. In contrast, the Th-1-polarizing cytokine IL-12 was produced at very low levels and remained unmodulated by the Bordetella TTSS. In dendritic cells, ERK was transiently activated, but this failed to alter cytokine profiles. These results suggest that the Bordetella TTSS modulates antigen-presenting cells in a cell type-specific manner and the secretion of high levels of IL-6 and IL-10 by macrophages might be important for pathogen clearance.
    MeSH term(s) Adenylate Cyclase Toxin/physiology ; Animals ; Bordetella bronchiseptica/immunology ; Bordetella bronchiseptica/metabolism ; Cells, Cultured ; Down-Regulation ; Interleukin-10/biosynthesis ; Interleukin-6/biosynthesis ; MAP Kinase Signaling System ; Macrophage Activation ; Mice ; Mitogen-Activated Protein Kinases/physiology ; Phosphorylation
    Chemical Substances Adenylate Cyclase Toxin ; Interleukin-6 ; Interleukin-10 (130068-27-8) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2005-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.73.1.308-316.2005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Downregulation of Mitogen-Activated Protein Kinases by the Bordetella bronchiseptica Type III Secretion System Leads to Attenuated Nonclassical Macrophage Activation

    Reissinger, Annette / Skinner, Jason A / Yuk, Ming H

    Infection and immunity. 2005 Jan., v. 73, no. 1

    2005  

    Abstract: Bordetella bronchiseptica utilizes a type III secretion system (TTSS) to establish a persistent infection of the murine respiratory tract. Previous studies have shown that the Bordetella TTSS mediated cytotoxicity in different cell types, inhibition of ... ...

    Abstract Bordetella bronchiseptica utilizes a type III secretion system (TTSS) to establish a persistent infection of the murine respiratory tract. Previous studies have shown that the Bordetella TTSS mediated cytotoxicity in different cell types, inhibition of NF-[kappa]B in epithelial cells, and differentiation of dendritic cells into a semimature state. Here we demonstrate modulation of mitogen-activated protein kinase (MAPK) signaling pathways and altered cytokine production in macrophages and dendritic cells by the Bordetella TTSS. In macrophages, the MAPKs ERK and p38 were downregulated. This resulted in attenuated production of interleukin- (IL-)6 and IL-10. In contrast, the Th-1-polarizing cytokine IL-12 was produced at very low levels and remained unmodulated by the Bordetella TTSS. In dendritic cells, ERK was transiently activated, but this failed to alter cytokine profiles. These results suggest that the Bordetella TTSS modulates antigen-presenting cells in a cell type-specific manner and the secretion of high levels of IL-6 and IL-10 by macrophages might be important for pathogen clearance.
    Keywords Bordetella bronchiseptica ; Type III secretion system ; cytotoxicity ; dendritic cells ; epithelial cells ; interleukin-10 ; interleukin-12 ; interleukin-6 ; macrophage activation ; macrophages ; mice ; mitogen-activated protein kinase ; pathogens ; respiratory system ; secretion ; signal transduction
    Language English
    Size p. 308-316.
    Publishing place American Society for Microbiology
    Document type Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Pseudohypoaldosteronism type 1 and the genes encoding prostasin, alpha-spectrin, and Nedd4.

    Ludwig, Michael / Bidlingmaier, Frank / Reissinger, Annette

    International journal of molecular medicine

    2004  Volume 14, Issue 6, Page(s) 1101–1104

    Abstract: Pseudohypoaldosteronism type 1 (PHA1), a rare disorder of infancy, presents with potential life-threatening salt wasting and failure to thrive. Thus far, PHA1 has been attributed to mutations affecting the mineralocorticoid receptor or any of the three ... ...

    Abstract Pseudohypoaldosteronism type 1 (PHA1), a rare disorder of infancy, presents with potential life-threatening salt wasting and failure to thrive. Thus far, PHA1 has been attributed to mutations affecting the mineralocorticoid receptor or any of the three subunits assembling the amiloride-sensitive epithelial sodium channel (ENaC). However, a lot of patients with a phenotype resembling PHA1, show no defects in these proteins, making it likely that further genes are involved in the aetiology of this disease. Recent studies have elucidated additional participants (alpha-spectrin and members of the families of transmembrane serine proteases, ubiquitin-protein ligases, and serum- and glucocorticoid-regulated kinases, respectively) regulating and/or interacting in the complex pathway of sodium retention in the amiloride-sensitive distal nephron. This led us to investigate whether PHA1 can also be associated with mutations in some of these genes. Our data suggest that at least the prostasin gene might be excluded as a causative locus.
    MeSH term(s) Endosomal Sorting Complexes Required for Transport ; Humans ; Mutation/genetics ; Nedd4 Ubiquitin Protein Ligases ; Pseudohypoaldosteronism/classification ; Pseudohypoaldosteronism/genetics ; Serine Endopeptidases/genetics ; Spectrin/genetics ; Ubiquitin-Protein Ligases/genetics
    Chemical Substances Endosomal Sorting Complexes Required for Transport ; Spectrin (12634-43-4) ; Nedd4 Ubiquitin Protein Ligases (EC 2.3.2.26) ; Nedd4 protein, human (EC 2.3.2.26) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Serine Endopeptidases (EC 3.4.21.-) ; prostasin (EC 3.4.21.-)
    Language English
    Publishing date 2004-12
    Publishing country Greece
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1444428-8
    ISSN 1107-3756
    ISSN 1107-3756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4942: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online: Collaborative study to establish a World Health Organization international standard for Hepatitis B e antigen (HBeAg)

    Reissinger, Annette / Volkers, Peter / Scheiblauer, Heinrich / Nick, Sigrid / WHO Expert Committee on Biological Standardization (2013: Geneva, Switzerland) / World Health Organization

    2013  

    Abstract: 37 p. ...

    Abstract 37 p.
    Keywords Hepatitis B e Antigens
    Language English
    Publisher World Health Organization
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Book ; Online: Collaborative study to establish a World Health Organization international standard for Hepatitis B e antigen (HBeAg)

    Reissinger, Annette / Volkers, Peter / Scheiblauer, Heinrich / Nick, Sigrid / WHO Expert Committee on Biological Standardization (2013: Geneva, Switzerland) / World Health Organization

    2013  

    Abstract: 37 p. ...

    Abstract 37 p.
    Keywords Hepatitis B e Antigens
    Language English
    Publisher World Health Organization
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article: Bordetella type III secretion and adenylate cyclase toxin synergize to drive dendritic cells into a semimature state.

    Skinner, Jason A / Reissinger, Annette / Shen, Hao / Yuk, Ming H

    Journal of immunology (Baltimore, Md. : 1950)

    2004  Volume 173, Issue 3, Page(s) 1934–1940

    Abstract: Bordetella bronchiseptica establishes persistent infection of the murine respiratory tract. We hypothesize that long-term colonization is mediated in part by bacteria-driven modulation of dendritic cells (DCs) leading to altered adaptive immune responses. ...

    Abstract Bordetella bronchiseptica establishes persistent infection of the murine respiratory tract. We hypothesize that long-term colonization is mediated in part by bacteria-driven modulation of dendritic cells (DCs) leading to altered adaptive immune responses. Bone marrow-derived DCs (BMDCs) from C57BL/6 mice infected with live B. bronchiseptica exhibited high surface expression of MHCII, CD86, and CD80. However, B. bronchiseptica-infected BMDCs did not exhibit significant increases in CD40 surface expression and IL-12 secretion compared with BMDCs treated with heat-killed B. bronchiseptica. The B. bronchiseptica type III secretion system (TTSS) mediated the increase in MHCII, CD86, and CD80 surface expression, while the inhibition of CD40 and IL-12 expression was mediated by adenylate cyclase toxin (ACT). IL-6 secretion was independent of the TTSS and ACT. These phenotypic changes may result from differential regulation of MAPK signaling in DCs. Wild-type B. bronchiseptica activated the ERK 1/2 signaling pathway in a TTSS-dependent manner. Additionally, ACT was found to inhibit p38 signaling. These data suggest that B. bronchiseptica drive DC into a semimature phenotype by altering MAPK signaling. These semimature DCs may induce tolerogenic immune responses that allow the persistent colonization of B. bronchiseptica in the host respiratory tract.
    MeSH term(s) Adenylate Cyclase Toxin/physiology ; Animals ; Antigens, CD/biosynthesis ; B7-1 Antigen/biosynthesis ; B7-2 Antigen ; Bordetella Infections/immunology ; Bordetella Infections/microbiology ; Bordetella bronchiseptica/immunology ; Bordetella bronchiseptica/physiology ; CD40 Antigens/biosynthesis ; Cell Differentiation/drug effects ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Dendritic Cells/pathology ; Histocompatibility Antigens Class II/biosynthesis ; Immune Tolerance ; Interleukin-12/biosynthesis ; Interleukin-12/genetics ; Interleukin-12/metabolism ; MAP Kinase Signaling System/drug effects ; Membrane Glycoproteins/biosynthesis ; Mice ; Mice, Inbred C57BL ; Phagocytosis
    Chemical Substances Adenylate Cyclase Toxin ; Antigens, CD ; B7-1 Antigen ; B7-2 Antigen ; CD40 Antigens ; Cd86 protein, mouse ; Histocompatibility Antigens Class II ; Membrane Glycoproteins ; Interleukin-12 (187348-17-0)
    Language English
    Publishing date 2004-05-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.173.3.1934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

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