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  1. Article ; Online: Giant desmoid fibromatosis of the pancreas.

    Chen, Jeng-Chang / Huang, Shih-Chiang

    Pediatrics and neonatology

    2022  Volume 64, Issue 3, Page(s) 344–346

    MeSH term(s) Humans ; Fibromatosis, Aggressive/diagnostic imaging ; Fibromatosis, Aggressive/surgery ; Pancreas
    Language English
    Publishing date 2022-10-26
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2441816-X
    ISSN 2212-1692 ; 1875-9572
    ISSN (online) 2212-1692
    ISSN 1875-9572
    DOI 10.1016/j.pedneo.2022.08.004
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  2. Article ; Online: Unusual clinical presentation of cervical extradural meningioma detected with neuromuscular ultrasound: A case report.

    Hsieh, Pei-Chen / Lu, Johnny Chuieng-Yi / Huang, Shih-Chiang / Toh, Cheng Hong / Kuo, Hung-Chou

    Experimental and therapeutic medicine

    2024  Volume 27, Issue 5, Page(s) 205

    Abstract: Extradural meningiomas are rare in the cervical region. A total of 70-77% of reported cases have occurred in the thoracic region. Tumors that occur in the cervical region may invade the adjacent nerve root and brachial plexus. Typically, diagnoses of ... ...

    Abstract Extradural meningiomas are rare in the cervical region. A total of 70-77% of reported cases have occurred in the thoracic region. Tumors that occur in the cervical region may invade the adjacent nerve root and brachial plexus. Typically, diagnoses of extradural meningioma are made after patients present with signs of myelopathy, such as progressive paresis and numbness. In the current study, a 64-year-old male patient presented with neck pain, numbness and mild weakness in the left hand over a 6-month period. The general neurological examination was unremarkable, except for mild grasping weakness on the left side. Needle electromyography revealed complex repetitive discharges in the left 5 and 6th cervical paraspinal muscles. Neuromuscular ultrasound revealed a lesion over the left 7th cervical root, which enabled the early detection of an extradural meningioma before notable focal neurological defects developed. The patient underwent a subtotal tumor excision, followed by radiotherapy for residual tumor. Histopathological examination confirmed atypical meningioma.
    Language English
    Publishing date 2024-03-19
    Publishing country Greece
    Document type Case Reports
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2024.12493
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  3. Article ; Online: Impact of resection margin on outcome in soft-tissue sarcomas of the extremities treated with limb-sparing surgery and postoperative radiotherapy.

    Chen, Chun-Chieh / Wu, Yao-Yu / Kao, Jo-Ting / Chang, Chih-Hsiang / Huang, Shih-Chiang / Shih, Hsin-Nung

    World journal of surgical oncology

    2024  Volume 22, Issue 1, Page(s) 113

    Abstract: Background: The standard curative treatments for extremity soft tissue sarcoma (ESTS) include surgical resection with negative margins and perioperative radiotherapy. However, the optimal resection margin remains controversial. This study aimed to ... ...

    Abstract Background: The standard curative treatments for extremity soft tissue sarcoma (ESTS) include surgical resection with negative margins and perioperative radiotherapy. However, the optimal resection margin remains controversial. This study aimed to evaluate the outcomes in ESTS between microscopically positive margin (R1) and microscopically negative margin (R0) according to the Union for International Cancer Control (UICC) (R + 1 mm) classification.
    Methods: Medical records of patients with localized ESTS who underwent primary limb-sparing surgery and postoperative radiotherapy between 2004 and 2015 were retrospectively reviewed. Patients were followed for at least 5 years or till local or distant recurrence was diagnosed during follow-up. Outcomes were local and distal recurrences and survival.
    Results: A total of 52 patients were included in this study, in which 17 underwent R0 resection and 35 underwent R1 resection. No significant differences were observed in rates of local recurrence (11.4% vs. 35.3%, p = 0.062) or distant recurrence (40.0% vs. 41.18%, p = 0.935) between R0 and R1 groups. Multivariate analysis showed that distant recurrences was associated with a Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) grade (Grade III vs. I, adjusted hazard ratio (aHR): 12.53, 95% confidence interval (CI): 2.67-58.88, p = 0.001) and tumor location (lower vs. upper extremity, aHR: 0.23, 95% CI: 0.07-0.7, p = 0.01). Kaplan-Meier plots showed no significant differences in local (p = 0.444) or distant recurrent-free survival (p = 0.161) between R0 and R1 groups.
    Conclusions: R1 margins, when complemented by radiotherapy, did not significantly alter outcomes of ESTS as R0 margins. Further studies with more histopathological types and larger cohorts are necessary to highlight the path forward.
    MeSH term(s) Humans ; Male ; Female ; Margins of Excision ; Middle Aged ; Sarcoma/surgery ; Sarcoma/pathology ; Sarcoma/radiotherapy ; Sarcoma/mortality ; Retrospective Studies ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/surgery ; Extremities/pathology ; Extremities/surgery ; Adult ; Follow-Up Studies ; Survival Rate ; Aged ; Prognosis ; Radiotherapy, Adjuvant/methods ; Radiotherapy, Adjuvant/statistics & numerical data ; Organ Sparing Treatments/methods ; Organ Sparing Treatments/statistics & numerical data ; Young Adult ; Soft Tissue Neoplasms/surgery ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/radiotherapy ; Soft Tissue Neoplasms/mortality ; Adolescent
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-024-03380-y
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  4. Article: Reply to Graziosi et al. Rationale in the Use of Adjuvant Chemotherapy in pT3N0M0 Gastric Cancer Resected Patients. Comment on "Chen et al. Prognostic Factors and the Role of Adjuvant Chemotherapy in Pathological Node-Negative T3 Gastric Cancer.

    Chen, Yi-Fu / Le, Puo-Hsien / Huang, Shih-Chiang / Chou, Wen-Chi / Hsu, Jun-Te

    Journal of personalized medicine

    2023  Volume 13, Issue 6

    Abstract: We appreciate the authors very much for their interest in our article "Prognostic factors and the role of adjuvant chemotherapy in pathological node-negative T3 gastric cancer" [ ... ]. ...

    Abstract We appreciate the authors very much for their interest in our article "Prognostic factors and the role of adjuvant chemotherapy in pathological node-negative T3 gastric cancer" [...].
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13060988
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  5. Article ; Online: Reply to Graziosi et al. Rationale in the Use of Adjuvant Chemotherapy in pT3N0M0 Gastric Cancer Resected Patients. Comment on “Chen et al. Prognostic Factors and the Role of Adjuvant Chemotherapy in Pathological Node-Negative T3 Gastric Cancer. J. Pers. Med. 2023, 13 , 553”

    Yi-Fu Chen / Puo-Hsien Le / Shih-Chiang Huang / Wen-Chi Chou / Jun-Te Hsu

    Journal of Personalized Medicine, Vol 13, Iss 988, p

    2023  Volume 988

    Abstract: We appreciate the authors very much for their interest in our article “Prognostic factors and the role of adjuvant chemotherapy in pathological node-negative T3 gastric cancer” [.] ...

    Abstract We appreciate the authors very much for their interest in our article “Prognostic factors and the role of adjuvant chemotherapy in pathological node-negative T3 gastric cancer” [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Stepwise training program: A novel practice schedule for laparoscopic suturing.

    Chen, Hsin-An / Huang, Shih-Wei / Shen, Shih-Chiang / Tsai, Kuei-Yen / Kuo, Hsin-Hong / Dallemagne, Bernard / Jen, Howard C / Wei, Chin-Hung

    Heliyon

    2023  Volume 9, Issue 12, Page(s) e22563

    Abstract: Purpose: We establish stepwise training program in which laparoscopic suturing is broken down to discrete steps. The purpose is to evaluate the learning outcomes of stepwise training program.: Materials and methods: Volunteer participants were ... ...

    Abstract Purpose: We establish stepwise training program in which laparoscopic suturing is broken down to discrete steps. The purpose is to evaluate the learning outcomes of stepwise training program.
    Materials and methods: Volunteer participants were enrolled from medical students and surgical trainees. Students took two courses of 2-h stepwise training, and a post-course (1st & 2nd) test was taken after each course; trainees took one course of stepwise training with a pre-course (1st) and a post-course (2nd) test. Attending surgeons took the test as control. Learning outcomes were assessed with laparoscopic suturing competency assessment tool (LS-CAT) and suturing time.
    Results: There were 10 students, 8 trainees and 6 surgeon controls. Suturing time and LS-CAT scores significantly improved between the 1st and 2nd test (
    Conclusions: Stepwise program effectively enhances laparoscopic suturing skill for medical students and surgical trainees. Catch-up effect was demonstrated in medical students with stepwise training.
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e22563
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  7. Article ; Online: Marked Response to Larotrectinib in Pelvic Spindle Cell Sarcoma With Concurrent TPM3-NTRK1 Fusion and CDK4/MDM2 Amplification: A Case Report.

    Huang, Wen-Kuan / Huang, Shih-Chiang / Chen, Chien-Ming / Lin, Po-Hung / Wu, Chiao-En / Chuang, Cheng-Keng / Yeh, Chun-Nan

    JCO precision oncology

    2023  Volume 7, Page(s) e2200528

    MeSH term(s) Humans ; Sarcoma/drug therapy ; Sarcoma/genetics ; Pyrazoles ; Pyrimidines ; Proto-Oncogene Proteins c-mdm2 ; Tropomyosin ; Cyclin-Dependent Kinase 4/genetics
    Chemical Substances larotrectinib (PF9462I9HX) ; Pyrazoles ; Pyrimidines ; MDM2 protein, human (EC 2.3.2.27) ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27) ; TPM3 protein, human ; Tropomyosin ; CDK4 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22)
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.22.00528
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  8. Article ; Online: Solitary fibrous tumor: An evolving and unifying entity with unsettled issues.

    Huang, Shih-Chiang / Huang, Hsuan-Ying

    Histology and histopathology

    2018  Volume 34, Issue 4, Page(s) 313–334

    Abstract: Solitary fibrous tumor (SFT) is a distinct fibroblastic neoplasm of intermediate biological potential, prototypically presenting as a pleura-associated tumor characterized by patternless proliferation of generally banal oval to spindle cells with ... ...

    Abstract Solitary fibrous tumor (SFT) is a distinct fibroblastic neoplasm of intermediate biological potential, prototypically presenting as a pleura-associated tumor characterized by patternless proliferation of generally banal oval to spindle cells with hemangiopericytoma-like staghorn vessels in fibrocollagenous stroma. Over the past decades, the clinicopathological spectrum of SFT has been ever-expanding with the incorporation of cases exhibiting myxoid, giant cell-containing, and fat-forming histology, as well as those from extrathoracic sites, including the meninx. Atypical, frankly malignant and even dedifferentiated variants have also been recognized in a subset of SFTs. Notably, the recent groundbreaking discovery of the disease-defining NAB2-STAT6 gene fusion, resulting from intrachromosomal inversion involving 12q13.3, has largely unified tumors with the aforementioned variations. The derived immunohistochemical detection of nuclear STAT6 expression has high diagnostic value in distinguishing SFTs from histologic mimics, although some relevant pitfalls have been proposed as a precaution. NAB2-STAT6 fusions yield numerous transcript subtypes associated with the clinicopathological variations. Despite mostly following a favorable course, SFT is notoriously difficult for prognostication because of the propensity for late relapse or even metastases in 10-40% of cases, which prompts several proposed schemes incorporating age, size, mitosis, and/or necrosis as factors for risk stratification. Mitotic figures >4/10 HPFs, TERT promoter and/or TP53 mutations have been considered as variables that are better correlated with aggressiveness. Although radiotherapy and chemotherapy provide unsatisfactory responses, a better understanding of SFT tumorigenesis may pave the way for new treatment modalities. In this review, we comprehensively discuss the recent advances of SFTs in diagnostic and molecular pathology.
    MeSH term(s) Humans ; Solitary Fibrous Tumors/genetics ; Solitary Fibrous Tumors/pathology ; Solitary Fibrous Tumors/therapy
    Language English
    Publishing date 2018-11-15
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 83911-5
    ISSN 1699-5848 ; 0213-3911
    ISSN (online) 1699-5848
    ISSN 0213-3911
    DOI 10.14670/HH-18-064
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  9. Article ; Online: Multidisciplinary management of a malignant rhabdoid tumor of the neck and mediastinum in an infant.

    Lo, Tzu-Ya / Huang, Shih-Chiang / Chang, Yu-Sheng / Wang, Yi-Lun / Chang, Tsung-Yen / Jaing, Tang-Her

    Pediatrics and neonatology

    2022  Volume 64, Issue 2, Page(s) 223–224

    MeSH term(s) Infant ; Humans ; Mediastinum/pathology ; Rhabdoid Tumor/surgery ; Rhabdoid Tumor/pathology ; Head and Neck Neoplasms/surgery
    Language English
    Publishing date 2022-11-01
    Publishing country Singapore
    Document type Letter
    ZDB-ID 2441816-X
    ISSN 2212-1692 ; 1875-9572
    ISSN (online) 2212-1692
    ISSN 1875-9572
    DOI 10.1016/j.pedneo.2022.09.007
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  10. Article ; Online: Stepwise training program

    Hsin-An Chen / Shih-Wei Huang / Shih-Chiang Shen / Kuei‐Yen Tsai / Hsin-Hong Kuo / Bernard Dallemagne / Howard C. Jen / Chin-Hung Wei

    Heliyon, Vol 9, Iss 12, Pp e22563- (2023)

    A novel practice schedule for laparoscopic suturing

    2023  

    Abstract: Purpose: We establish stepwise training program in which laparoscopic suturing is broken down to discrete steps. The purpose is to evaluate the learning outcomes of stepwise training program. Materials and methods: Volunteer participants were enrolled ... ...

    Abstract Purpose: We establish stepwise training program in which laparoscopic suturing is broken down to discrete steps. The purpose is to evaluate the learning outcomes of stepwise training program. Materials and methods: Volunteer participants were enrolled from medical students and surgical trainees. Students took two courses of 2-h stepwise training, and a post-course (1st & 2nd) test was taken after each course; trainees took one course of stepwise training with a pre-course (1st) and a post-course (2nd) test. Attending surgeons took the test as control. Learning outcomes were assessed with laparoscopic suturing competency assessment tool (LS-CAT) and suturing time. Results: There were 10 students, 8 trainees and 6 surgeon controls. Suturing time and LS-CAT scores significantly improved between the 1st and 2nd test (p < 0.01). In the both tests, suturing time and LS-CAT scores of students and trainees were similar. In the 1st test, surgeons had significantly better performance in suturing time and LS-CAT score than students and trainees; in the 2nd test, the LS-CAT scores of students and trainees were similar to the surgeon controls. Conclusions: Stepwise program effectively enhances laparoscopic suturing skill for medical students and surgical trainees. Catch-up effect was demonstrated in medical students with stepwise training.
    Keywords Laparoscopic suturing ; Stepwise training ; Practice schedule ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 370 ; 796
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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