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Article ; Online: Cooperated Moving Target Detection Approach for PA-FDA Dual-Mode Radar in Range-Ambiguous Clutter

Zhixin Liu / Shengqi Zhu / Jingwei Xu / Lan Lan / Xiongpeng He / Ximin Li

Remote Sensing, Vol 15, Iss 692, p

2023 Volume 692

Abstract: This paper proposes a cooperated range ambiguous clutter suppression method for moving target detection in the background of range-ambiguous clutter with a phased array (PA)–frequency diverse array (FDA) dual-mode radar. With the FDA mode, the range- ... ...

Abstract	This paper proposes a cooperated range ambiguous clutter suppression method for moving target detection in the background of range-ambiguous clutter with a phased array (PA)–frequency diverse array (FDA) dual-mode radar. With the FDA mode, the range-ambiguous clutters are discriminated in the transmit spatial frequency domain, and thus the clutter covariance matrixes (CCMs) corresponding to unambiguous and ambiguous regions can be independently estimated. Therefore, the enhanced CCM can be reconstructed by using a linear combination of these distinguished CCMs from different range regions. With the PA mode, the enhanced CCM is applied, thus taking advantages of its high beampattern gain as well as alleviating the range ambiguous clutter suppression problem. Simulation results are presented to verify the effectiveness of the proposed method in range-ambiguous clutter scenarios.
Keywords	frequency diverse array ; phased array ; range-ambiguous clutter ; space-time adaptive processing ; moving target ; Science ; Q
Subject code	910
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of endoplasmic reticulum stress-related gene signature for the prognosis and pattern in diffuse large B cell lymphoma.

Zhang, Chaofeng / Lin, Qi / Li, Chaoqi / Chen, Zhimin / Deng, Mengmeng / Weng, Huixin / Zhu, Xiongpeng

Scientific reports

2023 Volume 13, Issue 1, Page(s) 13894

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. This study aimed to determine the prognostic significance of endoplasmic reticulum (ER) stress-related genes in DLBCL. ER stress-related genes were obtained from the molecular ... ...

Abstract	Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. This study aimed to determine the prognostic significance of endoplasmic reticulum (ER) stress-related genes in DLBCL. ER stress-related genes were obtained from the molecular signatures database. Gene expression data and clinical outcomes from the gene expression omnibus and TCGA datasets were collected, and differentially expressed genes (DEGs) were screened out. Gene ontology enrichment analysis, the kyoto encyclopaedia of genes and genomes pathway analysis, and geneset enrichment analysis were used to analyse the possible biological function of ER stress-related DEGs in DLBCL. Protein-protein interaction network construction using the STRING online and hub genes were identified by cytoHubba on Cytoscape software. The significant prognosis-related genes were screened, and the differential expression was validated. The immune microenvironment assessment of significant genes were evaluated. Next, the nomogram was built using univariate and multivariate Cox regression analysis. 26 ER stress-related DEGs were screened. Functional enrichment analysis showed them to be involved in the regulation of the endoplasmic reticulum mainly. NUPR1 and TRIB3 were identified as the most significant prognostic-related genes by comparison with the GSE10846, GSE11318, and TCGA datasets. NUPR1 was correlated with a good prognosis and immune infiltration in DLBCL; on the other hand, high expression of TRIB3 significantly correlated with a poor prognosis, which was an independent prognostic factor for DLBCL. In summary, we identified NUPR1 and TRIB3 as critical ER stress-related genes in DLBCL. NUPR1 might be involved in immune infiltration in DLBCL, and TRIB3 might serve as a potential therapeutic target and prognostic factor in DLBCL.
MeSH term(s)	Adult ; Humans ; Prognosis ; Lymphoma, Large B-Cell, Diffuse/genetics ; Nomograms ; Databases, Chemical ; Endoplasmic Reticulum Stress/genetics ; Tumor Microenvironment/genetics
Language	English
Publishing date	2023-08-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-38568-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comprehensive analysis of the prognostic implication and immune infiltration of CISD2 in diffuse large B-cell lymphoma.

Zhang, ChaoFeng / Lin, Qi / Li, ChunTuan / Qiu, Yang / Chen, JingYu / Zhu, XiongPeng

Frontiers in immunology

2023 Volume 14, Page(s) 1277695

Abstract: Background: Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell lymphoma in adults. CDGSH iron sulfur domain 2 (CISD2) is an iron-sulfur protein and plays a critical role of cell proliferation. The aberrant expression of CISD2 is associated ... ...

Abstract	Background: Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell lymphoma in adults. CDGSH iron sulfur domain 2 (CISD2) is an iron-sulfur protein and plays a critical role of cell proliferation. The aberrant expression of CISD2 is associated with the progression of multiple cancers. However, its role in DLBCL remains unclear. Methods: The differential expression of CISD2 was identified via public databases, and quantitative real-time PCR (qRT-PCR) and western blot were used to identifed the expression of CISD2. We estimated the impact of CISD2 on clinical prognosis using the Kaplan-Meier plotter. Meanwhile, the drug sensitivity of CISD2 was assessed using CellMiner database. The 100 CISD2-related genes from STRING obtained and analyzed using the LASSO Cox regression. A CISD2 related signature for risk model (CISD2Risk) was established. The PPI network of CISD2Risk was performed, and functional enrichment was conducted through the DAVID database. The impacts of CISD2Risk on clinical features were analyzed. ESTIMATE, CIBERSORT, and MCP-counter algorithm were used to identify CISD2Risk associated with immune infiltration. Subsequently, Univariate and multivariate Cox regression analysis were applied, and a prognostic nomogram, accompanied by a calibration curve, was constructed to predict 1-, 3-, and 5-years survival probabilities. Results: CISD2 was upregulated in DLBCL patients comparing with normal controls via public datasets, similarly, CISD2 was highly expressed in DLBCL cell lines. Overexpression of CISD2 was associated with poor prognosis in DLBCL patients based on the GSE31312, the GSE32918, and GSE93984 datasets (P<0.05). Nine drugs was considered as a potential therapeutic agents for CISD2. By using the LASSO cox regression, twenty seven genes were identified to construct CISD2Risk, and biological functions of these genes might be involved in apoptosis and P53 signaling pathway. The high CISD2Risk value had a worse prognosis and therapeutic effect (P<0.05). The higher stromal score, immune score, and ESTIMATE score were associated with lowe CISD2Risk value, CISD2Risk was negatively correlated with several immune infiltrating cells (macrophages M0 and M1, CD8 T cells, CD4 naïve T cells, NK cell, etc) that might be correlated with better prognosis. Additionally, The high CISD2Risk was identified as an independent prognostic factor for DLBCL patients using both univariate and multivariate Cox regression. The nomogram produced accurate predictions and the calibration curves were in good agreement. Conclusion: Our study demonstrates that high expression of CISD2 in DLBCL patients is associated with poor prognosis. We have successfully constructed and validated a good prognostic prediction and efficacy monitoring for CISD2Risk that included 27 genes. Meanwhile, CISD2Risk may be a promising evaluator for immune infiltration and serve as a reference for clinical decision-making in DLBCL patients.
MeSH term(s)	Adult ; Humans ; Prognosis ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Nomograms ; Algorithms ; Apoptosis
Language	English
Publishing date	2023-12-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1277695
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Article ; Online: Robust Measurement-Driven Cardinality Balance Multi-Target Multi-Bernoulli Filter.

Yang, Biao / Zhu, Shengqi / He, Xiongpeng / Yu, Kun / Zhu, Jingjing

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 17

Abstract: The multi-target tracking filter under the Bayesian framework has strict requirements on the prior information of the target, such as detection probability density, clutter density, and target initial position information. This paper proposes a novel ... ...

Abstract	The multi-target tracking filter under the Bayesian framework has strict requirements on the prior information of the target, such as detection probability density, clutter density, and target initial position information. This paper proposes a novel robust measurement-driven cardinality balance multi-target multi-Bernoulli filter (RMD-CBMeMBer) for solving the multiple targets tracking problem when the detection probability density is unknown, the background clutter density is unknown, and the target's prior position information is lacking. In RMD-CBMeMBer filtering, the target state is first extended, so that the extended target state includes detection probability, kernel state, and indicators of target and clutter. Secondly, the detection probability is modeled as a Beta distribution, and the clutter is modeled as a clutter generator that is independent of each other and obeys the Poisson distribution. Then, the detection probability, kernel state, and clutter density are jointly estimated through filtering. In addition, the correlation function (CF) is proposed for creating new Bernoulli component (BC) by using the measurement information at the previous moment. Numerical experiments have verified that the RMD-CBMeMBer filter can solve the multi-target tracking problem under the condition of unknown target detection probability, unknown background clutter density and inadequate prior position information of the target. It can effectively estimate the target detection probability and the clutter density.
Language	English
Publishing date	2021-08-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21175717
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Article ; Online: Unambiguous Forward-Looking SAR Imaging on HSV-R Using Frequency Diverse Array.

Zhang, Mengdi / Liao, Guisheng / He, Xiongpeng / Zhu, Shengqi

Sensors (Basel, Switzerland)

2020 Volume 20, Issue 4

Abstract: It is a challenge to realize wide swath imaging due to the conflict between Doppler ambiguity and range ambiguity for hypersonic vehicle (HSV) radar. In addition, there are many conditions requiring the forward-looking imaging. In a forward-looking ... ...

Abstract	It is a challenge to realize wide swath imaging due to the conflict between Doppler ambiguity and range ambiguity for hypersonic vehicle (HSV) radar. In addition, there are many conditions requiring the forward-looking imaging. In a forward-looking synthetic aperture radar (SAR) system, left-right ambiguity arises, since two symmetrical targets have the same Doppler frequency magnitude. After selecting an appropriate pulse repetition frequency (PRF) to avoid Doppler ambiguity, we only need to solve the range ambiguity and left-right ambiguity. To handle these issues, this paper proposes an approach to resolve the range ambiguity and left-right ambiguity using the frequency diverse array (FDA). With the range-angle-dependent property of the transmit steering vector, FDA can distinguish the range ambiguous echoes in the spatial frequency domain. By performing transmit beamforming after range compensation, the echo from the desired range region can be extracted from ambiguous echoes. Then, the back projection (BP) algorithm is used to achieve imaging. Next, the echoes of all channels are processed by two receive beamformers, which are designed for the right and left sides, respectively. With the aforementioned procedures, an unambiguous image can be obtained. Simulation results have verified the effectiveness of the proposed approach.
Language	English
Publishing date	2020-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20041169
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Article ; Online: An Efficient Method for Ground Maneuvering Target Refocusing and Motion Parameter Estimation Based on DPT–KT–MFP

Mingming Tian / Guisheng Liao / Shengqi Zhu / Xiongpeng He / Yongjun Liu / Yunpeng Li

Remote Sensing, Vol 13, Iss 1092, p

2021 Volume 1092

Abstract: The image of ground maneuvering targets may be defocused due to the Doppler ambiguity, high-order range migration (RM), and Doppler frequency migration (DFM) caused by the target’s complex motions in a synthetic aperture radar (SAR) system. To settle ... ...

Abstract	The image of ground maneuvering targets may be defocused due to the Doppler ambiguity, high-order range migration (RM), and Doppler frequency migration (DFM) caused by the target’s complex motions in a synthetic aperture radar (SAR) system. To settle these problems, an efficient algorithm based on discrete polynomial-phase transform (DPT), keystone transform (KT), and matched filtering processing (MFP) is presented for ground maneuvering target refocusing and motion parameter estimation in this paper. Firstly, the DPT is applied to transform the cubic phase into the quadratic phase and simultaneously eliminate the quadratic RM, cubic RM, and quadratic DFM. Furthermore, the Doppler ambiguity containing Doppler center blur and Doppler spectrum ambiguity is also dealt with effectively by introducing a very small fixed lay time after DPT operation. Then, the KT is performed to correct the linear RM. After that, the matched filtering function related to the target’s equivalent third-order coefficient is constructed to compensate for the residual linear DFM in the range-time and slow-time domain. Lastly, a well-refocused image of the maneuvering target can be acquired, and the target’s motion parameters can be estimated effectively. The proposed algorithm has high computational efficiency and possesses favorable refocusing performance and motion parameter estimation precision. Simulation and real data processing results prove the effectiveness of the presented algorithm.
Keywords	synthetic aperture radar ; Doppler center blur ; Doppler spectrum ambiguity ; ground maneuvering target refocusing ; motion parameter estimation ; Science ; Q
Subject code	629
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: APDL1-CART cells exhibit strong PD-L1-specific activity against leukemia cells.

Peng, Qunyi / Zhu, Xiongpeng / Li, Chuntuan / Xin, Pengliang / Zheng, Yan / Liu, Shengquan

Aging

2021 Volume 13, Issue 5, Page(s) 7199–7210

Abstract: Chimeric antigen receptor (CAR) T cells target specific tumor antigens and lyse tumor cells in an MHC-independent manner. However, the efficacy of CAR-T cell and other cancer immunotherapies is limited by the expression of immune-checkpoint molecules ... ...

Abstract	Chimeric antigen receptor (CAR) T cells target specific tumor antigens and lyse tumor cells in an MHC-independent manner. However, the efficacy of CAR-T cell and other cancer immunotherapies is limited by the expression of immune-checkpoint molecules such as programmed death-ligand 1 (PD-L1) on tumor cells, which binds to PD-1 receptors on T cells leading to T cell inactivation and immune escape. Here, we incorporated a PD-L1-targeted single-chain variable fragment (scFv) fusion protein sequence into a CAR vector to generate human anti-PD-L1-CAR-T cells (aPDL1-CART cells) targeting the PD-L1 antigen. Unlike control T cells, aPDL1-CART cells significantly halted the expansion and reduced the viability of co-cultured leukemia cells (Raji, CD46, and K562) overexpressing PD-L1, and this effect was paralleled by increased secretion of IL-2 and IFN-γ. The antitumor efficacy of aPDL1-CART cells was also evaluated
MeSH term(s)	Animals ; B7-H1 Antigen/immunology ; Cell Line, Tumor ; Humans ; Immunotherapy, Adoptive/methods ; Interferon-gamma/metabolism ; Interleukin-2/metabolism ; Leukemia, Experimental/immunology ; Leukemia, Experimental/therapy ; Mice ; Neoplasm Transplantation
Chemical Substances	B7-H1 Antigen ; Interleukin-2 ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2021-02-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.202578
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Role and mechanism of PTEN in Burkitt's lymphoma.

Li, Chuntuan / Xu, Yahong / Xin, Pengliang / Zheng, Yan / Zhu, Xiongpeng

Oncology reports

2020 Volume 43, Issue 2, Page(s) 481–490

Abstract: The aim of the present study was to explore the possible mechanisms of phosphatase and tensin homolog (PTEN) in the pathogenesis of Burkitt's lymphoma, and provide novel information that can be used in the targeted treatment of this disease. PTEN ... ...

Abstract	The aim of the present study was to explore the possible mechanisms of phosphatase and tensin homolog (PTEN) in the pathogenesis of Burkitt's lymphoma, and provide novel information that can be used in the targeted treatment of this disease. PTEN lentiviral overexpression vector and short‑hairpin PTEN silencing vectors were constructed. The effect of PTEN on the growth and proliferation of CA46 and RAJI cells was analyzed using a Cell Counting Kit‑8 assay. Apoptosis was detected by Hoechst 33342 and propidium iodide double staining. Flow cytometry was used to analyze the cell cycle. A Transwell chamber was used to detect cell migration and invasion abilities. Western blot analysis was used to detect related protein changes. The mechanism of the effect of PTEN on the biological characteristics of Burkitt's lymphoma cells was subsequently analyzed. The results revealed that PTEN inhibited the proliferation of CA46 and RAJI cells by downregulating the expression of p‑AKT, It was indicated that the upregulation of proapoptotic proteins (including Bad and Bax) induced apoptosis, regulated cyclin (including P53, P21, CDK4, CDK6, cyclin D3 and cyclin H) to inhibit cell cycle progression, and mediated epithelial‑mesenchymal transition‑like cell markers (including E‑cadherin, N‑cadherin, β‑catenin, TCF‑8, vimentin, Slug and Snail) to inhibit cell migration and invasion. In conclusion, the tumor‑suppressor gene PTEN inhibited the phosphoinositide 3‑kinase/protein kinase B (PI3K/AKT) signaling pathway and inhibited the proliferation and migration of Burkitt's lymphoma cells, induced apoptosis and cell cycle arrest, thus playing a crucial role in the pathogenesis of Burkitt's lymphoma.
MeSH term(s)	Apoptosis ; Burkitt Lymphoma/metabolism ; Cell Cycle ; Cell Line, Tumor ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Gene Expression Regulation, Neoplastic ; Humans ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
Chemical Substances	AKT1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67)
Language	English
Publishing date	2020-01-09
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2020.7457
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Article: An Efficient Method for Ground Maneuvering Target Refocusing and Motion Parameter Estimation Based on DPT–KT–MFP

Tian, Mingming / Liao, Guisheng / Zhu, Shengqi / He, Xiongpeng / Liu, Yongjun / Li, Yunpeng

Remote Sensing. 2021 Mar. 12, v. 13, no. 6

2021

Abstract	The image of ground maneuvering targets may be defocused due to the Doppler ambiguity, high-order range migration (RM), and Doppler frequency migration (DFM) caused by the target’s complex motions in a synthetic aperture radar (SAR) system. To settle these problems, an efficient algorithm based on discrete polynomial-phase transform (DPT), keystone transform (KT), and matched filtering processing (MFP) is presented for ground maneuvering target refocusing and motion parameter estimation in this paper. Firstly, the DPT is applied to transform the cubic phase into the quadratic phase and simultaneously eliminate the quadratic RM, cubic RM, and quadratic DFM. Furthermore, the Doppler ambiguity containing Doppler center blur and Doppler spectrum ambiguity is also dealt with effectively by introducing a very small fixed lay time after DPT operation. Then, the KT is performed to correct the linear RM. After that, the matched filtering function related to the target’s equivalent third-order coefficient is constructed to compensate for the residual linear DFM in the range-time and slow-time domain. Lastly, a well-refocused image of the maneuvering target can be acquired, and the target’s motion parameters can be estimated effectively. The proposed algorithm has high computational efficiency and possesses favorable refocusing performance and motion parameter estimation precision. Simulation and real data processing results prove the effectiveness of the presented algorithm.
Keywords	algorithms ; filters ; image analysis ; information processing ; remote sensing ; synthetic aperture radar
Language	English
Dates of publication	2021-0312
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs13061092
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: FLT3 inhibitors in acute myeloid leukemia.

Wu, Mei / Li, Chuntuan / Zhu, Xiongpeng

Journal of hematology & oncology

2018 Volume 11, Issue 1, Page(s) 133

Abstract: FLT3 mutations are one of the most common findings in acute myeloid leukemia (AML). FLT3 inhibitors have been in active clinical development. Midostaurin as the first-in-class FLT3 inhibitor has been approved for treatment of patients with FLT3-mutated ... ...

Abstract	FLT3 mutations are one of the most common findings in acute myeloid leukemia (AML). FLT3 inhibitors have been in active clinical development. Midostaurin as the first-in-class FLT3 inhibitor has been approved for treatment of patients with FLT3-mutated AML. In this review, we summarized the preclinical and clinical studies on new FLT3 inhibitors, including sorafenib, lestaurtinib, sunitinib, tandutinib, quizartinib, midostaurin, gilteritinib, crenolanib, cabozantinib, Sel24-B489, G-749, AMG 925, TTT-3002, and FF-10101. New generation FLT3 inhibitors and combination therapies may overcome resistance to first-generation agents.
MeSH term(s)	Humans ; Leukemia, Myeloid, Acute/genetics ; Mutation ; fms-Like Tyrosine Kinase 3/antagonists & inhibitors
Chemical Substances	FLT3 protein, human (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
Language	English
Publishing date	2018-12-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2429631-4
ISSN	1756-8722 ; 1756-8722
ISSN (online)	1756-8722
ISSN	1756-8722
DOI	10.1186/s13045-018-0675-4
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