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Article ; Online: The prevalence of depression in people following limb amputation: A systematic review and meta-analysis.

Singh, Swarndeep / Saini, Romil / Mathur, Rahul / Sarkar, Siddharth / Sagar, Rajesh

2024 Volume 181, Page(s) 111677

Abstract: Objective: To estimate the prevalence of depression in people with limb amputation. Additionally, factors affecting the prevalence or pattern of depression following limb amputation were explored.: Methods: Systematic literature search to identify ... ...

Abstract	Objective: To estimate the prevalence of depression in people with limb amputation. Additionally, factors affecting the prevalence or pattern of depression following limb amputation were explored. Methods: Systematic literature search to identify all relevant studies assessing prevalence of depression following limb amputations was conducted through following databases: PubMed/ MEDLINE, Scopus, Embase, and Web of Science. Search period was since inception of database till December 2021. Meta-analyses using random-effects model were conducted to estimate pooled prevalence of depression. Results: A total of 61 studies comprising 9852 limb amputees were included. Pooled prevalence of depression following limb amputations was 33.85% (95% CI: 27.15% to 40.54%), with significant heterogeneity (I Conclusion: About one-third of all limb amputees suffered from clinically significant depression. This emphasizes need to sensitize health care professionals involved in providing care to people following limb amputation regarding the importance of periodically screening this vulnerable group of patients for depression and liaising with psychiatrists. Further, addressing risk factors identified in this review could help in reducing the rates of depression post-amputation.
Language	English
Publishing date	2024-04-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80166-5
ISSN	1879-1360 ; 0022-3999
ISSN (online)	1879-1360
ISSN	0022-3999
DOI	10.1016/j.jpsychores.2024.111677
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The use of Mycobacterium tuberculosis H37Ra-infected immunocompetent mice as an in vivo model of persisters.

Kumari, Neetu / Sharma, Romil / Ali, Juned / Chandra, Gyan / Singh, Sarika / Krishnan, Manju Y

Tuberculosis (Edinburgh, Scotland)

2024 Volume 145, Page(s) 102479

Abstract: Persistence of Mycobacterium tuberculosis (Mtb) is one of the challenges to successful treatment of tuberculosis (TB). In vitro models of non-replicating Mtb are used to test the efficacy of new molecules against Mtb persisters. The H37Ra strain is ... ...

Abstract	Persistence of Mycobacterium tuberculosis (Mtb) is one of the challenges to successful treatment of tuberculosis (TB). In vitro models of non-replicating Mtb are used to test the efficacy of new molecules against Mtb persisters. The H37Ra strain is attenuated for growth in macrophages and mice. We validated H37Ra-infected immunocompetent mice for testing anti-TB molecules against slow/non-replicating Mtb in vivo. Swiss mice were infected intravenously with H37Ra and monitored for CFU burden and histopathology for a period of 12 weeks. The bacteria multiplied at a slow pace reaching a maximum load of ∼10
MeSH term(s)	Animals ; Mice ; Mycobacterium tuberculosis ; Isoniazid/pharmacology ; Isoniazid/therapeutic use ; Rifampin/pharmacology ; Rifampin/therapeutic use ; Tuberculosis/drug therapy ; Tuberculosis/microbiology ; Pyrazinamide/therapeutic use ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use
Chemical Substances	Isoniazid (V83O1VOZ8L) ; Rifampin (VJT6J7R4TR) ; Pyrazinamide (2KNI5N06TI) ; Antitubercular Agents
Language	English
Publishing date	2024-01-18
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2046804-0
ISSN	1873-281X ; 1472-9792
ISSN (online)	1873-281X
ISSN	1472-9792
DOI	10.1016/j.tube.2024.102479
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Article: An Autobiographical Case Report on Papillary Thyroid Carcinoma with Positive Antithyroid Antibodies: Coincidence or Correlated?

Singh, Arkaja / Rao, Sameer / Rana, Dev Yash / Choudhary, Mrinal / Singh, Romil

Cureus

2023 Volume 15, Issue 9, Page(s) e44651

Abstract: The relationship between autoimmunity and cancer has been a gray area, with many theories but no solid proof so far. Hashimoto's thyroiditis is an autoimmune disorder and a major cause of hypothyroidism, while papillary thyroid carcinoma is the most ... ...

Abstract	The relationship between autoimmunity and cancer has been a gray area, with many theories but no solid proof so far. Hashimoto's thyroiditis is an autoimmune disorder and a major cause of hypothyroidism, while papillary thyroid carcinoma is the most common thyroid malignancy generally found in patients younger than 45 years of age. The literature on the correlation between these two disorders is somewhat based on potentially biased histopathological examination from pre-operative fine needle aspiration and post-thyroidectomy samples. Although recent studies are evaluating a possible holistic molecular, hormonal, and histopathological foundation for this correlation, a clear causal relationship has not been established yet. This report illustrates the author's case presentation, treatment, and eventual outcome of the disease when she was diagnosed with papillary thyroid cancer at the age of 25 years, with positive antithyroid peroxidase and antithyroglobulin antibodies.
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.44651
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Quality of web-based information on attention deficit hyperactivity disorder.

Singh, Swarndeep / Saini, Romil / Sagar, Rajesh

Asian journal of psychiatry

2022 Volume 71, Page(s) 103071

Abstract: Background and objective: The limited literature available on quality of online health information about attention deficit hyperactivity disorder (ADHD), reported mixed findings and was more than five years old. This study aimed to assess the content ... ...

Abstract	Background and objective: The limited literature available on quality of online health information about attention deficit hyperactivity disorder (ADHD), reported mixed findings and was more than five years old. This study aimed to assess the content quality, readability, aesthetics, and interactivity of current web-based information on ADHD. Methods: We screened first 50 links obtained on searching for ADHD using two popular search engines (Google and Bing), out of which 44 websites were selected for quality assessment. They were analysed using pre-decided study Performa, which included previously validated DISCERN instrument for content quality. Flesch-Kincaid grade level score and Flesch-Kincaid readability index were calculated for assessing readability. Results: About 61.4% of websites had DISCERN score ≥40, suggestive of good content quality. However, only 38.6% and 13.6% of websites were written at recommended reading level of eighth and sixth grade respectively. The DISCERN score had significant positive correlation with aesthetics and interactivity scores. Websites with the Health On Net (HON) label had better content quality. No significant difference in the readability, aesthetics, and interactivity of websites with and without the HON label. Conclusion: This study underscores the need for improving readability of web-based information on ADHD, and highlight important areas for improving the overall quality of websites. The use of HONCode label might guide general public in gauging the content quality of online health information, but not its readability or presentation.
MeSH term(s)	Attention Deficit Disorder with Hyperactivity/diagnosis ; Child, Preschool ; Comprehension ; Humans ; Internet ; Search Engine
Language	English
Publishing date	2022-03-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2456678-0
ISSN	1876-2026 ; 1876-2018
ISSN (online)	1876-2026
ISSN	1876-2018
DOI	10.1016/j.ajp.2022.103071
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Quality of online news media reports of child sexual abuse in India.

Singh, Swarndeep / Saini, Romil / Sagar, Rajesh

Industrial psychiatry journal

2022 Volume 31, Issue 2, Page(s) 336–340

Abstract: Background: Media plays an important role in creating awareness and shaping public opinion about child sexual abuse (CSA). Research suggests that sensible media reportage on CSA is important for positive impacts of media. However, most of the studies ... ...

Abstract	Background: Media plays an important role in creating awareness and shaping public opinion about child sexual abuse (CSA). Research suggests that sensible media reportage on CSA is important for positive impacts of media. However, most of the studies assessing the quality of CSA news reports are from western countries. Aim: To systematically assess the pattern of online news media reportage of CSA in India. Methodology: A total of 149 news reports on the topic of CSA in India, published online over a one-year period were analyzed. Framing of CSA and other news media characteristics were evaluated. Results: Framing of CSA was episodic in majority of news reports, with criminal-justice system-related details about individual cases mentioned in about 90% reports. Further, more than two-third news reports did not mention possible causes or reasons of CSA, and possible steps that people could take to prevent CSA. About one-fifth of news reports provided statistics, research findings, or correct information to dispel myths or wrong public stereotypes about CSA. Inclusion of child helpline or contact information of any child welfare/support services was missing in most of the news reports. Conclusion: This is the first study to systematically assess the quality of news media reports on CSA in India. It provides valuable baseline information about existing media practices and helps in identifying areas for further improvement of media reporting on CSA. There is a need to conduct regular workshops with media professionals to provide them adequate training and support for improving media reporting of CSA.
Language	English
Publishing date	2022-06-02
Publishing country	India
Document type	News
ZDB-ID	2580355-4
ISSN	0976-2795 ; 0972-6748
ISSN (online)	0976-2795
ISSN	0972-6748
DOI	10.4103/ipj.ipj_238_21
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Multiple Sclerosis Relapse Following COVID-19 Vaccination: A Case Report and Literature Review.

Kataria, Saurabh / Rogers, Sylvette / Bilal, Usama / Baktashi, Haisum / Singh, Romil

Cureus

2022 Volume 14, Issue 1, Page(s) e21374

Abstract: Mass vaccination against coronavirus disease 19 (COVID-19) has effectively controlled the pandemic and has been remarkably effective and safe. Reports of a few adverse events have been reported after post-marketing surveillance. We present a rare case of ...

Abstract	Mass vaccination against coronavirus disease 19 (COVID-19) has effectively controlled the pandemic and has been remarkably effective and safe. Reports of a few adverse events have been reported after post-marketing surveillance. We present a rare case of multiple sclerosis (MS) relapse in a female who presented with fatigue, involuntary eye movements, and numbness; autoimmunity following the COVID-19 vaccine has also been described. She was diagnosed with MS six years back and was in remission. She received her COVID-19 vaccine 18 days ago. Her clinical and radiological features confirmed the MS relapse. Her serology for COVID-19 immunoglobulin G (IgG) and IgM was positive, and she was managed with intravenous methylprednisolone and symptomatic management. Our case provides a possible association of vaccine-associated MS relapse; however, more evidence is warranted from future studies.
Language	English
Publishing date	2022-01-18
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.21374
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Intracranial Abscess and Proteus mirabilis: A Case Report and Literature Review.

Muddassir, Rabia / Khalil, Asfandyar / Singh, Romil / Taj, Shafaq / Khalid, Zoha

Cureus

2020 Volume 12, Issue 12, Page(s) e12326

Abstract: An intracranial abscess caused ... ...

Abstract	An intracranial abscess caused by
Language	English
Publishing date	2020-12-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.12326
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Article ; Online: Phenazopyridine-Induced Methaemoglobinaemia - The Aftermath of Dysuria Treatment

Amina Hamza / Adeel Nasrullah / Romil Singh / Briana DiSilvio

European Journal of Case Reports in Internal Medicine (2022)

2022

Abstract: Introduction: Phenazopyridine is an over-the-counter urinary analgesic commonly used to alleviate the burning and urgency associated with lower urinary tract infections. Methaemoglobinaemia is an uncommon adverse effect of phenazopyridine use. We report ... ...

Abstract	Introduction: Phenazopyridine is an over-the-counter urinary analgesic commonly used to alleviate the burning and urgency associated with lower urinary tract infections. Methaemoglobinaemia is an uncommon adverse effect of phenazopyridine use. We report a case of methaemoglobinaemia in a patient prescribed daily phenazopyridine to treat urethral and bladder irritation caused by a chronic indwelling Foley catheter. Case description: A 55-year-old female resident of a long-term acute care facility with a chronic Foley, tracheostomy and ventilator-dependent respiratory failure was observed to have generalized dusky skin and hypoxia. Pulse oximetry was reading in the high 80s despite administration of 100% FiO2. ABG revealed paO2 of 451, oxyhaemoglobin level 75% and methaemoglobin level 22%. Medication review indicated that the patient was prescribed phenazopyridine 400 mg TID for the previous 2 months. This medication was discontinued. Considering she was chronically taking mirtazapine, she can increase risk of serotonin syndrome should she be administered first-line treatment with methylene blue. Vitamin C was thus instead administered as a second-line agent. Serial ABGs showed a rapid decline in methaemoglobin levels and an increase in oxyhaemoglobin within 2 days. Discussion: Acquired methaemoglobinaemia is a rare adverse effect of treatment with phenazopyridine. This risk increases when drug dosage and duration exceed manufacturer specifications. Treatment typically includes cessation of the offending drug and administration of methylene blue in severe cases. A thorough medication reconciliation should be performed prior to methylene blue initiation, as patients taking serotonergic medications (for example, MAOIs, SSRIs, SNRIs, TCAs) are at increased risk of serotonin toxicity with co-administration of methylene blue. In these instances, ascorbic acid/vitamin C can be chosen as an alternative treatment agent. Conclusion: Work-up of refractory hypoxia should involve a thorough review of medications as even some ...
Keywords	methaemoglobinaemia ; phenazopyridine ; urinary tract infection ; serotonin syndrome ; arterial blood gas ; methylene blue ; case report ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	SMC MEDIA SRL
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Intestinal Perforation: A Rare Complication of Treatment With Bevacizumab.

Adhikari, Ramesh / Ghose, Medha / Tekin, Aysun / Singh, Simranjit / Singh, Romil

Cureus

2021 Volume 13, Issue 3, Page(s) e14093

Abstract: Bevacizumab, a monoclonal immunoglobulin-G1 antibody directed against vascular endothelial growth factor (VEGF), inhibits angiogenesis. Gastrointestinal perforation is a serious and often fatal adverse event related to bevacizumab use. Bevacizumab is ... ...

Abstract	Bevacizumab, a monoclonal immunoglobulin-G1 antibody directed against vascular endothelial growth factor (VEGF), inhibits angiogenesis. Gastrointestinal perforation is a serious and often fatal adverse event related to bevacizumab use. Bevacizumab is indicated in the treatment of colorectal malignancies, certain subtypes of non-small cell lung carcinoma, metastatic renal cell carcinomas, and cervical cancers. It is also indicated in the treatment of recurrent glioblastoma (GBM) in adult patients as the sole treatment agent or in combination with other antineoplastic medications. We present a case of a patient on bevacizumab currently with glioblastoma multiforme and seizures, who was previously treated with radiation treatment and temozolomide. The patient presented to the emergency room with abdominal pain, seizures and was diagnosed to have an intestinal perforation.
Language	English
Publishing date	2021-03-24
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.14093
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pseudoshock: A Challenging Presentation of Bilateral Subclavian Artery Stenosis.

Nasrullah, Adeel / Singh, Romil / Hamza, Amina / DiSilvio, Briana E

European journal of case reports in internal medicine

2022 Volume 9, Issue 7, Page(s) 3495

Abstract: Introduction: Subclavian artery stenosis (SAS) is a manifestation of peripheral artery disease (PAD). Presentation varies, ranging from arm claudication and muscle fatigue to symptoms which reflect vertebrobasilar hypoperfusion, among which are syncope, ...

Abstract	Introduction: Subclavian artery stenosis (SAS) is a manifestation of peripheral artery disease (PAD). Presentation varies, ranging from arm claudication and muscle fatigue to symptoms which reflect vertebrobasilar hypoperfusion, among which are syncope, ataxia and dysphagia. Although rare, severe bilateral SAS can exist and present as refractory hypotension. We describe a case of bilateral SAS masquerading as circulatory shock, or rather 'pseudoshock'. Case description: A 59-year-old female patient presented to the emergency department with complaints of dark stools. She was anaemic and hypotensive and therefore suspected to have an acute gastrointestinal bleed (GIB) with resultant haemorrhagic shock. Her hypotension was unresponsive to fluid resuscitation and blood transfusions. Bilateral upper extremity radial artery catheters confirmed low blood pressures. After her blood pressure failed to improve despite the addition of several vasopressors, a femoral artery catheter (FAC) was placed, which revealed significant hypertension discordant with the hypotension measured by the radial artery catheters. Review of CT angiography of the upper extremities revealed the presence of bilateral SAS which was deemed to be the aetiology of the falsely low blood pressure. Discussion: SAS should be suspected in patients with lower extremity PAD or a blood pressure (BP) differential of 15 mmHg or more between arms. When bilateral subclavian arteries are stenosed, this difference in BP may be concealed, making lower extremity BP measurements, as seen in non-invasive tests such as ankle brachial index (ABI) tests or through more invasive procedures such as FAC placement, critically important. Conclusion: Bilateral SAS may present as pseudo-hypotension. In cases of refractory shock of unclear aetiology, especially in patients with known PAD, a high index of suspicion is warranted for 'pseudoshock' secondary to severe vascular stenosis. Comparison of upper and lower extremity BP via invasive arterial catheters or non-invasive ABI tests can aid in the diagnosis of bilateral SAS. Learning points: Bilateral subclavian artery stenosis (SAS) may present as pseudo-hypotension and shock of unclear aetiology.In patients with underlying peripheral arterial disease, pseudoshock should be considered in the differential diagnosis.Comparison of upper and lower extremity blood pressure via invasive arterial catheters or the non-invasive ankle brachial index (ABI) test has diagnostic value for bilateral SAS.Pseudoshock is managed via secondary prevention with antiplatelets and statins for asymptomatic patients, and revascularization for symptomatic patients.
Language	English
Publishing date	2022-07-22
Publishing country	Italy
Document type	Journal Article
ISSN	2284-2594
ISSN (online)	2284-2594
DOI	10.12890/2022_003495
Database	MEDical Literature Analysis and Retrieval System OnLINE

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