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  1. Article ; Online: Commercial Methods for Antifungal Susceptibility Testing of Yeasts: Strengths and Limitations as Predictors of Resistance.

    Espinel-Ingroff, Ana

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 3

    Abstract: Susceptibility testing can yield variable results because it is method (commercial or reference), agent, and species dependent. Therefore, in order for results to be clinically relevant, MICs (minimal inhibitory concentrations) or MECs (minimal effective ...

    Abstract Susceptibility testing can yield variable results because it is method (commercial or reference), agent, and species dependent. Therefore, in order for results to be clinically relevant, MICs (minimal inhibitory concentrations) or MECs (minimal effective concentrations) should help in selecting the best treatment agent in the clinical setting. This is accomplished by categorical endpoints, ideally, breakpoints (BPs) and/or ECVs/ECOFFs (epidemiological cutoff values). BPs and ECVs are available by the reference methods (CLSI [Clinical and Laboratory Standards Institute] and EUCAST [European Committee on Antifungal Susceptibility Testing]) for a variety of species/agent combinations. The lack of clinical data precludes establishment of BPs for susceptibility testing by the commercial methods and ECVs have only been calculated for the Etest and SYO assays. The goal of this review is to summarize the variety of commercial methods for antifungal susceptibility testing and the potential value of Etest and SYO ECVs for detecting mutants/non-wild type (NWT)
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8030309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Methods for Antifungal Susceptibility Testing of the

    Espinel-Ingroff, Ana / Cantón, Emilia

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 5

    Abstract: When method-dependent categorical endpoints are available, namely either BPs or ECVs, MICs could aid in selecting the best treatment agent(s). BPs can categorize an isolate as either susceptible or resistant while the ECVs/ECOFFs can distinguish the wild ...

    Abstract When method-dependent categorical endpoints are available, namely either BPs or ECVs, MICs could aid in selecting the best treatment agent(s). BPs can categorize an isolate as either susceptible or resistant while the ECVs/ECOFFs can distinguish the wild type (WT, no known resistance mechanisms) from the Non-WT (NWT, harboring resistant mechanisms). Our literature review focused on the
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9050542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Commercial Methods for Antifungal Susceptibility Testing of Saprophytic Molds: Can They Be Used to Detect Resistance?

    Paranos, Paschalis / Espinel-Ingroff, Ana / Meletiadis, Joseph

    Journal of fungi (Basel, Switzerland)

    2024  Volume 10, Issue 3

    Abstract: Commercial tests are often employed in clinical microbiology laboratories for antifungal susceptibility testing of filamentous fungi. Method-dependent epidemiological cutoff values (ECVs) have been defined in order to detect non-wild-type (NWT) isolates ... ...

    Abstract Commercial tests are often employed in clinical microbiology laboratories for antifungal susceptibility testing of filamentous fungi. Method-dependent epidemiological cutoff values (ECVs) have been defined in order to detect non-wild-type (NWT) isolates harboring resistance mechanisms. We reviewed the literature in order to find studies where commercial methods were used to evaluate for in vitro susceptibility of filamentous fungi and assess their ability to detect NWT isolates according to the available ECVs. Data were found for the gradient concentration strips Etest and MIC Test Strips (MTS), broth microdilution Sensititre YeastOne (SYO), Micronaut-AM and the agar dilution VIPcheck assays. Applying itraconazole, voriconazole and posaconazole Etest ECVs for
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof10030214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Special Issue: Antifungal Agents Recently Approved or under Development.

    Espinel-Ingroff, Ana / Dannaoui, Eric

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 3

    Abstract: Many thanks to all contributors to the Special Issue on "Antifungal Agents Recently Approved or Under Development (Current Knowledge and Future Perspectives)" [ ... ]. ...

    Abstract Many thanks to all contributors to the Special Issue on "Antifungal Agents Recently Approved or Under Development (Current Knowledge and Future Perspectives)" [...].
    Language English
    Publishing date 2021-03-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7030239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Medical mycology in the United States

    Espinel-Ingroff, Ana Victoria

    a historical analysis (1894 - 1996)

    2003  

    Author's details by Ana Victoria Espinel-Ingroff
    Keywords Mycology / history ; Mycology / education ; United States ; USA ; Mykose ; Medizinische Mikrobiologie ; Geschichte 1894-1996
    Subject Klinische Mikrobiologie ; Molekulare Infektionsbiologie ; Mycosis ; Pilzinfektion ; Pilzkrankheit ; Mycose
    Language English
    Size XV, 221 S. : Ill.
    Publisher Kluwer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT013744438
    ISBN 1-4020-1067-2 ; 978-1-4020-1067-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 2977 order for loan Magazin

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  6. Article ; Online: Special Issue

    Ana Espinel-Ingroff / Eric Dannaoui

    Journal of Fungi, Vol 7, Iss 239, p

    Antifungal Agents Recently Approved or under Development

    2021  Volume 239

    Abstract: Many thanks to all contributors to the Special Issue on “Antifungal Agents Recently Approved or Under Development (Current Knowledge and Future Perspectives)” [.] ...

    Abstract Many thanks to all contributors to the Special Issue on “Antifungal Agents Recently Approved or Under Development (Current Knowledge and Future Perspectives)” [.]
    Keywords n/a ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Antifungal Susceptibly Testing by Concentration Gradient Strip Etest Method for Fungal Isolates: A Review.

    Dannaoui, Eric / Espinel-Ingroff, Ana

    Journal of fungi (Basel, Switzerland)

    2019  Volume 5, Issue 4

    Abstract: ...

    Abstract :
    Language English
    Publishing date 2019-11-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof5040108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Antifungal Resistance among Less Prevalent

    Espinel-Ingroff, Ana / Cantón, Emilia / Pemán, Javier

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 1

    Abstract: Fungal diseases and antifungal resistance continue to increase, including those caused by rare or emerging species. However, the majority of the published in vitro susceptibility data are for the most common fungal species. We reviewed the literature in ... ...

    Abstract Fungal diseases and antifungal resistance continue to increase, including those caused by rare or emerging species. However, the majority of the published in vitro susceptibility data are for the most common fungal species. We reviewed the literature in order to pool reference minimal inhibitory concentration (MIC) data (Clinical and Laboratory Standards Institute-CLSI and European Committee on Antimicrobial Susceptibility-EUCAST) for rare/non-prevalent
    Language English
    Publishing date 2021-01-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7010024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Antifungal Resistance in Cryptococcal Infections.

    Melhem, Marcia S C / Leite Júnior, Diniz Pereira / Takahashi, Juliana P F / Macioni, Milena Bronze / Oliveira, Lidiane de / de Araújo, Lisandra Siufi / Fava, Wellington S / Bonfietti, Lucas X / Paniago, Anamaria M M / Venturini, James / Espinel-Ingroff, Ana

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Antifungal therapy, especially with the azoles, could promote the incidence of less susceptible isolates ... ...

    Abstract Antifungal therapy, especially with the azoles, could promote the incidence of less susceptible isolates of
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13020128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Antifungal Resistance among Less Prevalent Candida Non- albicans and Other Yeasts versus Established and under Development Agents

    Ana Espinel-Ingroff / Emilia Cantón / Javier Pemán

    Journal of Fungi, Vol 7, Iss 24, p

    A Literature Review

    2021  Volume 24

    Abstract: Fungal diseases and antifungal resistance continue to increase, including those caused by rare or emerging species. However, the majority of the published in vitro susceptibility data are for the most common fungal species. We reviewed the literature in ... ...

    Abstract Fungal diseases and antifungal resistance continue to increase, including those caused by rare or emerging species. However, the majority of the published in vitro susceptibility data are for the most common fungal species. We reviewed the literature in order to pool reference minimal inhibitory concentration (MIC) data (Clinical and Laboratory Standards Institute—CLSI and European Committee on Antimicrobial Susceptibility—EUCAST) for rare/non-prevalent Candida and other yeast species. MIC results were compared with those for Candida albicans , C. glabrata , and C. krusei . Data were listed for twenty rare and emerging Candida spp., including C. auris , as well as two Cryptococcus spp., two Trichosporon spp., Saccharomyces cerevisiae and five Malassezia spp. The best detectors of antimicrobial resistance are the breakpoints, which are not available for the less common Candida species. However, epidemiological cutoff values (ECVs/ECOFFs) have been calculated using merely in vitro data for both reference methods for various non-prevalent yeasts and recently the CLSI has established ECVs for other Candida species. The ECV could identify the non-wild type (NWT or mutants) isolates with known resistance mechanisms. Utilizing these ECVs, we were able to report additional percentages of NWT, especially for non-prevalent species, by analyzing the MIC distributions in the literature. In addition, since several antifungal drugs are under development, we are listing MIC data for some of these agents.
    Keywords non-prevalent Candida ; antifungal resistance ; new and established antifungal agents ; Candida -non albicans ; other yeast pathogens ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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