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  1. Article ; Online: Novel approach for low-dose pulmonary delivery of hydroxychloroquine in COVID-19.

    Fassihi, Safa C / Nabar, Neel R / Fassihi, Reza

    British journal of pharmacology

    2020  Volume 177, Issue 21, Page(s) 4997–4998

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Chloroquine/administration & dosage ; Chloroquine/adverse effects ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Drug Delivery Systems ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/adverse effects ; Lung/metabolism ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; SARS-CoV-2
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF)
    Keywords covid19
    Language English
    Publishing date 2020-07-13
    Publishing country England
    Document type Letter
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15167
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  2. Article: Revision Total Knee Arthroplasty for Ballistic Component Damage From an Intra-articular Missile.

    Palosaari, Andrew A / Berger, Peter Z / Gross, Benjamin D / Fassihi, Safa C / Campbell, Joshua C

    Arthroplasty today

    2023  Volume 22, Page(s) 101172

    Abstract: Gunshot wounds (GSWs) and total knee arthroplasty (TKA) are increasingly common, yet a GSW to a TKA is a rare injury. A 60-year-old man sustained an intra-articular GSW to a prior TKA. The patient was scheduled for irrigation and debridement with ... ...

    Abstract Gunshot wounds (GSWs) and total knee arthroplasty (TKA) are increasingly common, yet a GSW to a TKA is a rare injury. A 60-year-old man sustained an intra-articular GSW to a prior TKA. The patient was scheduled for irrigation and debridement with polyethylene liner exchange. Intraoperatively, the new polyethylene liner was unable to engage the tibial tray. Damage to the locking mechanism on the tibial tray was suspected so total revision proceeded. Upon inspection of the explanted components, it was noted that a bullet fragment offline from the missile trajectory had blocked the locking of the polyethylene liner in the tibial tray. Expeditious antibiotics should be given and meticulous debridement should be performed to avoid unnecessary total component revision.
    Language English
    Publishing date 2023-07-22
    Publishing country United States
    Document type Case Reports
    ISSN 2352-3441
    ISSN 2352-3441
    DOI 10.1016/j.artd.2023.101172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Risk Factors for Blood Transfusions in Elective Single-Level Anterior Lumbar Interbody Fusion for Degenerative Conditions.

    Lee, Danny / Lee, Ryan / Fassihi, Safa C / Ramamurti, Pradip / Heyer, Jessica H / Iweala, Uchechi / Weinreb, Jeffrey / O'Brien, Joseph

    The Iowa orthopaedic journal

    2024  Volume 43, Issue 2, Page(s) 106–116

    Abstract: ... C-statistic) was 0.759 (p<0.001), indicating relatively strong discriminatory ability/predictability ...

    Abstract Background: ALIF (anterior lumbar interbody fusion) and other spinal fusion surgeries are among the most common orthopaedic procedures requiring blood transfusions. However, blood transfusions have been associated with various complications, including adverse reactions and infections. The present study aims to identify independent risk factors for blood transfusions in patients undergoing single-level ALIF specifically to better identify high risk patients and optimize perioperative management.
    Methods: All patients who had undergone single-level ALIF patients for the treatment of degenerative spinal conditions, excluding traumatic, pathologic, and infectious etiologies, were identified by querying a multi-institutional surgical registry from 2005 to 2018. Multi-level fusions, PLIF/TLIF, and posterior procedures were also excluded. Mann-Whitney-U-Tests were used to analyze continuous variables, while Fisher's-Exact-Tests/Bonferroni-Corrected-Tests were used for categorical variables. Multivariate logistic regression analysis with alternating backward stepwise elimination and forward entry was implemented to identify significant predictors for blood transfusions within 72 hours after incision. The predicted probabilities were used in post-regression diagnostics to generate a Receiver Operating Characteristic (ROC) curve to assess model performance.
    Results: 4,792 single-level ALIF patients met inclusion criteria - 183 (3.82%) had received blood transfusions within 72 hours after incision and 4,609 (96.18%) had not. Age ≥60 years (OR 1.954, p<0.001), preoperative transfusions (OR 33.758, p=0.023), extended operative times (≥197.0 minutes; 75th percentile) (OR 4.645, p<0.001), ASA≥3 (OR 1.395, p<0.001) and preoperative hematocrit levels (Hct) 30.00-37.99 (OR 1.562, p=0.016) and Hct <30.00 (OR 6.334, p<0.001) were shown to be significant independent risk factors for perioperative blood transfusions. The area under the ROC curve (AUROC; C-statistic) was 0.759 (p<0.001), indicating relatively strong discriminatory ability/predictability of the final model.
    Conclusion: Several independent risk factors including age ≥60 years, preoperative blood transfusions and extended operative times increased risk for blood transfusion following single-level ALIF. The present study aims to help surgeons identify high-risk patients to better communicate postoperative expectations and optimize patients to reduce the risk of transfusions and secondary complications.
    MeSH term(s) Humans ; Middle Aged ; Blood Transfusion ; Intervertebral Disc Degeneration/surgery ; Intervertebral Disc Degeneration/complications ; Lumbar Vertebrae/surgery ; Postoperative Complications/etiology ; Retrospective Studies ; Spinal Fusion/adverse effects ; Spinal Fusion/methods ; Treatment Outcome ; Aged ; Multicenter Studies as Topic
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1204065-4
    ISSN 1555-1377 ; 1541-5457
    ISSN (online) 1555-1377
    ISSN 1541-5457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 1381: Show issues Location:
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  5. Article ; Online: Novel approach for low‐dose pulmonary delivery of hydroxychloroquine in COVID‐19

    Fassihi, Safa C. / Nabar, Neel R. / Fassihi, Reza

    British Journal of Pharmacology

    2020  Volume 177, Issue 21, Page(s) 4997–4998

    Keywords Pharmacology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15167
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book ; Online: Novel Approach for Low-Dose Pulmonary Delivery of Hydroxychloroquine in COVID-19.

    Fassihi, Safa C. / Nabar, Neel R / Fassihi, Reza

    School of Medicine and Health Sciences Resident Works

    2020  

    Keywords COVID-19 ; Chloroquine ; Drug delivery ; Hydroxychloroquine ; Nebulization ; Respiratory pharmacology ; Medicine and Health Sciences ; covid19
    Publishing date 2020-06-19T07:00:00Z
    Publisher Health Sciences Research Commons
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Accuracy of ICD-10 Coding for Femoral Head Bearing Surfaces in Hip Arthroplasty.

    Rajahraman, Vinaya / Fassihi, Safa C / Patel, Vaidehi / Pope, Caleigh A / Rozell, Joshua C / Schwarzkopf, Ran

    The Journal of arthroplasty

    2022  Volume 38, Issue 5, Page(s) 794–797

    Abstract: Background: The International Classification of Diseases-10 Procedure Code System (ICD-10-PCS) introduced oxidized zirconium (OxZi) and niobium procedural codes to the types of femoral head bearing surfaces in 2017. These codes aimed to increase ... ...

    Abstract Background: The International Classification of Diseases-10 Procedure Code System (ICD-10-PCS) introduced oxidized zirconium (OxZi) and niobium procedural codes to the types of femoral head bearing surfaces in 2017. These codes aimed to increase procedural specificity in coding and improve data collection through administrative claims databases. This study aimed to assess the accuracy of ICD-10-PCS coding for femoral head bearing surfaces (cobalt chrome/metal, ceramic, and OxZi) in hip procedures.
    Methods: A retrospective analysis of 6,204 procedures utilizing femoral heads performed between October 1, 2017 and August 26, 2021 at a large, urban academic hospital was conducted. Operative reports and implant logs were queried to determine the femoral head bearing surface, which was used during the total hip arthroplasty. These results were then compared to the ICD-10-PCS codes in the billing records. Coding accuracy was subsequently determined and statistical differences between the three groups were evaluated.
    Results: The ICD-10-PCS coding was accurate for 90.8% (5,634/6,204) of cases. Coding accuracy for ceramic femoral heads (95.4%, 4,171/4,371) was significantly greater than that of both cobalt chrome/metal (73.7%, 606/822; P < .001) and OxZi (84.8%, 857/1,011; P < .001) femoral heads.
    Conclusion: While coding for ceramic femoral heads was very accurate, OxZi and cobalt chrome/metal femoral heads were miscoded at a rate of approximately 20%. These inaccuracies call for further evaluation of the ICD-10-PCS coding process to ensure that conclusions drawn from clinical research performed through administrative claims databases are not subject to error.
    MeSH term(s) Humans ; Arthroplasty, Replacement, Hip/methods ; Femur Head/surgery ; Hip Prosthesis ; Retrospective Studies ; International Classification of Diseases ; Zirconium ; Chromium Alloys ; Cobalt ; Prosthesis Design ; Prosthesis Failure
    Chemical Substances Zirconium (C6V6S92N3C) ; Chromium Alloys ; Cobalt (3G0H8C9362)
    Language English
    Publishing date 2022-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2022.12.002
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  8. Article: Erratum to 'Total Hip Arthroplasty in An Adult Patient With Pelvic Dysmorphism, Unilateral Sacroiliac Joint Autofusion, and Developmental Hip Dysplasia' [Arthroplasty Today 6 (2020) 41-47].

    Fassihi, Safa C / Lee, Danny / Tran, Andrew A / Lee, Ryan / Pollard, Tom / Stadecker, Monica / Stake, Seth / Hughes, Alice J / Thakkar, Savyasachi

    Arthroplasty today

    2022  Volume 15, Page(s) 235

    Abstract: This corrects the article DOI: 10.1016/j.artd.2019.10.006.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.artd.2019.10.006.].
    Language English
    Publishing date 2022-06-16
    Publishing country United States
    Document type Published Erratum
    ISSN 2352-3441
    ISSN 2352-3441
    DOI 10.1016/j.artd.2022.01.018
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  9. Article: Deep Vein Thrombosis after Cement Intravasation during Hip Hemiarthroplasty.

    Mathur, Abhay / Fassihi, Safa C / Ramamurti, Pradip / Doerre, Teresa

    Arthroplasty today

    2020  Volume 6, Issue 2, Page(s) 283–287

    Abstract: Cement intravasation occurs in hemiarthroplasty when pressurization of cement through the medullary canal backflows through the nutrient vessels. This case report describes a 70-year-old woman who underwent hip hemiarthroplasty for a displaced left ... ...

    Abstract Cement intravasation occurs in hemiarthroplasty when pressurization of cement through the medullary canal backflows through the nutrient vessels. This case report describes a 70-year-old woman who underwent hip hemiarthroplasty for a displaced left femoral neck fracture. Postoperative radiographs demonstrated radio-opacity consistent with local cement intravasation. A Doppler ultrasound study subsequently revealed a mobile thrombus at the confluence of the femoral and profunda femoris veins, as well as a nonmobile thrombus within the profunda femoris vein. The more proximal thrombus was determined to be cement that had intravasated during the index operation. The cement likely impeded venous flow, ultimately leading to the development of deep vein thrombosis just distal to the site of cement occlusion.
    Language English
    Publishing date 2020-04-13
    Publishing country United States
    Document type Case Reports
    ISSN 2352-3441
    ISSN 2352-3441
    DOI 10.1016/j.artd.2020.03.007
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  10. Article ; Online: Conversion Total Knee Arthroplasty.

    Ramamurti, Pradip / Fassihi, Safa C / Stake, Seth / Stadecker, Monica / Whiting, Zachariah / Thakkar, Savyasachi C

    JBJS reviews

    2021  Volume 9, Issue 9

    Abstract: Conversion total knee arthroplasty (TKA) represents a heterogeneous group of procedures and most commonly includes TKA performed after ligamentous reconstruction, periarticular open reduction and internal fixation (ORIF), high tibial osteotomy (HTO), ...

    Abstract »: Conversion total knee arthroplasty (TKA) represents a heterogeneous group of procedures and most commonly includes TKA performed after ligamentous reconstruction, periarticular open reduction and internal fixation (ORIF), high tibial osteotomy (HTO), and unicompartmental knee arthroplasty (UKA).
    »: Relative to patients undergoing primary TKA, patients undergoing conversion TKA often have longer operative times and higher surgical complexity, which may translate into higher postoperative complication rates.
    »: There is mixed evidence on implant survivorship and patient-reported outcome measures when comparing conversion TKA and primary TKA, with some studies noting no differences between the procedures and others finding decreased survivorship and outcome scores for conversion TKA.
    »: By gaining an improved understanding of the unique challenges facing patients undergoing conversion TKA, clinicians may better set patient expectations, make intraoperative adjustments, and guide postoperative care.
    MeSH term(s) Arthroplasty, Replacement, Knee/adverse effects ; Arthroplasty, Replacement, Knee/methods ; Humans ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/surgery ; Osteotomy/adverse effects ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Reoperation/adverse effects
    Language English
    Publishing date 2021-09-09
    Publishing country United States
    Document type Journal Article
    ISSN 2329-9185
    ISSN (online) 2329-9185
    DOI e20.00198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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