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  1. Article: Nerve Torsion as a Pattern of Parsonage-Turner Syndrome: Literature Review and Two Representative Cases.

    Glorioso, Davide / Palestini, Rita / Cuccagna, Cristina / Lauretti, Liverana / Padua, Luca

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: 1) Background: Parsonage-Turner Syndrome (PTS) is a rare peripheral nerve disease characterized by different degrees of nerve impairment. The recent development of nerve ultrasound has enabled the use of new data in the diagnosis of the disease. The aim ...

    Abstract (1) Background: Parsonage-Turner Syndrome (PTS) is a rare peripheral nerve disease characterized by different degrees of nerve impairment. The recent development of nerve ultrasound has enabled the use of new data in the diagnosis of the disease. The aim of this study is to conduct a literature review about the ultrasound evaluation of PTS and present two clinical cases that are characteristic of the disease. (2) Methods: A review of the literature from the last 10 years on the topic containing data regarding nerve ultrasound was performed. In addition, two cases of patients on whom nerve ultrasound was performed at the first evaluation and at follow-up after the indicated treatment were described. (3) Results: The results of our review show that although it is defined as plexopathy, PTS is most often a form of multifocal neuropathy. We also report the most frequently used ultrasound classification and possible prognostic correlations and report our experience with the description of two paradigmatic clinical cases. (4) Conclusions: Further studies are needed to understand the true prognostic power of each degree of nerve impairment and the possible implications in clinical practice regarding treatment indications.
    Language English
    Publishing date 2023-07-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Pivotal Role of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers in Hypertension Management and Cardiovascular and Renal Protection: A Critical Appraisal and Comparison of International Guidelines.

    Alcocer, Luis Antonio / Bryce, Alfonso / De Padua Brasil, David / Lara, Joffre / Cortes, Javier Moreno / Quesada, Daniel / Rodriguez, Pablo

    American journal of cardiovascular drugs : drugs, devices, and other interventions

    2023  Volume 23, Issue 6, Page(s) 663–682

    Abstract: Arterial hypertension is the main preventable cause of premature mortality worldwide. Across Latin America, hypertension has an estimated prevalence of 25.5-52.5%, although many hypertensive patients remain untreated. Appropriate treatment, started early ...

    Abstract Arterial hypertension is the main preventable cause of premature mortality worldwide. Across Latin America, hypertension has an estimated prevalence of 25.5-52.5%, although many hypertensive patients remain untreated. Appropriate treatment, started early and continued for the remaining lifespan, significantly reduces the risk of complications and mortality. All international and most regional guidelines emphasize a central role for renin-angiotensin-aldosterone system inhibitors (RAASis) in antihypertensive treatment. The two main RAASi options are angiotensin-converting enzyme inhibitors (ACEis) and angiotensin II receptor blockers (ARBs). Although equivalent in terms of blood pressure reduction, ACEis are preferably recommended by some guidelines to manage other cardiovascular comorbidities, with ARBs considered as an alternative when ACEis are not tolerated. This review summarizes the differences between ACEis and ARBs and their place in the international guidelines. It provides a critical appraisal of the guidelines based on available evidence from randomized controlled trials (RCTs) and meta-analyses, especially considering that hypertensive patients in daily practice often have other comorbidities. The observed differences in cardiovascular and renal outcomes in RCTs may be attributed to the different mechanisms of action of ACEis and ARBs, including increased bradykinin levels, potentiated bradykinin response, and stimulated nitric oxide production with ACEis. It may therefore be appropriate to consider ACEis and ARBs as different antihypertensive drugs classes within the same RAASi group. Although guideline recommendations only differentiate between ACEis and ARBs in patients with cardiovascular comorbidities, clinical evidence suggests that ACEis provide benefits in many hypertensive patients, as well as those with other cardiovascular conditions.
    MeSH term(s) Humans ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Angiotensin Receptor Antagonists/pharmacology ; Angiotensin Receptor Antagonists/therapeutic use ; Bradykinin/pharmacology ; Bradykinin/therapeutic use ; Hypertension ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Renin-Angiotensin System
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists ; Bradykinin (S8TIM42R2W) ; Antihypertensive Agents
    Language English
    Publishing date 2023-09-05
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2052547-3
    ISSN 1179-187X ; 1175-3277
    ISSN (online) 1179-187X
    ISSN 1175-3277
    DOI 10.1007/s40256-023-00605-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5487: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Novel approaches to treating Clostridium difficile-associated colitis.

    Padua, David / Pothoulakis, Charalabos

    Expert review of gastroenterology & hepatology

    2016  Volume 10, Issue 2, Page(s) 193–204

    Abstract: Clostridium difficile is being recognized as a growing threat to many health-care systems. Epidemiology data shows that infection rates are soaring and the disease burden is increasing. Despite the efficacy of standard treatments, it is becoming evident ... ...

    Abstract Clostridium difficile is being recognized as a growing threat to many health-care systems. Epidemiology data shows that infection rates are soaring and the disease burden is increasing. Despite the efficacy of standard treatments, it is becoming evident that novel therapeutics will be required to tackle this disease. These new treatments aim to enhance the intestinal microbial barrier, activate the immune system and neutralize the toxins that mediate this disease. Many of these therapies are still in the beginning stages of investigation, however, in the next few years, more clinical data will become available to help implement many of these exciting new therapeutic approaches.
    MeSH term(s) Animals ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Bacterial Vaccines/adverse effects ; Bacterial Vaccines/therapeutic use ; Clostridium Infections/diagnosis ; Clostridium Infections/microbiology ; Clostridium Infections/therapy ; Clostridium difficile/immunology ; Clostridium difficile/pathogenicity ; Colitis/microbiology ; Colitis/therapy ; Fecal Microbiota Transplantation/adverse effects ; Gastrointestinal Microbiome ; Humans ; Intestines/microbiology ; Probiotics/adverse effects ; Probiotics/therapeutic use ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Bacterial Vaccines
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1586/17474124.2016.1109444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6978: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: A Challenging Case of Severe Ulcerative Colitis following the Initiation of Secukinumab for Ankylosing Spondylitis.

    Ehrlich, Dean / Jamaluddin, Nimah / Pisegna, Joseph / Padua, David

    Case reports in gastrointestinal medicine

    2018  Volume 2018, Page(s) 9679287

    Abstract: Secukinumab is an interleukin-17 inhibitor used for the treatment of ankylosing spondylitis (AS), psoriasis, and psoriatic arthritis. The risk of exacerbating underlying inflammatory bowel disease (IBD) in patients being treated with secukinumab for ... ...

    Abstract Secukinumab is an interleukin-17 inhibitor used for the treatment of ankylosing spondylitis (AS), psoriasis, and psoriatic arthritis. The risk of exacerbating underlying inflammatory bowel disease (IBD) in patients being treated with secukinumab for other conditions is controversial. We document a patient with AS and previously undiagnosed IBD, found to be in a severe ulcerative colitis flare shortly after receiving the loading dose of secukinumab. There are no guidelines regarding biologic salvage therapy for IBD in the setting of active treatment with another biologic agent. After waiting one half-life of secukinumab, our patient had an excellent response to initiation of infliximab.
    Language English
    Publishing date 2018-02-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627636-7
    ISSN 2090-6536 ; 2090-6528
    ISSN (online) 2090-6536
    ISSN 2090-6528
    DOI 10.1155/2018/9679287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Microhardness and surface roughness of Biodentine exposed to mouthwashes.

    Arnez, Mayara Manfrin / Castelo, Raisa / Ugarte, David / Almeida, Leonardo de Pádua Andrade / Dotta, Tatiane Cristina / Catirse, Alma Blásida Concepcion Elizaur Benitez

    Journal of conservative dentistry : JCD

    2022  Volume 24, Issue 4, Page(s) 379–383

    Abstract: Aim: This study evaluates Vickers microhardness and surface roughness in Biodentine cement (M1) and glass-ionomer cement Fuji IX (M2), both immersed in mouthwash.: Materials and methods: Fifty-four samples were randomly distributed in distilled water ...

    Abstract Aim: This study evaluates Vickers microhardness and surface roughness in Biodentine cement (M1) and glass-ionomer cement Fuji IX (M2), both immersed in mouthwash.
    Materials and methods: Fifty-four samples were randomly distributed in distilled water (S1), Listerine Cool Mint (S2), and Colgate Plax (S3). Each sample was put in a flask with mouthwash for 2 min, under vibration, twice a day for 21 days. Microhardness and surface roughness were assessed at 48 h (T0), 7 days (T1), 14 days (T2), and 21 days (T3).
    Results: For roughness: time (T), solution (S) and material (M), TxM, and SxM and for microhardness: M, TxS, TxM, and SxM were statistically significant. T3, M1, M1T3, and M1S1 presented the highest surface roughness. M2, M1T0, M1T1, M1T2, M1S1, and M1S2 presented higher microhardness.
    Conclusion: Biodentine showed higher surface roughness for T1, T2, and T3 and higher microhardness for T0, T1, and T2 against Fuji IX. Biodentine presented higher microhardness independently of solution.
    Language English
    Publishing date 2022-01-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2064481-4
    ISSN 0972-0707
    ISSN 0972-0707
    DOI 10.4103/jcd.jcd_113_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5545: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Evaluating tofacitinib citrate in the treatment of moderate-to-severe active ulcerative colitis: design, development and positioning of therapy.

    Tran, Vivy / Shammas, Rania M / Sauk, Jenny S / Padua, David

    Clinical and experimental gastroenterology

    2019  Volume 12, Page(s) 179–191

    Abstract: The etiology of ulcerative colitis (UC) is complex and involves a host of genetic, epigenetic and environmental factors. Over the last thirty years, signaling pathways like the Janus kinase (JAK) signaling pathway have been implicated in its pathogenesis. ...

    Abstract The etiology of ulcerative colitis (UC) is complex and involves a host of genetic, epigenetic and environmental factors. Over the last thirty years, signaling pathways like the Janus kinase (JAK) signaling pathway have been implicated in its pathogenesis. Pharmacologic blockade of this pathway is available through several small molecule inhibitors, including tofacitinib. Tofacitinib is an orally administered pan-JAK inhibitor that was first approved by the Food and Drug Administration (FDA) for use in rheumatologic disorders such as rheumatoid arthritis and psoriatic arthritis. The FDA approved its use in moderate-to-severe active ulcerative colitis in 2018. The aim of this review will be to discuss the role of tofacitinib in ulcerative colitis. We will discuss the role of JAK-STAT signaling, clinical data available for tofacitinib, and the safety profile for this therapy. Tofacitinib's place in the UC management algorithm is currently being debated. This effective oral therapy is poised to be a mainstay of UC therapeutics. This review will highlight the key clinical features and detail the UC experience to date.
    Language English
    Publishing date 2019-05-02
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2520690-4
    ISSN 1178-7023
    ISSN 1178-7023
    DOI 10.2147/CEG.S150908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Encyclopedia of Parallel Computing

    Padua, David

    2011  

    Author's details edited by David Padua
    Keywords Computer science ; Computer system performance ; Software engineering
    Language English
    Size Online-Ressource
    Publisher Springer US
    Publishing place Boston, MA
    Document type Book ; Online
    ISBN 9780387097664 ; 9780387097664 ; 038709766X ; 038709766X
    DOI 10.1007/978-0-387-09766-4
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book ; Online: Encyclopedia of Parallel Computing

    Padua, David

    2011  

    Author's details edited by David Padua
    Keywords Computer science ; Computer system performance ; Software engineering
    Language English
    Size Online-Ressource
    Publisher Springer US
    Publishing place Boston, MA
    Document type Book ; Online
    ISBN 9780387097664 ; 9780387097664 ; 038709766X ; 038709766X
    DOI 10.1007/978-0-387-09766-4
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Article ; Online: Nerve Torsion as a Pattern of Parsonage–Turner Syndrome

    Davide Glorioso / Rita Palestini / Cristina Cuccagna / Liverana Lauretti / Luca Padua

    Journal of Clinical Medicine, Vol 12, Iss 4542, p

    Literature Review and Two Representative Cases

    2023  Volume 4542

    Abstract: 1) Background: Parsonage–Turner Syndrome (PTS) is a rare peripheral nerve disease characterized by different degrees of nerve impairment. The recent development of nerve ultrasound has enabled the use of new data in the diagnosis of the disease. The aim ...

    Abstract (1) Background: Parsonage–Turner Syndrome (PTS) is a rare peripheral nerve disease characterized by different degrees of nerve impairment. The recent development of nerve ultrasound has enabled the use of new data in the diagnosis of the disease. The aim of this study is to conduct a literature review about the ultrasound evaluation of PTS and present two clinical cases that are characteristic of the disease. (2) Methods: A review of the literature from the last 10 years on the topic containing data regarding nerve ultrasound was performed. In addition, two cases of patients on whom nerve ultrasound was performed at the first evaluation and at follow-up after the indicated treatment were described. (3) Results: The results of our review show that although it is defined as plexopathy, PTS is most often a form of multifocal neuropathy. We also report the most frequently used ultrasound classification and possible prognostic correlations and report our experience with the description of two paradigmatic clinical cases. (4) Conclusions: Further studies are needed to understand the true prognostic power of each degree of nerve impairment and the possible implications in clinical practice regarding treatment indications.
    Keywords amyotrophic neuralgia ; parsonage tuner ; echography ; ultrasonography ; nerve ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Choosing patient-reported outcome measures for shoulder pathology.

    Padua, Roberto / de Girolamo, Laura / Grassi, Alberto / Cucchi, Davide

    EFORT open reviews

    2021  Volume 6, Issue 9, Page(s) 779–787

    Abstract: This study was designed to identify the most frequent shoulder patient-reported outcome measures (PROMs) reported in high-quality literature.A systematic review was performed to identify shoulder PROMs, and their diffusion within the scientific ... ...

    Abstract This study was designed to identify the most frequent shoulder patient-reported outcome measures (PROMs) reported in high-quality literature.A systematic review was performed to identify shoulder PROMs, and their diffusion within the scientific literature was tested with a subsequent dedicated search in MEDLINE.506 studies were included in the final data analysis, for a total number of 36,553 patients.The Disabilities of the Arm, Shoulder and Hand questionnaire (DASH), the American Shoulder, Elbow Surgeons Score (ASES) and the Shoulder Pain and Disability Index (SPADI) were the most frequently reported PROMs in the analysed publications, with disease-specific PROMs being used with increasing frequency.A core set of outcome measures for future studies on patients with shoulder pathologies, based on the international acceptance and diffusion of each PROM, is needed.A combination of the DASH score for shoulder outcome assessment with more specific PROMs, such as the ASES for rotator cuff pathology and osteoarthritis and the SPADI for shoulder stiffness and shoulder pain of unspecified origin, is proposed as a recommended set of PROMs. Cite this article:
    Language English
    Publishing date 2021-09-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2844421-8
    ISSN 2058-5241 ; 2058-5241 ; 2396-7544
    ISSN (online) 2058-5241
    ISSN 2058-5241 ; 2396-7544
    DOI 10.1302/2058-5241.6.200109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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