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  1. Article ; Online: Actin reorganization is involved in vasoactive intestinal peptide induced human mast cells priming to fraktalkine-induced chemotaxis.

    El-Shazly, Amr E

    International journal of general medicine

    2008  Volume 1, Page(s) 27–31

    Abstract: We recently reported a novel neuro-immuno co-operation between vasoactive intestinal peptide (VIP) and fraktalkine (FKN) in recruiting human mast cells to the asthmatic airway that provided a classical example of priming effect on mast cells migratory ... ...

    Abstract We recently reported a novel neuro-immuno co-operation between vasoactive intestinal peptide (VIP) and fraktalkine (FKN) in recruiting human mast cells to the asthmatic airway that provided a classical example of priming effect on mast cells migratory function, but the role of the F-actin in human mast cell chemotaxis' priming is poorly defined. Therefore the aim of this study was to further investigate the biophysical role of the cytoskeletal element; the F-actin, intracellular reorganization and its polymerization in mast cell priming of chemotaxis function. In the present communication it is shown by immunofluoresence confocal microscopy analysis that physical F-actin intracellular reorganization in a membrane bound manner on human mast cell is involved in VIP-induced priming of human mast cell chemotaxis against FKN. The F-actin reorganization was calcium independent and without modification of its contents as assessed by fluorescence-activated cell scanning analysis. These results identify a novel role for the biophysical association of F-actin in the crosstalk between neuro-inflammatory mediators and mast cells and may be an important target for therapeutic modalities in allergic inflammation.
    Language English
    Publishing date 2008-11-30
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2452220-X
    ISSN 1178-7074 ; 1178-7074
    ISSN (online) 1178-7074
    ISSN 1178-7074
    DOI 10.2147/ijgm.s3759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nasal sodium cromoglycate (Lomusol) modulates the early phase reaction of mild to moderate persistent allergic rhinitis in patients mono-sensitized to house dust mite: a preliminary study.

    Lejeune, Margaux / Lefebvre, Philipe P / Delvenne, Philippe / El-Shazly, Amr E

    International immunopharmacology

    2015  Volume 26, Issue 1, Page(s) 272–276

    Abstract: We evaluated the clinical improvement of patients with mild to moderate persistent allergic rhinitis (AR) due to mono-sensitization to house dust mite (HDM) allergen, by sodium cromoglycate nasal spray (Lomusol 4%). Lomusol was used as a single agent ... ...

    Abstract We evaluated the clinical improvement of patients with mild to moderate persistent allergic rhinitis (AR) due to mono-sensitization to house dust mite (HDM) allergen, by sodium cromoglycate nasal spray (Lomusol 4%). Lomusol was used as a single agent treatment, and its anti-inflammatory effects, in the early phase reaction were evaluated. Herein we showed that Lomusol significantly improved the subjective nasal symptom scores especially nasal obstruction. This was associated with significant and specific reduction in neutrophils influx in nasal cytology but had no effect on other cell types. This selective anti-inflammatory effect on nasal cytology was associated with significant reduction in the levels of platelet activating factor (PAF) and histamine in nasal secretions but had no effect on PGD2, LTC4 or CysLt levels. Lomusol was also able to induce significant reduction in eosinophil cationic protein (ECP) levels in nasal secretions without altering the percentage of eosinophil influx in nasal cytology. Taken collectively, we showed the first evidence that nasal sodium cromoglycate possesses a selective inhibition on neutrophil recruitment into nasal cytology in the early phase reaction of AR patients mono-sensitized to HDM. This may be attributed to the ability of Lomusol to significantly reduce the amount of PAF recovered in nasal secretion. These results were associated with significant improvement in subjective symptom scores especially nasal obstruction that may in addition, be due to the ability of Lomusol to down-regulate eosinophil degranulation activity as well.
    MeSH term(s) Administration, Intranasal ; Adult ; Animals ; Anti-Allergic Agents/administration & dosage ; Anti-Allergic Agents/therapeutic use ; Cromolyn Sodium/administration & dosage ; Cromolyn Sodium/therapeutic use ; Female ; Humans ; Male ; Nasal Mucosa/drug effects ; Nasal Mucosa/immunology ; Nasal Provocation Tests ; Neutrophil Infiltration/drug effects ; Pyroglyphidae/immunology ; Rhinitis, Allergic/diagnosis ; Rhinitis, Allergic/drug therapy ; Rhinitis, Allergic/immunology ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Anti-Allergic Agents ; Cromolyn Sodium (Q2WXR1I0PK)
    Language English
    Publishing date 2015-05
    Publishing country Netherlands
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2015.02.004
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  3. Article: The safety of ureteral stenting with the use of potassium citrate for management of renal uric acid stones.

    Alenezi, Nawaf Abdulaziz / Zanaty, Fouad / Hodhod, Amr / El-Gharabawy, Mohammed / El-Sherif, Eid / Badawy, Atef / El-Shazly, Mohammed

    Urology annals

    2019  Volume 12, Issue 1, Page(s) 37–41

    Abstract: Objectives: The objective is to evaluate the relative risks of ureteric stents application while managing uric acid stones with potassium citrate in terms of stone encrustations and urinary tract infection (UTI).: Patients and methods: We ... ...

    Abstract Objectives: The objective is to evaluate the relative risks of ureteric stents application while managing uric acid stones with potassium citrate in terms of stone encrustations and urinary tract infection (UTI).
    Patients and methods: We prospectively enrolled patients with renal uric acid stones who received K citrate from 2013 to 2018. Patient's demographics were collected. All patients were evaluated using noncontrast computed tomography (CT) scan to measure the stone size and density. JJ ureteric stent was inserted prior to the initiation of treatment. At follow-up, all patients underwent urine analysis for pH and to detect UTI. CT was repeated at 1 month and those patients who showed incomplete stone resolution underwent another course of treatment for another month. CT was repeated prior to stent removal. The presence of encrustations was inspected and collected.
    Results: We collected 59 patients with a median age of 36 years (18-73) and median stone burden of 26 mm
    Conclusion: Short-term use of ureteral stents is safe during the management of uric acid stones with K citrate.
    Language English
    Publishing date 2019-11-07
    Publishing country India
    Document type Journal Article
    ISSN 0974-7796
    ISSN 0974-7796
    DOI 10.4103/UA.UA_60_19
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  4. Article: Aging of orbicularis oculi: anatomophysiologic consideration in upper blepharoplasty.

    Pottier, Françoise / El-Shazly, Nihal Z / El-Shazly, Amr E

    Archives of facial plastic surgery

    2008  Volume 10, Issue 5, Page(s) 346–349

    Abstract: Objective: To investigate the anatomophysiologic aging-related changes in the orbicularis oculi muscle.: Methods: We examined the full-thickness histologic characteristics of the upper eyelids from cadavers of 30-, 40-, 60-, and 70-year-old men and ... ...

    Abstract Objective: To investigate the anatomophysiologic aging-related changes in the orbicularis oculi muscle.
    Methods: We examined the full-thickness histologic characteristics of the upper eyelids from cadavers of 30-, 40-, 60-, and 70-year-old men and the muscle interference pattern (IP) of 68 healthy volunteers of both sexes aged 18 to 73 years.
    Results: Histologic analysis revealed that in the aging upper eyelid, changes were primarily in the skin and subcutaneous layers with the characteristic loss of collagen elastic fibers; however, the whole muscle layer was histologically intact, with no signs of aging; loss of fibers, loss of adherence to surrounding structure, or ptosis. Neurophysiologic studies of the electromyographic IP of the orbicularis oculi muscle confirmed that the full efficiency of orbicularis oculi function was intact in the age group studied (18-73 years) in both sexes.
    Conclusion: Our results suggest that the anatomophysiologic characteristics of the orbicularis oculi muscle remain intact through advancement of age.
    MeSH term(s) Adult ; Aged ; Aging/physiology ; Eyelids/cytology ; Female ; Humans ; Male ; Middle Aged
    Language English
    Publishing date 2008-09
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 1483844-8
    ISSN 1538-3660 ; 1521-2491
    ISSN (online) 1538-3660
    ISSN 1521-2491
    DOI 10.1001/archfaci.10.5.346
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    Zs.A 5869: Show issues Location:
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  5. Article ; Online: Actin reorganization is involved in vasoactive intestinal peptide induced human mast cells priming to fraktalkine-induced chemotaxis

    Amr E El-Shazly

    International Journal of General Medicine, Vol 2008, Iss default, Pp 27-

    2008  Volume 31

    Abstract: Amr E El-ShazlyDepartment of Oto-Rhino-Laryngology and Head and Neck Surgery, Liege ...

    Abstract Amr E El-ShazlyDepartment of Oto-Rhino-Laryngology and Head and Neck Surgery, Liege University Hospital (Centre hospitalier Universaitaire-C.H.U.), Liege, BelgiumAbstract: We recently reported a novel neuro-immuno co-operation between vasoactive intestinal peptide (VIP) and fraktalkine (FKN) in recruiting human mast cells to the asthmatic airway that provided a classical example of priming effect on mast cells migratory function, but the role of the F-actin in human mast cell chemotaxis’ priming is poorly defined. Therefore the aim of this study was to further investigate the biophysical role of the cytoskeletal element; the F-actin, intracellular reorganization and its polymerization in mast cell priming of chemotaxis function. In the present communication it is shown by immunofluoresence confocal microscopy analysis that physical F-actin intracellular reorganization in a membrane bound manner on uman mast cell is involved in VIP-induced priming of human mast cell chemotaxis against FKN. The F-actin reorganization was calcium independent and without modifi cation of its contents as assessed by fluorescence-activated cell scanning analysis. These results identify a novel role for the biophysical association of F-actin in the crosstalk between neuro-inflammatory mediators and mast cells and may be an important target for therapeutic modalities in allergic inflammation.Keywords: mast cells, chemotaxis, neuroimmuno-axis, F-actin intracellular reorganization, VIP, priming
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2008-08-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
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  6. Article ; Online: Variceal recurrence 4 years post endoscopic band ligation in hepatitis C patients who achieved sustained virological response with oral direct-acting antiviral therapy.

    Ibrahim, El-Sayed / Abdel-Samiee, Mohamed / Youssef, Mohamed I / El-Shazly, Helmy / A El-Gendy, Abd-ElAleem / Sakr, Ayman Ahmed / Elwazzan, Doaa / Nassar, Mervat Ragab / Aly Elshormilisy, Amr / Madkour, Ahmad / Kamal, Mostafa / Amrousy, Yasmine M / Elkhadry, Sally Waheed / Abdelsameea, Eman

    Journal of viral hepatitis

    2020  Volume 28, Issue 2, Page(s) 279–287

    Abstract: Oral Direct-acting antivirals (DAAs) are safe, highly effective altering disease burden and prognosis in hepatitis C patients. Sustained virologic response (SVR) is achieved nowadays in more than 90% of the treated patients and related to the ... ...

    Abstract Oral Direct-acting antivirals (DAAs) are safe, highly effective altering disease burden and prognosis in hepatitis C patients. Sustained virologic response (SVR) is achieved nowadays in more than 90% of the treated patients and related to the improvements in functions of the liver, fibrosis plus survival. Furthermore, portal hypertension is thought to be improved with achievement of virological response, parallel to the improvements in hepatic inflammation and fibrosis. We aimed to assess the recurrence rate of oesophageal varices by long-term follow-up in patients treated with different DAAs regimens who had achieved SVR. We studied 176 Child A cirrhotic HCV patients who achieved SVR after DAAs treatment and had a history of endoscopic oesophageal varices obliteration and were on maximum tolerated propranolol dose. They were subjected to follow-up upper gastrointestinal endoscopy repeated every 6 months for 4 years. Fifty-two patients (29.5%) had recurrence of oesophageal varices observed during the 4-years follow-up upper GIT endoscopy. On multivariate analysis, platelet count was the only significant variable, P-value = .007*. HbA1C, HOMA IR, BMI 1 and BMI 2 showed non-significant differences between the studied groups. By ROC analysis, we identified baseline platelet count of 96 000/µL with 100% sensitivity (95% confidence interval [CI] [91%-100%]) and 74% specificity (95% CI [65%-81%]). Spearman correlation showed a positive correlation between AFP, age, AST, Bilirubin, creatinine, INR. Patients who achieved SVR post DAAs showed a significant decrease in oesophageal varices recurrence post endoscopic obliteration. Baseline platelet count was found to be a strong independent predictor for oesophageal varices recurrence.
    MeSH term(s) Antiviral Agents/therapeutic use ; Child ; Endoscopy ; Esophageal and Gastric Varices/drug therapy ; Esophageal and Gastric Varices/epidemiology ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Humans ; Liver Cirrhosis/drug therapy ; Sustained Virologic Response
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2020-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1212497-7
    ISSN 1365-2893 ; 1352-0504
    ISSN (online) 1365-2893
    ISSN 1352-0504
    DOI 10.1111/jvh.13426
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    Zs.A 4119: Show issues Location:
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  7. Article ; Online: Defective eosinophil chemotaxis to eotaxin in a patient with chronic lower baseline CD4+ T-lymphocytes and elevated CD8+ T cells

    Amr E El-Shazly / Monique Henket / Philippe P Lefebvre

    International Journal of General Medicine, Vol 2009, Iss default, Pp 187-

    2009  Volume 194

    Abstract: Amr E El-Shazly1, Monique Henket2, Philippe P Lefebvre1, Renaud Louis21Department of Oto-Rhino ...

    Abstract Amr E El-Shazly1, Monique Henket2, Philippe P Lefebvre1, Renaud Louis21Department of Oto-Rhino-Laryngology and Head and Neck Surgery, GIGA-Research, Liege University Hospitals (Centre Hospitalier Universaitaire-C.H.U.). Liege-Belgium; 2Department of Pulmonology, GIGA-Research, Liege University Hospitals (Centre Hospitalier Universaitaire-C.H.U.). Liege-BelgiumBackground: Idiopathic selective CD4+ lower baseline cell count and an increase in CD8+ cells is an unusual immune defect. Whether this is a true variant of idiopathic CD4+ T lymphocytopenia (ICL) or a sequelae to recurrent infections is not clear.Objectives: The primary objective of this study was to investigate the expression and function of the cc-chemokine receptor CCR3 in eosinophils from a female patient with this disorder. A secondary objective was to study the in vitro ability of different cytokines to modulate the reversed CD4:CD8 ratio in this syndrome. Participants: A female patient suffering cellular immune defect with chronic lower baseline CD4+ counts with persistent increase in CD8+ cells, and positive skin test and radioallergosorbent test to pollens. Seven volunteers served as controls: five healthy subjects and two allergic volunteers (one asthmatic and one rhinitic).Results: The patient’s eosinophils had defective chemotaxis, shape changes, and F-actin reorganization against eotaxin, when compared to the controls. CCR3 surface and total expression was highest in allergic subjects and least in the patient with cellular immune defect. Culture of eosinophils with interleukin-7 (IL-7), but not IL-2 for 24 hours resulted in increased expression of CCR3 in both the patient and controls as evidenced by fluorescence-activated cell scanning (FACS) analysis. Confocal microscopy demonstrated cytoskeletal changes and F-actin reorganization of the patient’s eosinophils only after treatment with IL-7. Culture of the patient’s lymphocytes with IL-2, IL-7, IL-10, IL-17, IL-15, or phytohemagglutinin increased the number of the patient’s CD4+-expressing ...
    Keywords Medicine (General) ; R5-920
    Subject code 570
    Language English
    Publishing date 2009-10-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
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  8. Article ; Online: Characterization of hepatitis C virus-induced nasal mucosa remodelling.

    El-Shazly, Amr / Arafa, Mohammad / Roncarati, Patrick / Dortu, Estelle / Lefebvre, Philippe P / Delvenne, Philippe

    Histopathology

    2010  Volume 57, Issue 3, Page(s) 488–492

    MeSH term(s) Hepacivirus/genetics ; Hepacivirus/metabolism ; Hepatitis C/pathology ; Hepatitis C/virology ; Humans ; Nasal Mucosa/pathology ; Nasal Mucosa/virology ; RNA, Viral/metabolism ; Rhinitis/virology
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2010-09
    Publishing country England
    Document type Letter
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/j.1365-2559.2010.03629.x
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    Zs.A 1328: Show issues Location:
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  9. Article ; Online: Novel association between vasoactive intestinal peptide and CRTH2 receptor in recruiting eosinophils: a possible biochemical mechanism for allergic eosinophilic inflammation of the airways.

    El-Shazly, Amr E / Begon, Dominique Y / Kustermans, Gaelle / Arafa, Mohammad / Dortu, Estelle / Henket, Monique / Lefebvre, Philippe P / Louis, Renaud / Delvenne, Philippe

    The Journal of biological chemistry

    2012  Volume 288, Issue 2, Page(s) 1374–1384

    Abstract: We explored the relation between vasoactive intestinal peptide (VIP), CRTH2, and eosinophil recruitment. It is shown that CRTH2 expression by eosinophils from allergic rhinitis (AR) patients and eosinophil cell line (Eol-1 cells) was up-regulated by VIP ... ...

    Abstract We explored the relation between vasoactive intestinal peptide (VIP), CRTH2, and eosinophil recruitment. It is shown that CRTH2 expression by eosinophils from allergic rhinitis (AR) patients and eosinophil cell line (Eol-1 cells) was up-regulated by VIP treatment. This was functional and resulted in exaggerated migratory response of cells against PGD2. Nasal challenge of AR patients resulted in a significant increase of VIP contents in nasal secretion (ELISA), and the immunohistochemical studies of allergic nasal tissues showed significant expression of VIP in association with intense eosinophil recruitment. Biochemical assays showed that VIP-induced eosinophil chemotaxis from AR patients and Eol-1 cells was mediated through the CRTH2 receptor. Cell migration against VIP was sensitive to protein kinase C (PKC) and protein kinase A (PKA) inhibition but not to tyrosine kinase or p38 MAPK inhibition or calcium chelation. Western blot demonstrated a novel CRTH2-mediated cytosol-to-membrane translocation of PKC-ε, PKC-δ, and PKA-α, -γ, and -IIαreg in Eol-1 cells upon stimulation with VIP. Confocal images and FACS demonstrated a strong association and co-localization between VIP peptide and CRTH2 molecules. Further, VIP induced PGD2 secretion from eosinophils. Our results demonstrate the first evidence of association between VIP and CRTH2 in recruiting eosinophils.
    MeSH term(s) Amino Acid Sequence ; Base Sequence ; DNA Primers ; Enzyme-Linked Immunosorbent Assay ; Eosinophilia/metabolism ; Eosinophilia/pathology ; Eosinophils/cytology ; Flow Cytometry ; Humans ; Hypersensitivity/metabolism ; Hypersensitivity/pathology ; Immunohistochemistry ; Molecular Sequence Data ; Receptors, Immunologic/metabolism ; Receptors, Prostaglandin/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Trachea/metabolism ; Trachea/pathology ; Vasoactive Intestinal Peptide/chemistry ; Vasoactive Intestinal Peptide/metabolism
    Chemical Substances DNA Primers ; Receptors, Immunologic ; Receptors, Prostaglandin ; Vasoactive Intestinal Peptide (37221-79-7) ; prostaglandin D2 receptor (XZF106QU24)
    Language English
    Publishing date 2012-11-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M112.422675
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  10. Article: Endoscopic endonasal skull base surgery during the COVID-19 pandemic: A developing country perspective.

    Soliman, Mohamed A R / Elbaroody, Mohammad / Elsamman, Amr K / Refaat, Mohamed Ibrahim / Abd-Haleem, Ehab / Elhalaby, Walid / Gouda, Hazem / Safwat, Amr / Shazly, Mohamed El / Lasheen, Hisham / Younes, AbdelRahman / El-Hemily, Yousry / Elsaid, Ahmed / Kandel, Haitham / Lotfy, Mohamed / Refaee, Ehab El

    Surgical neurology international

    2020  Volume 11, Page(s) 310

    Abstract: Background: Although primarily a respiratory disorder, the coronavirus pandemic has paralyzed almost all aspects of health-care delivery. Emergency procedures are likely continuing in most countries, however, some of them raises certain concerns to the ... ...

    Abstract Background: Although primarily a respiratory disorder, the coronavirus pandemic has paralyzed almost all aspects of health-care delivery. Emergency procedures are likely continuing in most countries, however, some of them raises certain concerns to the surgeons such as the endoscopic endonasal skull base surgeries. The aim of this study is to present the current situation from a developing country perspective in dealing with such cases at the time of the COVID-19 pandemic.
    Methods: A cross-sectional analytical survey was distributed among neurosurgeons who performed emergency surgeries during the COVID-19 pandemic in Cairo, Egypt, between May 8, 2020, and June 7, 2020. The survey entailed patients' information (demographics, preoperative screening, and postoperative COVID-19 symptoms), surgical team information (demographics and postoperative COVID-19 symptoms), and operative information (personal protective equipment [PPE] utilization and basal craniectomy).
    Results: Our survey was completed on June 7, 2020 (16 completed, 100% response rate). The patients were screened for COVID-19 preoperatively through complete blood cell (CBC) (100%), computed tomography (CT) chest (68.8%), chest examination (50%), C-reactive protein (CRP) (50%), and serological testing (6.3%). Only 18.8% of the surgical team utilized N95 mask and goggles, 12.5% utilized face shield, and none used PAPRs. Regarding the basal craniectomy, 81.3% used Kerrison Rongeur and chisel, 25% used a high-speed drill, and 6.3% used a mucosal shaver. None of the patients developed any COVID-19 symptoms during the first 3 weeks postsurgery and one of the surgeons developed high fever with negative nasopharyngeal swabs.
    Conclusion: In developing countries with limited resources, preoperative screening using chest examination, CBC, and CT chest might be sufficient to replace Reverse transcription polymerase chain reaction. Developing countries require adequate support with screening tests, PPE, and critical care equipment such as ventilators.
    Keywords covid19
    Language English
    Publishing date 2020-09-25
    Publishing country United States
    Document type Journal Article
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.25259/SNI_547_2020
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