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Article: Comparison of pharmacokinetic profiles of seven major bioactive components in normal and non-alcoholic fatty liver disease (NAFLD) rats after oral administration of Ling-Gui-Zhu-Gan decoction by UPLC-MS/MS.

Nie, Wenlong / Yang, Yang / Li, Ling / Ding, Yue / Chen, Xingmi / Li, Ming / He, Ning / Ji, Guang / Zhang, Yong / Kang, Ping / Zhang, Tong

Frontiers in pharmacology

2023 Volume 14, Page(s) 1174742

Abstract: ... in the plasma of rats after the oral administration of Ling-Gui-Zhu-Gan decoction (LGZGD). Besides, this very ...

Abstract	A sensitive and rapid ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was hereby developed for the determination of seven components, namely, glycyrrhizic acid, glycyrrhetinic acid, dehydrotumulosic acid, isoliquiritin, liquiritin, atractylenolide III, and cinnamic acid, in the plasma of rats after the oral administration of Ling-Gui-Zhu-Gan decoction (LGZGD). Besides, this very method was methodologically validated for specificity, linearity, inter-day and intra-day precision, accuracy, matrix effect, extraction recovery, and stability. It was also successfully used for the first time to compare the pharmacokinetic characteristics of the seven components after oral administration of LGZGD to normal rats and non-alcoholic fatty liver disease (NAFLD) rats. The results indicated significant differences between the pharmacokinetic characteristics of normal and NAFLD rats. To further reveal the different pharmacokinetic behaviors, the expressions of enzymes and transporters in the liver of normal and NAFLD rats were detected using UPLC-MS/MS. In the NAFLD rats, UDP-glucuronosyltransferase 1-1 (UGT1A1) and nine transporters were significantly inhibited and a positive correlation was observed between them and the AUC of the major components. The present results indicate that the pharmacokinetic differences between the normal and NAFLD rats might be attributed to the significant lower expression levels of both the metabolic enzyme UGT1A1 and nine transporter proteins in the NAFLD rats than in the normal rats. Meanwhile, UGT1A1 and the nine transporter proteins might be used as potential biomarkers to assess the ameliorative effect of LGZGD on NAFLD, which could provide useful information to guide the clinical application of LGZGD.
Language	English
Publishing date	2023-05-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1174742
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Metabolomics and Network Pharmacology-Based Investigation into the Mechanisms Underlying the Therapeutic Effect of a New Chinese Traditional Medicine (Cui Nai Ling) on Bromocriptine-Induced Hypogalactia.

Meng, Xianglong / Lyu, Chenzi / Ma, Junnan / Zhang, Xiaoyan / Hu, Cong / Su, Xiaojuan / Ning, Chenxu / Xie, Wenbin / Zhang, Shuosheng

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 8857449

Abstract: As a traditional veterinary medicine to promote lactation, Cui Nai Ling (CNL) can not only increase ...

Abstract	As a traditional veterinary medicine to promote lactation, Cui Nai Ling (CNL) can not only increase milk supply and promote health but also improve the overall physiological function and immunity of the animals. In order to further improve CNL's effect on lactation, we have previously made a new CNL (NCNL) by adding Tetrapanacis Medulla and replacing Vaccariae Semen with fried Vaccariae Semen in CNL. We have demonstrated that the lactation-promoting effect of NCNL is better than that of CNL. However, the underlying mechanisms by which NCNL promotes lactation are unclear. In this study, we performed metabolomics, network pharmacology, and pharmacodynamic studies to explore the underlying mechanisms by which NCNL promotes lactation in rats with bromocriptine-induced hypogalactia. The results showed that NCNL significantly improved the loss of appetite in female adult rats and the weight loss of pups caused by the disorder of lactation. Biochemical analysis showed that NCNL could regulate the levels of PRL, T4, E2, Ca, UREA, GLU, ALT, AST, TCHO, and TG in serum. The pathological results showed that NCNL could promote lactation and increase the mammary gland index by improving breast acinar tissue morphology in rats with hypogalactia. Network pharmacology studies showed that NCNL promotes lactation through P13K-Akt, insulin resistance, and prolactin signaling pathways, among which the most frequently affected pathway was the P13K-Akt signaling pathway. Metabolomics studies showed that NCNL can significantly upregulate phenylalanine, tyrosine, and tryptophan biosynthesis and tyrosine metabolism pathways and downregulate cysteine and methionine metabolism pathways. NCNL can significantly increase the serum prolactin concentration, improve the glucose and lipid metabolism disorders, and regulate PI3K-Akt, insulin resistance, and prolactin pathways to affect the amino acids' metabolism in the mammary gland and ultimately exert its therapeutic effect on bromocriptine-induced postpartum hypogalactia. These findings revealed the effect and application value of NCNL on animals with postpartum hypogalactia.
Language	English
Publishing date	2021-06-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/8857449
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Article ; Online: Systems Pharmacology and Microbiome Dissection of Shen Ling Bai Zhu San Reveal Multiscale Treatment Strategy for IBD.

Lv, Wei-Jie / Liu, Cui / Li, Yue-Fei / Chen, Wen-Qian / Li, Zeng-Quan / Li, Yue / Xiong, Ying / Chao, Li-Min / Xu, Xiao-Long / Guo, Shi-Ning

Oxidative medicine and cellular longevity

2019 Volume 2019, Page(s) 8194804

Abstract: ... gut microbiota. Therefore, IBD therapy should be improved to utilize multiple strategies. Shen Ling ...

Abstract	Generally, inflammatory bowel disease (IBD) can be caused by psychology, genes, environment, and gut microbiota. Therefore, IBD therapy should be improved to utilize multiple strategies. Shen Ling Bai Zhu San (SLBZS) adheres to the aim of combating complex diseases from an integrative and holistic perspective, which is effective for IBD therapy. Herein, a systems pharmacology and microbiota approach was developed for these molecular mechanisms exemplified by SLBZS. First, by systematic absorption-distribution-metabolism-excretion (ADME) analysis, potential active compounds and their corresponding direct targets were retrieved. Then, the network relationships among the active compounds, targets, and disease were built to deduce the pharmacological actions of the drug. Finally, an "IBD pathway" consisting of several regulatory modules was proposed to dissect the therapeutic effects of SLBZS. In addition, the effects of SLBZS on gut microbiota were evaluated through analysis of the V3-V4 region and multivariate statistical methods. SLBZS significantly shifted the gut microbiota structure in a rat model. Taken together, we found that SLBZS has multidimensionality in the regulation of IBD-related physiological processes, which provides new sights into herbal medicine for the treatment of IBD.
MeSH term(s)	Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Microbiota
Chemical Substances	Drugs, Chinese Herbal ; shen ling bai zhu
Language	English
Publishing date	2019-06-23
Publishing country	United States
Document type	Journal Article
ISSN	1942-0994
ISSN (online)	1942-0994
DOI	10.1155/2019/8194804
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Article ; Online: Clinical Evidence and Potential Mechanisms of Complementary Treatment of Ling Gui Zhu Gan Formula for the Management of Serum Lipids and Obesity

Jiashuai Huang / Linjing Zhao / Jijia Sun / Lixin Wang / Jianrong Gu / Xijian Liu / Mengwen Yang / Yuting Wang / Ning Zhang / Jiamin Zhu / Shanshan Xu / Xinfeng Ren / Ying Su

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Objective. This study aims to evaluate the clinical effects of Ling Gui Zhu Gan formula (LGZG ...

Abstract	Objective. This study aims to evaluate the clinical effects of Ling Gui Zhu Gan formula (LGZG), a famous TCM formula, for the management of serum lipids and obesity and preliminarily elucidates the bioactive components and the potential mechanism. Methods. Cluster analysis was adopted to investigate the TCM herbs and their frequency of occurrence for treating hyperlipidemia and obesity in an academic experience database of Chinese famous TCM doctors (http://www.gjmlzy.com:83). Then, relevant randomized controlled trials (RCTs) about LGZG supplementation in improving lipid levels and obesity were retrieved and analyzed. Lastly, the integration of network pharmacology, as well as greedy algorithms, which are theoretically well founded for the set cover in computer science, was exploited to identify the bioactive components of LGZG and to reveal potential mechanisms for attenuation or reversal of hyperlipidemia and obesity. Results. Based on the cluster analysis of 104 cases in TCM academic experience database, four TCM herbs in LGZG showed high-use frequency for treating hyperlipidemia and obesity. Meta-analysis on 19 randomized controlled trials (RCTs) with 1716 participants indicated that LGZG supplementation significantly decreased the serum levels of total triglycerides, total cholesterol, low-density lipoprotein cholesterol, BMI, and body weight and increased high-density lipoprotein cholesterol, compared with clinical control groups. No serious adverse effect was detected in all studies. Twenty-one bioactive components of LGZG, mainly flavonoids (i.e., naringenin, kaempferol, and kumatakenin), saponins (i.e., hederagenin), and fatty acids (i.e., eicosenoic acid), had the potential benefits possibly by regulating multiple targets such as PTPN1, CYP19A1, and ESR2, as well as a few complex pathways including the TNF signaling pathway, PPAR signaling pathway, arachidonic acid metabolism, fat digestion, and absorption. Conclusion. The present study has proved the clinical value of LGZG as a complementary ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Metabolomics and Network Pharmacology-Based Investigation into the Mechanisms Underlying the Therapeutic Effect of a New Chinese Traditional Medicine (Cui Nai Ling) on Bromocriptine-Induced Hypogalactia

Xianglong Meng / Chenzi Lyu / Junnan Ma / Xiaoyan Zhang / Cong Hu / Xiaojuan Su / Chenxu Ning / Wenbin Xie / Shuosheng Zhang

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: As a traditional veterinary medicine to promote lactation, Cui Nai Ling (CNL) can not only increase ...

Abstract	As a traditional veterinary medicine to promote lactation, Cui Nai Ling (CNL) can not only increase milk supply and promote health but also improve the overall physiological function and immunity of the animals. In order to further improve CNL’s effect on lactation, we have previously made a new CNL (NCNL) by adding Tetrapanacis Medulla and replacing Vaccariae Semen with fried Vaccariae Semen in CNL. We have demonstrated that the lactation-promoting effect of NCNL is better than that of CNL. However, the underlying mechanisms by which NCNL promotes lactation are unclear. In this study, we performed metabolomics, network pharmacology, and pharmacodynamic studies to explore the underlying mechanisms by which NCNL promotes lactation in rats with bromocriptine-induced hypogalactia. The results showed that NCNL significantly improved the loss of appetite in female adult rats and the weight loss of pups caused by the disorder of lactation. Biochemical analysis showed that NCNL could regulate the levels of PRL, T4, E2, Ca, UREA, GLU, ALT, AST, TCHO, and TG in serum. The pathological results showed that NCNL could promote lactation and increase the mammary gland index by improving breast acinar tissue morphology in rats with hypogalactia. Network pharmacology studies showed that NCNL promotes lactation through P13K-Akt, insulin resistance, and prolactin signaling pathways, among which the most frequently affected pathway was the P13K-Akt signaling pathway. Metabolomics studies showed that NCNL can significantly upregulate phenylalanine, tyrosine, and tryptophan biosynthesis and tyrosine metabolism pathways and downregulate cysteine and methionine metabolism pathways. NCNL can significantly increase the serum prolactin concentration, improve the glucose and lipid metabolism disorders, and regulate PI3K-Akt, insulin resistance, and prolactin pathways to affect the amino acids’ metabolism in the mammary gland and ultimately exert its therapeutic effect on bromocriptine-induced postpartum hypogalactia. These findings ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	630
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ling classification describes endoscopic progressive process of achalasia and successful peroral endoscopy myotomy prevents endoscopic progression of achalasia.

Zhang, Wen-Gang / Linghu, En-Qiang / Chai, Ning-Li / Li, Hui-Kai

World journal of gastroenterology

2017 Volume 23, Issue 18, Page(s) 3309–3314

Abstract: Aim: To verify the hypothesis that the Ling classification describes the endoscopic progressive ... to 360 mo, with a median of 36 mo. Patients were classified with Ling type I (: Results: Symptom ... duration increased significantly with increasing Ling classification (from I to III) (: Conclusion ...

Abstract	Aim: To verify the hypothesis that the Ling classification describes the endoscopic progressive process of achalasia and determine the ability of successful peroral endoscopic myotomy (POEM) to prevent endoscopic progression of achalasia. Methods: We retrospectively reviewed the endoscopic findings, symptom duration, and manometric data in patients with achalasia. A total of 359 patients (197 women, 162 men) with a mean age of 42.1 years (range, 12-75 years) were evaluated. Symptom duration ranged from 2 to 360 mo, with a median of 36 mo. Patients were classified with Ling type I ( Results: Symptom duration increased significantly with increasing Ling classification (from I to III) ( Conclusion: The Ling classification represents the endoscopic progressive process of achalasia and may be able to serve as an endoscopic assessment criterion for achalasia. Successful POEM (Eckardt score ≤ 3) seems to have the ability to prevent endoscopic evolvement of achalasia. However, studies with larger populations are warranted to confirm our findings.
Language	English
Publishing date	2017-05-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v23.i18.3309
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Article: Correlation of the Structure and Bioactivity of Recombinant Fungal Immunomodulatory Protein, Ling‐Zhi‐8 (LZ‐8) Following Exposure to Denaturing Conditions

Huang, Wei‐Ning / Yang, Cheng‐Yao / Chen, Dz‐Chi / Chuang, Lu‐Te

Journal of food biochemistry. 2014 June, v. 38, no. 3

2014

Abstract: Ling‐Zhi‐8 (LZ‐8), a low‐molecular weight protein from Ganoderma lucidum, exerts immunomodulatory ...

Abstract	Ling‐Zhi‐8 (LZ‐8), a low‐molecular weight protein from Ganoderma lucidum, exerts immunomodulatory effects in vitro and in vivo. The aim of this study was to investigate the effects of exposure of LZ‐8 to denaturing conditions on its ability to suppress inflammatory responses in lipopolysaccharide (LPS)‐stimulated RAW 264.7 macrophages. Ultraviolet, fluorescence and circular dichroism spectroscopy analyses showed that LZ‐8 was not denatured by exposure to pH extremes, but was irreversibly denatured by temperatures above 55C. LZ‐8 lowered the production of nitric oxide and interleukin‐6, but had no effect on the level of tumor necrosis factor‐α. Heat and acid/alkali‐treated preparations of LZ‐8 had comparable capacity to suppress proinflammatory mediator production. Since native and denatured LZ‐8 were both anti‐inflammatory, it appears that this particular biological property of LZ‐8 is not dependent on the native structure of the protein, but, possibly on a relatively small peptide domain of LZ‐8. PRACTICAL APPLICATIONS: Recent evidence suggests that LZ‐8, a small protein originally isolated from G. lucidum, has immunomodulatory and anti‐carcinogenic properties. In this study, LZ‐8 exerted an anti‐inflammatory effect on LPS‐stimulated macrophages, but this effect was not dependent on the native protein structure, suggesting that the entire protein might not be responsible for the bioactive properties of LZ‐8. Since the biological functions of LZ‐8 were resistant to heating and exposure to acid or alkali, LZ‐8 could have applications in food‐processing industries and the production of pharmaceuticals. Furthermore, peptides derived from LZ‐8 may be potential targets for development of novel anti‐carcinogenic and immunomodulatory agents.
Keywords	Ganoderma lucidum ; bioactive properties ; circular dichroism spectroscopy ; drugs ; fluorescence ; fungal proteins ; heat ; heat treatment ; inflammation ; macrophages ; nitric oxide ; pH ; peptides ; protein structure ; recombinant proteins ; temperature ; tumor necrosis factor-alpha
Language	English
Dates of publication	2014-06
Size	p. 328-336.
Publishing place	Blackwell Pub
Document type	Article
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.12057
Database	NAL-Catalogue (AGRICOLA)

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Article: [Review on clinical application of needling techniques in chapter Guan Zhen (Official Needling Techniques) of Ling Shu (Spiritual Pivot)].

Kim, Leo-Wi / Guo, Nan-Nan / Ma, Liang-Xiao / Yang, Huan / Liu, Wan-Ning / Zhu, Jiang

Zhen ci yan jiu = Acupuncture research

2007 Volume 32, Issue 5, Page(s) 351–354

Abstract: ... Official Needling Techniques) of Ling Shu (Spiritual Pivot) were found through retrieving the data ...

Abstract	In the present paper, more than 380 theses related with clinical application of "nine needling techniques", "twelve needling techniques" and "five needling techniques" recorded in chapter Guan Zhen (Official Needling Techniques) of Ling Shu (Spiritual Pivot) were found through retrieving the data in the internet in latest 10 years. Among the 130 theses about clinical application of "nine needling techniques", 108 involve the application of opposing needling. Of the 180 theses about clinical application of "twelve needling techniques", 95 involve the application of triple needling. Out of the 60 theses on clinical application of "five needling techniques", 37 involve the application of Hegu needling (multi-direction needling). To sum up, the above-mentioned needling techniques were mainly applied to the treatment of diseases of dermatology, surgery, pediatrics, traumatology, five sense organs, etc.. It indicates that these needling techniques are widely being used in clinical practice now. Therefore, researchers should lay the stress on the scientific methodology, rigorous research process, as well as objective analysis of the results so as to make an objective conclusion and improve the level of the research.
MeSH term(s)	Acupuncture Therapy/methods ; Humans ; Medicine, Chinese Traditional
Language	Chinese
Publishing date	2007-10
Publishing country	China
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1283179-7
ISSN	1000-0607
ISSN	1000-0607
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Article ; Online: Ticagrelor monotherapy after a short course of dual antiplatelet therapy with ticagrelor plus aspirin following percutaneous coronary intervention in patients with versus without diabetes mellitus: a meta-analysis of randomized trials.

Ning, Chen / Ling, Fang / Liu, Deyi / Zhi, Zhang

BMC cardiovascular disorders

2024 Volume 24, Issue 1, Page(s) 166

Abstract: Background: Cardiovascular disease (CVD) is one among the major causes of mortality all round the globe. Several anti-platelet regimens have been proposed following percutaneous coronary intervention (PCI). In this analysis, we aimed to show the adverse ...

Abstract	Background: Cardiovascular disease (CVD) is one among the major causes of mortality all round the globe. Several anti-platelet regimens have been proposed following percutaneous coronary intervention (PCI). In this analysis, we aimed to show the adverse clinical outcomes associated with ticagrelor monotherapy after a short course of dual antiplatelet therapy (DAPT) with ticagrelor and aspirin following PCI in patients with versus without diabetes mellitus (DM). Methods: Electronic databases were searched by four authors from September to November 2023. Cardiovascular outcomes and bleeding events were the endpoints of this analysis. Revman 5.4 software was used to conduct this meta-analysis. Risk ratio (RR) and 95% confidence intervals (CI) were used to represent the results which were generated. Results: Three studies with a total number of 22,574 participants enrolled from years 2013 to 2019 were included in this analysis. Results of this analysis showed that DM was associated with significantly higher risks of major adverse cardiovascular events (RR: 1.73, 95% CI: 1.49 - 2.00; P = 0.00001), all-cause mortality (RR: 2.15, 95% CI: 1.73 - 2.66; P = 0.00001), cardiac death (RR: 2.82, 95% CI: 1.42 - 5.60; P = 0.003), stroke (RR: 1.78, 95% CI: 1.16 - 2.74; P = 0.009), myocardial infarction (RR: 1.63, 95% CI: 1.17 - 2.26; P = 0.004) and stent thrombosis (RR: 1.74, 95% CI: 1.03 - 2.94; P = 0.04) when compared to patients without DM. However, thrombolysis in myocardial infarction (TIMI) defined minor and major bleedings, bleeding defined according to the academic research consortium (BARC) type 3c (RR: 1.31, 95% CI: 0.14 - 11.90; P = 0.81) and BARC type 2, 3 or 5 (RR: 1.17, 95% CI: 0.85 - 1.62; P = 0.34) were not significantly different. Conclusion: In patients who were treated with ticagrelor monotherapy after a short course of DAPT with ticagrelor and aspirin, DM was an independent risk factor for the significantly increased adverse cardiovascular outcomes. However, TIMI and BARC defined bleeding events were not significantly different in patients with versus without DM.
MeSH term(s)	Humans ; Ticagrelor ; Aspirin/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Randomized Controlled Trials as Topic ; Myocardial Infarction ; Hemorrhage/chemically induced ; Diabetes Mellitus/drug therapy ; Treatment Outcome
Chemical Substances	Ticagrelor (GLH0314RVC) ; Aspirin (R16CO5Y76E) ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-024-03836-9
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Article ; Online: Assemblages of rhizospheric and root endospheric mycobiota and their ecological associations with functional traits of rice.

Guo, Junjie / Ning, Huiling / Li, Yong / Xu, Qicheng / Shen, Qirong / Ling, Ning / Guo, Shiwei

mBio

2024 Volume 15, Issue 3, Page(s) e0273323

Abstract: The soil-root interface harbors complex fungal communities that play vital roles in the fitness of host plants. However, little is known about the assembly rules and potential functions of rhizospheric and endospheric mycobiota. A greenhouse experiment ... ...

Abstract	The soil-root interface harbors complex fungal communities that play vital roles in the fitness of host plants. However, little is known about the assembly rules and potential functions of rhizospheric and endospheric mycobiota. A greenhouse experiment was conducted to explore the fungal communities inhabiting the rhizosphere and roots of 87 rice cultivars at the tillering stage via amplicon sequencing of the fungal internal transcribed spacer 1 region. The potential relationships between these communities and host plant functional traits were also investigated using Procrustes analysis, generalized additive model fitting, and correlation analysis. The fungal microbiota exhibited greater richness, higher diversity, and lower structural variability in the rhizosphere than in the root endosphere. Compared with the root endosphere, the rhizosphere supported a larger coabundance network, with greater connectivity and stronger cohesion. Null model-based analyses revealed that dispersal limitation was primarily responsible for rhizosphere fungal community assembly, while ecological drift was the dominant process in the root endosphere. The community composition of fungi in the rhizosphere was shown to be more related to plant functional traits, such as the root/whole plant biomass, root:shoot biomass ratio, root/shoot nitrogen (N) content, and root/shoot/whole plant N accumulation, than to that in the root endosphere. Overall, at the early stage of rice growth, diverse and complex rhizospheric fungal communities are shaped by stochastic-based processes and exhibit stronger associations with plant functional traits. Importance: The assembly processes and functions of root-associated mycobiota are among the most fascinating yet elusive topics in microbial ecology. Our results revealed that stochastic forces (dispersal limitation or ecological drift) act on fungal community assembly in both the rice rhizosphere and root endosphere at the early stage of plant growth. In addition, high covariations between the rhizosphere fungal community compositions and plant functional trait profiles were clearly demonstrated in the present study. This work provides empirical evidence of the root-associated fungal assembly principles and ecological relationships of plant functional traits with rhizospheric and root endospheric mycobiota, thereby potentially providing novel perspectives for enhancing plant performance.
MeSH term(s)	Oryza ; Microbiota ; Bacteria ; Fungi ; Plant Roots/microbiology ; Soil Microbiology ; Rhizosphere ; Soil/chemistry
Chemical Substances	Soil
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.02733-23
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