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Article: In search of COVID-19 transmission through an infected prey.

Natiq, Hayder / Saha, Asit

The European physical journal. Special topics

2022 , Page(s) 1–8

Abstract: This paper considers a nonlinear dynamical model of an ecosystem, which has been established through combining the classical Lotka-Volterra model with the classic SIR model. This nonlinear system consists of a generalist predator that subsists on two ... ...

Abstract	This paper considers a nonlinear dynamical model of an ecosystem, which has been established through combining the classical Lotka-Volterra model with the classic SIR model. This nonlinear system consists of a generalist predator that subsists on two prey species in which disease is becoming endemic in one of them. The dynamical analysis methods prove that the system has a chaotic attractor and extreme multistability behavior, where there are infinitely many attractors that coexist under certain conditions. The occurrence of extreme multistability demonstrates the high sensitivity of the system for the initial conditions, which means that tiny changes in the original prey species could enlarge and be widespread, and that could confirm through studying the complexity of the time series of the system's variables. Simulation results of the sample entropy algorithm show that the changes in the system's variables expand over time. It is reasonable now to consider the endemic in the prey species of the system could evolve to be pandemic such as COVID-19. Consequently, our results could provide a foresight about the unpredictability of the COVID-19 outbreak in its original host species as well as after the transmission to other species such as humans.
Language	English
Publishing date	2022-03-16
Publishing country	France
Document type	Journal Article
ZDB-ID	2267176-6
ISSN	1951-6401 ; 1951-6355
ISSN (online)	1951-6401
ISSN	1951-6355
DOI	10.1140/epjs/s11734-022-00429-5
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Article ; Online: Comment on "Homoclinic chaos in strongly dissipative strongly coupled complex dusty plasmas".

Saha, Asit / Banerjee, Santo

Physical review. E

2021 Volume 104, Issue 1-2, Page(s) 17201

Abstract: In a recent paper [S. Ghosh, Phys. Rev. E 103, 023205 (2021)2470-004510.1103/PhysRevE.103.023205], the transport properties of the two-dimensional weakly nonlinear quasilongitudinal dust lattice mode were investigated in a highly viscous, strongly ... ...

Abstract	In a recent paper [S. Ghosh, Phys. Rev. E 103, 023205 (2021)2470-004510.1103/PhysRevE.103.023205], the transport properties of the two-dimensional weakly nonlinear quasilongitudinal dust lattice mode were investigated in a highly viscous, strongly coupled, and weakly ionized plasma. Based on the computational results, the author predicted strong viscosity induced Shilnikov homoclinic chaos. In this Comment, it is shown that the dynamical system presented in the paper is inconsistent and incorrect because of an error in the expression of ε. As a result, period-2, period-4, chaotic and homoclinic chaotic phenomena do not exist, which were observed in the paper.
Language	English
Publishing date	2021-08-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.104.017201
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Article ; Online: Novel coronavirus SARS-CoV-2 (Covid-19) dynamics inside the human body.

Saha, Asit / Saha, Barsha

Reviews in medical virology

2020 Volume 30, Issue 5, Page(s) e2140

Abstract: A knowledge-based cybernetic framework model representing the dynamics of SARS-CoV-2 inside the human body has been studied analytically and in silico to explore the pathophysiologic regulations. The following modeling methodology was developed as a ... ...

Abstract	A knowledge-based cybernetic framework model representing the dynamics of SARS-CoV-2 inside the human body has been studied analytically and in silico to explore the pathophysiologic regulations. The following modeling methodology was developed as a platform to introduce a predictive tool supporting a therapeutic approach to Covid-19 disease. A time-dependent nonlinear system of ordinary differential equations model was constructed involving type-I cells, type-II cells, SARS-CoV-2 virus, inflammatory mediators, interleukins along with host pulmonary gas exchange rate, thermostat control, and mean pressure difference. This formalism introduced about 17 unknown parameters. Estimating these unknown parameters requires a mathematical association with the in vivo sparse data and the dynamic sensitivities of the model. The cybernetic model can simulate a dynamic response to the reduced pulmonary alveolar gas exchange rate, thermostat control, and mean pressure difference under a very critical condition based on equilibrium (steady state) values of the inflammatory mediators and system parameters. In silico analysis of the current cybernetical approach with system dynamical modeling can provide an intellectual framework to help experimentalists identify more active therapeutic approaches.
MeSH term(s)	Acute-Phase Proteins/antagonists & inhibitors ; Acute-Phase Proteins/genetics ; Acute-Phase Proteins/immunology ; Angiotensin-Converting Enzyme 2 ; Anti-Inflammatory Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/growth & development ; Betacoronavirus/pathogenicity ; Body Temperature ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Cytokines/antagonists & inhibitors ; Cytokines/genetics ; Cytokines/immunology ; Epithelial Cells/drug effects ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Gene Expression Regulation ; Host-Pathogen Interactions/drug effects ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Lung/drug effects ; Lung/immunology ; Lung/virology ; Macrophages, Alveolar/drug effects ; Macrophages, Alveolar/immunology ; Macrophages, Alveolar/virology ; Nonlinear Dynamics ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/immunology ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Pulmonary Gas Exchange/drug effects ; Pulmonary Gas Exchange/immunology ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology
Chemical Substances	Acute-Phase Proteins ; Anti-Inflammatory Agents ; Antiviral Agents ; Cytokines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-07-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1086043-5
ISSN	1099-1654 ; 1052-9276
ISSN (online)	1099-1654
ISSN	1052-9276
DOI	10.1002/rmv.2140
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Article ; Online: Comparison of traditional and upper thoracic epidural analgesia after off-pump coronary artery bypass graft surgery: A Quasi-experimental study.

Saha, Sanjoy Kumar / Ranjan, Redoy / Adhikary, Asit Baran

Health science reports

2022 Volume 5, Issue 5, Page(s) e774

Abstract: Background and aims: Surgical trauma initiates changes in central and peripheral nervous systems that need to be treated therapeutically to facilitate postoperative pain. The quality of postoperative analgesia is expected to affect clinical outcomes ... ...

Abstract	Background and aims: Surgical trauma initiates changes in central and peripheral nervous systems that need to be treated therapeutically to facilitate postoperative pain. The quality of postoperative analgesia is expected to affect clinical outcomes positively. Albeit optimal pain relief following cardiac surgery is often complex, researchers have tried to explore several techniques other than conventional ones during the last decade to find a unique analgesic method for postcardiac surgical patients. This study aims to find a unique analgesic approach that maximizes patient satisfaction after off-pump coronary artery bypass graft (OPCABG) surgery. Methods: The current study will compare the analgesic effect of upper thoracic epidural analgesia (TEA) with conventional analgesia after OPCAB graft surgery. For this, we will use a Quasi-experimental study design. Patients admitted for coronary artery bypass graft (CABG) surgery will be assigned into two groups. The control group (conventional) will receive intravenous opioids and nonsteroidal anti-inflammatory medications, and the study (case) group (TEA) will receive Inj. Bupivacaine 0.25% as an infusion through the epidural catheter. Physiologic parameters like hemodynamic and respiratory variables and pain scores will be recorded in predesigned format periodically. Results: We expect to analyze a total of 130 consecutive off-pump CABG surgery patients in Group A (Case, 65 patients) and Group B (Control, 65 patients). Study variables will be the visual analog scale score, hemodynamic parameters (heart rate, mean arterial pressure, and respiratory parameters (respiratory rate, PaO Conclusion: We expect thoracic epidural analgesia with local anesthetics will be a reliable postoperative analgesic option.
Language	English
Publishing date	2022-08-10
Publishing country	United States
Document type	Journal Article
ISSN	2398-8835
ISSN (online)	2398-8835
DOI	10.1002/hsr2.774
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Article ; Online: Comparison of traditional and upper thoracic epidural analgesia after off‐pump coronary artery bypass graft surgery

Sanjoy Kumar Saha / Redoy Ranjan / Asit Baran Adhikary

Health Science Reports, Vol 5, Iss 5, Pp n/a-n/a (2022)

A Quasi‐experimental study

2022

Abstract: Abstract Background and Aims Surgical trauma initiates changes in central and peripheral nervous systems that need to be treated therapeutically to facilitate postoperative pain. The quality of postoperative analgesia is expected to affect clinical ... ...

Abstract	Abstract Background and Aims Surgical trauma initiates changes in central and peripheral nervous systems that need to be treated therapeutically to facilitate postoperative pain. The quality of postoperative analgesia is expected to affect clinical outcomes positively. Albeit optimal pain relief following cardiac surgery is often complex, researchers have tried to explore several techniques other than conventional ones during the last decade to find a unique analgesic method for postcardiac surgical patients. This study aims to find a unique analgesic approach that maximizes patient satisfaction after off‐pump coronary artery bypass graft (OPCABG) surgery. Methods The current study will compare the analgesic effect of upper thoracic epidural analgesia (TEA) with conventional analgesia after OPCAB graft surgery. For this, we will use a Quasi‐experimental study design. Patients admitted for coronary artery bypass graft (CABG) surgery will be assigned into two groups. The control group (conventional) will receive intravenous opioids and nonsteroidal anti‐inflammatory medications, and the study (case) group (TEA) will receive Inj. Bupivacaine 0.25% as an infusion through the epidural catheter. Physiologic parameters like hemodynamic and respiratory variables and pain scores will be recorded in predesigned format periodically. Results We expect to analyze a total of 130 consecutive off‐pump CABG surgery patients in Group A (Case, 65 patients) and Group B (Control, 65 patients). Study variables will be the visual analog scale score, hemodynamic parameters (heart rate, mean arterial pressure, and respiratory parameters (respiratory rate, PaO2, PaCO2, PEFR, FEV1). After data collection, the result will be analyzed and published in the public domain and in journals. Conclusion We expect thoracic epidural analgesia with local anesthetics will be a reliable postoperative analgesic option.
Keywords	conventional analgesia ; off‐pump coronary artery bypass graft ; pain ; thoracic epidural analgesia ; VAS ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: Novel coronavirus SARS‐CoV ‐2 (Covid‐19) dynamics inside the human body

Saha, Asit / Saha, Barsha

Reviews in Medical Virology

2020 Volume 30, Issue 5

Keywords	Virology ; Infectious Diseases ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	1086043-5
ISSN	1099-1654 ; 1052-9276
ISSN (online)	1099-1654
ISSN	1052-9276
DOI	10.1002/rmv.2140
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Article ; Online: Domino synthesis of functionalized pyridine carboxylates under gallium catalysis: Unravelling the reaction pathway and the role of the nitrogen source counter anion.

Kumar, Dinesh / Sharma, Himanshu / Saha, Nirjhar / Chakraborti, Asit K

Chemistry, an Asian journal

2022 Volume 17, Issue 15, Page(s) e202200304

Abstract: The catalytic potential of various metal Lewis acid catalysts have been assessed to derive a high-yielding, multi-component domino synthesis of functionalized pyridines from (E)-3-(dimethylamino)-1-aryl/heteroaryl-prop-2-en-1-ones, 1,3-dicarbonyl ... ...

Abstract	The catalytic potential of various metal Lewis acid catalysts have been assessed to derive a high-yielding, multi-component domino synthesis of functionalized pyridines from (E)-3-(dimethylamino)-1-aryl/heteroaryl-prop-2-en-1-ones, 1,3-dicarbonyl compounds, and an ammonium salt (as the nitrogen precursor). Amongst the various metal halides, tetrafluoroborates, perchlorates, and triflates used as the catalyst, GaI
MeSH term(s)	Ammonium Compounds ; Anions ; Catalysis ; Gallium ; Nitrogen ; Pyridines
Chemical Substances	Ammonium Compounds ; Anions ; Pyridines ; Gallium (CH46OC8YV4) ; Nitrogen (N762921K75)
Language	English
Publishing date	2022-06-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2233006-9
ISSN	1861-471X ; 1861-4728
ISSN (online)	1861-471X
ISSN	1861-4728
DOI	10.1002/asia.202200304
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Article: Assessment of knowledge about malaria and LLIN ownership and its use in Bankura, West Bengal, India.

Dey, Arpita / Biswas, Asit Kumar / Jana, Kingsuk / Maji, Ardhendu Kumar / Saha, Pabitra

Journal of vector borne diseases

2023 Volume 60, Issue 2, Page(s) 142–153

Abstract: Background & objectives: Community participation is one of the key factors for implementation and success of a public health programme which depends upon knowledge about that disease. Therefore, understanding the community knowledge about malaria is ... ...

Abstract	Background & objectives: Community participation is one of the key factors for implementation and success of a public health programme which depends upon knowledge about that disease. Therefore, understanding the community knowledge about malaria is important for designing sustainable control programmes. This study was conducted to assess the knowledge about malaria, to evaluate long lasting insecticidal nets (LLINs) distribution and their use by LQAS method in endemic areas of Bankura district, West Bengal state, India Methods: It was a community based cross-sectional survey conducted in Bankura during December 2019-March 2020. Structured questionnaire under four categories: socio-demographic variables, knowledge of malaria, owner ship of LLINs and its use were used for the interview. Ownership of LLINs and its use were analysed by LQAS method. Data were analysed by binary logistic regression model and chi-squared test. Results: Out of 456 respondents, 88.59% had good knowledge, 97.37% had good ownership of LLIN and 78.95% used LLINs properly. The knowledge about malaria was significantly associated with education level (p-value<0.0001). Out of 24 lots studied, 3, 2, 4 lots were underperforming with respect to knowledge, ownership of LLIN and its use, respectively. Interpretation & conclusion: The study population had a good knowledge about malaria. In spite of good coverage of LLIN distribution, the use of LLINs was not up to the mark. LQAS analysis showed underperformance in few lots about knowledge, ownership of LLIN and its use. The IEC and BCC activities about LLIN should be done to achieve the impact of this intervention at the community level.
MeSH term(s)	Humans ; Ownership ; Cross-Sectional Studies ; Insecticide-Treated Bednets ; Mosquito Control/methods ; Malaria/epidemiology ; Malaria/prevention & control ; India/epidemiology ; Insecticides
Chemical Substances	Insecticides
Language	English
Publishing date	2023-07-07
Publishing country	India
Document type	Journal Article
ZDB-ID	2161218-3
ISSN	0972-9062
ISSN	0972-9062
DOI	10.4103/0972-9062.361164
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Article ; Online: Dynamical properties of dust-ion-acoustic wave solutions in a nonextensive collisional dusty plasma

Puja Sharma / Amiya Das / Jharna Tamang / Asit Saha

Journal of Taibah University for Science, Vol 15, Iss 1, Pp 710-

2021 Volume 720

Abstract: Dynamical properties of dust-ion-acoustic waves (DIAWs) are analysed in a collisional nonextensive dusty plasma composing of mobile ions, q-nonextensive electrons and stationary dust grains with slight collisions between dusts and ions. Reductive ... ...

Abstract	Dynamical properties of dust-ion-acoustic waves (DIAWs) are analysed in a collisional nonextensive dusty plasma composing of mobile ions, q-nonextensive electrons and stationary dust grains with slight collisions between dusts and ions. Reductive perturbation technique (RPT) is practiced to acquire the damped Korteweg-de Vries (DKdV) equation. In absence of collision between dusts and ions, the damping term vanishes and the DKdV equation reduces to the KdV equation. Bifurcation analysis of the dynamical system obtained from the KdV equation is carried out. Analytical solitary wave solution and numerical periodic wave solution of the KdV equation are presented. Approximate analytical DIAW solutions for the DKdV equation are furnished using the novel $ (G'/G) $ -expansion technique. As an outcome, novel approximate analytical solutions of DIAWs are obtained for the DKdV equation. The application of our work is significant to explore nonextensive plasma environment, such as, ionosphere of Earth.
Keywords	dusty plasma ; nonextensive distribution ; $ (g'/g) $ -expansion method ; damped kdv equation ; collisional plasma ; Science (General) ; Q1-390
Subject code	518
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Novel coronavirus SARS-CoV-2 (Covid-19) dynamics inside the human body

Saha, Asit / Saha, Barsha

Rev Med Virol

Abstract	A knowledge-based cybernetic framework model representing the dynamics of SARS-CoV-2 inside the human body has been studied analytically and in silico to explore the pathophysiologic regulations. The following modeling methodology was developed as a platform to introduce a predictive tool supporting a therapeutic approach to Covid-19 disease. A time-dependent nonlinear system of ordinary differential equations model was constructed involving type-I cells, type-II cells, SARS-CoV-2 virus, inflammatory mediators, interleukins along with host pulmonary gas exchange rate, thermostat control, and mean pressure difference. This formalism introduced about 17 unknown parameters. Estimating these unknown parameters requires a mathematical association with the in vivo sparse data and the dynamic sensitivities of the model. The cybernetic model can simulate a dynamic response to the reduced pulmonary alveolar gas exchange rate, thermostat control, and mean pressure difference under a very critical condition based on equilibrium (steady state) values of the inflammatory mediators and system parameters. In silico analysis of the current cybernetical approach with system dynamical modeling can provide an intellectual framework to help experimentalists identify more active therapeutic approaches.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #848179
Database	COVID19

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