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Book: Nanoagroceuticals and nanophytochemicals

Singh, Bhupinder / Katare, Om Prakash / Souto, Eliana B.

2019

Author's details	editor-in-chief: Bhupinder Singh ; editors Om Prakash Katare, Eliana B. Souto
Language	English
Size	xx, 331 Seiten, Illustrationen, Diagramme
Publisher	CRC Press
Publishing place	Boca Raton, Fla
Publishing country	United States
Document type	Book
HBZ-ID	HT019727162
ISBN	978-0-815-38977-4 ; 9781321139281 ; 0-815-38977-9 ; 1321139284
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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Article: Molecular insights into codon usage analysis of mitochondrial fission and fusion gene: relevance to neurodegenerative diseases.

Khandia, Rekha / Pandey, Megha Katare / Garg, Rajkumar / Khan, Azmat Ali / Baklanov, Igor / Alanazi, Amer M / Nepali, Prakash / Gurjar, Pankaj / Choudhary, Om Prakash

Annals of medicine and surgery (2012)

2024 Volume 86, Issue 3, Page(s) 1416–1425

Abstract: Mitochondrial dysfunction is the leading cause of neurodegenerative disorders like Alzheimer's disease and Parkinson's disease. Mitochondria is a highly dynamic organelle continuously undergoing the process of fission and fusion for even distribution of ... ...

Abstract	Mitochondrial dysfunction is the leading cause of neurodegenerative disorders like Alzheimer's disease and Parkinson's disease. Mitochondria is a highly dynamic organelle continuously undergoing the process of fission and fusion for even distribution of components and maintaining proper shape, number, and bioenergetic functionality. A set of genes governs the process of fission and fusion.
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000001725
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Synthetic biology approach revealed enhancement in haeme oxygenase-1 gene expression by codon pair optimization while reduction by codon deoptimization.

Khandia, Rekha / Pandey, Megha Katare / Khan, Azmat Ali / Baklanov, Igor / Alanazi, Amer M / Nepali, Prakash / Gurjar, Pankaj / Choudhary, Om Prakash

Annals of medicine and surgery (2012)

2024 Volume 86, Issue 3, Page(s) 1359–1369

Abstract: Haem oxygenase-1 (HO-1) is a ubiquitously expressed gene involved in cellular homoeostasis, and its imbalance in expression results in various disorders. To alleviate such disorders, HO-1 gene expression needs to be modulated. Codon usage bias results ... ...

Abstract	Haem oxygenase-1 (HO-1) is a ubiquitously expressed gene involved in cellular homoeostasis, and its imbalance in expression results in various disorders. To alleviate such disorders, HO-1 gene expression needs to be modulated. Codon usage bias results from evolutionary forces acting on any nucleotide sequence and determines the gene expression. Like codon usage bias, codon pair bias also exists, playing a role in gene expression. In the present study, HO-1 gene was recoded by manipulating codon and codon pair bias, and four such constructs were made through codon/codon pair deoptimization and codon/codon pair optimization to reduce and enhance the HO-1 gene expression. Codon usage analysis was done for these constructs for four tissues brain, heart, pancreas and liver. Based on codon usage in different tissues, gene expression of these tissues was determined in terms of the codon adaptation index. Based on the codon adaptation index, minimum free energy, and translation efficiency, constructs were evaluated for enhanced or decreased HO-1 expression. The analysis revealed that for enhancing gene expression, codon pair optimization, while for reducing gene expression, codon deoptimization is efficacious. The recoded constructs developed in the study could be used in gene therapy regimens to cure HO-1 over or underexpression-associated disorders.
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000001465
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Article ; Online: Correction to "Heparin Encapsulated Metered-Dose Topical 'Nano-Spray Gel' Liposomal Formulation Ensures Rapid On-Site Management of Frostbite Injury by Inflammatory Cytokines Scavenging".

Vaghasiya, Kalpesh / Sharma, Ankur / Kumar, Kushal / Ray, Eupa / Adlakha, Suneera / Katare, Om Prakash / Hota, Sunil Kumar / Verma, Rahul K

ACS biomaterials science & engineering

2022 Volume 8, Issue 6, Page(s) 2724–2725

Language	English
Publishing date	2022-06-02
Publishing country	United States
Document type	Published Erratum
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.2c00397
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Article ; Online: Protamine sulphate coated poly (lactide-co-glycolide) nanoparticles of MUC-1 peptide improved cellular uptake and cytokine release in mouse antigen presenting cells.

Jyoti, Kiran / Katare, Om Prakash / Kamboj, Anjoo / Madan, Jitender

Journal of microencapsulation

2020 Volume 37, Issue 8, Page(s) 566–576

Abstract: Aim: MUC-1-peptide (M-1-pep) loaded poly (lactide-co-glycolide) nanoparticles were coated with protamine sulphate (PS), M-1-pep-PS-P-NPs for targeting antigen presenting cells (APCs) to evoke cytokine release.: Methods and results: M-1-pep-PS-P-NPs ... ...

Abstract	Aim: MUC-1-peptide (M-1-pep) loaded poly (lactide-co-glycolide) nanoparticles were coated with protamine sulphate (PS), M-1-pep-PS-P-NPs for targeting antigen presenting cells (APCs) to evoke cytokine release. Methods and results: M-1-pep-PS-P-NPs were tailored by emulsion-diffusion evaporation method and characterised Conclusion: M-1-pep-PS-P-B-NPs must be evaluated
MeSH term(s)	Animals ; Antigens/chemistry ; Clathrin/chemistry ; Cytokines/metabolism ; Diffusion ; Endocytosis ; In Vitro Techniques ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mucin-1/chemistry ; Nanoparticles/chemistry ; Neoplasm Transplantation ; Particle Size ; Phagocytosis ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; RAW 264.7 Cells ; Signal Transduction
Chemical Substances	Antigens ; Clathrin ; Cytokines ; Mucin-1 ; muc1 protein, mouse ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS)
Language	English
Publishing date	2020-09-22
Publishing country	England
Document type	Journal Article
ZDB-ID	843632-0
ISSN	1464-5246 ; 0265-2048
ISSN (online)	1464-5246
ISSN	0265-2048
DOI	10.1080/02652048.2020.1823500
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Article ; Online: Role of Novel Drug Delivery Systems in Coronavirus Disease-2019 (COVID-19): Time to Act Now.

Mittal, Neeraj / Garg, Varun / Bhadada, Sanjay Kumar / Katare, Om Prakash

Current drug delivery

2020 Volume 18, Issue 3, Page(s) 289–296

Abstract: The Coronavirus disease 2019 (COVID-19) has found its roots from Wuhan (China). COVID-19 is caused by a novel coronavirus SARS-CoV2, previously named as 2019-nCoV. It has spread across the globe and was declared as a pandemic by the World Health ... ...

Abstract	The Coronavirus disease 2019 (COVID-19) has found its roots from Wuhan (China). COVID-19 is caused by a novel coronavirus SARS-CoV2, previously named as 2019-nCoV. It has spread across the globe and was declared as a pandemic by the World Health Organization (WHO) on 11th March, 2020. Currently, there is no standard drug or vaccine available for the treatment, therefore, repurposing of existing drugs is the only solution. Novel Drug Delivery Systems (NDDS) will be boon for the repurposing of drugs. The role of various NDDS in repurposing of existing drugs for the treatment of various viral diseases and their relevance in COVID-19 has been discussed in this paper. It focuses on the currently ongoing research in the implementation of NDDS in COVID-19. Moreover, it describes the role of NDDS in vaccine development for COVID-19. This paper also emphasizes how NDDS will help to develop the improved delivery systems (dosage forms) of existing therapeutic agents and also explore the new insights to find out the void spaces for potential targeted delivery. Therefore, in these tough times, NDDS and nanotechnology can be a safeguard to humanity.
MeSH term(s)	Antiviral Agents/administration & dosage ; COVID-19/drug therapy ; COVID-19/epidemiology ; COVID-19/virology ; COVID-19 Vaccines ; Drug Delivery Systems ; Drug Repositioning ; Humans ; Pandemics ; SARS-CoV-2/isolation & purification
Chemical Substances	Antiviral Agents ; COVID-19 Vaccines
Keywords	covid19
Language	English
Publishing date	2020-09-17
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2185284-4
ISSN	1875-5704 ; 1567-2018
ISSN (online)	1875-5704
ISSN	1567-2018
DOI	10.2174/1567201817666200916090710
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Article ; Online: Systematically Optimized Imiquimod-Loaded Novel Hybrid Vesicles by Employing Design of Experiment (DoE) Approach with Improved Biocompatibility, Stability, and Dermatokinetic Profile.

Sharma, Mandeep / Sharma, Gajanand / Singh, Bhupinder / Katare, Om Prakash

AAPS PharmSciTech

2019 Volume 20, Issue 4, Page(s) 156

Abstract: The present research work explored the possibility of harnessing the benefits of vesicular carriers for overcoming imiquimod-associated complaints or side effects. Hybrid vesicles were prepared by the most common and easily scalable method, i.e., thin ... ...

Abstract	The present research work explored the possibility of harnessing the benefits of vesicular carriers for overcoming imiquimod-associated complaints or side effects. Hybrid vesicles were prepared by the most common and easily scalable method, i.e., thin film hydration. The chaffing of myriad of factors, both process and material related, affecting the desirable attributes of conceived vesicles, was performed through Taguchi design. Based upon the analysis of Pareto chart and prior experiences, concentration of phospholipid and poloxamer 407 was selected for optimization by 2 levels, 13 run central composite design (CCD). The optimized hybrid vesicles contained 1% w/v phospholipid and 3% w/v poloxamer 407. The optimized hybrid vesicles were incorporated into the 3% w/v carbopol 940 gel and characterized for morphology, physicochemical properties, and rheological behavior. The release (%) and skin retention (% of total dose) across rat skin from gel at same amount of formulation was more than Imiquad®. The gel delivered the loaded cargo, preferably, in the viable region of skin and formed local depot in confocal microscopic studies. The gel followed one compartment open body dermatokinetic model in rat skin. There was not any harmful effect on the mice skin after repeated applications. The gel was stable at room conditions for 1 year.
MeSH term(s)	Adjuvants, Immunologic ; Animals ; Drug Carriers/chemical synthesis ; Drug Carriers/pharmacokinetics ; Drug Stability ; Female ; Gels/chemistry ; Imiquimod/chemical synthesis ; Imiquimod/pharmacokinetics ; Male ; Mice ; Organ Culture Techniques ; Particle Size ; Phospholipids/chemistry ; Phospholipids/pharmacokinetics ; Rats ; Rheology ; Skin/drug effects ; Skin/metabolism ; Skin Absorption/drug effects ; Skin Absorption/physiology
Chemical Substances	Adjuvants, Immunologic ; Drug Carriers ; Gels ; Phospholipids ; Imiquimod (P1QW714R7M)
Language	English
Publishing date	2019-03-29
Publishing country	United States
Document type	Journal Article
ISSN	1530-9932
ISSN (online)	1530-9932
DOI	10.1208/s12249-019-1331-1
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Article ; Online: Nanotechnological interventions in dermatophytosis: from oral to topical, a fresh perspective.

Bangia, Riya / Sharma, Gajanand / Dogra, Sunil / Katare, Om Prakash

Expert opinion on drug delivery

2019 Volume 16, Issue 4, Page(s) 377–396

Abstract: Introduction: The dermatophytosis are the infections, which are the most common infections worldwide, with the serious problem of high recurrence. These are characterized by invasion and multiplication of various species of dermatophytes in keratinized ... ...

Abstract	Introduction: The dermatophytosis are the infections, which are the most common infections worldwide, with the serious problem of high recurrence. These are characterized by invasion and multiplication of various species of dermatophytes in keratinized tissues that can affect skin, hair, and nails. Areas covered: This article aims to gather information about novel strategies for effective treatment of dermatophytosis by incorporating antifungals into nanoformulations to overcome the limitations of the conventional treatment strategies. Updates related to nanosystems and research progress regarding the animal and clinical studies are also included. The current treatment options for dermatophytosis, along with the marketed formulations and patents, are also highlighted. Expert opinion: For treating dermatophytosis, several therapeutic interventions are available which provide good clinical cure rates, but they have some demerits, including resistance to the antifungal agents and adverse effects associated with them. In recent years, efforts have been documented to incorporate various antifungal agents into novel carriers in order to offer better therapeutic action and overcome the limitations of the conventional treatment strategies for dermatophytosis. The success has been achieved in obtaining these formulations with enhanced antifungal activity, prolonged retention of drug, improved efficacy, increased skin penetration of the drug, and sustained release of drug.
MeSH term(s)	Animals ; Antifungal Agents/administration & dosage ; Drug Compounding ; Humans ; Nails/microbiology ; Nanostructures ; Skin/microbiology ; Tinea/drug therapy
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2019-04-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2167286-6
ISSN	1744-7593 ; 1742-5247
ISSN (online)	1744-7593
ISSN	1742-5247
DOI	10.1080/17425247.2019.1593962
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Article ; Online: Topical Drug Delivery of Anti-infectives Employing Lipid-Based Nanocarriers: Dermatokinetics as an Important Tool.

Thakur, Kanika / Sharma, Gajanand / Singh, Bhupindar / Katare, Om Prakash

Current pharmaceutical design

2019 Volume 24, Issue 43, Page(s) 5108–5128

Abstract: Background: The therapeutic approaches for the management of topical infections have always been a difficult approach due to lack of efficacy of conventional topical formulations, high frequency of topical applications and non-patient compliance. The ... ...

Abstract	Background: The therapeutic approaches for the management of topical infections have always been a difficult approach due to lack of efficacy of conventional topical formulations, high frequency of topical applications and non-patient compliance. The major challenge in the management of topical infections lies in antibiotic resistance which leads to severe complications and hospitalizations resulting in economic burden and high mortality rates. Methods: Topical delivery employing lipid-based carriers has been a promising strategy to overcome the challenges of poor skin permeation and retention along with large doses which need to be administered systemically. The use of lipid-based delivery systems is a promising strategy for the effective topical delivery of antibiotics and overcoming drug-resistant strains in the skin. The major systems include transfersomes, niosomes, ethosomes, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion and nanoemulsion as the most promising drug delivery approaches to treat infectious disorders. The main advantages of these systems include lipid bilayer structure which mimics the cell membrane and can fuse with infectious microbes. The numerous advantages associated with nanocarriers like enhanced efficacy, improvement in bioavailability, controlled drug release and ability to target the desired infectious pathogen have made these carriers successful. Conclusion: Despite the number of strides taken in the field of topical drug delivery in infectious diseases, it still requires extensive research efforts to have a better perspective of the factors that influence drug permeation along with the mechanism of action with regard to skin penetration and deposition. The final objective of the therapy is to provide a safe and effective therapeutic approach for the management of infectious diseases affecting topical sites leading to enhanced therapeutic efficacy and patient-compliance.
MeSH term(s)	Administration, Topical ; Animals ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/therapeutic use ; Communicable Diseases/drug therapy ; Drug Carriers/chemistry ; Drug Delivery Systems ; Humans ; Lipids/chemistry ; Nanoparticles/chemistry
Chemical Substances	Anti-Infective Agents ; Drug Carriers ; Lipids
Language	English
Publishing date	2019-01-18
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612825666190118155843
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Article ; Online: Evaluation of efficacy and safety of a novel lipogel containing diclofenac: A randomized, placebo controlled, double-blind clinical trial in patients with signs and symptoms of osteoarthritis.

Bhatia, Amit / Goni, Vijay / Chopra, Shruti / Singh, Bhupinder / Katare, Om Prakash

Contemporary clinical trials communications

2020 Volume 20, Page(s) 100664

Abstract: Background: Effectiveness and safety of pharmaceuticals is the prime concern of every osteoarthritis (OA) treatment. Chronic administration of NSAIDs, especially in case of geriatrics, through oral route tend to compromise the patient's safety, whereas ... ...

Abstract	Background: Effectiveness and safety of pharmaceuticals is the prime concern of every osteoarthritis (OA) treatment. Chronic administration of NSAIDs, especially in case of geriatrics, through oral route tend to compromise the patient's safety, whereas topical treatments are not found to be effective owing their poor ability to deliver drug molecules.Thus, the present study deals with a randomized, double-blind, controlled trial conducted on patients with knee osteoarthritis (OA) for comparing the performance of a novel topical gel (liposomal gel) of diclofenac with a placebo and a marketed gel. Methods: The patients were treated and evaluated for 6 weeks as per the Western Ontario McMaster Universities (WOMAC) Index for OA. Patients were also observed for any adverse events. All the results were analyzed statistically using Kruskal-Wallis test, followed by Student's t-test at p ≤ 0.05. Results: Patients treated with liposomal gel showed statistically significantly improvements in treatment in comparison to the other tested formulations. All the treatments were found to be well tolerated with no report of adverse event. The results unequivocally demonstrated the superiority of the diclofenac liposomal gel, in the relieving the symptoms of OA of the knee, in comparison to placebo and marketed gel. Conclusion: From above results it was revealed that the drug in liposome have higher therapeutic potential. Thus, this can be a safe and effective option for the management of chronic OA especially for geriatric patients.
Language	English
Publishing date	2020-10-07
Publishing country	Netherlands
Document type	Journal Article
ISSN	2451-8654
ISSN (online)	2451-8654
DOI	10.1016/j.conctc.2020.100664
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