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  1. Article: Non-traumatic Rectus Sheath Hematoma During Direct Oral Anticoagulation.

    Hideyama, Takuto / Watanabe, Eri / Ido, Nobuhiro / Terashi, Hiroo / Aizawa, Hitoshi

    Cureus

    2023  Volume 15, Issue 9, Page(s) e45876

    Abstract: We report a case of anticoagulation therapy complicated by a non-traumatic rectus sheath hematoma (RSH). RSH is a relatively rare occurrence caused by bleeding into the rectus sheath following the rupture of the superior and inferior epigastric vessels ... ...

    Abstract We report a case of anticoagulation therapy complicated by a non-traumatic rectus sheath hematoma (RSH). RSH is a relatively rare occurrence caused by bleeding into the rectus sheath following the rupture of the superior and inferior epigastric vessels combined with a primary tear of the rectus muscle fibers. Herein, we report a rare presentation of RSH in a 73-year-old man taking the direct oral anticoagulant (DOAC) apixaban orally. The patient presented with sudden right abdominal pain after a severe cough, which worsened with cough and movement. The Fothergill and Carnett signs were positive. The platelet count, renal function test, and the prothrombin time/international normalized ratio were within the normal range. The activated partial thromboplastin time was 40.0 s, slightly longer than normal. Computed tomography (CT) of the abdomen and pelvis showed RSH, and DOAC therapy was temporarily discontinued. Subsequently, RSH resolution was confirmed via CT four weeks after the onset. DOACs are safer and more efficacious than warfarin for patients with non-valvular atrial fibrillation. However, RSH is a potential complication of anticoagulant therapy. This case report demonstrates that RSH should be considered in the differential diagnosis of sudden-onset abdominal pain and mass in patients on DOACs.
    Language English
    Publishing date 2023-09-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.45876
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  2. Article: Effect of Serum Perampanel Concentration on Sporadic Amyotrophic Lateral Sclerosis Progression.

    Kato, Haruhisa / Naito, Makiko / Saito, Tomoko / Hideyama, Takuto / Terashi, Hiroo / Kwak, Shin / Aizawa, Hitoshi

    Journal of clinical neurology (Seoul, Korea)

    2023  Volume 19, Issue 3, Page(s) 280–287

    Abstract: Background and purpose: To clarify the effect of perampanel (PER) on sporadic amyotrophic lateral sclerosis (sALS) progression, the relationship between the changes in Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) scores and ... ...

    Abstract Background and purpose: To clarify the effect of perampanel (PER) on sporadic amyotrophic lateral sclerosis (sALS) progression, the relationship between the changes in Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) scores and serum PER concentrations was investigated.
    Methods: 12 patients with sALS from our hospital who agreed to participate and completed the PER for sALS randomized phase 2 study were included. After completing the study, we retrospectively obtained serum PER concentration data from the patients. Based on their mean PER concentrations, we divided the patients who had been taking PER into two groups: four patients with a mean PER concentration of ≥400 ng/mL were assigned to the H group, and three with a mean PER concentration of <400 ng/mL were assigned to the L group. The control group consisted of five patients who had been taking a placebo. We obtained the ALSFRS-R scores of each patient at 36 and 48 weeks after randomization. The differences in ALSFRS-R scores at baseline (0 weeks) and each subsequent week were used in the analysis.
    Results: At 48 weeks, there were no differences in the degree of deterioration of the bulbar, upper and lower limb, and respiratory ALSFRS-R subscores and total ALSFRS-R score. However, at 36 weeks, the bulbar subscore was significantly lower in the H group than in the control group (
    Conclusions: Because high PER concentrations may exacerbate bulbar symptoms in patients with sALS, serum PER measurements may be beneficial when patients with sALS are taking PER.
    Language English
    Publishing date 2023-03-13
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2022.0213
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  3. Article ; Online: Nuclear pore destruction and loss of nuclear TDP-43 in FUS mutation-related amyotrophic lateral sclerosis motor neurons.

    Aizawa, Hitoshi / Teramoto, Sayaka / Hideyama, Takuto / Kato, Haruhisa / Terashi, Hiroo / Suzuki, Yasuhiro / Kimura, Takashi / Kwak, Shin

    Journal of the neurological sciences

    2022  Volume 436, Page(s) 120187

    MeSH term(s) Amyotrophic Lateral Sclerosis/genetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Motor Neurons ; Mutation/genetics ; Nuclear Pore/metabolism ; RNA-Binding Protein FUS/genetics
    Chemical Substances DNA-Binding Proteins ; FUS protein, human ; RNA-Binding Protein FUS
    Language English
    Publishing date 2022-02-16
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2022.120187
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Pathological features of glial cells and motor neurons in the anterior horn of the spinal cord in sporadic ALS using ADAR2 conditional knockout mice.

    Naito, Makiko / Hideyama, Takuto / Teramoto, Sayaka / Saito, Tomoko / Kato, Haruhisa / Terashi, Hiroo / Kwak, Shin / Aizawa, Hitoshi

    Journal of the neurological sciences

    2022  Volume 444, Page(s) 120520

    Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the selective degeneration of motor neurons (MNs). In the MNs of patients with ALS, adenosine deaminase acting on RNA 2 (ADAR2)-mediated RNA editing of GluA2 ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the selective degeneration of motor neurons (MNs). In the MNs of patients with ALS, adenosine deaminase acting on RNA 2 (ADAR2)-mediated RNA editing of GluA2 mRNA at the Q/R site is profoundly deficient. In genetically modified mice (ADAR2
    MeSH term(s) Mice ; Animals ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; Mice, Knockout ; Neurodegenerative Diseases/pathology ; Motor Neurons/pathology ; Spinal Cord/pathology ; Astrocytes/pathology ; Disease Models, Animal ; Adenosine Deaminase/genetics ; RNA-Binding Proteins/genetics
    Chemical Substances ADAR2 protein, mouse (EC 3.5.4.4) ; Adenosine Deaminase (EC 3.5.4.4) ; RNA-Binding Proteins
    Language English
    Publishing date 2022-12-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2022.120520
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 308: Show issues Location:
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  5. Article: Prolyl Isomerase Pin1 Expression in the Spinal Motor Neurons of Patients With Sporadic Amyotrophic Lateral Sclerosis.

    Kato, Haruhisa / Naito, Makiko / Saito, Tomoko / Hideyama, Takuto / Suzuki, Yasuhiro / Kimura, Takashi / Kwak, Shin / Aizawa, Hitoshi

    Journal of clinical neurology (Seoul, Korea)

    2022  Volume 18, Issue 4, Page(s) 463–469

    Abstract: Background and purpose: Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease. Selective deficiency of edited adenosine deaminase acting on RNA 2 (ADAR2), a key molecule in the acquisition of Ca: Methods: Specimens of the spinal cord ... ...

    Abstract Background and purpose: Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease. Selective deficiency of edited adenosine deaminase acting on RNA 2 (ADAR2), a key molecule in the acquisition of Ca
    Methods: Specimens of the spinal cord were obtained from the lumbar region in eight sALS patients and age-matched five controls after postmortem examinations. The specimens were double stained with anti-Pin1 and anti-TAR DNA-binding protein of 43 kDa (TDP-43) antibodies, and examined under a fluorescence microscope.
    Results: This study analyzed 254 and 422 spinal motor neurons from 8 sALS patients and 5 control subjects, respectively. The frequency of motor neurons with high cytoplasmic Pin1 expression from the spinal cord did not differ significantly between sALS specimens without cytoplasmic TDP-43 inclusions and control specimens. However, in sALS specimens, neurons for which the Pin1 immunoluminescence intensity in the cytoplasm was at least twice that in the background were more common in specimens with cytoplasmic TDP-43 inclusions (
    Conclusions: In sALS, neurons with higher expression levels of Pin1 levels had more TDP-43 inclusions. Despite the feedback mechanism between Pin1 and ADAR2 being unclear, since Pin1 positively regulates ADAR2, our results suggest that higher Pin1 expression levels in motor neurons with TDP-43 pathology from sALS patients represent a compensatory mechanism.
    Language English
    Publishing date 2022-07-21
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2022.18.4.463
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  6. Article ; Online: Spontaneous Intracranial Hypotension with a Reversible Splenial Lesion after Swimming.

    Uchigami, Hirokazu / Seki, Tomonari / Hideyama, Takuto / Katsumata, Junko / Maekawa, Risa / Shiio, Yasushi

    Internal medicine (Tokyo, Japan)

    2020  Volume 59, Issue 20, Page(s) 2593–2596

    Abstract: Spontaneous intracranial hypotension (SIH) is an important cause of headache mainly associated with spinal cerebrospinal fluid leakage. We herein report the case of a 51-year-old man who developed SIH after swimming. Brain magnetic resonance imaging (MRI) ...

    Abstract Spontaneous intracranial hypotension (SIH) is an important cause of headache mainly associated with spinal cerebrospinal fluid leakage. We herein report the case of a 51-year-old man who developed SIH after swimming. Brain magnetic resonance imaging (MRI) showed a transient high-intensity lesion in the splenium of the corpus callosum (SCC), in addition to bilateral subdural hematomas (SDH) and pseudo-subarachnoid hemorrhage on brain computed tomography. The splenial lesion disappeared and SDH improved after an epidural blood patch. This case emphasizes that transient SCC lesions could coexist with SIH and that SIH should be considered in the differential diagnosis of SCC lesions.
    MeSH term(s) Hematoma, Subdural/complications ; Humans ; Intracranial Hypotension/complications ; Magnetic Resonance Imaging/adverse effects ; Male ; Middle Aged ; Subarachnoid Hemorrhage/complications ; Swimming/physiology
    Language English
    Publishing date 2020-06-23
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.4971-20
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 240: Show issues Location:
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  7. Article: [A Case Suspected of CLIPPERS Syndrome with Cerebral White Matter Lesions].

    Kawabe, Miho / Maekawa, Risa / Tsuchiya, Kazuhiro / Hideyama, Takuto / Shiio, Yasushi

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2018  Volume 104, Issue 10, Page(s) 2193–2200

    MeSH term(s) Chronic Disease ; Humans ; Lymphadenitis/diagnostic imaging ; Lymphadenitis/drug therapy ; Magnetic Resonance Imaging ; Male ; Steroids/therapeutic use ; White Matter/diagnostic imaging ; Young Adult
    Chemical Substances Steroids
    Language Japanese
    Publishing date 2018-08-30
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
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  8. Article ; Online: A central nervous system metastasis of melanoma with stroke-like onset of left-lower quadrantanopsia.

    Arakawa, Akira / Mitsutake, Akihiko / Hideyama, Takuto / Sato, Tatsuya / Katsumata, Junko / Seki, Tomonari / Maekawa, Risa / Ohno, Makoto / Narita, Yoshitaka / Shiio, Yasushi

    Journal of general and family medicine

    2020  Volume 21, Issue 3, Page(s) 77–79

    Abstract: Stroke mimics" mean diseases presenting with acute neurological impairments that are taken for stroke. Discriminating them is crucial to avoid improper treatment or delayed correct treatment. We describe a 48-year-old woman presenting with a sudden ... ...

    Abstract "Stroke mimics" mean diseases presenting with acute neurological impairments that are taken for stroke. Discriminating them is crucial to avoid improper treatment or delayed correct treatment. We describe a 48-year-old woman presenting with a sudden onset of scintillating scotoma and left-lower quadrantanopsia. Hyperacute cerebral infarction was suspected. However, brain magnetic resonance imaging (MRI) revealed a mass at the cortico-medullary junction in the right occipital lobe. We diagnosed her as metastatic melanoma. We suspected that neurological deficits can be attributed to seizure, and therefore introduced levetiracetam. She showed neurological improvement immediately. Our case demonstrated the importance of considering brain tumor as a differential diagnosis in patients presenting with acute-onset neurological deficits. In addition to appropriate treatment of tumor, the use of newer antiepileptic drugs resulted in good neurological prognosis in metastatic brain tumors.
    Language English
    Publishing date 2020-02-11
    Publishing country Japan
    Document type Case Reports
    ISSN 2189-7948
    ISSN (online) 2189-7948
    DOI 10.1002/jgf2.301
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  9. Article ; Online: [Anti-Hu antibody positive sensory neuronopathy causing painful legs and moving toes (PLMT) in a 75-year-old female with small cell lung cancer (SCLC)].

    Tsujimoto, Yuki / Hao, Akihito / Sato, Tatsuya / Hideyama, Takuto / Shibuya, Hideki / Shiio, Yasushi

    Rinsho shinkeigaku = Clinical neurology

    2018  Volume 58, Issue 11, Page(s) 677–681

    Abstract: The case is a 75-year-old female. She had dysesthesia in the distal extremities and truncal ataxia, and they had progressed in two months. Neurological examination revealed the findings of segmental dysesthesia in the distal extremities, impaired deep ... ...

    Abstract The case is a 75-year-old female. She had dysesthesia in the distal extremities and truncal ataxia, and they had progressed in two months. Neurological examination revealed the findings of segmental dysesthesia in the distal extremities, impaired deep sensations in the trunk and four limbs, and painful legs and moving toes (PLMT). After workup, she was diagnosed with small cell lung cancer and her blood sample was positive for anti-Hu antibody. We concluded that her neurological symptoms were attributable to sensory neuronopathy associated with paraneoplastic syndrome. No cases with PLMT caused by paraneoplastic syndrome have been reported so far. She had chemotherapy to lung cancer and Duloxetine without improvement of PLMT. On the other hand, intravenous immunoglobulin treatment improved lightening pain in the toes without improvement of moving toes.
    MeSH term(s) Aged ; Antineoplastic Agents/therapeutic use ; Ataxia/etiology ; Autoantibodies/blood ; Duloxetine Hydrochloride/therapeutic use ; ELAV Proteins/immunology ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Leg ; Lung Neoplasms/complications ; Lung Neoplasms/drug therapy ; Movement Disorders/etiology ; Pain/drug therapy ; Pain/etiology ; Paraneoplastic Polyneuropathy/etiology ; Paraneoplastic Syndromes/etiology ; Paresthesia/etiology ; Small Cell Lung Carcinoma/complications ; Small Cell Lung Carcinoma/drug therapy ; Toes
    Chemical Substances Antineoplastic Agents ; Autoantibodies ; ELAV Proteins ; Immunoglobulins, Intravenous ; Duloxetine Hydrochloride (9044SC542W)
    Language Japanese
    Publishing date 2018-10-27
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 604200-4
    ISSN 1882-0654 ; 0009-918X
    ISSN (online) 1882-0654
    ISSN 0009-918X
    DOI 10.5692/clinicalneurol.cn-001198
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  10. Article ; Online: A Japanese family with primary familial brain calcification presenting with paroxysmal kinesigenic dyskinesia - A comprehensive mutational analysis.

    Mitsutake, Akihiko / Matsukawa, Takashi / Porto, Kristine Joyce L / Sato, Tatsuya / Katsumata, Junko / Seki, Tomonari / Maekawa, Risa / Hideyama, Takuto / Tanaka, Masaki / Ishiura, Hiroyuki / Toda, Tatsushi / Tsuji, Shoji / Shiio, Yasushi

    Journal of the neurological sciences

    2020  Volume 418, Page(s) 117091

    MeSH term(s) Basal Ganglia Diseases ; Brain/diagnostic imaging ; Dystonia/complications ; Dystonia/genetics ; Humans ; Japan
    Language English
    Publishing date 2020-08-11
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2020.117091
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