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  1. Article: [Preface].

    Koyama, Ryuta

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2023  Volume 158, Issue 5, Page(s) 347

    Language Japanese
    Publishing date 2023-09-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.23003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 439: Show issues Location:
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  2. Article ; Online: Microglia and GABA: Diverse functions of microglia beyond GABA-receiving cells.

    Andoh, Megumi / Koyama, Ryuta

    Neuroscience research

    2022  Volume 187, Page(s) 52–57

    Abstract: Neurotransmitters modulate intracellular signaling not only in neurons but also in glial cells such as astrocytes, which form tripartite synapses, and oligodendrocytes, which produce the myelin sheath on axons. Another major glial cell type, microglia, ... ...

    Abstract Neurotransmitters modulate intracellular signaling not only in neurons but also in glial cells such as astrocytes, which form tripartite synapses, and oligodendrocytes, which produce the myelin sheath on axons. Another major glial cell type, microglia, which are often referred to as brain-resident immune cells, also express receptors for neurotransmitters. Recent studies have mainly focused on excitatory neurotransmitters such as glutamate, and few have examined microglial responses to the inhibitory neurotransmitter GABA. Microglia can also structurally and functionally modulate inhibitory neuronal circuits, but the underlying molecular mechanisms remain largely unknown. Since the well-regulated balance of excitatory/inhibitory (E/I) neurotransmission is believed to be the basis of proper brain function, understanding how microglia regulate and respond to inhibitory neurotransmission will help us deepen our knowledge of neuron-glia interactions. In this review, we discuss the mechanisms by which GABA alters microglial behavior and the possibility that microglia are more than just GABA-receiving cells.
    MeSH term(s) Microglia/metabolism ; Synaptic Transmission ; GABAergic Neurons/metabolism ; Neurotransmitter Agents/metabolism ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Neurotransmitter Agents ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2022-09-21
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 605842-5
    ISSN 1872-8111 ; 0168-0102 ; 0921-8696
    ISSN (online) 1872-8111
    ISSN 0168-0102 ; 0921-8696
    DOI 10.1016/j.neures.2022.09.008
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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Exercise, microglia, and beyond - workout to communicate with microglia.

    Andoh, Megumi / Koyama, Ryuta

    Neural regeneration research

    2020  Volume 15, Issue 11, Page(s) 2029–2030

    Language English
    Publishing date 2020-05-11
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.282241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Synaptic phagocytosis by multiple glial cell types].

    Kono, Rena / Ikegaya, Yuji / Koyama, Ryuta

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2023  Volume 158, Issue 5, Page(s) 348–352

    Abstract: Neurons in the brain build circuits by synapsing with each other, and glial cells are involved in the formation and elimination of synapses. Glial cells include microglia, astrocytes, and oligodendrocytes, each with distinctive functions supported by ... ...

    Abstract Neurons in the brain build circuits by synapsing with each other, and glial cells are involved in the formation and elimination of synapses. Glial cells include microglia, astrocytes, and oligodendrocytes, each with distinctive functions supported by different gene expression patterns and morphologies, but all have been shown to regulate the number of synapses in the neuronal circuits through a common function, synaptic phagocytosis. It has also been reported that specific glial cell types phagocytose specific synapses in different brain regions and at different times, and some of the molecular mechanisms involved in each phagocytotic process have been elucidated. For example, microglia, the most frequently reported glial cell type in relation to synaptic phagocytes, are known to recognize various "eat me signals" including complement and phagocytose synapses, contributing to the refinement of neuronal circuits during development. More recently, astrocytes and oligodendrocyte precursor cells have also been shown to be involved in synaptic phagocytosis. Interestingly, there are also reports of different types of glial cells phagocytosing the same types of synapses. And in some cases, it has been suggested that different glial cell types regulate each other's synaptic phagocytosis. In this review, we will discuss the significance of synaptic phagocytosis by multiple types of glial cells by presenting recent studies on synaptic phagocytosis by glial cells.
    MeSH term(s) Neuroglia ; Neurons ; Astrocytes ; Microglia ; Phagocytosis
    Language Japanese
    Publishing date 2023-08-10
    Publishing country Japan
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.23004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: Assessing Microglial Dynamics by Live Imaging.

    Andoh, Megumi / Koyama, Ryuta

    Frontiers in immunology

    2021  Volume 12, Page(s) 617564

    Abstract: Microglia are highly dynamic in the brain in terms of their ability to migrate, proliferate, and phagocytose over the course of an individual's life. Real-time imaging is a useful tool to examine how microglial behavior is regulated and how it affects ... ...

    Abstract Microglia are highly dynamic in the brain in terms of their ability to migrate, proliferate, and phagocytose over the course of an individual's life. Real-time imaging is a useful tool to examine how microglial behavior is regulated and how it affects the surrounding environment. However, microglia are sensitive to environmental stimuli, so they possibly change their state during live imaging
    MeSH term(s) Animals ; Biomarkers ; Cell Communication ; Cell Culture Techniques ; Cell Tracking ; Cells, Cultured ; Diagnostic Imaging/methods ; Gene Expression ; Genes, Reporter ; Humans ; Immunohistochemistry ; Microglia/physiology ; Molecular Imaging/methods ; Signal Transduction
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-03-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.617564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Replacement of Mouse Microglia With Human Induced Pluripotent Stem Cell (hiPSC)-Derived Microglia in Mouse Organotypic Slice Cultures.

    Ogaki, Ari / Ikegaya, Yuji / Koyama, Ryuta

    Frontiers in cellular neuroscience

    2022  Volume 16, Page(s) 918442

    Abstract: Microglia, the major immune cells in the brain, are reported to differ in gene expression patterns among species. Therefore, it would be preferable in some cases to use human microglia rather than mouse microglia in microglia-targeted disease research. ... ...

    Abstract Microglia, the major immune cells in the brain, are reported to differ in gene expression patterns among species. Therefore, it would be preferable in some cases to use human microglia rather than mouse microglia in microglia-targeted disease research. In the past half a decade, researchers have developed
    Language English
    Publishing date 2022-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2022.918442
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  7. Article ; Online: Microglia regulate synaptic development and plasticity.

    Andoh, Megumi / Koyama, Ryuta

    Developmental neurobiology

    2021  Volume 81, Issue 5, Page(s) 568–590

    Abstract: Synapses are fundamental structures of neural circuits that transmit information between neurons. Thus, the process of neural circuit formation via proper synaptic connections shapes the basis of brain functions and animal behavior. Synapses continuously ...

    Abstract Synapses are fundamental structures of neural circuits that transmit information between neurons. Thus, the process of neural circuit formation via proper synaptic connections shapes the basis of brain functions and animal behavior. Synapses continuously undergo repeated formation and elimination throughout the lifetime of an organism, reflecting the dynamics of neural circuit function. The structural transformation of synapses has been described mainly in relation to neural activity-dependent strengthening and weakening of synaptic functions, that is, functional plasticity of synapses. An increasing number of studies have unveiled the roles of microglia, brain-resident immune cells that survey the brain parenchyma with highly motile processes, in synapse formation and elimination as well as in regulating synaptic function. Over the past 15 years, the molecular mechanisms underlying microglia-dependent regulation of synaptic plasticity have been thoroughly studied, and researchers have reported that the disruption of microglia-dependent regulation causes synaptic dysfunction that leads to brain diseases. In this review, we will broadly introduce studies that report the roles of microglia in synaptic plasticity and the possible underlying molecular mechanisms.
    MeSH term(s) Animals ; Microglia/physiology ; Neurogenesis/physiology ; Neuronal Plasticity/physiology ; Neurons/physiology ; Synapses/physiology
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2256184-5
    ISSN 1932-846X ; 1097-4695 ; 1932-8451 ; 0022-3034
    ISSN (online) 1932-846X ; 1097-4695
    ISSN 1932-8451 ; 0022-3034
    DOI 10.1002/dneu.22814
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 853: Show issues Location:
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  8. Article ; Online: Comparative Review of Microglia and Monocytes in CNS Phagocytosis

    Megumi Andoh / Ryuta Koyama

    Cells, Vol 10, Iss 2555, p

    2021  Volume 2555

    Abstract: Macrophages maintain tissue homeostasis by phagocytosing and removing unwanted materials such as dead cells and cell debris. Microglia, the resident macrophages of the central nervous system (CNS), are no exception. In addition, a series of recent ... ...

    Abstract Macrophages maintain tissue homeostasis by phagocytosing and removing unwanted materials such as dead cells and cell debris. Microglia, the resident macrophages of the central nervous system (CNS), are no exception. In addition, a series of recent studies have shown that microglia phagocytose the neuronal synapses that form the basis of neural circuit function. This discovery has spurred many neuroscientists to study microglia. Importantly, in the CNS parenchyma, not only microglia but also blood-derived monocytes, which essentially differentiate into macrophages after infiltration, exert phagocytic ability, making the study of phagocytosis in the CNS even more interesting and complex. In particular, in the diseased brain, the phagocytosis of tissue-damaging substances, such as myelin debris in multiple sclerosis (MS), has been shown to be carried out by both microglia and blood-derived monocytes. However, it remains largely unclear why blood-derived monocytes need to invade the parenchyma, where microglia are already abundant, to assist in phagocytosis. We will also discuss whether this phagocytosis can affect the fate of the phagocytosing cell itself as well as the substance being phagocytosed and the surrounding environment in addition to future research directions. In this review, we will introduce recent studies to answer a question that often arises when studying microglial phagocytosis: under what circumstances and to what extent blood-derived monocytes infiltrate the CNS and contribute to phagocytosis. In addition, the readers will learn how recent studies have experimentally distinguished between microglia and infiltrating monocytes. Finally, we aim to contribute to the progress of phagocytosis research by discussing the effects of phagocytosis on phagocytic cells.
    Keywords microglia ; macrophage ; monocyte ; phagocytosis ; infiltration ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: [Microglial Response to Brain Temperature and Neuronal Circuit Reorganization].

    Onodera, Junya / Ikegaya, Yuji / Koyama, Ryuta

    Brain and nerve = Shinkei kenkyu no shinpo

    2022  Volume 74, Issue 2, Page(s) 133–142

    Abstract: Brain tissue is vulnerable to temperature changes, which are known to affect the structure and function of neural circuits. Owing to their dynamic ramified processes, microglia, which serve as immune cells in the brain, are associated with surveillance ... ...

    Abstract Brain tissue is vulnerable to temperature changes, which are known to affect the structure and function of neural circuits. Owing to their dynamic ramified processes, microglia, which serve as immune cells in the brain, are associated with surveillance of the brain environment and mediate synaptic pruning to reorganize neural circuits. In this section, we discuss the possible role of microglia as temperature sensors in the brain via thermosensitive transient receptor potential channels and their role in reorganization of neural circuits.
    MeSH term(s) Brain ; Microglia ; Neurons ; Synapses ; Temperature
    Language Japanese
    Publishing date 2022-01-30
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416201998
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Comparative Review of Microglia and Monocytes in CNS Phagocytosis.

    Andoh, Megumi / Koyama, Ryuta

    Cells

    2021  Volume 10, Issue 10

    Abstract: Macrophages maintain tissue homeostasis by phagocytosing and removing unwanted materials such as dead cells and cell debris. Microglia, the resident macrophages of the central nervous system (CNS), are no exception. In addition, a series of recent ... ...

    Abstract Macrophages maintain tissue homeostasis by phagocytosing and removing unwanted materials such as dead cells and cell debris. Microglia, the resident macrophages of the central nervous system (CNS), are no exception. In addition, a series of recent studies have shown that microglia phagocytose the neuronal synapses that form the basis of neural circuit function. This discovery has spurred many neuroscientists to study microglia. Importantly, in the CNS parenchyma, not only microglia but also blood-derived monocytes, which essentially differentiate into macrophages after infiltration, exert phagocytic ability, making the study of phagocytosis in the CNS even more interesting and complex. In particular, in the diseased brain, the phagocytosis of tissue-damaging substances, such as myelin debris in multiple sclerosis (MS), has been shown to be carried out by both microglia and blood-derived monocytes. However, it remains largely unclear why blood-derived monocytes need to invade the parenchyma, where microglia are already abundant, to assist in phagocytosis. We will also discuss whether this phagocytosis can affect the fate of the phagocytosing cell itself as well as the substance being phagocytosed and the surrounding environment in addition to future research directions. In this review, we will introduce recent studies to answer a question that often arises when studying microglial phagocytosis: under what circumstances and to what extent blood-derived monocytes infiltrate the CNS and contribute to phagocytosis. In addition, the readers will learn how recent studies have experimentally distinguished between microglia and infiltrating monocytes. Finally, we aim to contribute to the progress of phagocytosis research by discussing the effects of phagocytosis on phagocytic cells.
    MeSH term(s) Animals ; Central Nervous System/physiology ; Disease Models, Animal ; Mice ; Microglia/metabolism ; Monocytes/metabolism ; Phagocytosis/physiology
    Language English
    Publishing date 2021-09-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10102555
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