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  1. Article ; Online: Axi-cel in LBCL: fulfill two needs with one deed.

    Ghosh, Nilanjan

    Blood

    2022  Volume 140, Issue 21, Page(s) 2183–2185

    MeSH term(s) Humans ; Antigens, CD19 ; Immunotherapy, Adoptive ; Lymphoma, Large B-Cell, Diffuse ; Patient Reported Outcome Measures
    Chemical Substances axicabtagene ciloleucel (U2I8T43Y7R) ; Antigens, CD19
    Language English
    Publishing date 2022-11-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022017564
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  2. Article ; Online: An assessment of crucial structural contributors of HDAC6 inhibitors through fragment-based non-linear pattern recognition and molecular dynamics simulation approaches.

    Banerjee, Suvankar / Jana, Sandeep / Jha, Tarun / Ghosh, Balaram / Adhikari, Nilanjan

    Computational biology and chemistry

    2024  Volume 110, Page(s) 108051

    Abstract: Amidst the ... ...

    Abstract Amidst the Zn
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ISSN 1476-928X
    ISSN (online) 1476-928X
    DOI 10.1016/j.compbiolchem.2024.108051
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  3. Article ; Online: Fragment-based discovery of new potential DNMT1 inhibitors integrating multiple pharmacophore modeling, 3D-QSAR, virtual screening, molecular docking, ADME, and molecular dynamics simulation approaches.

    Lanka, Goverdhan / Banerjee, Suvankar / Adhikari, Nilanjan / Ghosh, Balaram

    Molecular diversity

    2024  

    Abstract: DNA methyl transferases (DNMTs) are one of the crucial epigenetic modulators associated with a wide variety of cancer conditions. Among the DNMT isoforms, DNMT1 is correlated with bladder, pancreatic, and breast cancer, as well as acute myeloid leukemia ... ...

    Abstract DNA methyl transferases (DNMTs) are one of the crucial epigenetic modulators associated with a wide variety of cancer conditions. Among the DNMT isoforms, DNMT1 is correlated with bladder, pancreatic, and breast cancer, as well as acute myeloid leukemia and esophagus squamous cell carcinoma. Therefore, the inhibition of DNMT1 could be an attractive target for combating cancers and other metabolic disorders. The disadvantages of the existing nucleoside and non-nucleoside DNMT1 inhibitors are the main motive for the discovery of novel promising inhibitors. Here, pharmacophore modeling, 3D-QSAR, and e-pharmacophore modeling of DNMT1 inhibitors were performed for the large fragment database screening. The resulting fragments with high dock scores were combined into molecules. The current study revealed several constitutional pharmacophoric features that can be essential for selective DNMT1 inhibition. The fragment docking and virtual screening identified 10 final hit molecules that exhibited good binding affinities in terms of docking score, binding free energies, and acceptable ADME properties. Also, the modified lead molecules (GL1b and GL2b) designed in this study showed effective binding with DNMT1 confirmed by their docking scores, binding free energies, 3D-QSAR predicted activities and acceptable drug-like properties. The MD simulation studies also suggested that leads (GL1b and GL2b) formed stable complexes with DNMT1. Therefore, the findings of this study can provide effective information for the development/identification of novel DNMT1 inhibitors as effective anticancer agents.
    Language English
    Publishing date 2024-04-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1376507-3
    ISSN 1573-501X ; 1381-1991
    ISSN (online) 1573-501X
    ISSN 1381-1991
    DOI 10.1007/s11030-024-10837-5
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    Zs.A 4946: Show issues Location:
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  4. Article: Secretome Analysis of

    Sinha, Nilanjan / Patra, Sourav Kumar / Ghosh, Sanjay

    Frontiers in microbiology

    2022  Volume 13, Page(s) 847832

    Abstract: Macrophomina ... ...

    Abstract Macrophomina phaseolina
    Language English
    Publishing date 2022-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.847832
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  5. Article ; Online: A combined ligand-based and structure-based

    Jana, Sandeep / Banerjee, Suvankar / Baidya, Sandip Kumar / Ghosh, Balaram / Jha, Tarun / Adhikari, Nilanjan

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–17

    Abstract: Human meprin β is a ... ...

    Abstract Human meprin β is a Zn
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2298394
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  6. Article ; Online: On Water Governance

    Nilanjan Ghosh

    Ecology, Economy and Society – The INSEE Journal, Vol 1, Iss

    From a Reductionist Paradigm to a Holistic One

    2018  Volume 2

    Keywords Human ecology. Anthropogeography ; GF1-900 ; Economic theory. Demography ; HB1-3840
    Language English
    Publishing date 2018-07-01T00:00:00Z
    Publisher Nandan Nawn
    Document type Article ; Online
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  7. Article ; Online: Reverse Regioselective Cp*Co(III)-Catalyzed [4 + 2] C-H Annulation of

    Ghosh, Arijit / Rana, Tamanna / Bhaduri, Nilanjan / Pawar, Amit B

    Organic letters

    2023  Volume 25, Issue 43, Page(s) 7878–7883

    Abstract: We have developed a Cp*Co(III)-catalyzed reverse regioselective [4 + 2] annulation ... ...

    Abstract We have developed a Cp*Co(III)-catalyzed reverse regioselective [4 + 2] annulation of
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c03115
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  8. Article ; Online: Public-Private Partnership for Treatment of Congenital Heart Diseases: Experiences From an Indian State.

    Das, Debasis / Dutta, Nilanjan / Das, Shubhadeep / Sharma, Manish Kumar / Chattopadhyay, Amitabha / Ghosh, Sanjiban / Das, Jayita Nandy

    World journal for pediatric & congenital heart surgery

    2024  , Page(s) 21501351231215257

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2550261-X
    ISSN 2150-136X ; 2150-1351
    ISSN (online) 2150-136X
    ISSN 2150-1351
    DOI 10.1177/21501351231215257
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  9. Article ; Online: Cardiovascular Complications in Patients with Kawasaki Disease in a Tertiary Care Hospital in West Bengal, Eastern India- A Prospective Clinical Study

    Sayani Pan / Uttam Kumar Roy / Nilanjan Ghosh / Tarak Nath Ghosh

    Journal of Clinical and Diagnostic Research, Vol 17, Iss 6, Pp SC10-SC

    2023  Volume 14

    Abstract: Introduction: Kawasaki Disease (KD) is an acute self-limiting systemic vasculitis involving medium and small-sized arteries. It may soon replace rheumatic fever to become the most common cause of acquired heart disease in Indian children. Coronary Artery ...

    Abstract Introduction: Kawasaki Disease (KD) is an acute self-limiting systemic vasculitis involving medium and small-sized arteries. It may soon replace rheumatic fever to become the most common cause of acquired heart disease in Indian children. Coronary Artery Aneurysm (CAA) which can develop in 15-25% of untreated children remains the most dreaded complication of KD. Predicting the risk of CAA and taking timely measures can help in reducing the fatality of the condition. Aim: To study the spectrum of cardiovascular complications in patients with KD and also to assess associated risk factors for developing CAA in the patients under study. Materials and Methods: This prospective clinical study was carried out in the Paediatric Medicine Ward, Burdwan Medical College and Hospital, West Bengal, Eastern India, from 1st January, 2020 to 31st May, 2021. Total 52 children diagnosed with KD, aged between one month to 12 years, were included and followed-up for six months. Data regarding demographic variables, duration of fever, Intravenous Immunoglobulin (IVIG) resistance, hepatomegaly, neutrophilia, thrombocytopenia, haematocrit, Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), hepatic transaminases (alanine transaminase, aspartate amino-transferase), hyponatremia, hypoalbuminemia, and N-terminal-brain natriuretic peptide (NT-proBNP) were collected. Univariate and multivariate regression analyses were done using these variables for assessment of risk factors. Results: In the present study, out of 52 children, 28 (53.85%) were males and 24 (46.15%) were females with mean age of 3.74±2.55 years. Cardiovascular complications were observed in 27 (51.92%) patients, of whom 19 (35.54%) had CAA. Duration of fever ≥10 days, IVIG resistance, thrombocytopenia, low hematocrit, Alanine Transaminase (ALT) ≥100 U/L, hypoalbuminemia, and raised NT-proBNP were proven to be significant risk factors for development of CAA on univariate analysis. Thrombocytopenia and raised NT-proBNP came across as significant on binary logistic ...
    Keywords aneurysm ; coronary arteries ; echocardiography ; risk factors ; vasculitis ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A fragment-based exploration of diverse MMP-9 inhibitors through classification-dependent structural assessment.

    Baidya, Sandip Kumar / Banerjee, Suvankar / Ghosh, Balaram / Jha, Tarun / Adhikari, Nilanjan

    Journal of molecular graphics & modelling

    2023  Volume 126, Page(s) 108671

    Abstract: Matrix metalloproteinases (MMPs) are belonging to the ... ...

    Abstract Matrix metalloproteinases (MMPs) are belonging to the Zn
    MeSH term(s) Matrix Metalloproteinase 9 ; Matrix Metalloproteinase Inhibitors/pharmacology ; Matrix Metalloproteinase Inhibitors/chemistry ; Sulfonamides/chemistry ; Drug Discovery
    Chemical Substances Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Matrix Metalloproteinase Inhibitors ; Sulfonamides
    Language English
    Publishing date 2023-11-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1396450-1
    ISSN 1873-4243 ; 1093-3263
    ISSN (online) 1873-4243
    ISSN 1093-3263
    DOI 10.1016/j.jmgm.2023.108671
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    Zs.A 3491: Show issues Location:
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