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Article: Microfluidic wearable electrochemical sweat sensors for health monitoring.

Ramachandran, Balaji / Liao, Ying-Chih

Biomicrofluidics

2022 Volume 16, Issue 5, Page(s) 51501

Abstract: Research on remote health monitoring through wearable sensors has attained popularity in recent decades mainly due to aging population and expensive health care services. Microfluidic wearable sweat sensors provide economical, non-invasive mode of sample ...

Abstract	Research on remote health monitoring through wearable sensors has attained popularity in recent decades mainly due to aging population and expensive health care services. Microfluidic wearable sweat sensors provide economical, non-invasive mode of sample collection, important physiological information, and continuous tracking of human health. Recent advances in wearable sensors focus on electrochemical monitoring of biomarkers in sweat and can be applicable in various fields like fitness monitoring, nutrition, and medical diagnosis. This review focuses on the evolution of wearable devices from benchtop electrochemical systems to microfluidic-based wearable sensors. Major classification of wearable sensors like skin contact-based and biofluidic-based sensors are discussed. Furthermore, sweat chemistry and related biomarkers are explained in addition to integration of microfluidic systems in wearable sweat sensors. At last, recent advances in wearable electrochemical sweat sensors are discussed, which includes tattoo-based, paper microfluidics, patches, wrist band, and belt-based wearable sensors.
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1932-1058
ISSN	1932-1058
DOI	10.1063/5.0116648
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Functional association of oestrogen receptors with HPV infection in cervical carcinogenesis.

Ramachandran, Balaji

Endocrine-related cancer

2017 Volume 24, Issue 4, Page(s) R99–R108

Abstract: Repeated parity and usage of oral contraceptives have demonstrated an increased risk of cervical cancer (CC) in HPV-infected women. These lifestyle observations raise the likelihood that oestrogens and HPV infection might act synergistically to affect ... ...

Abstract	Repeated parity and usage of oral contraceptives have demonstrated an increased risk of cervical cancer (CC) in HPV-infected women. These lifestyle observations raise the likelihood that oestrogens and HPV infection might act synergistically to affect cancers of the cervix.
Language	English
Publishing date	2017-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1218450-0
ISSN	1479-6821 ; 1351-0088
ISSN (online)	1479-6821
ISSN	1351-0088
DOI	10.1530/ERC-16-0571
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Barrier Performance of Spray Coated Cellulose Nanofibre Film

Kirubanandan Shanmugam / Narendhar Chandrasekar / Ramachandran Balaji

Micro, Vol 3, Iss 14, Pp 192-

2023 Volume 207

Abstract: Cellulose nanofibre (CNF) is the sustainable nanomaterial used for developing high-performance barrier materials that are renewable, recyclable, and biodegradable. The CNF film has very low oxygen permeability; however, its water vapor permeability is ... ...

Abstract	Cellulose nanofibre (CNF) is the sustainable nanomaterial used for developing high-performance barrier materials that are renewable, recyclable, and biodegradable. The CNF film has very low oxygen permeability; however, its water vapor permeability is significantly higher than that of conventional packaging plastics. The fabrication method influences their barrier properties of the film. A spray-coating CNF on a stainless-steel plate was developed to form a compact film with two unique surfaces, namely a smooth layer on the base side and rough layer on the free side. It improves both the ease of preparation of the film and reduces the water vapour permeability via tailoring the basis weight and thickness of the film through simple adjusting CNF content in the suspension. The air permanence of the film from 1.0 wt.% to 2.0 wt.% CNF suspension is less than 0.003 µm/Pa·S confirming that is an impermeable film and proves a good packaging material. SEM, optical profilometry, and AFM revealed that the spray-coated surface was smooth and glossy. For sprayed CNF films with basis weight between 86.26 ± 13.61 and 155.85 ± 18.01 g/m 2 , WVP were ranged from 6.99 ± 1.17 × 10 −11 to 4.19 ± 1.45 × 10 −11 g/m·Pa·S. In comparison, the WVP of 100 g/m 2 vacuum filtered CNF film was 5.50 ± 0.84 × 10 −11 g/m·Pa·S, spray-coated film (of 96.6 g/m 2 ) also show similar permeability at around 5.34 ± 0.603 × 10 −11 g/m·Pa·S. The best performance was achieved with spraying of 2.0 wt.% CNF and a water vapour permeability of 3.91 × 10 −11 g/m·s·Pa. Spray coated CNF film is impermeable against air and water vapour and a potential alternative to synthetic plastics.
Keywords	cellulose nanofibre (CNF) ; spray coating ; basis weight ; thickness ; water vapour transmission rate ; water vapour permeability ; Physics ; QC1-999 ; Microscopy ; QH201-278.5 ; Microbiology ; QR1-502 ; Chemistry ; QD1-999
Subject code	333
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Construction of an electrochemical sensor towards environmental hazardous 4-nitrophenol based on Nd(OH)

Sundaresan, Ruspika / Mariyappan, Vinitha / Chen, Shen-Ming / Ramachandran, Balaji / Paulsamy, Raja / Rasu, Ramachandran

Environmental science and pollution research international

2023

Abstract: The toxicity of 4-nitrophenol (4-NP) is one of the most common threats to the environment; therefore, developing a simple and sensitive analytical method to detect 4-NP is crucial. In this study, we prepared the Nd(OH) ...

Abstract	The toxicity of 4-nitrophenol (4-NP) is one of the most common threats to the environment; therefore, developing a simple and sensitive analytical method to detect 4-NP is crucial. In this study, we prepared the Nd(OH)
Language	English
Publishing date	2023-02-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-25688-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluation of the feasibility and acceptability of ReWin-A digital therapeutic rehabilitation innovation for people with stroke-related disabilities in India.

Kamalakannan, Sureshkumar / Karunakaran, Vijay / Balaji, Ashwin / Vijaykaran, Aadi Sai / Ramachandran, Sivakumar / Nagarajan, Ramakumar

Frontiers in neurology

2023 Volume 13, Page(s) 936787

Abstract: Background: Developing culturally appropriate, scalable interventions to meet the growing needs for stroke rehabilitation is a significant problem of public health concern. Therefore, systematic development and evaluation of a scalable, inclusive, ... ...

Abstract	Background: Developing culturally appropriate, scalable interventions to meet the growing needs for stroke rehabilitation is a significant problem of public health concern. Therefore, systematic development and evaluation of a scalable, inclusive, technology-driven solution for community-based stroke care are of immense public health importance in India. ReWin is a digital therapeutics platform that was developed systematically. This study aimed to evaluate its feasibility and acceptability in an Indian context. Objectives: Phase-1: To pilot the intervention for identifying operational issues and finalize the intervention. Phase-2: To assess the feasibility and acceptability of ReWin intervention in an Indian context. Methods: Design: Mixed-methods research design. Setting: Participant's home and rehabilitation centers. Participants were selected from rehabilitation centers in South India. Participants: Ten stroke survivors and their caregivers, as well as four rehabilitation service providers were recruited for phase 1. Thirty stroke survivors who were treated and discharged from the hospital, and their caregivers as well as 10 rehabilitation service providers were recruited for Phase 2. Intervention: ReWin a digital therapeutic platform with the provider and patient app for the rehabilitation of physical disabilities following stroke was piloted. Process: Evaluation of the intervention was completed in two phases. In the first phase, the preliminary intervention was field-tested with 10 stroke survivors and four rehabilitation service providers for 2 weeks. In the second phase, the finalized intervention was provided to a further 30 stroke survivors to be used in their homes with support from their carers as well as to 10 rehabilitation service providers for 4 weeks. Outcome measures: Primary outcomes: (1) operational difficulties in using the ReWin intervention; (2) feasibility and acceptability of the ReWin intervention in an Indian setting. Results: Field-testing identified operational difficulties related to 1. Therapeutic content; 2. Format; 3. Navigation; 4. Connectivity, 5. Video-streaming, 6. Language; and 7. Comprehensibility of the animated content. The intervention was reviewed, revised and finalized before pilot testing. Findings from the pilot testing showed that the ReWin intervention was feasible and acceptable. About 76% of the participants had used ReWin for more than half of the intervention period of 4 weeks. Ninety percentage of the stroke care providers and about 60% of the stroke survivors and caregivers felt that the content of ReWin was very relevant to the needs of the stroke survivors. Forty percentage of the stroke survivors and caregivers rated ReWin intervention as excellent. Another 45% of the stroke survivors and caregivers as well as 90% of the stroke care providers rated ReWin intervention as very good based on its overall credibility, usability, and user-friendliness. Conclusions: ReWin has all the essential components to connect care providers and consumers not just for stroke rehabilitation but for several other health conditions with the use of several other technological features that support rehabilitation of persons with disabilities and strengthen rehabilitation in health systems worldwide. It is critical to amalgamate ReWin and other evidence-based interventions for rehabilitation to innovate scalable solutions and promote universal health coverage for stroke care worldwide.
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.936787
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Concomitant Occurrence of the Ossified Posterior Longitudinal Ligament with a Posterior C2 Defect.

Thandapani, Manikandan / Pothu, Sudheer Kumar / Govindasamy, Ramachandran / Rudrappa, Satish / Vaithialingam, Balaji

Asian journal of neurosurgery

2023 Volume 18, Issue 3, Page(s) 688–689

Language	English
Publishing date	2023-09-22
Publishing country	India
Document type	Journal Article
ZDB-ID	2621446-5
ISSN	2248-9614 ; 1793-5482
ISSN (online)	2248-9614
ISSN	1793-5482
DOI	10.1055/s-0043-1771321
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Article ; Online: Design and fabrication of La-based perovskites incorporated with functionalized carbon nanofibers for the electrochemical detection of roxarsone in water and food samples.

John Felix, Mariya Antony / Rex Shanlee, Santhiyagu Sahayaraj / Chen, Shen-Ming / Ruspika, Sundaresan / Balaji, Ramachandran / Chandrasekar, Narendhar / Doss, Periyanayagam Arockia

Analytical methods : advancing methods and applications

2024

Abstract: The pentavalent arsenic compound roxarsone (RSN) is used as a feed additive in poultry for rapid growth, eventually ending up in poultry litter. Poultry litter contains chicken manure, which plays a vital role as an affordable fertilizer by providing ... ...

Abstract	The pentavalent arsenic compound roxarsone (RSN) is used as a feed additive in poultry for rapid growth, eventually ending up in poultry litter. Poultry litter contains chicken manure, which plays a vital role as an affordable fertilizer by providing rich nutrients to agricultural land. Consequently, the extensive use of poultry droppings serves as a conduit for the spread of toxic forms of arsenic in the soil and surface water. RSN can be easily oxidized to release highly carcinogenic As(III) and As(IV) species. Thus, investigations were conducted for the sensitive detection of RSN electrochemically by developing a sensor material based on lanthanum manganese oxide (LMO) and functionalized carbon nanofibers (f-CNFs). The successfully synthesised LMO/f-CNF composite was confirmed by chemical, compositional, and morphological studies. The electrochemical activity of the prepared composite material was examined using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The obtained results confirmed that LMO/f-CNF showed enhanced electrocatalytic activity and improved current response with a good linear range (0.01-0.78 μM and 2.08-497 μM, respectively), exhibiting a low limit of detection (LOD) of 0.004 μM with a high sensitivity of 13.24 μA μM
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/d4ay00264d
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Retrospective Study on Antinuclear Antibody Patterns in Systemic Lupus Erythematosus Patients and Its Correlation With Serological Markers.

Ramachandran, Aishwarya / Kumar, Kennedy / Sankaralingam, Rajeswari / Chinnadurai, Saranya / Chilukuri, Balaji

Cureus

2023 Volume 15, Issue 12, Page(s) e50049

Abstract: Introduction: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Detection of antinuclear antibodies (ANAs) aids in the diagnosis of SLE. The indirect immunofluorescence (IIF) assay is often used a routine screening test for the ... ...

Abstract	Introduction: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Detection of antinuclear antibodies (ANAs) aids in the diagnosis of SLE. The indirect immunofluorescence (IIF) assay is often used a routine screening test for the detection of ANA. The pathogenic role and significance of various patterns produced in IIF is yet to be explored. Aim: This study aimed to detect ANA patterns generated by IIF and correlate these patterns with specific antibodies detected by line immunoassay. We also investigated the significance of each ANA pattern and its association with specific serological SLE markers, such as complement molecules, anti-dsDNA, antiphospholipid antibody, and C-reactive protein (CRP), along with associations with direct Coombs test (DCT). Materials and methods: We conducted a retrospective study that included 204 patients newly diagnosed with SLE according to the European Alliance of Associations for Rheumatology/American College of Rheumatology (EULAR/ACR) criteria. The detection and pattern determination of ANA was performed by IIF using HEp-20-10. Furthermore, line immunoassay was performed, and the antibody profile of each sample was obtained. Other immunodiagnostic markers were analyzed, including C3, C4, anti-dsDNA, antiphospholipid antibodies (anti-cardiolipin antibodies, anti-beta-2-glycoprotein I, and lupus anticoagulant), CRP, and DCT. Results: Of the 204 samples, the most frequent ANA pattern observed was nucleus speckled (52.9%), followed by nucleus homogenous (27.5%), mixed (13.7%), and cytoplasm speckled (5.9%). The nucleus homogenous pattern showed the most pathogenic immune profile due to its close association with markers of disease activity, namely, high anti-dsDNA titer, low C3 level, and DCT positivity. Conclusion: This study showed that the most common pattern associated with SLE is nucleus speckled, followed by the nucleus homogenous pattern. Based on associations with specific serological markers, the nucleus homogenous pattern may be linked to a high disease activity in SLE.
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.50049
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Thoracic Compressive Myelopathy in a Patient With Takayasu Arteritis.

Chandrasekar, Nandyal / Thandapani, Manikandan / Govindasamy, Ramachandran / Rudrappa, Satish / Vaithialingam, Balaji

Cureus

2023 Volume 15, Issue 1, Page(s) e33496

Abstract: Takayasu arteritis (TA), also known as occlusive thromboaortopathy, is a type of chronic inflammatory arteritis that primarily affects large vessels. Compressive thoracic myelopathy is a rare and distinct manifestation of TA. We present the case of a 60- ... ...

Abstract	Takayasu arteritis (TA), also known as occlusive thromboaortopathy, is a type of chronic inflammatory arteritis that primarily affects large vessels. Compressive thoracic myelopathy is a rare and distinct manifestation of TA. We present the case of a 60-year-old woman who developed gradually progressive spastic paraplegia over one year. Magnetic resonance imaging revealed a well-defined extra-dual, intensely enhancing ventrodorsal lesion with severe spinal cord impingement. The aortogram revealed dilatation of the aortic arch (with narrowing of arch vessels) and descending aorta, as well as a right paravertebral soft tissue mass at the D4 level. Given the likelihood of TA, the patient underwent decompressive laminectomy and spinal fusion due to severe spinal cord compression. The biopsy of the dural-based lesion revealed an inflammatory granuloma, and the patient was treated postoperatively with oral prednisolone and mycophenolate mofetil. After six months of immunotherapy, there was excellent neurological recovery and near-total resolution of the lesion.
Language	English
Publishing date	2023-01-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.33496
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Article: Challenges in modeling EWS-FLI1-driven transgenic mouse model for Ewing sarcoma.

Ramachandran, Balaji / Rajkumar, Thangarajan / Gopisetty, Gopal

American journal of translational research

2021 Volume 13, Issue 11, Page(s) 12181–12194

Abstract: EWS-FLI1 is a master regulator of Ewing sarcoma (ES) oncogenesis. Although EWS-FLI1 represents a clear therapeutic target, targeted therapeutic inhibitors are lacking. Scientific literature has indicated accumulating information pertaining to EWS-FLI1 ... ...

Abstract	EWS-FLI1 is a master regulator of Ewing sarcoma (ES) oncogenesis. Although EWS-FLI1 represents a clear therapeutic target, targeted therapeutic inhibitors are lacking. Scientific literature has indicated accumulating information pertaining to EWS-FLI1 translocation, pathogenesis, function, oncogenic partnerships, and potential clinical relevance. However, attempts to develop EWS-FLI1-driven human-like ES mouse models or in
Language	English
Publishing date	2021-11-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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