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  1. Article ; Online: Preservation of von Willebrand Factor Activity With the ModulHeart Device.

    Georges, Gabriel / Trudeau, François / Potvin, Jeannot / Potus, François / Martineau, Sandra / Généreux, Philippe

    JACC. Basic to translational science

    2023  Volume 9, Issue 1, Page(s) 33–42

    Abstract: von Willebrand Factor (VWF) destruction is common with current heart pumps. This study evaluates VWF activity with ModulHeart, a novel device using 3 micropumps in parallel. In model 1, ModulHeart was compared with Impella devices in vitro. In model 2, 3 ...

    Abstract von Willebrand Factor (VWF) destruction is common with current heart pumps. This study evaluates VWF activity with ModulHeart, a novel device using 3 micropumps in parallel. In model 1, ModulHeart was compared with Impella devices in vitro. In model 2, 3 healthy swine received ModulHeart. Model 3 includes VWF data from patients who underwent protected percutaneous coronary intervention with ModulHeart. In models 1, 2, and 3, ModulHeart resulted in preservation of VWF, whereas there was a 27% and 19% reduction in VWF activity with the Impella CP and 5.0, respectively. ModulHeart features a unique design and demonstrated preservation of VWF activity.
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2023.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sirtuin 3 and Uncouplin Protein 2, the Missing Link Between Genetics, Metabolism, and Pulmonary Arterial Hypertension.

    Lajoie, Annie C / Potus, François

    Journal of the American Heart Association

    2021  Volume 10, Issue 23, Page(s) e023065

    MeSH term(s) Bone Morphogenetic Protein Receptors, Type II ; Familial Primary Pulmonary Hypertension ; Humans ; Pulmonary Arterial Hypertension ; Sirtuin 3
    Chemical Substances Bone Morphogenetic Protein Receptors, Type II (EC 2.7.11.30) ; Sirtuin 3 (EC 3.5.1.-)
    Language English
    Publishing date 2021-11-02
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.121.023065
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  3. Article ; Online: The future of group 2 pulmonary hypertension: Exploring clinical trials and therapeutic targets.

    Awada, Charifa / Boucherat, Olivier / Provencher, Steeve / Bonnet, Sébastien / Potus, François

    Vascular pharmacology

    2023  Volume 151, Page(s) 107180

    Abstract: Pulmonary hypertension due to left heart disease (PH-LHD) or group 2 PH is the most common and lethal form of PH, occurring secondary to left ventricular systolic or diastolic heart failure (HF), left-sided valvular diseases, and congenital abnormalities. ...

    Abstract Pulmonary hypertension due to left heart disease (PH-LHD) or group 2 PH is the most common and lethal form of PH, occurring secondary to left ventricular systolic or diastolic heart failure (HF), left-sided valvular diseases, and congenital abnormalities. It is subdivided into isolated postcapillary PH (IpcPH) and combined pre- and post-capillary PH (CpcPH), with the latter sharing many similarities with group 1 PH. CpcPH is associated with worse outcomes and increased morbidity and mortality when compared to IpcPH. Although IpcPH can be improved by treatment of the underlying LHD, CpcPH is an incurable disease for which no specific treatment exists, likely due to the lack of understanding of its underlying mechanisms. Furthermore, drugs approved for PAH are not recommended for group 2 PH, as they are either ineffective or even deleterious. With this major unmet medical need, a better understanding of mechanisms and the identification of effective treatment strategies for this deadly condition are urgently needed. This review presents relevant background of the molecular mechanisms underlying PH-LHD that could translate into innovative therapeutic targets and explores novel targets currently being evaluated in clinical trials.
    MeSH term(s) Humans ; Hypertension, Pulmonary ; Treatment Outcome ; Ventricular Dysfunction, Left ; Heart Failure
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2082846-9
    ISSN 1879-3649 ; 1537-1891 ; 1879-3649
    ISSN (online) 1879-3649 ; 1537-1891
    ISSN 1879-3649
    DOI 10.1016/j.vph.2023.107180
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  4. Article ; Online: Pulmonary hypertension thresholds: time to lower further?

    Provencher, Steeve / Boucherat, Olivier / Potus, Francois / Bonnet, Sebastien

    The Lancet. Respiratory medicine

    2020  Volume 8, Issue 9, Page(s) 834–836

    MeSH term(s) Humans ; Hypertension, Pulmonary ; Retrospective Studies ; Vascular Resistance
    Language English
    Publishing date 2020-07-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(20)30326-X
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  5. Article ; Online: Right Ventricle and Epigenetics: A Systematic Review.

    Toro, Victoria / Jutras-Beaudoin, Naomie / Boucherat, Olivier / Bonnet, Sebastien / Provencher, Steeve / Potus, François

    Cells

    2023  Volume 12, Issue 23

    Abstract: There is an increasing recognition of the crucial role of the right ventricle (RV) in determining the functional status and prognosis in multiple conditions. In the past decade, the epigenetic regulation (DNA methylation, histone modification, and non- ... ...

    Abstract There is an increasing recognition of the crucial role of the right ventricle (RV) in determining the functional status and prognosis in multiple conditions. In the past decade, the epigenetic regulation (DNA methylation, histone modification, and non-coding RNAs) of gene expression has been raised as a critical determinant of RV development, RV physiological function, and RV pathological dysfunction. We thus aimed to perform an up-to-date review of the literature, gathering knowledge on the epigenetic modifications associated with RV function/dysfunction. Therefore, we conducted a systematic review of studies assessing the contribution of epigenetic modifications to RV development and/or the progression of RV dysfunction regardless of the causal pathology. English literature published on PubMed, between the inception of the study and 1 January 2023, was evaluated. Two authors independently evaluated whether studies met eligibility criteria before study results were extracted. Amongst the 817 studies screened, 109 studies were included in this review, including 69 that used human samples (e.g., RV myocardium, blood). While 37 proposed an epigenetic-based therapeutic intervention to improve RV function, none involved a clinical trial and 70 are descriptive. Surprisingly, we observed a substantial discrepancy between studies investigating the expression (up or down) and/or the contribution of the same epigenetic modifications on RV function or development. This exhaustive review of the literature summarizes the relevant epigenetic studies focusing on RV in human or preclinical setting.
    MeSH term(s) Humans ; Heart Ventricles/pathology ; Epigenesis, Genetic ; Ventricular Dysfunction, Right ; Myocardium/pathology ; Ventricular Function, Right/physiology
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12232693
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  6. Article ; Online: Commentary on: Xbp1s-Ddit3, DNA damage and pulmonary hypertension.

    Lemay, Sarah-Eve / Bonnet, Sebastien / Potus, François

    Clinical science (London, England : 1979)

    2021  Volume 136, Issue 1, Page(s) 163–166

    Abstract: In this commentary, we discuss new observations stating that spliced X-box-binding protein 1 (Xbp1s)-DNA damage-inducible transcript 3 (Ddit3) promotes monocrotaline (MCT)-induced pulmonary hypertension (Jiang et al., Clinical Science (2021) 135(21), ... ...

    Abstract In this commentary, we discuss new observations stating that spliced X-box-binding protein 1 (Xbp1s)-DNA damage-inducible transcript 3 (Ddit3) promotes monocrotaline (MCT)-induced pulmonary hypertension (Jiang et al., Clinical Science (2021) 135(21), https://doi.org/10.1042/CS20210612). Xbp1s-Ddit3 is involved in the regulation of endoplasmic reticulum stress but is also associated with DNA damage repair machinery. Pathologic DNA damage repair mechanisms have emerged as critical determinants of pulmonary hypertension development. We discuss the potential relationship among Xbp1s-Ddit3, DNA damage, and pulmonary hypertension. Although Xbp1s-Ddit3 contributes to the regulation of cell proliferation and apoptosis and the development of vascular lesions, whether Xbp1s is a friend or foe remains controversial.
    MeSH term(s) Apoptosis ; DNA Damage ; Endoplasmic Reticulum Stress/genetics ; Humans ; Hypertension, Pulmonary/chemically induced ; Hypertension, Pulmonary/genetics ; Monocrotaline ; Transcription Factor CHOP/genetics ; X-Box Binding Protein 1/genetics
    Chemical Substances DDIT3 protein, human ; X-Box Binding Protein 1 ; XBP1 protein, human ; Transcription Factor CHOP (147336-12-7) ; Monocrotaline (73077K8HYV)
    Language English
    Publishing date 2021-12-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20211095
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  7. Article: COVID-19 and the pulmonary vasculature.

    Provencher, Steeve / Potus, François / Bonnet, Sébastien

    Pulmonary circulation

    2020  Volume 10, Issue 3, Page(s) 2045894020933088

    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1177/2045894020933088
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  8. Article ; Online: Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice.

    Potus, Francois / Martin, Ashley Y / Snetsinger, Brooke / Archer, Stephen L

    Journal of visualized experiments : JoVE

    2020  , Issue 160

    Abstract: Assessment of cardiac function is essential to conduct cardiovascular and pulmonary-vascular preclinical research. Pressure-volume loops (PV loops) generated by recording both pressure and volume during cardiac catheterization are vital when assessing ... ...

    Abstract Assessment of cardiac function is essential to conduct cardiovascular and pulmonary-vascular preclinical research. Pressure-volume loops (PV loops) generated by recording both pressure and volume during cardiac catheterization are vital when assessing both systolic and diastolic cardiac function. Left and right heart function are closely related, reflected in ventricular interdependence. Thus, recording biventricular function in the same animal is important to get a complete assessment of cardiac function. In this protocol, a closed chest approach to cardiac catheterization consistent with the way catheterization is performed in patients is adopted in mice. While challenging, the closed chest strategy is a more physiological approach, because opening the chest results in major changes in preload and afterload that create artifacts, most notably a fall in systemic blood pressure. While high-resolution echocardiography is used to assess rodents, cardiac catheterization is invaluable, particularly when assessing diastolic pressures in both ventricles. Described here is a procedure to perform invasive, closed chest, sequential left and right ventricular pressure-volume (PV) loops in the same animal. PV loops are acquired using admittance technology with a mouse pressure-volume catheter and pressure-volume system acquisition. The procedure is described, beginning with the neck dissection, which is required to access the right jugular vein and the right carotid artery, to the insertion and positioning of the catheter, and finally the data acquisition. Then, the criteria required to ensure the acquisition of high-quality PV loops are discussed. Finally, the analysis of the left and right ventricular PV loops and the different hemodynamic parameters available to quantify systolic and diastolic ventricular function are briefly described.
    MeSH term(s) Anesthesia ; Animals ; Blood Pressure/physiology ; Body Temperature ; Cardiac Catheterization ; Catheters ; Data Analysis ; Diastole/physiology ; Heart Ventricles/physiopathology ; Hemodynamics ; Mice, Inbred C57BL ; Pressure ; Systole/physiology
    Language English
    Publishing date 2020-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/61088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hypusine Signaling Promotes Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.

    Lemay, Sarah-Eve / Grobs, Yann / Romanet, Charlotte / Martineau, Sandra / Salem, Mabrouka / Shimauchi, Tsukasa / Breuils-Bonnet, Sandra / Bourgeois, Alice / Théberge, Charlie / Pelletier, Andréanne / Potus, François / Provencher, Steeve / Bonnet, Sébastien / Boucherat, Olivier

    American journal of respiratory and critical care medicine

    2024  

    Abstract: Rationale: The ubiquitous polyamine spermidine is essential for cell survival and proliferation. One important function of spermidine is to serve as a substrate for hypusination, a post-translational modification process that occurs exclusively on ... ...

    Abstract Rationale: The ubiquitous polyamine spermidine is essential for cell survival and proliferation. One important function of spermidine is to serve as a substrate for hypusination, a post-translational modification process that occurs exclusively on eukaryotic translation factor 5A (eIF5A) and ensures efficient translation of various gene products. Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by progressive obliteration of the small pulmonary arteries (PAs) due to excessive proliferation of PA smooth muscle cells (PASMCs) and suppressed apoptosis.
    Objectives: To characterize the role of hypusine signaling in PAH.
    Methods: Molecular, genetic, and pharmacological approaches were used both in vitro and in vivo to investigate the role of hypusine signaling in pulmonary vascular remodeling.
    Measurements and main results: Hypusine forming enzymes (deoxyhypusine synthase, DHPS and deoxyhypusine hydroxylase, DOHH) and hypusinated eIF5A are overexpressed in distal PAs and isolated PASMCs from PAH patients and animal models.
    Conclusions: These findings support inhibiting hypusine signaling as a potential treatment for PAH.
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202305-0909OC
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  10. Article ; Online: Time Is Running Out in Pulmonary Arterial Hypertension: The Epigenetic Clock Is Clicking.

    El Kabbout, Reem / Azhar, Nabil / Breuils-Bonnet, Sandra / Martineau, Sandra / Krishna, Vinod / Kalyana-Sundaram, Shanker / Boucherat, Olivier / Provencher, Steeve / Bonnet, Sébastien / Potus, François

    American journal of respiratory cell and molecular biology

    2024  Volume 70, Issue 2, Page(s) 140–143

    MeSH term(s) Humans ; Pulmonary Arterial Hypertension/genetics ; Familial Primary Pulmonary Hypertension ; Epigenesis, Genetic
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Letter
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2023-0335LE
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