LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 51

Search options

  1. Article: A call for collaboration: linking local and non-local rangeland communities to build resilience

    Phelps, David / Kelly, Dana

    Rangeland journal. 2020, v. 42, no. 5

    2020  

    Abstract: The people who live in Australia’s rangelands are vital for maintaining natural systems, agricultural production, infrastructure for tourism and many services and products which benefit the nation. However, the number of people living within many ... ...

    Abstract The people who live in Australia’s rangelands are vital for maintaining natural systems, agricultural production, infrastructure for tourism and many services and products which benefit the nation. However, the number of people living within many rangeland regions is declining, services are being withdrawn and resilience undermined. Social capital is an important concept within the resilience literature. Bonding social capital is based strong ties within relatively homogenous local groups, bridging social capital is based on ties between more diverse local groups and linking social capital is based on ties between local and external groups. Within the rangelands, there are often strong bonding and bridging social capitals based on internal social and formal connections, but gaps in linking social capital due to weak or imbalanced connections with external groups and organisations. There is evidence that all three social capitals are needed for regional resilience, and the gap in linking is thus a key issue. People who live outside the rangelands can help rebuild this resilience by linking their skills, knowledge and expertise with local groups and communities. Many city-based scientists, policy makers, influencers and other professionals work in and have empathy for the rangelands. By connecting meaningfully with local groups such as Landcare, service clubs, philanthropic groups or Indigenous Rangers, they would find many benefits to their own endeavours through improved policies, knowledge and service delivery. Central-western Queensland is provided as an example where many such mutual benefits and networks already exist, offering pathways for linking local residents with external experts. Current platforms offer opportunities for a greater range of external academic institutions and organisations to engage with locals, with everyone standing to gain.
    Keywords educational institutions ; experts ; issues and policy ; knowledge ; literature ; organizations ; professionals ; rangelands ; scientists ; social capital ; tourism ; Queensland
    Language English
    Size p. 265-275.
    Publishing place CSIRO Publishing
    Document type Article
    Note NAL-light
    ZDB-ID 1082716-x
    ISSN 1036-9872
    ISSN 1036-9872
    DOI 10.1071/RJ20048
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4216: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Overcoming drought vulnerability in rangeland communities: lessons from central-western Queensland

    Phelps, David / Kelly, Dana

    Rangeland journal. 2019, v. 41, no. 3

    2019  

    Abstract: Drought and climate variability are an increasing global problem, especially in rangelands which may lack robust socioeconomic systems. Vulnerability is being applied in drought and climate change policy theory, by describing exposure and sensitivity ... ...

    Abstract Drought and climate variability are an increasing global problem, especially in rangelands which may lack robust socioeconomic systems. Vulnerability is being applied in drought and climate change policy theory, by describing exposure and sensitivity factors, and adaptive capacity. In this paper we examine these vulnerability factors in central-western Queensland (CWQ), Australia, as a case study to test the idea that vulnerability and resilience must be considered together to build strong and enduring rangeland communities. The region’s economy and employment are strongly coupled with rain-fed agriculture. Drought is a key risk to CWQ communities, with 13 extended droughts recorded since 1898. The region has been officially in drought since 2013 following well below-average rainfall, and remains in drought in 2019. The impact has led to reductions in town business turnover of 30–60%, loss of livelihoods and outmigration of 20%. Outmigration corresponds to the recent periods of drought. Social networks have been destabilised, highlighting that the cascading impacts of drought are complex, interrelated and affect the whole community. Regionally led responses have helped to re-build social cohesion, provide mental health support and stimulate economic activity and employment. These actions provide examples of a systemic, whole-of-community approach, that (1) captures place-based advantages; (2) enhances internal and external socioeconomic networks; (3) engages meaningfully through multi-level consultation; and (4) seeks to build sustained financial investment. A common theme of success is partnerships which provide external support for regionally-identified issues and solutions. There has been considerable investment of public, philanthropic and private funds in drought relief and infrastructure programs. This has occurred through a whole-of-community approach, and suggests a move towards policy which aims to build long-term regional resilience. CWQ has linked vulnerability and resilience by asking of both internally and externally led drought relief ‘will this action build or undermine community resilience’. This approach could also be applied to the design of drought policies and responses in other rangeland regions.
    Keywords case studies ; climate ; drought ; economic investment ; employment ; environmental policy ; infrastructure ; livelihood ; mental health ; rain ; rainfed farming ; rangelands ; risk ; social cohesion ; social networks ; Queensland
    Language English
    Size p. 251-270.
    Publishing place CSIRO Publishing
    Document type Article
    ZDB-ID 1082716-x
    ISSN 1036-9872
    ISSN 1036-9872
    DOI 10.1071/RJ18052
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4216: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Looking beyond the D.U.S.T. – building resilient rangeland communities

    Kelly, Dana / Phelps, David

    Rangeland journal. 2019, v. 41, no. 3

    2019  

    Abstract: The role of towns and small business is poorly understood, yet towns are vital for the long-term viability of communities in rural and remote Australia. This case study in the central western region of Queensland (CWQ) examines the impacts of drought on ... ...

    Abstract The role of towns and small business is poorly understood, yet towns are vital for the long-term viability of communities in rural and remote Australia. This case study in the central western region of Queensland (CWQ) examines the impacts of drought on rural towns and how to build a resilient regional community and alleviate hardship. Evidence was collected during drought from town businesses through surveys, interviews and a public meeting in 2017. Towns in CWQ are especially exposed to the risks of drought, as approximately half of the businesses are directly linked to agriculture. Townspeople are major contributors to social cohesion and resilience in rural and regional communities, which are often service and maintenance centres of nationally important infrastructure such as roads for inter-state freight transport and tourism. Drought and declining grazier incomes have led to reduced spending in towns. Populations have dropped sharply, as itinerant agricultural workers leave the region. The complex economic and social flow-on impacts of drought have resulted in lower socioeconomic resilience. The majority of community members interviewed expressed a desire to build secure livelihoods, which echoes other research where existing and new rangelands livelihoods are seen as contributing to the success of the nation, a common global desire. Local organisations in CWQ display innovative business and community strategies. Future actions need to support and build on these initiatives. A framework with the acronym D.U.S.T. has been developed, with associated actions aimed at building resilience in these communities. D.U.S.T. is appropriate for this often-dusty region, and stands for: D. Decide to act; U. Understand the context; S. Support and develop local capacities and institutions; and T. Transform regional governance. The key for decision-makers is to work with local people who understand the contextual complexity and local needs. Actions need to be based on principles of adaptability, equity and inclusiveness, and working with the whole of the community. Building on existing collaborations and innovations as well as transforming governance and secure funding arrangements are needed. Lessons from the communities in CWQ may help other rural and remote regions build resilience to cope with the unpredictable financial, social and environmental future.
    Keywords case studies ; decision making ; drought ; farm labor ; freight ; funding ; governance ; income ; interviews ; livelihood ; rangelands ; risk ; roads ; small businesses ; social cohesion ; surveys ; tourism ; towns ; viability ; Queensland
    Language English
    Size p. 233-250.
    Publishing place CSIRO Publishing
    Document type Article
    ZDB-ID 1082716-x
    ISSN 1036-9872
    ISSN 1036-9872
    DOI 10.1071/RJ18047
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4216: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: The Road Toward Transformative Treatments for Food Allergy.

    Phelps, Allyssa / Bruton, Kelly / Grydziuszko, Emily / Koenig, Joshua F E / Jordana, Manel

    Frontiers in allergy

    2022  Volume 3, Page(s) 826623

    Abstract: A series of landmark studies have provided conclusive evidence that the early administration of food allergens dramatically prevents the emergence of food allergy. One of the greatest remaining challenges is whether patients with established food allergy ...

    Abstract A series of landmark studies have provided conclusive evidence that the early administration of food allergens dramatically prevents the emergence of food allergy. One of the greatest remaining challenges is whether patients with established food allergy can return to health. This challenge is particularly pressing in the case of allergies against peanut, tree nuts, fish, and shellfish which are lifelong in most patients and may elicit severe reactions. The standard of care for food allergy is allergen avoidance and the timely administration of epinephrine upon accidental exposure. Epinephrine, and other therapeutic options like antihistamines provide acute symptom relief but do not target the underlying pathology of the disease. In principle, any transformative treatment for established food allergy would require the restoration of a homeostatic immunological state. This may be attained through either an active, non-harmful immune response (immunological tolerance) or a lack of a harmful immune response (e.g., anergy), such that subsequent exposures to the allergen do not elicit a clinical reaction. Importantly, such a state must persist beyond the course of the treatment and exert its protective effects permanently. In this review, we will discuss the immunological mechanisms that maintain lifelong food allergies and are, consequently, those which must be dismantled or reprogrammed to instate a clinically non-reactive state. Arguably, the restoration of such a state in the context of an established food allergy would require a reprogramming of the immune response against a given food allergen. We will discuss existing and experimental therapeutic strategies to eliminate IgE reactivity and, lastly, will propose outstanding questions to pave the road to the development of novel, transformative therapeutics in food allergy.
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-6101
    ISSN (online) 2673-6101
    DOI 10.3389/falgy.2022.826623
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Heterogeneity, subsets, and plasticity of T follicular helper cells in allergy.

    Grydziuszko, Emily / Phelps, Allyssa / Bruton, Kelly / Jordana, Manel / Koenig, Joshua F E

    The Journal of allergy and clinical immunology

    2022  Volume 150, Issue 5, Page(s) 990–998

    Abstract: Antibody responses are critical for protection against pathogens. However, diseases such as allergic rhinitis or food allergy result from aberrant production of IgE antibodies against otherwise innocuous environmental antigens. The production of allergen- ...

    Abstract Antibody responses are critical for protection against pathogens. However, diseases such as allergic rhinitis or food allergy result from aberrant production of IgE antibodies against otherwise innocuous environmental antigens. The production of allergen-specific IgE requires interaction between B cells and CD4<sup>+</sup> T cells, and a granular understanding of these interactions is required to develop novel therapies for allergic disease. CD4<sup>+</sup> T cells are exceptionally heterogeneous in their transcriptional, epigenetic, and proteomic profiles, which poses significant challenges when attempting to define subsets relevant to the study of allergy among a continuum of cells. Defining subsets such as the T follicular helper (T<sub>FH</sub>) cell cluster provides a shorthand to understand the functions of CD4<sup>+</sup> T cells in antibody production and supports mechanistic experimentation for hypothesis-driven discovery. With a focus on allergic disease, this Rostrum article broadly discusses heterogeneity among CD4<sup>+</sup> T cells and provides a rationale for subdividing T<sub>FH</sub> cells into both functional and cytokine-skewed subsets. Further, it highlights the plasticity demonstrated by T<sub>FH</sub> cells during the primary response and after recall, and it explores the possibility of harnessing this plasticity to reprogram immunity for therapeutic benefit in allergic disease.
    MeSH term(s) Humans ; T-Lymphocytes, Helper-Inducer ; T Follicular Helper Cells ; Proteomics ; Hypersensitivity ; Immunoglobulin E ; T-Lymphocyte Subsets
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.08.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.92: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Response to Bodiwala and Skole.

    Fischer, Monika / Phelps, Emmalee / Kao, Dina / Xu, Huiping / Kelly, Colleen

    The American journal of gastroenterology

    2017  Volume 112, Issue 2, Page(s) 391–392

    Language English
    Publishing date 2017-02-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.1038/ajg.2016.560
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.36: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Memory Generation and Re-Activation in Food Allergy.

    Koenig, Joshua F E / Bruton, Kelly / Phelps, Allyssa / Grydziuszko, Emily / Jiménez-Saiz, Rodrigo / Jordana, Manel

    ImmunoTargets and therapy

    2021  Volume 10, Page(s) 171–184

    Abstract: Recent evidence has highlighted the critical role of memory cells in maintaining lifelong food allergies, thereby identifying these cells as therapeutic targets. ... ...

    Abstract Recent evidence has highlighted the critical role of memory cells in maintaining lifelong food allergies, thereby identifying these cells as therapeutic targets. IgG
    Language English
    Publishing date 2021-06-09
    Publishing country New Zealand
    Document type Journal Article ; Review
    ISSN 2253-1556
    ISSN 2253-1556
    DOI 10.2147/ITT.S284823
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Perturbations to Homeostasis in Experimental Models Revealed Innate Pathways Driving Food Allergy.

    Bruton, Kelly / Koenig, Joshua F E / Phelps, Allyssa / Jordana, Manel

    Frontiers in immunology

    2020  Volume 11, Page(s) 603272

    Abstract: While type 2 immunity has been conventionally viewed as beneficial against helminths, venoms, and poisons, and harmful in allergy, contemporary research has uncovered its critical role in the maintenance of homeostasis. The initiation of a type 2 immune ... ...

    Abstract While type 2 immunity has been conventionally viewed as beneficial against helminths, venoms, and poisons, and harmful in allergy, contemporary research has uncovered its critical role in the maintenance of homeostasis. The initiation of a type 2 immune response involves an intricate crosstalk between structural and immune cells. Structural cells react to physical and chemical tissue perturbations by secreting alarmins, which signal the innate immune system to restore homeostasis. This pathway acts autonomously in the context of sterile injury and in the presence of foreign antigen initiates an adaptive Th2 response that is beneficial in the context of venoms, toxins, and helminths, but not food allergens. The investigation of the triggers and mechanisms underlying food allergic sensitization in humans is elusive because sensitization is a silent process. Therefore, the central construct driving food allergy modeling is based on introducing perturbations of tissue homeostasis along with an allergen which will result in an immunological and clinical phenotype that is consistent with that observed in humans. The collective evidence from multiple models has revealed the pre-eminent role of innate cells and molecules in the elicitation of allergic sensitization. We posit that, with the expanding use of technologies capable of producing formidable datasets, models of food allergy will continue to have an indispensable role to delineate mechanisms and establish causal relationships.
    MeSH term(s) Animals ; Cell Communication ; Disease Models, Animal ; Epithelial Cells/immunology ; Epithelial Cells/metabolism ; Food Hypersensitivity/immunology ; Food Hypersensitivity/metabolism ; Homeostasis ; Humans ; Immunity, Innate ; Signal Transduction ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
    Language English
    Publishing date 2020-12-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.603272
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Type 2-polarized memory B cells hold allergen-specific IgE memory.

    Koenig, Joshua F E / Knudsen, Niels Peter H / Phelps, Allyssa / Bruton, Kelly / Hoof, Ilka / Lund, Gitte / Libera, Danielle Della / Lund, Anders / Christensen, Lars Harder / Glass, David R / Walker, Tina D / Fang, Allison / Waserman, Susan / Jordana, Manel / Andersen, Peter S

    Science translational medicine

    2024  Volume 16, Issue 733, Page(s) eadi0944

    Abstract: Allergen-specific immunoglobulin E (IgE) antibodies mediate pathology in diseases such as allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to circulating IgE by regenerating IgE-producing plasma cells upon allergen encounter. Here, we ...

    Abstract Allergen-specific immunoglobulin E (IgE) antibodies mediate pathology in diseases such as allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to circulating IgE by regenerating IgE-producing plasma cells upon allergen encounter. Here, we report a population of type 2-polarized MBCs defined as CD23
    MeSH term(s) Humans ; Rhinitis, Allergic, Seasonal/metabolism ; Memory B Cells ; Allergens ; Immunoglobulin E ; Rhinitis, Allergic ; Immunoglobulin G ; Food Hypersensitivity
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0) ; Immunoglobulin G
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.adi0944
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6941: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Physical Health and Disability Among U.S. Adults Recently on Community Supervision.

    Winkelman, Tyler N A / Phelps, Michelle S / Mitchell, Kelly Lyn / Jennings, Latasha / Shlafer, Rebecca J

    Journal of correctional health care : the official journal of the National Commission on Correctional Health Care

    2020  Volume 26, Issue 2, Page(s) 129–137

    Abstract: Estimates of chronic conditions and disability among individuals on community supervision in the United States are lacking. We used 2015-2016 data from the National Survey on Drug Use and Health ( ...

    Abstract Estimates of chronic conditions and disability among individuals on community supervision in the United States are lacking. We used 2015-2016 data from the National Survey on Drug Use and Health (
    MeSH term(s) Adult ; Chronic Disease ; Community Integration ; Disabled Persons ; Female ; Health Status ; Health Surveys ; Humans ; Male ; Prevalence ; Prisoners ; Substance-Related Disorders ; United States
    Language English
    Publishing date 2020-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2233559-6
    ISSN 1940-5200 ; 1078-3458
    ISSN (online) 1940-5200
    ISSN 1078-3458
    DOI 10.1177/1078345820915920
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top