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Article ; Online: Myoepithelioma, myoepithelioma-like, and chondroid soft-tissue tumors arising at acral sites: a review.

Patton, Ashley / Billings, Steven D / Fritchie, Karen J

2023 Volume 140, Page(s) 66–74

Abstract: Myoepithelial neoplasms comprise a histologically and immunophenotypically diverse spectrum of entities. The following review is a comprehensive summary of acral lesions demonstrating myoepithelial-like and chondroid histomorphology, as well as recently ... ...

Abstract	Myoepithelial neoplasms comprise a histologically and immunophenotypically diverse spectrum of entities. The following review is a comprehensive summary of acral lesions demonstrating myoepithelial-like and chondroid histomorphology, as well as recently described mimics that are diagnostically challenging to distinguish. The salient clinicopathologic, immunophenotypic, and molecular features of each entity are described.
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2023.04.003
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Article ; Online: Soft Tissue Special Issue: Biphenotypic Sinonasal Sarcoma: A Review with Emphasis on Differential Diagnosis.

Gross, John / Fritchie, Karen

Head and neck pathology

2020 Volume 14, Issue 1, Page(s) 33–42

Abstract: Biphenotypic sinonasal sarcoma is an anatomically restricted low-grade malignant neoplasm with dual neural and myogenic differentiation composed of a monotonous population of spindled cells with herringbone/fascicular architecture. These tumors ... ...

Abstract	Biphenotypic sinonasal sarcoma is an anatomically restricted low-grade malignant neoplasm with dual neural and myogenic differentiation composed of a monotonous population of spindled cells with herringbone/fascicular architecture. These tumors demonstrate a unique immunoprofile with relatively consistent S100-protein and actin expression in conjunction with more variable desmin, myogenin and myoD1 staining. SOX10 is uniformly negative. Genetically, the majority of tumors harbor PAX3-MAML3 fusions, with alternate PAX3 partners including FOXO1, NCOA1, NCOA2 and WWTR1. Although the differential diagnosis of BSNS is broad, careful morphologic inspection together with targeted ancillary studies is often sufficient to arrive at the correct diagnosis. As these tumors have significant local recurrence rates but lack metastatic potential, awareness and accurate diagnosis of this rare and newly described neoplasm is critical for appropriate management.
MeSH term(s)	Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Diagnosis, Differential ; Humans ; Paranasal Sinus Neoplasms/diagnosis ; Paranasal Sinus Neoplasms/genetics ; Paranasal Sinus Neoplasms/pathology ; Sarcoma/diagnosis ; Sarcoma/genetics ; Sarcoma/pathology ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/genetics ; Soft Tissue Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2020-01-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2407834-7
ISSN	1936-0568 ; 1936-055X
ISSN (online)	1936-0568
ISSN	1936-055X
DOI	10.1007/s12105-019-01092-4
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Article ; Online: Tumoral calcinosis of the knee treated with open, physeal sparing iliotibial band ACL reconstruction.

Ryan, Patrick M / Sprowls, Gregory R / Ward, Russell A / Zriek, Riyam / Fritchie, Karen

The Knee

2023 Volume 43, Page(s) 1–9

Abstract: Tumoral calcinosis is a hereditary disease of calcium and phosphate metabolism causing peri-articular tumors of calcium deposits. We present a case of tumoral calcinosis in a 13-year-old male with a history of a 12q13.11 genetic deletion. Surgical ... ...

Abstract	Tumoral calcinosis is a hereditary disease of calcium and phosphate metabolism causing peri-articular tumors of calcium deposits. We present a case of tumoral calcinosis in a 13-year-old male with a history of a 12q13.11 genetic deletion. Surgical resection of the tumor necessitated resection of the ACL in its entirety with curettage and adjuvant therapy to the lateral femoral notch, which resulted in ligamentous instability and bony structural incompetency at the femoral insertion. Given the patient's radiographically-apparent skeletal immaturity, and lack of reliable bony architecture to accommodate a femoral ACL tunnel, ACL reconstruction was performed using a physeal-sparing technique. This is a case of tumoral calcinosis treated with, to our knowledge, the first ACL reconstruction using this modified open technique.
Language	English
Publishing date	2023-05-16
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	1200476-5
ISSN	1873-5800 ; 0968-0160
ISSN (online)	1873-5800
ISSN	0968-0160
DOI	10.1016/j.knee.2023.04.018
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Zs.A 4043: Show issues

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Article ; Online: Solitary fibrous tumor of head and neck region; A clinicopathological study of 67 cases emphasizing the diversity of histological features and utility of various risk stratification models.

Tariq, Muhammad Usman / Asghari, Tamana / Armstrong, Susan M / Ahmed, Arsalan / Fritchie, Karen / Din, Nasir Ud

Pathology, research and practice

2023 Volume 249, Page(s) 154777

Abstract: Background: Head and neck SFT (HNSFT) exhibit diverse histological features and can mimic various neoplasms with different treatment and behavior. While risk stratification systems have been developed for this tumor at various anatomic sites, a specific ...

Abstract	Background: Head and neck SFT (HNSFT) exhibit diverse histological features and can mimic various neoplasms with different treatment and behavior. While risk stratification systems have been developed for this tumor at various anatomic sites, a specific scheme for head and neck tumors is lacking. Our aim was to describe the histologic patterns present in HNSFT cases as well as assess the utility of risk assessment models in this location. Methods: A retrospective review of pathology reports and microscopy glass slides of HNSFT cases diagnosed between January 2010 and August 2022 was performed.STAT6 was additionally performed on selected cases if needed. Follow up was obtained and various risk stratification models were applied. Results: Sixty seven cases of HNSFT were collected (age range from 11 to 87 years; median 42 years; M:F 1.6:1). Most common tumor sites were orbit (n = 21; 31.3 %), sinonasal tract (n = 18; 26.9 %), and oral cavity (n = 13; 19.4 %). Tumor size ranged from 1 to 16 cm (median 4cm). Apart from common histological features, tumor cells also showed focal epithelioid morphology, clear cell change and nuclear atypia in a subset of cases. Stromal findings included myxoid and lipomatous change, pseudoglandular spaces, pseudovascular spaces and multinucleated stromal giant cells. CD34 and STAT6 were expressed in 57/67 (85.1 %) and 56/56 (100 %) cases, respectively. Recurrence was observed in 4/26 (15.4 %) cases, while none (0/22) of the patients experienced distant metastasis (follow up 1-150 months; median 20.5 months). Clinical outcome was partially concordant with risk-categories of different risk stratification models. Conclusion: Knowledge about histological diversity of HNSFT is essential for establishing correct diagnosis. Current risk stratification models do not perfectly predict outcome, and larger studies are needed to develop more accurate criteria for aggressive behavior.
MeSH term(s)	Humans ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Hemangiopericytoma ; Solitary Fibrous Tumors ; Mouth ; Lipoma ; Antigens, CD34
Chemical Substances	Antigens, CD34
Language	English
Publishing date	2023-08-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.154777
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Article ; Online: Diagnostically Challenging "Fatty" Retroperitoneal Tumors.

Fritchie, Karen J

Surgical pathology clinics

2015 Volume 8, Issue 3, Page(s) 375–397

Abstract: A variety of benign and malignant retroperitoneal mesenchymal lesions may have a component of adipose tissue, including entities such as lipoma, myolipoma, angiomyolipoma, solitary fibrous tumor, genital stromal tumors, and well-differentiated/ ... ...

Abstract	A variety of benign and malignant retroperitoneal mesenchymal lesions may have a component of adipose tissue, including entities such as lipoma, myolipoma, angiomyolipoma, solitary fibrous tumor, genital stromal tumors, and well-differentiated/dedifferentiated liposarcoma. Although definitive diagnosis is usually straightforward on the complete resection specimen, it is often more difficult to workup these lesions on small biopsy samples. This review focuses on challenging diagnostic scenarios of retroperitoneal lesions with a "fatty" component and provides major differential diagnoses for commonly encountered morphologic patterns, clinicopathologic features of the various entities, and strategy for use of ancillary techniques, such as immunohistochemistry and cytogenetic studies.
MeSH term(s)	Diagnosis, Differential ; Humans ; Lipoma/diagnosis ; Lipoma/pathology ; Liposarcoma/diagnosis ; Liposarcoma/pathology ; Retroperitoneal Neoplasms/diagnosis ; Retroperitoneal Neoplasms/pathology ; Stromal Cells/pathology
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1875-9157
ISSN (online)	1875-9157
DOI	10.1016/j.path.2015.05.008
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Article ; Online: What is new in pericytomatous, myoid, and myofibroblastic tumors?

John, Ivy / Fritchie, Karen J

Virchows Archiv : an international journal of pathology

2019 Volume 476, Issue 1, Page(s) 57–64

Abstract: Recent advances in molecular techniques in soft tissue pathology, including the widespread application of next-generation sequencing, have led to significant progress in our understanding of mesenchymal tumors. Recognition of the genetic signatures of ... ...

Abstract	Recent advances in molecular techniques in soft tissue pathology, including the widespread application of next-generation sequencing, have led to significant progress in our understanding of mesenchymal tumors. Recognition of the genetic signatures of these neoplasms not only clarifies the relationship of these entities but also provides a mechanism for more accurate diagnosis. More importantly, insight into the genetic underpinnings of these lesions may offer therapeutic targets for cases not amenable to surgical treatment. This review highlights the clinicopathologic features and novel molecular findings in pericytic, myoid, and myofibroblastic tumors.
MeSH term(s)	Fibroma/genetics ; Fibroma/pathology ; Gene Rearrangement ; Humans ; Myofibroma/genetics ; Myofibroma/pathology ; Neoplasms, Connective and Soft Tissue/genetics ; Neoplasms, Connective and Soft Tissue/pathology ; Pericytes/pathology ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; Receptor, Platelet-Derived Growth Factor beta/genetics ; Zinc Finger Protein GLI1/genetics
Chemical Substances	GLI1 protein, human ; KRAS protein, human ; Zinc Finger Protein GLI1 ; Receptor, Platelet-Derived Growth Factor beta (EC 2.7.10.1) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2019-11-08
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-019-02700-y
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Article ; Online: CD10 (neprilysin) expression: a potential adjunct in the distinction of hibernoma from morphologic mimics.

Gjorgova-Gjeorgjievski, Sandra / Fritchie, Karen / Folpe, Andrew L

Human pathology

2021 Volume 110, Page(s) 12–19

Abstract: Although the morphologic diagnosis of hibernoma is usually straightforward, some hibernomas have atypical morphologic features, mimicking atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs). In addition, the multivacuolated brown fat ... ...

Abstract	Although the morphologic diagnosis of hibernoma is usually straightforward, some hibernomas have atypical morphologic features, mimicking atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs). In addition, the multivacuolated brown fat cells may be mistaken for lipoblasts by pathologists, especially those without significant soft tissue tumor exposure. Thus, we continue to receive in consultation cases of hibernoma sent for MDM2 fluorescence in situ hybridization testing to exclude ALT/WDL. Testing hibernomas for MDM2 amplification, however, adds cost and delays the final diagnosis. Recently, we have noted expression of neprilysin (CD10, CALLA), a zinc-dependent metalloproteinase involved in the inactivation of various peptide hormones, in brown fat cells, and wished to explore the potential utility of this widely available, inexpensive ancillary test in the differential diagnosis of hibernoma. Formalin-fixed, paraffin-embedded tissue sections from well-characterized cases of hibernoma (n = 48), brown fat (n = 21), ALTs/WDLs (n = 17), pleomorphic liposarcomas (PLPSs) (n = 6), lipomas (n = 5), and fat necrosis (n = 5) were immunostained for CD10, using a commercially available antibody and routine laboratory protocols. CD10 expression was evaluated in both adipocytes and in surrounding stromal cells. The hibernomas occurred in 28 men and 20 women, ranging from 11 to 76 years of age and involved the extremities (n = 25), pelvis (n = 7), abdomen/pelvis/retroperitoneum (n = 7), head and neck region (n = 6), back (n = 2), and chest (n = 1). All showed diffuse, strong CD10 expression in multivacuolated brown fat cells and in the majority of adjacent univacuolated fat cells. Brown adipose tissue from various anatomic structures showed an identical pattern of immunoreactivity. In contrast, CD10 expression was present in the adipocytes of only 3 of 17 (18%) ALTs/WDLs and was absent in lipomas and fat necrosis. Lipoblasts expressed CD10 in 3 PLPSs. Expression of CD10 by surrounding fibroblastic stromal cells was more widespread, present in 13 hibernomas, 10 ALTs/WDLs, 1 instance of fat necrosis, 6 PLPSs, and 4 examples of brown fat. We conclude that immunohistochemistry for CD10 may represent a useful, rapid and inexpensive ancillary test in the differential diagnosis of hibernoma from potential morphologic mimics, especially when morphologic features favor hibernoma. CD10 expression in adipocytes, however, should be rigorously distinguished from fibroblastic stromal cell CD10 expression, a nonspecific finding.
MeSH term(s)	Adipocytes/metabolism ; Adipocytes/pathology ; Adolescent ; Adult ; Aged ; Biomarkers, Tumor/metabolism ; Child ; Diagnosis, Differential ; Female ; Humans ; Lipoma/diagnosis ; Lipoma/metabolism ; Lipoma/pathology ; Liposarcoma/diagnosis ; Liposarcoma/metabolism ; Liposarcoma/pathology ; Male ; Middle Aged ; Neprilysin/metabolism ; Proto-Oncogene Proteins c-mdm2/genetics ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/metabolism ; Soft Tissue Neoplasms/pathology ; Young Adult
Chemical Substances	Biomarkers, Tumor ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27) ; Neprilysin (EC 3.4.24.11)
Language	English
Publishing date	2021-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2020.12.012
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Zs.A 722: Show issues

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Article ; Online: Myoepithelioma-like hyalinising epithelioid tumour of the foot: biopsy diagnosis, with molecular confirmation.

Neyaz, Azfar / Omman, Reeba A / Wald, Abigail I / Herradura, Armando / Fritchie, Karen J / John, Ivy

Histopathology

2022 Volume 81, Issue 6, Page(s) 847–849

MeSH term(s)	Humans ; Myoepithelioma/diagnosis ; Myoepithelioma/pathology ; Biopsy ; Neoplasms
Language	English
Publishing date	2022-09-19
Publishing country	England
Document type	Letter
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
DOI	10.1111/his.14788
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Zs.A 1328: Show issues

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Article ; Online: Update on Peripheral Nerve Sheath Tumors.

Martinez, Anthony P / Fritchie, Karen J

Surgical pathology clinics

2018 Volume 12, Issue 1, Page(s) 1–19

Abstract: Recent work has revealed SMARCB1/INI1 loss by immunohistochemistry in a subset of epithelioid schwannomas and explored the significance of cytologic atypia and increased mitotic activity in these tumors. Additional studies have evaluated the utility and ... ...

Abstract	Recent work has revealed SMARCB1/INI1 loss by immunohistochemistry in a subset of epithelioid schwannomas and explored the significance of cytologic atypia and increased mitotic activity in these tumors. Additional studies have evaluated the utility and limitations of histone H3K27 trimethylation in diagnosis of high-grade and low-grade malignant peripheral nerve sheath tumors. New terminology regarding nerve sheath tumors in neurofibromatosis type 1 patients was proposed during a 2016 conference to better define guidelines for classification of this group of tumors. This review highlights novel findings and practical applications relating to these topics in peripheral nerve sheath tumors.
MeSH term(s)	Biomarkers, Tumor/genetics ; DNA Methylation ; Diagnosis, Differential ; Histones/metabolism ; Humans ; Immunohistochemistry ; Nerve Sheath Neoplasms/classification ; Nerve Sheath Neoplasms/diagnosis ; Nerve Sheath Neoplasms/genetics ; Nerve Sheath Neoplasms/pathology ; Prognosis ; Terminology as Topic
Chemical Substances	Biomarkers, Tumor ; Histones
Language	English
Publishing date	2018-12-17
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1875-9157
ISSN (online)	1875-9157
DOI	10.1016/j.path.2018.10.001
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Article ; Online: Extranodal Follicular Dendritic Cell Sarcoma of the Head and Neck Region: A Clinicopathological Study of 7 Cases.

Din, Nasir Ud / Ahmad, Zubair / Rahim, Shabina / Fritchie, Karen / Tariq, Muhammad Usman / Ahmed, Arsalan

International journal of surgical pathology

2022 Volume 31, Issue 6, Page(s) 1067–1074

Abstract: Background. ...

Abstract	Background.
MeSH term(s)	Humans ; Male ; Female ; Adult ; Child ; Adolescent ; Young Adult ; Middle Aged ; Aged ; Dendritic Cell Sarcoma, Follicular/diagnosis ; Dendritic Cell Sarcoma, Follicular/surgery ; Dendritic Cell Sarcoma, Follicular/pathology ; Sarcoma/pathology ; Head and Neck Neoplasms/diagnosis
Language	English
Publishing date	2022-11-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336393-1
ISSN	1940-2465 ; 1066-8969
ISSN (online)	1940-2465
ISSN	1066-8969
DOI	10.1177/10668969221133352
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