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Book ; Thesis: Gadophrin (Gadolinium-Mesoporphyrin) in der kernspintomographischen Darstellung des akuten Myokardinfarktes und myokardialer Perfusionszustände

Köbe, Julia

eine tierexperimentelle Studie

2000

Author's details	vorgelegt von Julia Köbe
Language	German
Size	89 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Aachen, Techn. Hochsch., Diss., 2000
HBZ-ID	HT012891076
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Catheter Ablation of Ventricular Tachycardia in the Presence of Mechanical Aortic and Mitral Valve Replacement.

Wolfes, Julian / Köbe, Julia / Ellermann, Christian / Frommeyer, Gerrit / Ghezelbash, Farshad / Eckardt, Lars

JACC. Clinical electrophysiology

2023 Volume 10, Issue 2, Page(s) 429–438

MeSH term(s)	Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Tachycardia, Ventricular/surgery ; Arrhythmias, Cardiac/surgery ; Catheter Ablation
Language	English
Publishing date	2023-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2846739-5
ISSN	2405-5018 ; 2405-500X ; 2405-500X
ISSN (online)	2405-5018 ; 2405-500X
ISSN	2405-500X
DOI	10.1016/j.jacep.2023.10.034
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Therapy of supraventricular and ventricular arrhythmias in adults with congenital heart disease-narrative review.

Wasmer, Kristina / Eckardt, Lars / Baumgartner, Helmut / Köbe, Julia

Cardiovascular diagnosis and therapy

2021 Volume 11, Issue 2, Page(s) 550–562

Abstract: Arrhythmias are among the most common late complications in adults with congenital heart disease (ACHD) and a frequent reason for hospital admission. Both, supraventricular and ventricular arrhythmias, not only cause debilitating symptoms, but may be ... ...

Abstract	Arrhythmias are among the most common late complications in adults with congenital heart disease (ACHD) and a frequent reason for hospital admission. Both, supraventricular and ventricular arrhythmias, not only cause debilitating symptoms, but may be life-threatening by increasing risk of stroke, causing or worsening heart failure and being associated with sudden death. Substrate and risk for arrhythmia differs widely between congenital defects with specific arrhythmias being much more common in some patients than others. Atrial macroreentrant arrhythmias are particularly frequent in patients with atrial septal defects and repair that involves atrial incisions including patients with transposition of the great arteries (TGA) and atrial switch. Accessory pathways and related arrhythmias are often associated with Ebstein's anomaly and congenitally corrected TGA. Monomorphic ventricular arrhythmias occur in patients with ventricular incisions, namely patients with Tetralogy of Fallot. Changes in surgical repair techniques influence arrhythmia prevalence and substrate as well as anatomical access for catheter ablation procedures. In addition, epidemiologic changes associated with improved long-term survival will further increase the prevalence of atrial fibrillation in ACHD. This article summarizes current understanding of prevalence of specific arrhythmias, underlying mechanisms, medical and interventional treatment options and their outcome in ACHD.
Language	English
Publishing date	2021-05-04
Publishing country	China (Republic : 1949- )
Document type	Journal Article ; Review
ZDB-ID	2685043-6
ISSN	2223-3660 ; 2223-3652
ISSN (online)	2223-3660
ISSN	2223-3652
DOI	10.21037/cdt-20-634
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Article ; Online: Reduzierter biventrikulärer Stimulationsanteil durch Extrasystolen : Behandlungsstrategien für eine optimierte kardiale Resynchronisation.

Rath, Benjamin / Köbe, Julia / Reinke, Florian / Eckardt, Lars

Herzschrittmachertherapie & Elektrophysiologie

2021 Volume 32, Issue 1, Page(s) 41–47

Abstract: Cardiac resynchronization therapy (CRT) is an integral part in the treatment of chronic heart failure. However, a high degree of biventricular pacing is essential for the effectiveness of this therapy. In addition to atrial fibrillation, premature ... ...

Title translation	Management of premature ventricular ectopy in cardiac resynchronization therapy : Treatment strategies for an optimized cardiac resynchronization.
Abstract	Cardiac resynchronization therapy (CRT) is an integral part in the treatment of chronic heart failure. However, a high degree of biventricular pacing is essential for the effectiveness of this therapy. In addition to atrial fibrillation, premature ventricular contractions (PVC) are a common cause of reduced biventricular stimulation in CRT. In addition to the prognostically unfavorable reduction of biventricular pacing, PVC are generally associated with reduced outcome in the presence of structural heart disease. Options to increase biventricular stimulation percentage by reprogramming the CRT devices are limited in the majority of cases. Due to the mutual relationship between cardiomyopathy and ventricular arrhythmias, adequate heart failure therapy is essential for the reduction of ventricular ectopy. In addition to beta-blocker therapy, specific antiarrhythmic medication is mostly limited to class III antiarrhythmic drugs due to the structural heart disease usually present in CRT patients. Catheter ablation is superior to pharmacological therapy especially in the field of idiopathic PVC, but promising data are also available for catheter ablation of PVC in structural heart disease and CRT nonresponders.
MeSH term(s)	Cardiac Resynchronization Therapy ; Cardiac Resynchronization Therapy Devices ; Heart Failure/therapy ; Humans ; Treatment Outcome ; Ventricular Premature Complexes/diagnosis ; Ventricular Premature Complexes/therapy
Language	German
Publishing date	2021-01-29
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1082953-2
ISSN	1435-1544 ; 0938-7412
ISSN (online)	1435-1544
ISSN	0938-7412
DOI	10.1007/s00399-021-00745-8
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Article: Narrative review of: risk stratification and implantable cardioverter-defibrillator therapy in adults with congenital heart disease.

Köbe, Julia / Willy, Kevin / Eckardt, Lars / Baumgartner, Helmut / Wasmer, Kristina

Cardiovascular diagnosis and therapy

2021 Volume 11, Issue 2, Page(s) 538–549

Abstract: Fortunately, the population of adults with congenital heart disease (ACHD) is growing due to improved operation techniques. Life expectancy is continuously rising, nevertheless, sudden cardiac death is one of the leading causes of mortality in ACHD late ... ...

Abstract	Fortunately, the population of adults with congenital heart disease (ACHD) is growing due to improved operation techniques. Life expectancy is continuously rising, nevertheless, sudden cardiac death is one of the leading causes of mortality in ACHD late after initial diagnosis. Risk stratification in ACHD remains challenging as large study results are missing, congenital defects and operation methods differ considerably between individual patients and results from acquired heart diseases are often not conferrable. The purpose of this narrative review is to objectively summarize the current knowledge on arrhythmogenic risk of ACHD and to give an overview on implantable cardioverter-defibrillator (ICD) therapy in this collective. Remarkable progress has been made in electrophysiological understanding of critical areas of slow conduction especially in patients with Tetralogy of Fallot (ToF). In patients with transposition of the great arteries after atrial baffling (Mustard/Senning procedure) atrial arrhythmias play a crucial role in sudden cardiac death. ICD therapy in ACHD may pose special technical challenges due to limited access for intracardiac leads. The introduction of the totally subcutaneous ICD improved therapeutic options for ACHD especially when contraindications for transvenous leads are present. Risk stratification in ACHD has to be seen as a team approach, requires thorough understanding of congenital heart defects and the operation techniques and needs unconventional technical approaches in some cases.
Language	English
Publishing date	2021-05-04
Publishing country	China (Republic : 1949- )
Document type	Journal Article ; Review
ZDB-ID	2685043-6
ISSN	2223-3660 ; 2223-3652
ISSN (online)	2223-3660
ISSN	2223-3652
DOI	10.21037/cdt-20-633
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Article ; Online: Relevance of mexiletine in the era of evolving antiarrhythmic therapy of ventricular arrhythmias.

Alhourani, Nawar / Wolfes, Julian / Könemann, Hilke / Ellermann, Christian / Frommeyer, Gerrit / Güner, Fatih / Lange, Philipp Sebastian / Reinke, Florian / Köbe, Julia / Eckardt, Lars

Clinical research in cardiology : official journal of the German Cardiac Society

2024

Abstract: Despite impressive developments in the field of ventricular arrhythmias, there is still a relevant number of patients with ventricular arrhythmias who require antiarrhythmic drug therapy and may, e.g., in otherwise drug and/or ablation refractory ... ...

Abstract	Despite impressive developments in the field of ventricular arrhythmias, there is still a relevant number of patients with ventricular arrhythmias who require antiarrhythmic drug therapy and may, e.g., in otherwise drug and/or ablation refractory situations, benefit from agents known for decades, such as mexiletine. Through its capability of blocking fast sodium channels in cardiomyocytes, it has played a minor to moderate antiarrhythmic role throughout the recent decades. Nevertheless, certain patients with structural heart disease suffering from drug-refractory, i.e., mainly amiodarone refractory ventricular arrhythmias, as well as those with selected forms of congenital long QT syndrome (LQTS) may nowadays still benefit from mexiletine. Here, we outline mexiletine's cellular and clinical electrophysiological properties. In addition, the application of mexiletine may be accompanied by various potential side effects, e.g., nausea and tremor, and is limited by several drug-drug interactions. Thus, we shed light on the current therapeutic role of mexiletine for therapy of ventricular arrhythmias and discuss clinically relevant aspects of its indications based on current evidence.
Language	English
Publishing date	2024-02-14
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-024-02383-9
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Article ; Online: In-Hospital Pulmonary Arterial Embolism after Catheter Ablation of Over 45,000 Cardiac Arrhythmias: Individualized Case Analysis of Multicentric Data.

Doldi, Florian / Geßler, Nele / Anwar, Omar / Kahle, Ann-Kathrin / Scherschel, Katharina / Rath, Benjamin / Köbe, Julia / Lange, Philipp Sebastian / Frommeyer, Gerrit / Metzner, Andreas / Meyer, Christian / Willems, Stephan / Kuck, Karl-Heinz / Eckardt, Lars

Thrombosis and haemostasis

2024

Abstract: Objective and background: Data on incidence of in-hospital pulmonary embolisms (PE) after catheter ablation (CA) are scarce. To gain further insights, we sought to provide new findings through case-based analyses of administrative data.: Methods: ... ...

Abstract	Objective and background: Data on incidence of in-hospital pulmonary embolisms (PE) after catheter ablation (CA) are scarce. To gain further insights, we sought to provide new findings through case-based analyses of administrative data. Methods: Incidences of PE after CA of supraventricular tachycardias (SVT), atrial fibrillation (AF), atrial flutter (AFlu), and ventricular tachycardias (VT) in three German tertiary centers between 2005 and 2020 were determined and coded by the G-DRG (German Diagnosis Related Groups System) and OPS (German Operation and Procedure Classification) systems. An administrative search was performed with a consecutive case-based analysis. Results: Overall, 47,344 ablations were analyzed (10,037 SVT; 28,048 AF; 6,252 AFlu; 3,007 VT). PE occurred in 14 (0.03%) predominantly female ( Conclusion: Over a 15-year period, incidence of PE after ablation is low, particularly low in patients with ablation for AF/AFlu. This is most likely due to stricter anticoagulation management in these patients compared with those receiving SVT/VT ablation procedures and could argue for continuation of OAC prior to ablation. Optimizing periprocedural anticoagulation management should be subject of further prospective trials.
Language	English
Publishing date	2024-03-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/s-0044-1785519
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Uh III Zs.192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Impact of atrial fibrillation on 1-year outcome in patients with implantable cardioverter defibrillator or cardiac resynchronization therapy with defibrillator: results from the German DEVICE Registry.

Feickert, Sebastian / Ewertsen, Niels Christian / Köbe, Julia / Kleemann, Thomas / Jehle, Joachim / Senges, Jochen / Hochadel, Matthias / Andresen, Dietrich / Stellbrink, Christoph / Eckardt, Lars / Spitzer, Stefan / Brachmann, Johannes / Ince, Hüseyin / D'Ancona, Giuseppe

Journal of thoracic disease

2024 Volume 16, Issue 3, Page(s) 1825–1835

Abstract: Background: Atrial fibrillation (AF) is a cardiac arrhythmia frequently documented in patients requiring implantable cardioverter defibrillators (ICDs) and/or cardiac resynchronization therapy with defibrillator (CRT-D). Patients with diagnosed AF at ... ...

Abstract	Background: Atrial fibrillation (AF) is a cardiac arrhythmia frequently documented in patients requiring implantable cardioverter defibrillators (ICDs) and/or cardiac resynchronization therapy with defibrillator (CRT-D). Patients with diagnosed AF at the point of ICD or CRT-D implantation may have an impaired follow-up outcome. Methods: The German DEVICE I-II registry is a nationwide prospective multicentre database of patients implanted with ICD and CRT-D with clinical follow-up data. We analysed a 1-year follow up of implanted patients with AF and with sinus rhythm (SR). Results: A total of 4,929 ICD/CRT patients are included in the present analysis: 946 (19.2%) were in AF and 3,983 (80.8%) were SR at time of device implantation. AF patients had a significantly more comorbid profile including older age {72 [interquartile range (IQR), 66-77] Conclusions: Our clinical data on an extended cohort of contemporary patients confirm the significant impact of AF, and its associated comorbidities, upon mortality and major adverse events after implantation of ICD/CRT.
Language	English
Publishing date	2024-03-27
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-274
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Article ; Online: Outcome of patients with idiopathic ventricular fibrillation and correlation with ECG markers of early repolarization.

Rath, Benjamin / Willy, Kevin / Ellermann, Christian / Leitz, Patrick / Köbe, Julia / Reinke, Florian / Lange, Philipp Sebastian / Frommeyer, Gerrit / Eckardt, Lars

Clinical research in cardiology : official journal of the German Cardiac Society

2022 Volume 112, Issue 12, Page(s) 1748–1753

Abstract: Background: Early repolarization pattern (ERP) has been associated with idiopathic ventricular fibrillation (IVF) and with cardiovascular mortality in the general population. As there is limited data about long- term outcome of IVF, the aim of our study ...

Abstract	Background: Early repolarization pattern (ERP) has been associated with idiopathic ventricular fibrillation (IVF) and with cardiovascular mortality in the general population. As there is limited data about long- term outcome of IVF, the aim of our study was to observe ventricular arrhythmia (VA) recurrences in these patients and to identify a possible correlation of VA with ECG markers of early repolarization. Methods and results: We investigated 56 consecutive IVF patients who received an implantable cardioverter-defibrillator for secondary prevention. ERP was defined as a J-point elevation ≥ 0.1 mV in two or more contiguous inferior or lateral leads. Markers of early repolarization were present in 32.1% of cases with a preponderance of QRS slurring (77.8%). During a mean follow-up of 41.2 months, 11 patients (19.6%) received in total 18 adequate ICD-therapies. VF was most the common cause for ICDtherapy (61.1%) but monomorphic VT also occurred in four patients. Presence of ERP was associated with a significant trend towards arrhythmia recurrences. 38.9% patients with ERP received appropriate ICD-therapies whereas only 10.5% of patients without ERP had arrhythmia recurrence (p = 0.05). Inappropriate ICD-therapies occurred in seven patients (12.5%) with a non-significant trend towards a higher incidence in patients with a transvenous ICD (p = 0.15). Conclusion: A significant correlation between ERP and VA recurrences in patients with IVF could be observed. Though monomorphic VA also play a role in the studied IVF-population, our data support the use of the S-ICD in this collective.
MeSH term(s)	Humans ; Electrocardiography ; Ventricular Fibrillation/diagnosis ; Ventricular Fibrillation/therapy ; Arrhythmias, Cardiac/etiology ; Heart ; Defibrillators, Implantable/adverse effects ; Tachycardia, Ventricular
Language	English
Publishing date	2022-11-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-022-02125-9
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Article ; Online: Ventricular arrhythmia burden in ICD patients during the second wave of the COVID-19 pandemic.

Rath, Benjamin / Doldi, Florian / Willy, Kevin / Ellermann, Christian / Köbe, Julia / Güner, Fatih / Reinke, Florian / Lange, Philipp Sebastian / Frommeyer, Gerrit / Eckardt, Lars

Clinical research in cardiology : official journal of the German Cardiac Society

2023

Abstract: Aim: COVID-19 has been associated with cardiovascular complications including ventricular arrhythmias (VA) and an increased number of out-of-hospital cardiac arrests. Nevertheless, several authors described a decrease of VA burden in patients with an ... ...

Abstract	Aim: COVID-19 has been associated with cardiovascular complications including ventricular arrhythmias (VA) and an increased number of out-of-hospital cardiac arrests. Nevertheless, several authors described a decrease of VA burden in patients with an implantable defibrillator (ICD) during the first wave of the COVID-19 pandemic. The objective of this study was to determine if these observations could be transferred to later periods of the pandemic as well. Methods: We retrospectively analyzed a total of 1674 patients with an ICD presenting in our outpatient clinic during the second wave of the COVID-19 pandemic and during a control period for the occurrence of VA requiring ICD interventions. Results: Seven hundred ninety-five patients with an ICD had a device interrogation in our ambulatory clinic during the second wave of the COVID-19 pandemic compared to eight hundred seventy-nine patients in the control period. There was significant higher amount of adequate ICD therapies in the course of the COVID-19 period. Thirty-six patients (4.5%) received in total eighty-five appropriate ICD interventions during COVID-19, whereas only sixteen patients (1.8%) had sustained VA in the control period (p = 0.01). Conclusion: In contrast to the first wave of COVID-19, which was characterized by a decrease or least stable number of ICD therapies in several centers, we found a significant increase of VA in ICD patients during the second wave of COVID-19. Possible explanations for this observation include higher infectious rates, potential cardiac side effects of the vaccination as well as personal behavioral changes, or reduced utilization of medical services.
Language	English
Publishing date	2023-10-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-023-02320-2
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