Article ; Online: Bacterial conversion of a host weapon into a nutritional signal.
The Journal of biological chemistry
2022 Volume 298, Issue 11, Page(s) 102600
Abstract: Bacteria engulfed by phagocytic cells must resist oxidation damage and adapt to cellular hypoxia, but the mechanisms involved in this process are not completely elucidated. Recent work by Kim et al. in the Journal of Biological Chemistry investigated how ...
Abstract | Bacteria engulfed by phagocytic cells must resist oxidation damage and adapt to cellular hypoxia, but the mechanisms involved in this process are not completely elucidated. Recent work by Kim et al. in the Journal of Biological Chemistry investigated how the intracellular pathogen Salmonella enterica activates gene expression required to counteract oxidative damage. The authors show that this bacterium utilizes host oxidative molecules to activate regulatory proteins that enhance the production of effector molecules, counteracting the host weapon NADPH oxidase and inducing a protective response. |
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MeSH term(s) | NADPH Oxidases/metabolism ; Salmonella enterica/genetics ; Oxidative Stress ; Oxidation-Reduction ; Phagocytes/metabolism ; Bacterial Proteins/metabolism |
Chemical Substances | NADPH Oxidases (EC 1.6.3.-) ; Bacterial Proteins |
Language | English |
Publishing date | 2022-10-14 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2997-x |
ISSN | 1083-351X ; 0021-9258 |
ISSN (online) | 1083-351X |
ISSN | 0021-9258 |
DOI | 10.1016/j.jbc.2022.102600 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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