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Article ; Online: Detection of barley malt syrup as an adulterant in honey by

Biswas, Anisha / Hazra, Sudipta Kumar / Chaudhari, Sachin R

2023 Volume 429, Page(s) 136842

Abstract: Currently, Barley Malt Syrup (BMS) is one of the forms of growing adulteration in honey. However, there have been no reports regarding its identification by NMR. In this aspect, we proposed ... ...

Abstract	Currently, Barley Malt Syrup (BMS) is one of the forms of growing adulteration in honey. However, there have been no reports regarding its identification by NMR. In this aspect, we proposed a
MeSH term(s)	Honey/analysis ; Hordeum ; Proton Magnetic Resonance Spectroscopy ; Food Contamination/analysis ; Carbohydrates ; Sugars
Chemical Substances	Carbohydrates ; Sugars
Language	English
Publishing date	2023-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.136842
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Article ; Online: Organic Supercapacitors as the Next Generation Energy Storage Device: Emergence, Opportunity, and Challenges.

Biswas, Sudipta / Chowdhury, Ananya

Chemphyschem : a European journal of chemical physics and physical chemistry

2022 Volume 24, Issue 3, Page(s) e202200567

Abstract: Harnessing new materials for developing high-energy storage devices set off research in the field of organic supercapacitors. Various attractive properties like high energy density, lower device weight, excellent cycling stability, and impressive ... ...

Abstract	Harnessing new materials for developing high-energy storage devices set off research in the field of organic supercapacitors. Various attractive properties like high energy density, lower device weight, excellent cycling stability, and impressive pseudocapacitive nature make organic supercapacitors suitable candidates for high-end storage device applications. This review highlights the overall progress and future of organic supercapacitors. Sustainable energy production and storage depend on low cost, large supercapacitor packs with high energy density. Organic supercapacitors with high pseudocapacitance, lightweight form factor, and higher device potential are alternatives to other energy storage devices. There are many recent ongoing research works that focus on organic electrolytes along with the material aspect of organic supercapacitors. This review summarizes the current research status and the chemistry behind the storage mechanism in organic supercapacitors to overcome the challenges and achieve superior performance for future opportunities.
Language	English
Publishing date	2022-11-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2025223-7
ISSN	1439-7641 ; 1439-4235
ISSN (online)	1439-7641
ISSN	1439-4235
DOI	10.1002/cphc.202200567
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Article ; Online: Electrochemistry-enabled residue-specific modification of peptides and proteins.

Bandyopadhyay, Ayan / Biswas, Pranay / Kundu, Sudipta K / Sarkar, Rajib

Organic & biomolecular chemistry

2024 Volume 22, Issue 6, Page(s) 1085–1101

Abstract: Selective chemical reactions at precise amino acid residues of peptides and proteins have become an exploding field of research in the last few decades. With the emerging utility of bioconjugated peptides and proteins as drug leads and therapeutic agents, ...

Abstract	Selective chemical reactions at precise amino acid residues of peptides and proteins have become an exploding field of research in the last few decades. With the emerging utility of bioconjugated peptides and proteins as drug leads and therapeutic agents, the design of smart protocols to modulate and conjugate biomolecules has become necessary. During this modification, the most important concern of biochemists is to keep intact the structural integrity of the biomolecules. Hence, a soft and selective biocompatible reaction environment is necessary. Electrochemistry, a mild and elegant tunable reaction platform to synthesize complex molecules while avoiding harsh and toxic chemicals, can provide such a reaction condition. However, this strategy is yet to be fully exploited in the field of selective modification of polypeptides. With this possibility, the use of electrochemistry as a reaction toolbox in peptide and protein chemistry is flourishing day by day. Unfortunately, there is no suitable review article summarizing the residue-specific modification of biomolecules. The present review provides a comprehensive summary of the latest manifested electrochemical approaches for the modulation of five redox-active amino acid residues, namely cysteine, tyrosine, tryptophan, histidine and methionine, found in peptides and proteins. The article also highlights the incredible potential of electrochemistry for the regio- as well as chemoselective bioconjugation strategy of biomolecules.
MeSH term(s)	Electrochemistry ; Proteins/chemistry ; Peptides/chemistry ; Amino Acids ; Methionine/chemistry
Chemical Substances	Proteins ; Peptides ; Amino Acids ; Methionine (AE28F7PNPL)
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d3ob01857a
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Article: Alterations in blood component utilization in a tertiary care hospital in eastern India in the COVID-19 pandemic.

Das, Sudipta Sekhar / Biswas, Rathindra Nath

Asian journal of transfusion science

2022 Volume 16, Issue 1, Page(s) 36–40

Abstract: Background: With shortages of blood globally in the COVID-19 pandemic, many hospitals and blood centers have successfully implemented blood conservation strategies and strategies to maintain blood donations and blood inventory. Here, we reported our ... ...

Abstract	Background: With shortages of blood globally in the COVID-19 pandemic, many hospitals and blood centers have successfully implemented blood conservation strategies and strategies to maintain blood donations and blood inventory. Here, we reported our experience of utilization of blood components for transfusion in the current COVID-19 pandemic and discussed the patient blood management (PBM) methods and importance of judicious blood usage in any pandemic. Materials and methods: The retrospective study of 8 months was divided into pre-COVID and COVID periods. Parameters that included number of blood requisitions, blood components reserved and transfused, clinical speciality wise blood usage in both the periods were analysed. Blood utilization indices were computed using recommended equations. Results: We observed an unusual pattern of blood utilization with significant disruption on blood supply and demand chain in this pandemic. A mean drop of 50.7% blood requisitions was observed in the COVID period. The period observed transfusion of 3608 units of blood components with a mean drop of 49.7% when compared to pre-COVID period. Mean drop of 46.6%, 54.4%, 53.4% and 52.7% were observed in packed red blood cell, fresh frozen plasma, platelet concentrate and cryoprecipitate transfusions in the COVID period. Blood component utilization was significantly reduced in most clinical specialities. The mean cross match to transfusion ratio in the COVID period was 1.28 with a mean increase in transfusion probability and transfusion index by 18.2% and 22.2% respectively. Conclusion: Although a constant transfusion support was needed in few clinical specialities throughout the pandemic, strict adherence to PBM protocols and practice of first in, first out method of blood dispensing helped the blood centre to support all patients needing blood transfusion.
Language	English
Publishing date	2022-05-26
Publishing country	India
Document type	Journal Article
ZDB-ID	2267310-6
ISSN	1998-3565 ; 0973-6247
ISSN (online)	1998-3565
ISSN	0973-6247
DOI	10.4103/ajts.AJTS_122_20
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Article ; Online: Participation of follicular superoxides, inflammatory modulators, and endocrine factors in zebrafish (Danio rerio) ovulation: Cross-talk between PKA and MAPK signaling in Pgr regulation of ovulatory markers.

Ghosh, Soumyajyoti / Biswas, Subhasri / Mukherjee, Urmi / Karmakar, Sampurna / Maitra, Sudipta

Molecular and cellular endocrinology

2024 Volume 585, Page(s) 112180

Abstract: The ovulatory response involves diverse molecular determinants, the interplay between which remains less investigated in fish. This study explores the temporal changes in the follicular microenvironment, regulatory factors, and underlying signaling ... ...

Abstract	The ovulatory response involves diverse molecular determinants, the interplay between which remains less investigated in fish. This study explores the temporal changes in the follicular microenvironment, regulatory factors, and underlying signaling events during ovulation in female zebrafish subjected to 14L:10D at 28 ± 1 °C in vivo vis-à-vis in hCG-stimulated full-grown (FG) follicles in vitro. Congruent with reduced GSH levels, SOD, and GPx activity, a graded increase in follicular free radicals, Nox4, and p38 MAPK phosphorylation in the morning hour groups (05:00 and 06:30) correlates positively with the ovulatory surge in inflammatory mediators (Tnf-α, Il-1β, Il-6, Nos2, and Cox-2). Further, elevated Pgr expression and its nuclear translocation, congruent with follicular lhcgr, star, and hsd20b2 upregulation in vivo, corroborates well with the transcriptional activation of genes (pla2g4aa, ptgesl, ptger4b, mmp9, adamts9), triggering ovulation in this species. Mechanistically, an elevated ovulatory response in hCG-treated FG follicles in vitro involves the upregulation of inflammatory mediators, pgr and ovulation-associated genes in a manner sensitive to PKA- and MAPK3/1-mediated signaling.
MeSH term(s)	Animals ; Female ; Zebrafish/metabolism ; Superoxides/metabolism ; Ovulation/genetics ; Ovarian Follicle/metabolism ; Inflammation Mediators/metabolism
Chemical Substances	Superoxides (11062-77-4) ; Inflammation Mediators
Language	English
Publishing date	2024-02-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2024.112180
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Article ; Online: Molecular Thermodynamic Origin of Substrate Promiscuity in the Enzyme Laccase: Toward a Broad-Spectrum Degrader of Dye Effluents.

Mitra, Sudipta / Sil, Arnab / Biswas, Ranjit / Chakrabarty, Suman

The journal of physical chemistry letters

2023 Volume 14, Issue 7, Page(s) 1892–1898

Abstract: Industrial dye effluents have emerged as significant health hazard. Laccases found in white rot fungi can degrade an assortment of dyes. Here, we explore the molecular thermodynamic origin of the substrate promiscuity in laccases using a combination of ... ...

Abstract	Industrial dye effluents have emerged as significant health hazard. Laccases found in white rot fungi can degrade an assortment of dyes. Here, we explore the molecular thermodynamic origin of the substrate promiscuity in laccases using a combination of steady-state UV-visible absorption spectroscopy, molecular docking, and molecular dynamics (MD) simulation studies on the interaction of laccase with five dye molecules with varying charge, size, and shape. The spectroscopic studies confirm that all of these dyes can be degraded by laccase. Using MD simulations, we have demonstrated the presence of various distinct conformations of a loop in the protein active site that can accommodate the wide range of dye molecules. We have also shown that the diverse selection of dye molecules may exhibit surprisingly similar binding affinity due to cancellation of different thermodynamic factors. Our results highlight the potential of laccase as a multipurpose degrader for industrial dye effluents.
MeSH term(s)	Laccase/chemistry ; Laccase/metabolism ; Molecular Docking Simulation ; Coloring Agents/chemistry ; Basidiomycota ; Thermodynamics
Chemical Substances	Laccase (EC 1.10.3.2) ; Coloring Agents
Language	English
Publishing date	2023-02-13
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.2c03126
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Article: Role of insulin-like growth factor 1 (IGF1) in the regulation of mitochondrial bioenergetics in zebrafish oocytes: lessons from

Biswas, Subhasri / Ghosh, Soumyajyoti / Maitra, Sudipta

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1202693

Abstract: Optimal mitochondrial functioning is indispensable for acquiring oocyte competence and meiotic maturation, whilst mitochondrial dysfunction may lead to diminished reproductive potential and impaired fertility. The role of the intra-ovarian IGF system in ... ...

Abstract	Optimal mitochondrial functioning is indispensable for acquiring oocyte competence and meiotic maturation, whilst mitochondrial dysfunction may lead to diminished reproductive potential and impaired fertility. The role of the intra-ovarian IGF system in ovarian follicular dynamics has been implicated earlier. Although several studies have demonstrated the role of the IGF axis in facilitating mitochondrial function over a multitude of cell lines, its role in oocyte energy metabolism remains largely unexplored. Here using zebrafish, the relative importance of IGF1 in modulating oocyte mitochondrial bioenergetics has been investigated. A dramatic increase in ovarian
Language	English
Publishing date	2023-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1202693
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Article ; Online: Rapid eye movement sleep loss associated cytomorphometric changes and neurodegeneration.

Ranjan, Amit / Biswas, Sudipta / Mallick, Birendra Nath

Sleep medicine

2023 Volume 110, Page(s) 25–34

Abstract: Rapid eye movement sleep (REMS) is essential for leading normal healthy living at least in higher-order mammals, including humans. In this review, we briefly survey the available literature for evidence linking cytomorphometric changes in the brain due ... ...

Abstract	Rapid eye movement sleep (REMS) is essential for leading normal healthy living at least in higher-order mammals, including humans. In this review, we briefly survey the available literature for evidence linking cytomorphometric changes in the brain due to loss of REMS. As a mechanism of action, we add evidence that REMS loss elevates noradrenaline (NA) levels in the brain, which affects neuronal cytomorphology. These changes may be a compensatory mechanism as the changes return to normal after the subjects recover from the loss of REMS or if during REMS deprivation, the subjects are treated with NA-adrenoceptor antagonist prazosin (PRZ). We had proposed earlier that one of the fundamental functions of REMS is to maintain the level of NA in the brain. We elaborate on this idea to propose that if REMS loss continues without recovery, the sustained level of NA breaks down neurophysiologically active compensatory mechanism/s starting with changes in the neuronal cytomorphology, followed by their degeneration, leading to acute and chronic pathological conditions. Identification of neuronal cytomorphological changes could prove to be of significance for predicting future neuronal (brain) damage as well as an indicator for REMS health. Although current brain imaging techniques may not enable us to visualize changes in neuronal cytomorphology, given the rapid technological progress including use of artificial intelligence, we are optimistic that it may be a reality soon. Finally, we propose that maintenance of optimum REMS must be considered a criterion for leading a healthy life.
MeSH term(s)	Animals ; Humans ; Sleep, REM/physiology ; Artificial Intelligence ; Brain/pathology ; Sleep Deprivation/complications ; Prazosin ; Mammals
Chemical Substances	Prazosin (XM03YJ541D)
Language	English
Publishing date	2023-07-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2012041-2
ISSN	1878-5506 ; 1389-9457
ISSN (online)	1878-5506
ISSN	1389-9457
DOI	10.1016/j.sleep.2023.07.022
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Article ; Online: Detection of barley malt syrup as an adulterant in honey by 1H NMR profile

Biswas, Anisha / Hazra, Sudipta K. / Chaudhari, Sachin R.

Food Chemistry. 2023 July 12, p.136842-

2023 , Page(s) 136842–

Abstract	Currently, Barley Malt Syrup (BMS) is one of the forms of growing adulteration in honey. However, there have been no reports regarding its identification by NMR. In this aspect, we proposed a ¹H NMR profiling method to discriminate between authentic and honey adulterated with BMS. The authenticated honey samples were artificially adulterated with varying percentages of BMS. It was found that a marker peak primarily falling around the 5.40 ppm region exhibited discrimination between pure and adulterated samples. Furthermore, NMR data of the samples were analyzed using statistical models. The findings demonstrate that NMR sugar profiles region, when combined with PCA analysis, can effectively detect varying degrees of adulteration. Despite qualitative nature of the outcomes, spiking studies have revealed that approach can reliably identify sugar addition at levels as low as 5–10%. Overall, NMR-based approach proves to be effective in detecting BMS as an adulterant in honey.
Keywords	adulterants ; adulterated products ; food chemistry ; honey ; malting barley ; sugars ; syrups ; Honey authenticity ; Honey adulteration ; Barley syrup ; NMR ; Quality control ; Food safety
Language	English
Dates of publication	2023-0712
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.136842
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Role of insulin-like growth factor 1 (IGF1) in the regulation of mitochondrial bioenergetics in zebrafish oocytes

Subhasri Biswas / Soumyajyoti Ghosh / Sudipta Maitra

Frontiers in Cell and Developmental Biology, Vol

lessons from in vivo and in vitro investigations

2023 Volume 11

Abstract	Optimal mitochondrial functioning is indispensable for acquiring oocyte competence and meiotic maturation, whilst mitochondrial dysfunction may lead to diminished reproductive potential and impaired fertility. The role of the intra-ovarian IGF system in ovarian follicular dynamics has been implicated earlier. Although several studies have demonstrated the role of the IGF axis in facilitating mitochondrial function over a multitude of cell lines, its role in oocyte energy metabolism remains largely unexplored. Here using zebrafish, the relative importance of IGF1 in modulating oocyte mitochondrial bioenergetics has been investigated. A dramatic increase in ovarian lhcgr and igf1 expression accompanied heightened ATP levels and mitochondrial polarization in full-grown (FG) oocytes resuming meiotic maturation and ovulation in vivo. Concomitant with elevated igf1 expression and IGF1R phosphorylation, hCG (LH analog) stimulation of FG follicles in vitro prompted a sharp increase in NRF-1 and ATP levels, suggesting a positive influence of gonadotropin action on igf1 expression vis-à-vis oocyte bioenergetics. While recombinant IGF1 administration enhanced mitochondrial function, IGF1R immunodepletion or priming with PI3K inhibitor wortmannin could abrogate NRF-1 immunoreactivity, expression of respiratory chain subunits, ΔΨM, and ATP content. Mechanistically, activation of PI3K/Akt signaling in IGF1-treated follicles corroborated well with the rapid phosphorylation of GSK3β at Ser9 (inactive) followed by PGC-1β accumulation. While selective inhibition of GSK3β promoted PGC-1β, Akt inhibition could abrogate IGF1-induced p-GSK3β (Ser9) and PGC-1β immunoreactive protein indicating Akt-mediated GSK3β inactivation and PGC-1β stabilization. The IGF1-depleted follicles showed elevated superoxide anions, subdued steroidogenic potential, and attenuated G2-M1 transition. In summary, this study highlights the importance of IGF1 signaling in oocyte bioenergetics prior to resumption of meiosis.
Keywords	mitochondria ; gonadotropin (GtH) ; PGC-1β/NRF-1 ; insulin-like growth factor 1 (IGF1) ; AKT/GSK3β signaling ; oocyte maturation ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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