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  1. Article: Editorial: Molecular mechanisms in ocular development and disease.

    Shyam, Rajalekshmy / Shu, Daisy Y / Zuniga-Sanchez, Elizabeth / Vasudevan, Deepika

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1244123

    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1244123
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  2. Article ; Online: Editorial

    Rajalekshmy Shyam / Daisy Y. Shu / Elizabeth Zuniga-Sanchez / Deepika Vasudevan

    Frontiers in Cell and Developmental Biology, Vol

    Molecular mechanisms in ocular development and disease

    2023  Volume 11

    Keywords eye developent ; retina ; cornea ; ophthalmological disease ; optic nerve ; photoreceptor ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Integrated stress response signaling acts as a metabolic sensor in fat tissues to regulate oocyte maturation and ovulation.

    Grmai, Lydia / Michaca, Manuel / Lackner, Emily / Nampoothiri V P, Narayanan / Vasudevan, Deepika

    Cell reports

    2024  Volume 43, Issue 3, Page(s) 113863

    Abstract: Reproduction is an energy-intensive process requiring systemic coordination. However, the inter-organ signaling mechanisms that relay nutrient status to modulate reproductive output are poorly understood. Here, we use Drosophila melanogaster as a model ... ...

    Abstract Reproduction is an energy-intensive process requiring systemic coordination. However, the inter-organ signaling mechanisms that relay nutrient status to modulate reproductive output are poorly understood. Here, we use Drosophila melanogaster as a model to establish the integrated stress response (ISR) transcription factor, Atf4, as a fat tissue metabolic sensor that instructs oogenesis. We demonstrate that Atf4 regulates lipase activity to mediate yolk lipoprotein synthesis in the fat body. Depletion of Atf4 in the fat body also blunts oogenesis recovery after amino acid deprivation and re-feeding, suggestive of a nutrient-sensing role for Atf4. We also discovered that Atf4 promotes secretion of a fat-body-derived neuropeptide, CNMamide, which modulates neural circuits that promote egg-laying behavior (ovulation). Thus, we posit that ISR signaling in fat tissue acts as a "metabolic sensor" that instructs female reproduction-directly by impacting yolk lipoprotein production and follicle maturation and systemically by regulating ovulation.
    MeSH term(s) Animals ; Female ; Drosophila melanogaster/physiology ; Oogenesis/physiology ; Ovulation ; Oocytes ; Lipoproteins
    Chemical Substances Lipoproteins
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Synthetic Strategies of N-Heterocyclic Olefin (NHOs) and Their Recent Application of Organocatalytic Reactions and Beyond.

    G, Mahantesh / Sharma, Deepika / Dandela, Rambabu / Dhayalan, Vasudevan

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 70, Page(s) e202302106

    Abstract: N-heterocyclic olefin (NHO) derivatives have an electron-rich as well as highly polarized carabon-carbon (C=C) double bond because of the electron-donating nature of nitrogen and sulphur atoms. While NHOs have been developing as novel organocatalysts and ...

    Abstract N-heterocyclic olefin (NHO) derivatives have an electron-rich as well as highly polarized carabon-carbon (C=C) double bond because of the electron-donating nature of nitrogen and sulphur atoms. While NHOs have been developing as novel organocatalysts and ligands for transition-metal complexes in various organic compound syntheses, different research groups are currently interested in preparing imidazole and triazolium-based chiral NHO catalysts. Some of them have been used for enantioselective organic transformations, but were still elusive. N-heterocyclic olefins, the alkylidene derivatives of N-heterocyclic carbenes (NHC), have shown promising results as effective promoters for numerous organic syntheses such as asymmetric catalysis, hydroborylation, hydrosilylation, reduction, CO
    Language English
    Publishing date 2023-11-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202302106
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  5. Article: Editorial: mRNA Translational Control as a Mechanism of Post-transcriptional Gene Regulation.

    Kiss, Daniel L / Vasudevan, Deepika / Ho, C Kiong / Caliskan, Neva

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 947516

    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.947516
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  6. Article ; Online: Mitochondrial remodelling is essential for female germ cell differentiation and survival.

    Monteiro, Vernon Leander / Safavian, Darya / Vasudevan, Deepika / Hurd, Thomas Ryan

    PLoS genetics

    2023  Volume 19, Issue 1, Page(s) e1010610

    Abstract: Stem cells often possess immature mitochondria with few inner membrane invaginations, which increase as stem cells differentiate. Despite this being a conserved feature across many stem cell types in numerous organisms, how and why mitochondria undergo ... ...

    Abstract Stem cells often possess immature mitochondria with few inner membrane invaginations, which increase as stem cells differentiate. Despite this being a conserved feature across many stem cell types in numerous organisms, how and why mitochondria undergo such remodelling during stem cell differentiation has remained unclear. Here, using Drosophila germline stem cells (GSCs), we show that Complex V drives mitochondrial remodelling during the early stages of GSC differentiation, prior to terminal differentiation. This endows germline mitochondria with the capacity to generate large amounts of ATP required for later egg growth and development. Interestingly, impairing mitochondrial remodelling prior to terminal differentiation results in endoplasmic reticulum (ER) lipid bilayer stress, Protein kinase R-like ER kinase (PERK)-mediated activation of the Integrated Stress Response (ISR) and germ cell death. Taken together, our data suggest that mitochondrial remodelling is an essential and tightly integrated aspect of stem cell differentiation. This work sheds light on the potential impact of mitochondrial dysfunction on stem and germ cell function, highlighting ER lipid bilayer stress as a potential major driver of phenotypes caused by mitochondrial dysfunction.
    MeSH term(s) Animals ; Female ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Lipid Bilayers/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Germ Cells/metabolism ; Drosophila/metabolism ; Cell Differentiation/genetics
    Chemical Substances Drosophila Proteins ; Lipid Bilayers
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1010610
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  7. Article ; Online: Drosophila Unfolded Protein Response (UPR) Assays In Vitro and In Vivo.

    Katow, Hidetaka / Vasudevan, Deepika / Ryoo, Hyung Don

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2378, Page(s) 261–277

    Abstract: Wildtype or mutant proteins expressed beyond the capacity of a cell's protein folding system could be detrimental to general cellular function and survival. In response to misfolded protein overload in the endoplasmic reticulum (ER), eukaryotic cells ... ...

    Abstract Wildtype or mutant proteins expressed beyond the capacity of a cell's protein folding system could be detrimental to general cellular function and survival. In response to misfolded protein overload in the endoplasmic reticulum (ER), eukaryotic cells activate the Unfolded Protein Response (UPR) that helps cells restore protein homeostasis in the endoplasmic reticulum (ER). As part of the UPR, cells attenuate general mRNA translation and activate transcription factors that induce stress-responsive gene expression.UPR signaling draws research interest in part because conditions that cause chronic protein misfolding in the ER or those that impair UPR signaling underlie several diseases including neurodegeneration, diabetes, and cancers. Model organisms are frequently employed in the field as the UPR pathways are generally well-conserved throughout phyla. Here, we introduce experimental procedures to detect UPR in Drosophila melanogaster.
    MeSH term(s) Animals ; Drosophila ; Drosophila melanogaster/genetics ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress/physiology ; Unfolded Protein Response
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1732-8_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Integrated Stress Response signaling acts as a metabolic sensor in fat tissues to regulate oocyte maturation and ovulation.

    Grmai, Lydia / Michaca, Manuel / Lackner, Emily / Nampoothiri V P, Narayanan / Vasudevan, Deepika

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Reproduction is an energy-intensive process requiring systemic coordination. However, the inter-organ signaling mechanisms that relay nutrient status to modulate reproductive output are poorly understood. Here, we ... ...

    Abstract Reproduction is an energy-intensive process requiring systemic coordination. However, the inter-organ signaling mechanisms that relay nutrient status to modulate reproductive output are poorly understood. Here, we use
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.27.530289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Editorial

    Daniel L. Kiss / Deepika Vasudevan / C. Kiong Ho / Neva Caliskan

    Frontiers in Molecular Biosciences, Vol

    mRNA Translational Control as a Mechanism of Post-transcriptional Gene Regulation

    2022  Volume 9

    Keywords mRNA translational control ; RNA binding proteins ; noncanonical translation factors ; ribosome frameshifting ; translation initiation factors ; ribosome profiling ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Recent Advances in the Practical Synthesis of C1 Deuterated Aromatic Aldehydes Enabled by Catalysis and Beyond.

    Sharma, Deepika / Chatterjee, Rana / Dhayalan, Vasudevan / Dhanusuraman, Ragupathy / Dandela, Rambabu

    Chemistry, an Asian journal

    2022  Volume 17, Issue 18, Page(s) e202200485

    Abstract: ... ...

    Abstract C
    MeSH term(s) Aldehydes ; Catalysis ; Deuterium ; Isotope Labeling
    Chemical Substances Aldehydes ; Deuterium (AR09D82C7G)
    Language English
    Publishing date 2022-08-10
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202200485
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