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Article: Resilience and its relationship with disability in persons with bipolar disorder and schizophrenia: A comparative study.

Datta, Arnab / Chetia, Dhrubajyoti

2023 Volume 65, Issue 3, Page(s) 361–367

Abstract: Background: Resilience is the capacity to bounce back from adversity. Severe mental illnesses are associated with poor and heterogeneous functional outcomes. Symptom remission is inadequate to achieve patient-oriented outcome, and positive ... ...

Abstract	Background: Resilience is the capacity to bounce back from adversity. Severe mental illnesses are associated with poor and heterogeneous functional outcomes. Symptom remission is inadequate to achieve patient-oriented outcome, and positive psychopathology constructs like resilience have emerged as possible mediators. An exploration of resilience and its association with functional outcomes can drive therapeutic endeavors. Aim: To assess and compare the influence of resilience on disability among patients diagnosed and treated for bipolar disorder and schizophrenia in a tertiary care facility. Methods: Study design - Hospital-based, cross-sectional, comparative design; study population - patients of bipolar disorder and schizophrenia with 2-5 years illness and Clinical Global Impression - Severity (CGI-S) <4; sampling procedure - consecutive sampling; sample size - 30 patients each; scales used - Connor-Davidson Resilience Scale (CD-RISC), Indian Disability Evaluation and Assessment Scale (IDEAS), and CGI-S; patients were evaluated with IDEAS, and 15 persons with and without a significant disability were recruited in each group of schizophrenia and bipolar disorder. Results: The mean CD-RISC 25 score for persons with schizophrenia was 73.60 ± 13.87, whereas that for persons with bipolar disorder was 78.10 ± 15.26. For schizophrenia, only CDRISC-25 scores are statistically significant ( Conclusion: When disability is factored in, resilience is comparable in persons with schizophrenia and bipolar disorder. Resilience independently predicts disability in both groups. However, the type of disorder does not significantly affect the relationship between resilience and disability. Irrespective of diagnosis, higher resilience is associated with lower disability.
Language	English
Publishing date	2023-03-03
Publishing country	India
Document type	Journal Article
ZDB-ID	221523-8
ISSN	0019-5545
ISSN	0019-5545
DOI	10.4103/indianjpsychiatry.indianjpsychiatry_238_22
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Article: A Rare Case of Blood & Sweat: Hematohidrosis.

Chatterjee, Abhijit / Chowdhury, Dip K / Kundu, Arnab / Datta, Jayanta

The Journal of the Association of Physicians of India

2023 Volume 70, Issue 10, Page(s) 11–12

Abstract: Hematohidrosis is an uncommon pathophysiological condition of sweating blood. A young lady with abrupt bleeding from the skin (since January 2017) was brought to the emergency. The bleeding was vanished after mopping with no site of injury, but it ... ...

Abstract	Hematohidrosis is an uncommon pathophysiological condition of sweating blood. A young lady with abrupt bleeding from the skin (since January 2017) was brought to the emergency. The bleeding was vanished after mopping with no site of injury, but it reappeared soon enough confirming its nature. Bleeding time (BT), clotting time (CT), and the prothrombin time (PT) was within normal limit. This patient is confirmed as a case of hematohidrosis by the method of exclusion and the presence of blood was finalized by benzidine test as well as biochemical and microscopic examination of it. Now, no treatment is available as per the latest pieces of evidence. Also, the cause of it is not known till date. Psychological anxiety is a predisposing cause for hematohidrosis.
MeSH term(s)	Humans ; Sweating ; Sweat/physiology ; Hemorrhage/etiology ; Skin
Language	English
Publishing date	2023-06-25
Publishing country	India
Document type	Case Reports ; Journal Article
ZDB-ID	800766-4
ISSN	0004-5772
ISSN	0004-5772
DOI	10.5005/japi-11001-0121
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Article ; Online: Contralateral Hyperhidrosis after Intracerebral Hemorrhage.

Purkayastha, Arnab / Mathew, Nycin K / Chakraborty, Uddalak / Datta, Amlan K / Sharma, Dibya J

Neurology India

2023 Volume 71, Issue 5, Page(s) 1045–1046

MeSH term(s)	Humans ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/diagnostic imaging ; Hyperhidrosis/etiology
Language	English
Publishing date	2023-11-01
Publishing country	India
Document type	Letter
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.388075
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Article ; Online: Application of lamellar nickel hydroxide membrane as a tunable platform for ionic thermoelectric studies.

Gogoi, Raktim / Ghosh, Arnab / Deka, Priyamjeet / Datta, K K R / Raidongia, Kalyan

Materials horizons

2023 Volume 10, Issue 8, Page(s) 3072–3081

Abstract: The recent trend in thermoelectric literature suggests that ionic thermoelectric (i-TE) materials are ideal for directly converting low-grade waste heat into electricity. Here, we developed a unique platform for i-TE studies by stacking two-dimensional ... ...

Abstract	The recent trend in thermoelectric literature suggests that ionic thermoelectric (i-TE) materials are ideal for directly converting low-grade waste heat into electricity. Here, we developed a unique platform for i-TE studies by stacking two-dimensional sheets of β-Ni(OH)
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2744250-0
ISSN	2051-6355 ; 2051-6347
ISSN (online)	2051-6355
ISSN	2051-6347
DOI	10.1039/d3mh00479a
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Article ; Online: How to assemble a scale-invariant gradient.

Datta, Arnab / Ghosh, Sagnik / Kondev, Jane

eLife

2022 Volume 11

Abstract: Intracellular protein gradients serve a variety of functions, such as the establishment of cell polarity or to provide positional information for gene expression in developing embryos. Given that cell size in a population can vary considerably, for the ... ...

Abstract	Intracellular protein gradients serve a variety of functions, such as the establishment of cell polarity or to provide positional information for gene expression in developing embryos. Given that cell size in a population can vary considerably, for the protein gradients to work properly they often have to be scaled to the size of the cell. Here, we examine a model of protein gradient formation within a cell that relies on cytoplasmic diffusion and cortical transport of proteins toward a cell pole. We show that the shape of the protein gradient is determined solely by the cell geometry. Furthermore, we show that the length scale over which the protein concentration in the gradient varies is determined by the linear dimensions of the cell, independent of the diffusion constant or the transport speed. This gradient provides scale-invariant positional information within a cell, which can be used for assembly of intracellular structures whose size is scaled to the linear dimensions of the cell, such as the cytokinetic ring and actin cables in budding yeast cells.
MeSH term(s)	Actins/metabolism ; Cell Polarity ; Cytoplasm/metabolism ; Diffusion ; Saccharomycetales/metabolism
Chemical Substances	Actins
Language	English
Publishing date	2022-03-21
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.71365
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Article ; Online: Phytocompounds from

Datta, Sutapa / Sarkar, Indrani / Goswami, Nabajyoti / Mahanta, Saurov / Borah, Probodh / Sen, Arnab

Journal of biomolecular structure & dynamics

2023 , Page(s) 1–18

Abstract: Monkeypox is a communicable disease similar to smallpox, primarily occurring in African countries. However, recently it has spread to countries outside Africa and may arise as the next threat after COVID-pandemic. The causative organism, i.e. Monkeypox ... ...

Abstract	Monkeypox is a communicable disease similar to smallpox, primarily occurring in African countries. However, recently it has spread to countries outside Africa and may arise as the next threat after COVID-pandemic. The causative organism, i.e. Monkeypox Virus (MPV) spreads from one individual to another primarily through inhalation of respiratory droplets or through contact with skin lesions of infected individuals. No known drugs are available specifically for MPV. Due to its similarity with smallpox, treatment of monkeypox is being attempted through the administration of the smallpox vaccine. Therefore, we evaluated the efficacy of the plant
Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2291166
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Article ; Online: In Vitro Oxygen Glucose Deprivation Model of Ischemic Stroke: A Proteomics-Driven Systems Biological Perspective.

Babu, Manju / Singh, Nikhil / Datta, Arnab

Molecular neurobiology

2022 Volume 59, Issue 4, Page(s) 2363–2377

Abstract: Oxygen glucose deprivation (OGD) of brain cells is the commonest in vitro model of ischemic stroke that is used extensively for basic and preclinical stroke research. Protein mass spectrometry is one of the most promising and rapidly evolving ... ...

Abstract	Oxygen glucose deprivation (OGD) of brain cells is the commonest in vitro model of ischemic stroke that is used extensively for basic and preclinical stroke research. Protein mass spectrometry is one of the most promising and rapidly evolving technologies in biomedical research. A systems-level understanding of cell-type-specific responses to oxygen and glucose deprivation without systemic influence is a prerequisite to delineate the response of the neurovascular unit following ischemic stroke. In this systematic review, we summarize the proteomics studies done on different OGD models. These studies have followed an expression or interaction proteomics approach. They have been primarily used to understand the cellular pathophysiology of ischemia-reperfusion injury or to assess the efficacy of interventions as potential treatment options. We compile the limitations of OGD model and downstream proteomics experiment. We further show that despite having limitations, several proteins shortlisted as altered in in vitro OGD-proteomics studies showed comparable regulation in ischemic stroke patients. This showcases the translational potential of this approach for therapeutic target and biomarker discovery. We next discuss the approaches that can be adopted for cell-type-specific validation of OGD-proteomics results in the future. Finally, we briefly present the research questions that can be addressed by OGD-proteomics studies using emerging techniques of protein mass spectrometry. We have also created a web resource compiling information from OGD-proteomics studies to facilitate data sharing for community usage. This review intends to encourage preclinical stroke community to adopt a hypothesis-free proteomics approach to understand cell-type-specific responses following ischemic stroke.
MeSH term(s)	Brain Ischemia/metabolism ; Glucose/metabolism ; Humans ; Ischemic Stroke ; Oxygen/metabolism ; Proteomics ; Reperfusion Injury/metabolism ; Stroke/metabolism
Chemical Substances	Glucose (IY9XDZ35W2) ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-01-26
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-022-02745-2
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Article ; Online: Neem and Turmeric in the management of Covid Associated Mucormycosis (CAM) derived through network pharmacology.

Datta, Sutapa / Sarkar, Indrani / Sen, Gargi / Sen, Arnab

Journal of biomolecular structure & dynamics

2022 Volume 41, Issue 8, Page(s) 3281–3294

Abstract: Mucormycosis or 'Black Fungus' has been known to target immunocompromised individuals even before the emergence of COVID-19. Nevertheless, the present circumstances provide the best opening for Covid Associated Mucormycosis (CAM), as the global pandemic ... ...

Abstract	Mucormycosis or 'Black Fungus' has been known to target immunocompromised individuals even before the emergence of COVID-19. Nevertheless, the present circumstances provide the best opening for Covid Associated Mucormycosis (CAM), as the global pandemic is engulfing a large part of human population making them immunocompromised. This drastic increase in Mucormycosis infections has to be addressed as early as possible. There is a growing tendency of relying upon herbal drugs that have minimal side effects and does not compromise our immune system. Recently, the concept of network pharmacology has grabbed the attention of modern science, especially advanced medical sciences. This is a new discipline that can use computational power to systematically catalogue the molecular interactions between botanical formulations and the human body. In this study, Neem and Turmeric was considered as the target plants and an attempt was made to reveal various aspects through which phytocompounds derived from them may effectively manage CAM menace. We have taken a step-by-step approach for identifying the target proteins and ligands associated with Mucormycosis treatment. Functional network analysis and Molecular docking approaches were applied to validate our findings. Quercetin derived from both Neem and Turmeric was found to be one of the main phytocompounds working against Mucormycosis. Along with that, Caffeic acid, Curcumin, Kaempferol, Tetrahydrocurcumin and Myricetin also play a pivotal role in fighting against Black-Fungus. A thorough analysis of our result suggested a triple-front attack on the fungal pathogens and the approaches are necrosis inhibition, iron chelation and immuno-boosting.Communicated by Ramaswamy H. Sarma.
MeSH term(s)	Humans ; Mucormycosis/drug therapy ; Curcuma ; Network Pharmacology ; Molecular Docking Simulation ; COVID-19
Language	English
Publishing date	2022-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2022.2048077
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Article ; Online: How to assemble a scale-invariant gradient

Arnab Datta / Sagnik Ghosh / Jane Kondev

eLife, Vol

2022 Volume 11

Abstract	Intracellular protein gradients serve a variety of functions, such as the establishment of cell polarity or to provide positional information for gene expression in developing embryos. Given that cell size in a population can vary considerably, for the protein gradients to work properly they often have to be scaled to the size of the cell. Here, we examine a model of protein gradient formation within a cell that relies on cytoplasmic diffusion and cortical transport of proteins toward a cell pole. We show that the shape of the protein gradient is determined solely by the cell geometry. Furthermore, we show that the length scale over which the protein concentration in the gradient varies is determined by the linear dimensions of the cell, independent of the diffusion constant or the transport speed. This gradient provides scale-invariant positional information within a cell, which can be used for assembly of intracellular structures whose size is scaled to the linear dimensions of the cell, such as the cytokinetic ring and actin cables in budding yeast cells.
Keywords	intracellular ; protein ; gradients ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
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Article ; Online: Quantitative Proteomics of Medium-Sized Extracellular Vesicle-Enriched Plasma of Lacunar Infarction for the Discovery of Prognostic Biomarkers.

Datta, Arnab / Chen, Christopher / Gao, Yong-Gui / Sze, Siu Kwan

International journal of molecular sciences

2022 Volume 23, Issue 19

Abstract: Lacunar infarction (LACI), a subtype of acute ischemic stroke, has poor mid- to long-term prognosis due to recurrent vascular events or incident dementia which is difficult to predict using existing clinical data. Herein, we aim to discover blood-based ... ...

Abstract	Lacunar infarction (LACI), a subtype of acute ischemic stroke, has poor mid- to long-term prognosis due to recurrent vascular events or incident dementia which is difficult to predict using existing clinical data. Herein, we aim to discover blood-based biomarkers for LACI as a complementary prognostic tool. Convalescent plasma was collected from forty-five patients following a non-disabling LACI along with seventeen matched control subjects. The patients were followed up prospectively for up to five years to record an occurrence of adverse outcome and grouped accordingly (i.e., LACI-no adverse outcome, LACI-recurrent vascular event, and LACI-cognitive decline without any recurrence of vascular events). Medium-sized extracellular vesicles (MEVs), isolated from the pooled plasma of four groups, were analyzed by stable isotope labeling and 2D-LC-MS/MS. Out of 573 (FDR < 1%) quantified proteins, 146 showed significant changes in at least one LACI group when compared to matched healthy control. A systems analysis revealed that major elements (~85%) of the MEV proteome are different from the proteome of small-sized extracellular vesicles obtained from the same pooled plasma. The altered MEV proteins in LACI patients are mostly reduced in abundance. The majority of the shortlisted MEV proteins are not linked to commonly studied biological processes such as coagulation, fibrinolysis, or inflammation. Instead, they are linked to oxygen-glucose deprivation, endo-lysosomal trafficking, glucose transport, and iron homeostasis. The dataset is provided as a web-based data resource to facilitate meta-analysis, data integration, and targeted large-scale validation.
MeSH term(s)	Biomarkers/metabolism ; Chromatography, Liquid ; Extracellular Vesicles/metabolism ; Glucose ; Humans ; Iron ; Ischemic Stroke ; Oxygen ; Prognosis ; Proteome/metabolism ; Proteomics ; Stroke, Lacunar ; Tandem Mass Spectrometry
Chemical Substances	Biomarkers ; Proteome ; Iron (E1UOL152H7) ; Glucose (IY9XDZ35W2) ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-10-01
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231911670
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