LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 55

Search options

  1. Article ; Online: Immune regulation and therapeutic application of T regulatory cells in liver diseases.

    Ajith, Ananya / Merimi, Makram / Arki, Mandana Kazem / Hossein-Khannazer, Nikoo / Najar, Mehdi / Vosough, Massoud / Sokal, Etienne Marc / Najimi, Mustapha

    Frontiers in immunology

    2024  Volume 15, Page(s) 1371089

    Abstract: ... ...

    Abstract CD4
    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; Carcinoma, Hepatocellular ; Liver Neoplasms ; Cytokines ; Tumor Microenvironment
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1371089
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Immunomodulatory performance of GMP-compliant, clinical-grade mesenchymal stromal cells from four different sources.

    Arki, Mandana Kazem / Moeinabadi-Bidgoli, Kasra / Niknam, Bahareh / Mohammadi, Parvaneh / Hassan, Moustapha / Hossein-Khannazer, Nikoo / Vosough, Massoud

    Heliyon

    2024  Volume 10, Issue 2, Page(s) e24948

    Abstract: Inflammatory and autoimmune diseases are among the most challenging disorders for health care professionals that require systemic immune suppression which associates with various side effects. Mesenchymal stromal cells (MSCs) are capable of regulating ... ...

    Abstract Inflammatory and autoimmune diseases are among the most challenging disorders for health care professionals that require systemic immune suppression which associates with various side effects. Mesenchymal stromal cells (MSCs) are capable of regulating immune responses, mainly through paracrine effects and cell-cell contact. Since MSCs are advanced therapy medicinal products (ATMPs), they must follow Good Manufacturing Practice (GMP) regulations to ensure their safety and efficacy. In this study, we evaluated the immunomodulatory effects of GMP-compliant clinical grade MSCs obtained from four different sources (bone marrow, adipose tissue, Wharton's Jelly, and decidua tissue) on allogeneic peripheral blood mononuclear cells (PBMCs). Our results revealed that WJ-MSCs were the most successful group in inhibiting PBMC proliferation as confirmed by BrdU analysis. Moreover, WJ-MSCs were the strongest group in enhancing the regulatory T cell population of PBMCs. WJ-MSCs also had the highest secretory profile of prostaglandin E2 (PGE-2), anti-inflammatory cytokine, while interleukin-10 (IL-10) secretion was highest in the DS-MSC group. DS-MSCs also had the lowest secretion of IL-12 and IL-17 inflammatory cytokines. Transcriptome analysis revealed that WJ-MSCs had the lowest expression of IL-6, while DS-MSCs were the most potent group in the expression of immunomodulatory factors such as hepatocyte growth factor (HGF) and transforming growth factor-β (TGF- β). Taken together, our results indicated that GMP-compliant Wharton's Jelly and decidua-derived MSCs showed the best immunomodulatory performance considering paracrine factors.
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24948
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Low-Level Laser Therapy for Rheumatoid Arthritis: A Review of Experimental Approaches.

    Hossein-Khannazer, Nikoo / Kazem Arki, Mandana / Keramatinia, Aliasghar / Rezaei-Tavirani, Mostafa

    Journal of lasers in medical sciences

    2022  Volume 13, Page(s) e62

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2022-12-10
    Publishing country Iran
    Document type Journal Article ; Review
    ZDB-ID 2658681-2
    ISSN 2228-6721 ; 2008-9783
    ISSN (online) 2228-6721
    ISSN 2008-9783
    DOI 10.34172/jlms.2022.62
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Low-Level Laser Therapy in the Treatment of Autoimmune Thyroiditis.

    Hossein-Khannazer, Nikoo / Kazem Arki, Mandana / Keramatinia, Liasghar / Rezaei-Tavirani, Mostafa

    Journal of lasers in medical sciences

    2022  Volume 13, Page(s) e34

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2022-08-24
    Publishing country Iran
    Document type Journal Article ; Review
    ZDB-ID 2658681-2
    ISSN 2228-6721 ; 2008-9783
    ISSN (online) 2228-6721
    ISSN 2008-9783
    DOI 10.34172/jlms.2022.34
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Review on Kidney-Liver Crosstalk: Pathophysiology of Their Disorders.

    Rad, Niloofar Khoshdel / Heydari, Zahra / Tamimi, Amir Hossein / Zahmatkesh, Ensieh / Shpichka, Anastasia / Barekat, Maryam / Timashev, Peter / Hossein-Khannazer, Nikoo / Hassan, Moustapha / Vosough, Massoud

    Cell journal

    2024  Volume 26, Issue 2, Page(s) 98–111

    Abstract: Kidney-liver crosstalk plays a crucial role in normal and certain pathological conditions. In pathologic states, both renal-induced liver damage and liver-induced kidney diseases may happen through these kidney-liver interactions. This bidirectional ... ...

    Abstract Kidney-liver crosstalk plays a crucial role in normal and certain pathological conditions. In pathologic states, both renal-induced liver damage and liver-induced kidney diseases may happen through these kidney-liver interactions. This bidirectional crosstalk takes place through the systemic conditions that mutually influence both the liver and kidneys. Ischemia and reperfusion, cytokine release and pro-inflammatory signaling pathways, metabolic acidosis, oxidative stress, and altered enzyme activity and metabolic pathways establish the base of this interaction between the kidneys and liver. In these concomitant kidney-liver diseases, the survival rates strongly correlate with early intervention and treatment of organ dysfunction. Proper care of a nephrologist and hepatologist and the identification of pathological conditions using biomarkers at early stages are necessary to prevent the complications induced by this complex and potentially vicious cycle. Therefore, understanding the characteristics of this crosstalk is essential for better management. In this review, we discussed the available literature concerning the detrimental effects of kidney failure on liver functions and liver-induced kidney diseases.
    Language English
    Publishing date 2024-02-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2647430-X
    ISSN 2228-5814 ; 2228-5806
    ISSN (online) 2228-5814
    ISSN 2228-5806
    DOI 10.22074/cellj.2023.2007757.1376
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Developed Bone Biomaterials Incorporated with MicroRNAs to Promote Bone Regeneration: A Systematic Review, Bioinformatics, and Meta-analysis Study.

    Shams, Roshanak / Behmanesh, Ali / Mazhar, Farid Najd / Vaghari, Amir Ali / Hossein-Khannazer, Nikoo / Agarwal, Tarun / Vosough, Massoud / Padrón, José M

    ACS biomaterials science & engineering

    2023  Volume 9, Issue 9, Page(s) 5186–5204

    Abstract: This systematic review and meta-analysis focused on the effectiveness of biomaterials integrated with specific microRNAs (miRNAs) for bone fracture repair treatment. We conducted a comprehensive search of the PubMed, Web of Science, and Scopus databases, ...

    Abstract This systematic review and meta-analysis focused on the effectiveness of biomaterials integrated with specific microRNAs (miRNAs) for bone fracture repair treatment. We conducted a comprehensive search of the PubMed, Web of Science, and Scopus databases, identifying 42 relevant papers up to March 2022. Hydrogel-based scaffolds were the most commonly used, incorporating miRNAs like miR-26a, miR-21, and miR-222, with miR-26a being the most prevalent. The meta-analysis revealed significant benefits of incorporating miRNAs into scaffolds for bone repair, particularly in hydrogel scaffolds. However, some controversies were observed among studies, presenting challenges in selecting appropriate miRNAs for this purpose. The study concludes that incorporating specific miRNAs into bone biomaterials enhances bone regeneration, but further trials comparing different biomaterials and miRNAs are necessary to validate their potential applications for bone tissue regeneration.
    MeSH term(s) MicroRNAs/genetics ; MicroRNAs/therapeutic use ; Biocompatible Materials/therapeutic use ; Bone Regeneration/genetics ; Hydrogels/therapeutic use ; Computational Biology
    Chemical Substances MicroRNAs ; Biocompatible Materials ; Hydrogels
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.3c00178
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Stem Cell-based and Advanced Therapeutic Modalities for Parkinson's Disease: A Risk-effectiveness Patient-centered Analysis.

    Salahi, Sarvenaz / Mousavi, Maryam Alsadat / Azizi, Gholamreza / Hossein-Khannazer, Nikoo / Vosough, Massoud

    Current neuropharmacology

    2022  Volume 20, Issue 12, Page(s) 2320–2345

    Abstract: Treatment of Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, is currently considered a challenging issue since it causes substantial disability, poor quality of life, and mortality. Despite remarkable progress in advanced ... ...

    Abstract Treatment of Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, is currently considered a challenging issue since it causes substantial disability, poor quality of life, and mortality. Despite remarkable progress in advanced conventional therapeutic interventions, the global burden of the disease has nearly doubled, prompting us to assess the riskeffectiveness of different treatment modalities. Each protocol could be considered as the best alternative treatment depending on the patient's situation. Prescription of levodopa, the most effective available medicine for this disorder, has been associated with many complications, i.e., multiple episodes of "off-time" and treatment resistance. Other medications, which are typically used in combination with levodopa, may have several adverse effects as well. As a result, the therapies that are more in line with human physiology and make the least interference with other pathways are worth investigating. On the other hand, remaining and persistent symptoms after therapy and the lack of effective response to the conventional approaches have raised expectations towards innovative alternative approaches, such as stem cell-based therapy. It is critical to not overlook the unexplored side effects of innovative approaches due to the limited number of research. In this review, we aimed to compare the efficacy and risk of advanced therapies with innovative cell-based and stemcell- based modalities in PD patients. This paper recapitulated the underlying factors/conditions, which could lead us to more practical and established therapeutic outcomes with more advantages and few complications. It could be an initial step to reconsider the therapeutic blueprint for patients with Parkinson's disease.
    MeSH term(s) Humans ; Parkinson Disease/drug therapy ; Levodopa/therapeutic use ; Antiparkinson Agents/therapeutic use ; Quality of Life ; Patient-Centered Care
    Chemical Substances Levodopa (46627O600J) ; Antiparkinson Agents
    Language English
    Publishing date 2022-02-01
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X20666220201100238
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: The Role of Low-Level Laser Therapy in the Treatment of Multiple Sclerosis: A Review Study.

    Hossein-Khannazer, Nikoo / Kazem Arki, Mandana / Keramatinia, Aliasghar / Rezaei-Tavirani, Mostafa

    Journal of lasers in medical sciences

    2021  Volume 12, Page(s) e88

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2021-12-28
    Publishing country Iran
    Document type Journal Article ; Review
    ZDB-ID 2658681-2
    ISSN 2228-6721 ; 2008-9783
    ISSN (online) 2228-6721
    ISSN 2008-9783
    DOI 10.34172/jlms.2021.88
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Amniotic Membrane and Its Derivatives: Novel Therapeutic Modalities in Liver Disorders.

    Arki, Mandana Kazem / Moeinabadi-Bidgoli, Kasra / Hossein-Khannazer, Nikoo / Gramignoli, Roberto / Najimi, Mustapha / Vosough, Massoud

    Cells

    2023  Volume 12, Issue 16

    Abstract: The liver is a vital organ responsible for metabolic and digestive functions, protein synthesis, detoxification, and numerous other necessary functions. Various acute, chronic, and neoplastic disorders affect the liver and hamper its biological functions. ...

    Abstract The liver is a vital organ responsible for metabolic and digestive functions, protein synthesis, detoxification, and numerous other necessary functions. Various acute, chronic, and neoplastic disorders affect the liver and hamper its biological functions. Most of the untreated liver diseases lead to inflammation and fibrosis which develop into cirrhosis. The human amniotic membrane (hAM), the innermost layer of the fetal placenta, is composed of multiple layers that include growth-factor rich basement membrane, epithelial and mesenchymal stromal cell layers. hAM possesses distinct beneficial anti-fibrotic, anti-inflammatory and pro-regenerative properties via the secretion of multiple potent trophic factors and/or direct differentiation into hepatic cells which place hAM-based therapies as potential therapeutic strategies for the treatment of chronic liver diseases. Decellularized hAM is also an ideal scaffold for liver tissue engineering as this biocompatible niche provides an excellent milieu for cell proliferation and hepatocytic differentiation. Therefore, the current review discusses the therapeutic potential of hAM and its derivatives in providing therapeutic solutions for liver pathologies including acute liver failure, metabolic disorders, liver fibrosis as well as its application in liver tissue engineering.
    MeSH term(s) Humans ; Female ; Pregnancy ; Amnion ; Liver Diseases/therapy ; Liver Cirrhosis/therapy ; Hepatocytes
    Language English
    Publishing date 2023-08-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12162114
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Cell and cell-derivative-based therapy for liver diseases: current approaches and future promises.

    Zahmatkesh, Ensieh / Khoshdel Rad, Niloofar / Hossein-Khannazer, Nikoo / Mohamadnejad, Mehdi / Gramignoli, Roberto / Najimi, Mustapha / Malekzadeh, Reza / Hassan, Moustapha / Vosough, Massoud

    Expert review of gastroenterology & hepatology

    2023  Volume 17, Issue 3, Page(s) 237–249

    Abstract: Introduction: According to the recent updates from World Health Organization, liver diseases are the 12th most common cause of mortality. Currently, orthotopic liver transplantation (OLT) is the most effective and the only treatment for end-stage liver ... ...

    Abstract Introduction: According to the recent updates from World Health Organization, liver diseases are the 12th most common cause of mortality. Currently, orthotopic liver transplantation (OLT) is the most effective and the only treatment for end-stage liver diseases. Owing to several shortcomings like finite numbers of healthy organ donors, lifelong immunosuppression, and complexity of the procedure, cell and cell-derivatives therapies have emerged as a potential therapeutic alternative for liver diseases. Various cell types and therapies have been proposed and their therapeutic effects evaluated in preclinical or clinical studies, including hepatocytes, hepatocyte-like cells (HLCs) derived from stem cells, human liver stem cells (HLSCs), combination therapies with various types of cells, organoids, and implantable cell-biomaterial constructs with synthetic and natural polymers or even decellularized extracellular matrix (ECM).
    Areas covered: In this review, we highlighted the current status of cell and cell-derivative-based therapies for liver diseases. Furthermore, we discussed future prospects of using HLCs, liver organoids, and their combination therapies.
    Expert opinion: Promising application of stem cell-based techniques including iPSC technology has been integrated into novel techniques such as gene editing, directed differentiation, and organoid technology. iPSCs offer promising prospects to represent novel therapeutic strategies and modeling liver diseases.
    MeSH term(s) Humans ; Liver Diseases/therapy ; Liver Diseases/metabolism ; Liver/metabolism ; Hepatocytes/metabolism ; Induced Pluripotent Stem Cells/metabolism ; End Stage Liver Disease/therapy ; Cell Differentiation
    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2023.2172398
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6978: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top