Article ; Online: Precursory or early lesions of follicular lymphoma: clinical features, pathology, and genetics.
Journal of clinical and experimental hematopathology : JCEH
2023 Volume 63, Issue 2, Page(s) 65–72
Abstract: Follicular lymphoma (FL) is an indolent B-cell lymphoma with a germinal center (GC) B cell phenotype that typically harbors t(14;18)(q32;q21). t(14;18) juxtaposes IGH on 14q32 and BCL2 on 18q21, resulting in overexpression of the anti-apoptotic BCL2 ... ...
| Abstract | Follicular lymphoma (FL) is an indolent B-cell lymphoma with a germinal center (GC) B cell phenotype that typically harbors t(14;18)(q32;q21). t(14;18) juxtaposes IGH on 14q32 and BCL2 on 18q21, resulting in overexpression of the anti-apoptotic BCL2 protein. However, t(14;18) is also found in the peripheral blood or lymphoid nodes (LNs) of otherwise healthy individuals. Moreover, overt FL has several additional gene alterations involved in epigenetic modification, JAK/STAT signaling, immune modulation, and NF-κB signaling, indicating multi-step lymphomagenesis in FL. There are two early or precursory lesions of FL: t(14;18)-positive cells in the peripheral blood of otherwise healthy individuals and in situ follicular B-cell neoplasm (ISFN). t(14;18)-positive cells are found in 10%-50% of healthy populations, and their incidence and frequency increase with age. The detection of t(14;18) in peripheral blood is a predictive factor for an increased risk of overt FL development. In contrast, ISFN is a histopathologically recognizable precursory lesion, in which t(14;18)-positive cells are confined to the GC of otherwise reactive LNs. ISFN is usually detected incidentally, with an incidence ranging from 2.0% to 3.2%. Occasional ISFN cases have concurrent or metachronous clonally related overt FL or aggressive B-cell lymphoma of a GC phenotype. t(14;18)-positive cells in peripheral blood and isolated ISFN, by themselves, are asymptomatic with limited clinical significance; however, investigations of t(14;18)-positive precursory or early lesions offer meaningful insights into the pathogenesis of FL. This review summarizes the epidemiology, clinical features, pathology, and genetics of precursory or early lesions of FL. |
|---|---|
| MeSH term(s) | Humans ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/genetics ; B-Lymphocytes ; Lymph Nodes ; Lymphoma, B-Cell ; Proto-Oncogene Proteins c-bcl-2 |
| Chemical Substances | Proto-Oncogene Proteins c-bcl-2 |
| Language | English |
| Publishing date | 2023-06-26 |
| Publishing country | Japan |
| Document type | Review ; Journal Article |
| ZDB-ID | 2395568-5 |
| ISSN | 1880-9952 ; 1880-9952 |
| ISSN (online) | 1880-9952 |
| ISSN | 1880-9952 |
| DOI | 10.3960/jslrt.23010 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.