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Article ; Online: Microplastics in hot water.

Schwabl, Philipp

Nature food

2020 Volume 1, Issue 11, Page(s) 671–672

Language	English
Publishing date	2020-02-17
Publishing country	England
Document type	Journal Article
ISSN	2662-1355
ISSN (online)	2662-1355
DOI	10.1038/s43016-020-00174-9
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Article ; Online: Molecular surveillance of malaria scales up.

Schwabl, Philipp / Neafsey, Daniel E

Trends in parasitology

2021 Volume 37, Issue 12, Page(s) 1020–1021

Abstract: Parasite and vector genetic data can guide malaria control, and technological advances are enabling more informative genetic data generation at unprecedented scales. Jacob et al. employ multiplexed amplicon sequencing to profile parasite genetic ... ...

Abstract	Parasite and vector genetic data can guide malaria control, and technological advances are enabling more informative genetic data generation at unprecedented scales. Jacob et al. employ multiplexed amplicon sequencing to profile parasite genetic diversity from thousands of malaria samples, illuminating spatiotemporal patterns of drug resistance to inform regional drug policy change.
MeSH term(s)	Drug Resistance/genetics ; Humans ; Malaria/epidemiology ; Malaria/parasitology ; Malaria, Falciparum/parasitology ; Plasmodium falciparum/genetics
Language	English
Publishing date	2021-10-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2036227-4
ISSN	1471-5007 ; 1471-4922
ISSN (online)	1471-5007
ISSN	1471-4922
DOI	10.1016/j.pt.2021.09.010
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Article: Molecular surveillance of malaria scales up

Schwabl, Philipp / Neafsey, Daniel E.

Trends in parasitology. 2021 Dec., v. 37, no. 12

2021

Abstract	Parasite and vector genetic data can guide malaria control, and technological advances are enabling more informative genetic data generation at unprecedented scales. Jacob et al. employ multiplexed amplicon sequencing to profile parasite genetic diversity from thousands of malaria samples, illuminating spatiotemporal patterns of drug resistance to inform regional drug policy change.
Keywords	drug resistance ; drugs ; genetic variation ; issues and policy ; malaria ; monitoring ; parasites ; parasitology
Language	English
Dates of publication	2021-12
Size	p. 1020-1021.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2036227-4
ISSN	1471-5007 ; 1471-4922
ISSN (online)	1471-5007
ISSN	1471-4922
DOI	10.1016/j.pt.2021.09.010
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Correction: Vector mapping and bloodmeal metabarcoding demonstrate risk of urban Chagas disease transmission in Caracas, Venezuela.

Segovia, Maikell / Schwabl, Philipp / Sueto, Salem / Nakad, Candy Cherine / Londoño, Juan Carlos / Rodriguez, Marlenes / Paiva, Manuel / Llewellyn, Martin Stephen / Carrasco, Hernán José

PLoS neglected tropical diseases

2023 Volume 17, Issue 7, Page(s) e0011489

Abstract: This corrects the article DOI: 10.1371/journal.pntd.0010613.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pntd.0010613.].
Language	English
Publishing date	2023-07-14
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011489
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Article ; Online: Vascular Targets for the Treatment of Portal Hypertension.

Brusilovskaya, Ksenia / Königshofer, Philipp / Schwabl, Philipp / Reiberger, Thomas

Seminars in liver disease

2019 Volume 39, Issue 4, Page(s) 483–501

Abstract: Portal hypertension is the main driver for severe complications in patients with liver cirrhosis. With improved understanding of molecular pathways that promote hepatic vascular remodeling, vasoconstriction, and sinusoidal capillarization potential ... ...

Abstract	Portal hypertension is the main driver for severe complications in patients with liver cirrhosis. With improved understanding of molecular pathways that promote hepatic vascular remodeling, vasoconstriction, and sinusoidal capillarization potential vascular targets for the treatment of portal hypertension have been identified. Inhibition of vascular endothelial and platelet-derived growth factors-driven angiogenesis has been shown to reduce portal pressure and decrease hepatic inflammation. Angiopoietin/Tie signaling represents additional promising vascular targets in liver disease. The eNOS-NO-sGC-cGMP pathway modulates sinusoidal vasoconstriction and capillarization. Nuclear farnesoid X receptor (FXR) agonists decrease intrahepatic vascular resistance by inhibition of fibrogenesis and sinusoidal remodeling. Statins ameliorate endothelial dysfunction, decrease portal pressure, and reduce fibrogenesis. Anticoagulation with low-molecular heparin or anti-Xa inhibitors improved portal hypertension by deactivation of hepatic stellate cells and potentially via reduction of sinusoidal microthrombosis. This review summarizes important vascular targets for treatment of portal hypertension that have shown promising results in experimental studies.
MeSH term(s)	Anticoagulants/therapeutic use ; Cyclic GMP/metabolism ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypertension, Portal/physiopathology ; Hypertension, Portal/therapy ; Neovascularization, Pathologic/physiopathology ; Neovascularization, Pathologic/prevention & control ; Nitric Oxide/metabolism ; Receptors, Cytoplasmic and Nuclear/agonists ; Soluble Guanylyl Cyclase/metabolism
Chemical Substances	Anticoagulants ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Receptors, Cytoplasmic and Nuclear ; farnesoid X-activated receptor (0C5V0MRU6P) ; Nitric Oxide (31C4KY9ESH) ; Soluble Guanylyl Cyclase (EC 4.6.1.2) ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2019-07-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603177-8
ISSN	1098-8971 ; 0272-8087
ISSN (online)	1098-8971
ISSN	0272-8087
DOI	10.1055/s-0039-1693115
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Article ; Online: Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension.

Petrenko, Oleksandr / Königshofer, Philipp / Brusilovskaya, Ksenia / Hofer, Benedikt S / Bareiner, Katharina / Simbrunner, Benedikt / Jühling, Frank / Baumert, Thomas F / Lupberger, Joachim / Trauner, Michael / Kauschke, Stefan G / Pfisterer, Larissa / Simon, Eric / Rendeiro, André F / de Rooij, Laura P M H / Schwabl, Philipp / Reiberger, Thomas

iScience

2024 Volume 27, Issue 3, Page(s) 109301

Abstract: Persistent liver injury triggers a fibrogenic program that causes pathologic remodeling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression and early regression ... ...

Abstract	Persistent liver injury triggers a fibrogenic program that causes pathologic remodeling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression and early regression remain understudied. Here, we generated hepatic transcriptome profiles in two well-established liver disease models at peak fibrosis and during spontaneous regression after the removal of the inducing agents. We linked the dynamics of key disease readouts, such as portal pressure, collagen area, and transaminase levels, to differentially expressed genes, enabling the identification of transcriptomic signatures of progressive vs. regressive liver fibrosis and portal hypertension. These candidate biomarkers (e.g.,
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109301
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Article ; Online: Vector mapping and bloodmeal metabarcoding demonstrate risk of urban Chagas disease transmission in Caracas, Venezuela.

Segovia, Maikell / Schwabl, Philipp / Sueto, Salem / Nakad, Candy Cherine / Londoño, Juan Carlos / Rodriguez, Marlenes / Paiva, Manuel / Llewellyn, Martin Stephen / Carrasco, Hernán José

PLoS neglected tropical diseases

2023 Volume 17, Issue 3, Page(s) e0010613

Abstract: Chagas disease is a significant public health risk in rural and semi-rural areas of Venezuela. Triatomine infection by the aetiological agent Trypanosoma cruzi is also observed in the Metropolitan District of Caracas (MDC), where foodborne T. cruzi ... ...

Abstract	Chagas disease is a significant public health risk in rural and semi-rural areas of Venezuela. Triatomine infection by the aetiological agent Trypanosoma cruzi is also observed in the Metropolitan District of Caracas (MDC), where foodborne T. cruzi outbreaks occasionally occur but active vector-to-human transmission (infection during triatomine bloodmeal) is considered absent. Citizen science-based domiciliary triatomine collection carried out between 2007 and 2013 in the MDC has advanced understanding of urban T. cruzi prevalence patterns and represents an important public awareness-building tool. The present study reports on the extension of this triatomine collection program from 2014 to 2019 and uses mitochondrial metabarcoding to assess feeding behavior in a subset of specimens. The combined, thirteen-year dataset (n = 4872) shows a high rate of T. cruzi infection (75.2%) and a predominance of Panstrongylus geniculatus (99.01%) among triatomines collected in domiciliary areas by MDC inhabitants. Collection also involved nymphal stages of P. geniculatus in 18 of 32 MDC parishes. Other collected species included Triatoma nigromaculata, Triatoma maculata, Rhodnius prolixus, and Panstrongylus rufotuberculatus. Liquid intestinal content indicative of bloodmeal was observed in 53.4% of analyzed specimens. Dissection pools representing 108 such visually blooded P. geniculatus specimens predominantly tested positive for human cytochrome b DNA (22 of 24 pools). Additional bloodmeal sources detected via metabarcoding analysis included key sylvatic T. cruzi reservoirs (opossum and armadillo), rodents, and various other synanthropic and domesticated animals. Results suggest a porous sylvatic-domiciliary transmission interface and ongoing adaptation of P. geniculatus to the urban ecotope. Although P. geniculatus defecation traits greatly limit the possibility of active T. cruzi transmission for any individual biting event, the cumulation of this low risk across a vast metropolitan population warrants further investigation. Efforts to prevent triatomine contact with human food sources also clearly require greater attention to protect Venezuela's capital from Chagas disease.
MeSH term(s)	Animals ; Humans ; Venezuela/epidemiology ; Chagas Disease/epidemiology ; Trypanosoma cruzi/genetics ; Triatoma ; Panstrongylus
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0010613
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Article ; Online: Perspectives on environmental heterogeneity and seasonal modulation of stress response in neotropical birds.

Gonzalez-Gomez, Paulina L / Villavicencio, Camila P / Quispe, Rene / Schwabl, Philipp / Cornelius, Jamie M / Ramenofsky, Marilyn / Krause, Jesse S / Wingfield, John C

Hormones and behavior

2023 Volume 152, Page(s) 105359

Abstract: Corticosterone (CORT), the main glucocorticoid in birds, regulates physiological and behavioral traits linked to predictable and unpredictable environmental fluctuations (i.e., stressors). Baseline and stress-induced CORT concentrations are known to ... ...

Abstract	Corticosterone (CORT), the main glucocorticoid in birds, regulates physiological and behavioral traits linked to predictable and unpredictable environmental fluctuations (i.e., stressors). Baseline and stress-induced CORT concentrations are known to fluctuate seasonally, linked to life history stages (LHS) such as breeding, molt, and wintering stage. These variations have been relatively well described in North American birds, but poorly addressed in neotropical species. To fill this gap, we explored how baseline and stress-induced CORT variation by LHS was affected by seasonality and environmental heterogeneity (i.e., frequency of unpredictable events such as droughts, flashfloods, etc) within the Neotropics using two approaches. First, we reviewed all currently available data about CORT concentrations for neotropical bird species. Second, we performed an in-depth analysis comparing the CORT responses of the two most common species of the Zonotrichia genus from North and South America (Z. leucophrys and Z. capensis, respectively) and their subspecies to seasonality and environmental heterogeneity. These species have been analyzed with the same methodology, allowing for an in-depth comparison of CORT variations. Despite scant data on neotropical bird species, we observed overlap between molt and breeding, and lower fluctuations of CORT among LHS. These patterns would be considered atypical compared to those described for North temperate species. Further, we found no significant associations between environmental heterogeneity and the stress-responses. In Zonotrichia we observed a positive association between baseline and stress-induced concentrations of CORT and latitude. We also observed differences by LHS. Both baseline and stress-induced CORT concentrations were higher during breeding and lower during molt. In addition, for both species, the overall pattern of seasonal modulation of stress response was heavily influenced by the migration strategy, with long-distance migrants showing significantly higher stress-induced CORT levels. Our results highlight the need for more data collection in the Neotropics. Comparative data would shed further light on the sensitivity of the adrenocortical response to stress under different scenarios of environmental seasonality and unpredictability.
MeSH term(s)	Animals ; Seasons ; Corticosterone ; Glucocorticoids ; Passeriformes/physiology ; Life Cycle Stages ; Stress, Physiological/physiology
Chemical Substances	Corticosterone (W980KJ009P) ; Glucocorticoids
Language	English
Publishing date	2023-04-12
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	214409-8
ISSN	1095-6867 ; 0018-506X
ISSN (online)	1095-6867
ISSN	0018-506X
DOI	10.1016/j.yhbeh.2023.105359
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Article ; Online: Subcutaneous therapy for portal hypertension: PHIN-214, a partial vasopressin receptor 1A agonist.

Castillo, Gerardo M / Yao, Yao / Guerra, Rebecca E / Jiang, Han / Nishimoto-Ashfield, Akiko / Lyubimov, Alexander V / Alfaro, Joshua F / Striker, Kali A / Buynov, Nikolay / Schwabl, Philipp / Bolotin, Elijah M

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 171, Page(s) 116068

Abstract: Cirrhosis is a liver disease that leads to increased intrahepatic resistance, portal hypertension (PH), and splanchnic hyperemia resulting in ascites, variceal bleeding, and hepatorenal syndrome. Terlipressin, a prodrug that converts to a short half-life ...

Abstract	Cirrhosis is a liver disease that leads to increased intrahepatic resistance, portal hypertension (PH), and splanchnic hyperemia resulting in ascites, variceal bleeding, and hepatorenal syndrome. Terlipressin, a prodrug that converts to a short half-life vasopressin receptor 1 A (V1a) full agonist [8-Lys]-Vasopressin (LVP), is an intravenous treatment for PH complications, but hyponatremia and ischemic side effects require close monitoring. We developed PHIN-214 which converts into PHIN-156, a more biologically stable V1a partial agonist. PHIN-214 enables once-daily subcutaneous administration without causing ischemia or tissue necrosis and has a 10-fold higher therapeutic index than terlipressin in healthy rats. As V1a partial agonists, PHIN-214 and PHIN-156 exhibited maximum activities of 28 % and 42 % of Arginine vasopressin (AVP), respectively. The potency of PHIN-156 and LVP relative to AVP is comparable for V1a (5.20 and 1.65 nM, respectively) and V1b (102 and 115 nM, respectively) receptors. However, the EC
MeSH term(s)	Humans ; Rats ; Animals ; Receptors, Vasopressin/metabolism ; Terlipressin ; Hyponatremia ; Esophageal and Gastric Varices ; Gastrointestinal Hemorrhage ; Vasopressins ; Arginine Vasopressin/pharmacology
Chemical Substances	Receptors, Vasopressin ; Terlipressin (7Z5X49W53P) ; Vasopressins (11000-17-2) ; Arginine Vasopressin (113-79-1)
Language	English
Publishing date	2024-01-04
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.116068
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Article: Novel treatment options for portal hypertension.

Schwabl, Philipp / Laleman, Wim

Gastroenterology report

2017 Volume 5, Issue 2, Page(s) 90–103

Abstract: Portal hypertension is most frequently associated with cirrhosis and is a major driver for associated complications, such as variceal bleeding, ascites or hepatic encephalopathy. As such, clinically significant portal hypertension forms the prelude to ... ...

Abstract	Portal hypertension is most frequently associated with cirrhosis and is a major driver for associated complications, such as variceal bleeding, ascites or hepatic encephalopathy. As such, clinically significant portal hypertension forms the prelude to decompensation and impacts significantly on the prognosis of patients with liver cirrhosis. At present, non-selective β-blockers, vasopressin analogues and somatostatin analogues are the mainstay of treatment but these strategies are far from satisfactory and only target splanchnic hyperemia. In contrast, safe and reliable strategies to reduce the increased intrahepatic resistance in cirrhotic patients still represent a pending issue. In recent years, several preclinical and clinical trials have focused on this latter component and other therapeutic avenues. In this review, we highlight novel data in this context and address potentially interesting therapeutic options for the future.
Language	English
Publishing date	2017-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2710871-5
ISSN	2052-0034
ISSN	2052-0034
DOI	10.1093/gastro/gox011
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