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  1. Article: [Besprechung von:] Kaldor, Nicholas: The scourge of monetarism. Oxford 1982

    Peston, Maurice / Kaldor, Nicholas

    The economic journal : the journal of the Royal Economic Society Vol. 93 , p. 421-422

    1983  Volume 93, Page(s) 421–422

    Author's details Maurice Peston
    Publisher Blackwell
    Publishing place Oxford [u.a.]
    Document type Article
    ZDB-ID 3025-9
    Database ECONomics Information System

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  2. Article ; Online: Resident memory T cells develop regional dialects.

    Maurice, Nicholas J / Jameson, Stephen C

    Nature immunology

    2023  Volume 24, Issue 2, Page(s) 209–210

    MeSH term(s) Memory T Cells ; Language ; Immunologic Memory ; CD8-Positive T-Lymphocytes
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01416-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Mitochondrial Dysfunction in Bacterial Infections.

    Maurice, Nicholas M / Sadikot, Ruxana T

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 8

    Abstract: Mitochondria are critical in numerous cellular processes, including energy generation. Bacterial pathogens target host cell mitochondria through various mechanisms to disturb the host response and improve bacterial survival. We review recent advances in ... ...

    Abstract Mitochondria are critical in numerous cellular processes, including energy generation. Bacterial pathogens target host cell mitochondria through various mechanisms to disturb the host response and improve bacterial survival. We review recent advances in the understanding of how bacteria cause mitochondrial dysfunction through perturbations in mitochondrial cell-death pathways, energy production, mitochondrial dynamics, mitochondrial quality control, DNA repair, and the mitochondrial unfolded protein response. We also briefly highlight possible therapeutic approaches aimed at restoring the host mitochondrial function as a novel strategy to enhance the host response to bacterial infection.
    Language English
    Publishing date 2023-08-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12081005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lung cancer screening at the VA: Past, present and future.

    Maurice, Nicholas M / Tanner, Nichole T

    Seminars in oncology

    2022  

    Abstract: Lung cancer is responsible for more deaths annually in the United States than breast, prostate and colon cancers combined. Lung cancer screening with annual low-dose computed tomography reduces lung cancer mortality in high-risk patients through early ... ...

    Abstract Lung cancer is responsible for more deaths annually in the United States than breast, prostate and colon cancers combined. Lung cancer screening with annual low-dose computed tomography reduces lung cancer mortality in high-risk patients through early detection. The incidence of lung cancer is higher in the veteran population compared to the general population due, in part, to the prevalence of tobacco use. Early detection of lung cancer is therefore an important goal of the Veterans Health Administration (VHA), the largest integrated health care system in the United States. The following will review previous and current initiatives undertaken by the VHA to implement and expand access to lung cancer screening and will highlight target areas of interest to improve uptake and quality of lung cancer screening. Through these initiatives and programs, the VHA aims to provide high quality and equitable access to lung cancer screening for all Veterans that incorporates research that will improve outcomes and potentially inform and optimize the practice of Lung cancer screening across the United States.
    Language English
    Publishing date 2022-06-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189220-4
    ISSN 1532-8708 ; 0093-7754
    ISSN (online) 1532-8708
    ISSN 0093-7754
    DOI 10.1053/j.seminoncol.2022.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells.

    Maurice, Nicholas J / Taber, Alexis K / Prlic, Martin

    Journal of immunology (Baltimore, Md. : 1950)

    2021  Volume 206, Issue 3, Page(s) 455–462

    Abstract: Memory T cells ( ... ...

    Abstract Memory T cells (T
    MeSH term(s) Animals ; Bystander Effect/immunology ; CD8-Positive T-Lymphocytes/immunology ; Humans ; Immunity, Heterologous ; Immunologic Memory ; Infections/immunology ; Lymphocyte Activation ; Neoplasms/immunology ; Vaccines/immunology
    Chemical Substances Vaccines
    Language English
    Publishing date 2021-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2000937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Allosteric Site at the Biotin Carboxylase Dimer Interface Mediates Activation and Inhibition in

    Laseke, Amanda J / Boram, Trevor J / Schneider, Nicholas O / Lohman, Jeremy R / St Maurice, Martin

    Biochemistry

    2023  Volume 62, Issue 17, Page(s) 2632–2644

    Abstract: Allosteric regulation of the essential anaplerotic enzyme, pyruvate carboxylase (PC), is vital for metabolic homeostasis. PC catalyzes the bicarbonate- and ATP-dependent carboxylation of pyruvate to form oxaloacetate. Dysregulation of PC activity can ... ...

    Abstract Allosteric regulation of the essential anaplerotic enzyme, pyruvate carboxylase (PC), is vital for metabolic homeostasis. PC catalyzes the bicarbonate- and ATP-dependent carboxylation of pyruvate to form oxaloacetate. Dysregulation of PC activity can impact glucose and redox metabolism, which contributes to the pathogenicity of many diseases. To maintain homeostasis, PC is allosterically activated by acetyl-CoA and allosterically inhibited by l-aspartate. In this study, we further characterize the molecular basis of allosteric regulation in
    MeSH term(s) Allosteric Site ; Pyruvate Carboxylase/genetics ; Staphylococcus aureus/genetics ; Acetyl Coenzyme A ; Aspartic Acid ; Polymers
    Chemical Substances Pyruvate Carboxylase (EC 6.4.1.1) ; biotin carboxylase (EC 6.3.4.14) ; Acetyl Coenzyme A (72-89-9) ; Aspartic Acid (30KYC7MIAI) ; Polymers
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.3c00280
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  7. Article ; Online: A 10-year retrospective cohort study of non-tubal ectopic pregnancy management outcomes in an Australian tertiary centre.

    Loh, Wei-Guo Nicholas / Adno, Alan Maurice / Reid, Shannon

    Australasian journal of ultrasound in medicine

    2022  Volume 25, Issue 4, Page(s) 166–175

    Abstract: Introduction: Non-tubal ectopic pregnancy (NTEP) is a rare but significant early pregnancy complication which can result in maternal morbidity and mortality. There is however a lack of evidence-based guidelines for the management of NTEP.: Purpose: ... ...

    Abstract Introduction: Non-tubal ectopic pregnancy (NTEP) is a rare but significant early pregnancy complication which can result in maternal morbidity and mortality. There is however a lack of evidence-based guidelines for the management of NTEP.
    Purpose: To evaluate the success rates of expectant, medical and surgical management in the treatment of NTEP at our tertiary centre.
    Methods: Retrospective cohort study from 2010 to 2020. All NTEP were classified by ectopic sites. Primary management was classified by expectant, medical [systemic methotrexate (Sys-MTX) and/or local ultrasound-guided injection of MTX and/or KCl intra-sac (L-MTX, L-MTX/KCl)] or surgical. Primary management was considered successful if no change in intervention was required. Treatment complications were compared.
    Results: Twenty-four NTEP were identified, which included 14 interstitial pregnancies (IP), 9 caesarean scar pregnancies (CSP) and 1 ovarian pregnancy (OP), which gave NTEP an incidence of 7.12% among all EP (4.15% for IP, 2.67% for CSP and 0.30% for OP). The success of primary surgical management was 100% (7/7), primary medical management was 76.9% (10/13) and primary expectant management was 33.3% (1/3). Primary medical management had a non-statistically significant greater mean time to serum ß-human Chorionic Gonadotrophin <5 IU/L, mean length of hospitalisation, mean number of follow-up visits and hospital re-presentation/readmissions compared to primary surgical management. There was no other difference in complication rates between the treatment management groups.
    Conclusion: Surgery remains the most effective way to manage NTEP. However, medical management can be a safe and effective alternative option in carefully selected cases.
    Language English
    Publishing date 2022-08-03
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2843953-3
    ISSN 2205-0140 ; 1836-6864
    ISSN (online) 2205-0140
    ISSN 1836-6864
    DOI 10.1002/ajum.12312
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  8. Article ; Online: Circulating Tumour DNA Detection By The Urine-Informed Analysis Of Archival Serum Samples From Muscle-Invasive Bladder Cancer Patients.

    BinHumaid, Faisal S / Goel, Anshita / Gordon, Naheema S / Abbotts, Ben / Cheng, K K / Zeegers, Maurice P / James, Nicholas D / Altaweel, Waleed M / Seyam, Raouf M / Meyer, Brian F / Arnold, Roland / Ward, Douglas G / Bryan, Richard T

    European urology

    2024  Volume 85, Issue 5, Page(s) 508–509

    MeSH term(s) Humans ; Circulating Tumor DNA/genetics ; Urinary Bladder Neoplasms/pathology ; Biomarkers, Tumor/genetics ; Muscles/pathology
    Chemical Substances Circulating Tumor DNA ; Biomarkers, Tumor
    Language English
    Publishing date 2024-02-01
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2024.01.016
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  9. Article ; Online: Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8

    Jarjour, Nicholas N / Wanhainen, Kelsey M / Peng, Changwei / Gavil, Noah V / Maurice, Nicholas J / Borges da Silva, Henrique / Martinez, Ryan J / Dalzell, Talia S / Huggins, Matthew A / Masopust, David / Hamilton, Sara E / Jameson, Stephen C

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 43, Page(s) e2209021119

    Abstract: Interleukin-15 (IL-15) is often considered a central regulator of memory ... ...

    Abstract Interleukin-15 (IL-15) is often considered a central regulator of memory CD8
    MeSH term(s) CD8-Positive T-Lymphocytes ; Interleukin-15 ; Immunologic Memory ; T-Lymphocyte Subsets
    Chemical Substances Interleukin-15
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2209021119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Effect of PGC-1alpha-SIRT3 Pathway Activation on

    Maurice, Nicholas M / Bedi, Brahmchetna / Yuan, Zhihong / Lin, Kuo-Chuan / Goldberg, Joanna B / Hart, C Michael / Bailey, Kristina L / Sadikot, Ruxana T

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 2

    Abstract: The innate immune response ... ...

    Abstract The innate immune response to
    Language English
    Publishing date 2022-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11020116
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