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  1. Article ; Online: Heavy metal contamination in soil and groundwater around industrial areas of Kollam District, Kerala, India.

    George, Anila / Venugopal, Aiswarya / Vashisht, Ajay Kumar

    Environmental monitoring and assessment

    2023  Volume 195, Issue 2, Page(s) 265

    Abstract: The present study was intended for assessing the contamination level of various heavy metals in surface soil and groundwater around the automobile workshops situated at different locations in the Kollam District of Kerala state, India. The procured soil ... ...

    Abstract The present study was intended for assessing the contamination level of various heavy metals in surface soil and groundwater around the automobile workshops situated at different locations in the Kollam District of Kerala state, India. The procured soil and groundwater samples were analyzed for cadmium, zinc, iron, lead, nickel, chromium, copper, manganese, and arsenic using atomic absorption spectrophotometer by following standard procedures. The contamination level of these metals was assessed using the pollution indices like enrichment factor (EF), geo-accumulation index (Igeo), contamination factor (CF), and pollution load index (PLI). The results revealed that the concentrations of all analyzed metals in the surface soils of the automobile workshops were higher than the control. On the contrary, the concentration of no heavy metal in the groundwater was either equal to or higher than the limit prescribed by WHO. However, the concentration levels of Fe, Pb, Cu, and Zn were either equal to or higher than the control values. Based on the Igeo, CF, and EF, it was found that the contamination intensity of the heavy metals in soil decreased in the following order: Fe > Pb > Cd > As > Cr > Zn > Cu > Ni > Mn. From the results of PLI, it was interpreted that the sampling sites S2, S4, and S5 were highly polluted. Non-contamination of underground water from the age-old workshops is the uniqueness of the present study against the other studies, which were completed in alluvial formations with inverse results. In the studied region, the groundwater is stored in the hard rock formations and its hydraulics remains different from alluvial aquifers.
    MeSH term(s) Soil ; Lead ; Environmental Monitoring/methods ; Metals, Heavy/analysis ; Groundwater ; Soil Pollutants/analysis ; Risk Assessment
    Chemical Substances Soil ; Lead (2P299V784P) ; Metals, Heavy ; Soil Pollutants
    Language English
    Publishing date 2023-01-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-022-10880-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Association of Biochemical Parameters and Screening for Mutations in the MCU Gene in Alzheimer's Disease Patients.

    Venugopal, Anila / Iyer, Mahalaxmi / Narayanasamy, Arul / Ravimanickam, T / Gopalakrishnan, Abilash Valsala / Yadav, Mukesh Kumar / Kumar, Nachimuthu Senthil / Vellingiri, Balachandar

    Molecular neurobiology

    2024  

    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-024-03929-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Heavy metal contamination in soil and groundwater around industrial areas of Kollam District, Kerala, India

    George, Anila / Venugopal, Aiswarya / Vashisht, Ajay Kumar

    Environ Monit Assess. 2023 Feb., v. 195, no. 2 p.265-265

    2023  

    Abstract: The present study was intended for assessing the contamination level of various heavy metals in surface soil and groundwater around the automobile workshops situated at different locations in the Kollam District of Kerala state, India. The procured soil ... ...

    Abstract The present study was intended for assessing the contamination level of various heavy metals in surface soil and groundwater around the automobile workshops situated at different locations in the Kollam District of Kerala state, India. The procured soil and groundwater samples were analyzed for cadmium, zinc, iron, lead, nickel, chromium, copper, manganese, and arsenic using atomic absorption spectrophotometer by following standard procedures. The contamination level of these metals was assessed using the pollution indices like enrichment factor (EF), geo-accumulation index (Igeo), contamination factor (CF), and pollution load index (PLI). The results revealed that the concentrations of all analyzed metals in the surface soils of the automobile workshops were higher than the control. On the contrary, the concentration of no heavy metal in the groundwater was either equal to or higher than the limit prescribed by WHO. However, the concentration levels of Fe, Pb, Cu, and Zn were either equal to or higher than the control values. Based on the Igeo, CF, and EF, it was found that the contamination intensity of the heavy metals in soil decreased in the following order: Fe > Pb > Cd > As > Cr > Zn > Cu > Ni > Mn. From the results of PLI, it was interpreted that the sampling sites S2, S4, and S5 were highly polluted. Non-contamination of underground water from the age-old workshops is the uniqueness of the present study against the other studies, which were completed in alluvial formations with inverse results. In the studied region, the groundwater is stored in the hard rock formations and its hydraulics remains different from alluvial aquifers.
    Keywords arsenic ; atomic absorption spectrometry ; automobiles ; cadmium ; chromium ; copper ; fluid mechanics ; groundwater ; heavy metals ; iron ; lead ; manganese ; nickel ; pollution load ; soil ; zinc ; India
    Language English
    Dates of publication 2023-02
    Size p. 265.
    Publishing place Springer International Publishing
    Document type Article ; Online
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-022-10880-5
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Association of Biochemical Parameters and Screening for Mutations in the MCU Gene in Alzheimer's Disease Patients.

    Venugopal, Anila / Iyer, Mahalaxmi / Narayanasamy, Arul / Ravimanickam, T / Gopalakrishnan, Abilash Valsala / Yadav, Mukesh Kumar / Kumar, Nachimuthu Senthil / Vellingiri, Balachandar

    Molecular neurobiology

    2023  

    Abstract: The most prevalent form of dementia, Alzheimer's disease (AD) is a chronic illness that is on the rise among the geriatric population. Even though research into its biochemical, genetic, and cytogenetic pathways has advanced, its aetiology is still ... ...

    Abstract The most prevalent form of dementia, Alzheimer's disease (AD) is a chronic illness that is on the rise among the geriatric population. Even though research into its biochemical, genetic, and cytogenetic pathways has advanced, its aetiology is still unclear and complex. In this study, we recruited sixty-eight participants diagnosed with AD where the cytogenetic, biochemical parameters and genetic mutations were analysed. Our results revealed chromosomal aberrations such as aneuploidies in the peripheral blood of Alzheimer's disease patients. Biochemical parameters revealed no statistical significance in the study though a pattern could be observed in the serum levels. Further few novel mutations at the c.21 C > T, c.56G > A were observed in the MCU gene of mitochondrial calcium uniporter. All these findings reveal the need for a larger cohort study to gain a better and more detailed understanding of the aetiology of Alzheimer's disease.
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03820-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mitochondrial calcium uniporter as a potential therapeutic strategy for Alzheimer's disease.

    Venugopal, Anila / Iyer, Mahalaxmi / Balasubramanian, Venkatesh / Vellingiri, Balachandar

    Acta neuropsychiatrica

    2019  Volume 32, Issue 2, Page(s) 65–71

    Abstract: Alzheimer's disease (AD), a neurodegenerative disorder, is the leading cause of dementia in the world whose aetiology is still unclear. AD was always related to ageing though there have been instances where people at an early age also succumb to this ... ...

    Abstract Alzheimer's disease (AD), a neurodegenerative disorder, is the leading cause of dementia in the world whose aetiology is still unclear. AD was always related to ageing though there have been instances where people at an early age also succumb to this disease. With medical advancements, the mortality rate has significantly reduced which also makes people more prone to AD. AD is rare, yet the prominent disease has been widely studied with several hypotheses trying to understand the workings of its onset. The most recent and popular hypothesis in AD is the involvement of mitochondrial dysfunction and calcium homeostasis in the development of the disease though their exact roles are not known. With the sudden advent of the mitochondrial calcium uniporter (MCU), many previously known pathological hallmarks of AD may be better understood. Several studies have shown the effect of excess calcium in mitochondria and the influence of MCU complex in mitochondrial function. In this article, we discuss the possible involvement of MCU in AD by linking the uniporter to mitochondrial dysfunction, calcium homeostasis, reactive oxygen species, neurotransmitters and the hallmarks of AD - amyloid plaque formation and tau tangle formation.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Animals ; Calcium/metabolism ; Calcium Channels/metabolism ; Humans ; Mitochondrial Diseases/metabolism
    Chemical Substances Calcium Channels ; mitochondrial calcium uniporter ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-12-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1154361-9
    ISSN 1601-5215 ; 0924-2708
    ISSN (online) 1601-5215
    ISSN 0924-2708
    DOI 10.1017/neu.2019.39
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Role of Rapid On-site Evaluation in CT-guided Fine Needle Aspiration Cytology of Lung Nodules.

    Anila, K R / Nayak, Nileena / Venugopal, M / Jayasree, K

    Journal of cytology

    2018  Volume 35, Issue 4, Page(s) 229–232

    Abstract: Objective: To prospectively investigate the value of rapid on-site evaluation (ROSE) in transthoracic fine needle aspiration cytology (FNAC) of patients with pulmonary nodules. Computed tomography (CT)-guided FNA is commonly employed for the diagnosis ... ...

    Abstract Objective: To prospectively investigate the value of rapid on-site evaluation (ROSE) in transthoracic fine needle aspiration cytology (FNAC) of patients with pulmonary nodules. Computed tomography (CT)-guided FNA is commonly employed for the diagnosis of lung lesions and the most common reason for not being able to provide a diagnosis in FNA is inadequacy of samples.
    Materials and methods: This was a prospective study conducted in the departments of pathology and radiology of our cancer centre. This study had approval from the institutional review board and ethical committee of our institute. Fifty consecutive cases undergoing CT-guided transthoracic FNAC in our centre were included in the study. The smear submitted for ROSE was stained using toluidine blue stain. The specimen adequacy and diagnosis in ROSE was compared with that of the final cytology report, and the concordance regarding adequacy and diagnosis were noted.
    Results: Smears were adequate in 34 cases (68%) and inadequate in 16 cases (32%) Out of the 16 inadequate cases, 5 (31%) were converted to adequate due to the application of ROSE, thus increasing the adequate number of cases to 39 (78%). A diagnosis of malignancy was made in all 39 adequate cases. Sensitivity of ROSE in determining adequacy was 92% and specificity was 100%. The most common malignancy was adenocarcinoma in 26 cases. Pnemothorax occurred in 2 cases. No significant complications occurred in other cases.
    Conclusion: CT-guided FNA with ROSE is a safe and useful tool in the diagnostic work-up of lung cancer patients. A multidisciplinary approach along with onsite evaluation of adequacy will increase the diagnostic utility of cytology in lung lesions.
    Language English
    Publishing date 2018-10-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 645018-0
    ISSN 0970-9371
    ISSN 0970-9371
    DOI 10.4103/JOC.JOC_134_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Therapeutic potential of Hsp27 in neurological diseases

    Anila Venugopal / Kasthuri Sundaramoorthy / Balachandar Vellingiri

    Egyptian Journal of Medical Human Genetics, Vol 20, Iss 1, Pp 1-

    2019  Volume 8

    Abstract: Abstract Background Heat shock proteins (Hsps) are widely reported in normal cellular dynamics under stress and non-stress conditions, and parallelly, the studies regarding its role in disease condition are also progressing steadily. The function of Hsps ...

    Abstract Abstract Background Heat shock proteins (Hsps) are widely reported in normal cellular dynamics under stress and non-stress conditions, and parallelly, the studies regarding its role in disease condition are also progressing steadily. The function of Hsps in neurodegenerative disorders is puzzling and not fully understood. This review aims to focus on the role of Hsp27 in normal and diseased conditions and emphasize its therapeutic potential. Hsp27 Hsp27, in particular, has shown to be involved in cell viability and actin cytoskeleton remodeling and also shown to improve many disease conditions. Phosphorylated Hsp27 modulates the p53 pathway by downregulating cellular senescence and also lowers reactive oxygen species to protect TNFα-mediated apoptosis. Hsp27 is also known to interfere with mitochondria-dependent and mitochondria-independent cell apoptotic stimulation. Conclusion This article will highlight the various functions of Hsp27 especially as an anti-apoptotic factor and stress response factor and its therapeutic potential in preventing neuronal apoptosis in neurological diseases. This review also includes a comparison of the therapeutic potential of Hsp27 with regard to other small Hsps.
    Keywords Heat shock proteins ; Hsp27 ; Neurological diseases ; Therapeutic ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Subject code 610
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Monogenic diseases in India.

    Venugopal, Anila / Chandran, Manojkumar / Eruppakotte, Nimmisha / Kizhakkillach, Soumya / Breezevilla, Sanuj C / Vellingiri, Balachandar

    Mutation research. Reviews in mutation research

    2018  Volume 776, Page(s) 23–31

    Abstract: Studies on monogenic diseases are considered valuable because they give insights and expand our knowledge on gene function and regulation. Despite all the current advancement in science and technology, a deep understanding and knowledge as to why only ... ...

    Abstract Studies on monogenic diseases are considered valuable because they give insights and expand our knowledge on gene function and regulation. Despite all the current advancement in science and technology, a deep understanding and knowledge as to why only those particular genes are affected in a disease is still vague. We also lack profound illumination as to why only certain mutations are seen in a disease. Though useful from a research perspective, a majority of these diseases are lethal resulting in death of the affected individual. Unfortunately, in the fast - growing land of India, the incidence of monogenic diseases is very high with few counter-measures in place. This article encompasses a list of all monogenic diseases ever to be reported in India with special focus on five diseases which has been stated to have the highest incidence in India. Here, we discuss about the limited research carried out in India on these high incidence monogenic diseases, the other diseases related to those genes, the range of treatments available for these diseases in India in contrast to its availability around the world and the need to develop treatment strategies to reduce the mortality and morbidity due to these rare but daunting diseases.
    MeSH term(s) Anemia, Sickle Cell/epidemiology ; Anemia, Sickle Cell/genetics ; Anemia, Sickle Cell/therapy ; Genetic Diseases, Inborn/epidemiology ; Genetic Diseases, Inborn/genetics ; Genetic Diseases, Inborn/therapy ; Humans ; Huntington Disease/epidemiology ; Huntington Disease/genetics ; Huntington Disease/therapy ; Incidence ; India/epidemiology ; Muscular Dystrophy, Duchenne/epidemiology ; Muscular Dystrophy, Duchenne/genetics ; Muscular Dystrophy, Duchenne/therapy ; Mutation ; Neurofibromatosis 1/epidemiology ; Neurofibromatosis 1/genetics ; Neurofibromatosis 1/therapy ; beta-Thalassemia/epidemiology ; beta-Thalassemia/genetics ; beta-Thalassemia/therapy
    Language English
    Publishing date 2018-03-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2727833-5
    ISSN 1388-2139 ; 1383-5742
    ISSN (online) 1388-2139
    ISSN 1383-5742
    DOI 10.1016/j.mrrev.2018.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: mTOR signalling pathway - A root cause for idiopathic autism?

    Ganesan, Harsha / Balasubramanian, Venkatesh / Iyer, Mahalaxmi / Venugopal, Anila / Subramaniam, Mohana Devi / Cho, Ssang-Goo / Vellingiri, Balachandar

    BMB reports

    2019  Volume 52, Issue 7, Page(s) 424–433

    Abstract: Autism spectrum disorder (ASD) is a complex neurodevelopmental monogenic disorder with a strong genetic influence. Idiopathic autism could be defined as a type of autism that does not have a specific causative agent. Among signalling cascades, mTOR ... ...

    Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental monogenic disorder with a strong genetic influence. Idiopathic autism could be defined as a type of autism that does not have a specific causative agent. Among signalling cascades, mTOR signalling pathway plays a pivotal role not only in cell cycle, but also in protein synthesis and regulation of brain homeostasis in ASD patients. The present review highlights, underlying mechanism of mTOR and its role in altered signalling cascades as a triggering factor in the onset of idiopathic autism. Further, this review discusses how distorted mTOR signalling pathway stimulates truncated translation in neuronal cells and leads to downregulation of protein synthesis at dendritic spines of the brain. This review concludes by suggesting downstream regulators such as p70S6K, eIF4B, eIF4E of mTOR signalling pathway as promising therapeutic targets for idiopathic autistic individuals. [BMB Reports 2019; 52(7): 424-433].
    MeSH term(s) Autistic Disorder/metabolism ; Humans ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances TOR Serine-Threonine Kinases (EC 2.7.1.1)
    Language English
    Publishing date 2019-06-11
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2410389-5
    ISSN 1976-670X ; 1976-6696
    ISSN (online) 1976-670X
    ISSN 1976-6696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Solid-pseudopapillary neoplasm of the pancreas: A classical presentation with unique paranuclear dot like immunostaining with CD 99.

    Nair Anila, Kunjulekshmi Amma Raveendran / Nayak, Nileena / Muralee, Madhu / Venugopal, Bhaskaran Pillai / Mony, Rari P

    Indian journal of pathology & microbiology

    2015  Volume 58, Issue 3, Page(s) 365–367

    Abstract: A 32-year-old lady presented with a history of abdominal pain and upper abdominal discomfort of 3 months duration. Her imaging studies done at a local hospital showed a solid-cystic mass involving head of the pancreas. The patient was referred to our ... ...

    Abstract A 32-year-old lady presented with a history of abdominal pain and upper abdominal discomfort of 3 months duration. Her imaging studies done at a local hospital showed a solid-cystic mass involving head of the pancreas. The patient was referred to our surgical oncology department. On examination, there was a nontender mass in the epigastrium. An ultrasound scan guided fine-needle aspiration (FNA) was done which was showing classical features of solid-pseudo papillary neoplasm of the pancreas. With this preoperative diagnosis patient was taken up for surgery. Per operatively, there was a solid-cystic mass in the head of the pancreas. Pancreaticoduodenectomy was done. Histopathology and immunohistochemistry (IHC) confirmed the diagnosis of solid-pseudo papillary neoplasm of the pancreas. Apart from the routine IHC panel, CD 99 immunostain was also done which demonstrated the characteristic paranuclear dot-like staining observed in previous studies in the literature.
    MeSH term(s) 12E7 Antigen ; Adult ; Antigens, CD/analysis ; Biomarkers, Tumor/analysis ; Biopsy, Fine-Needle ; Carcinoma, Papillary/diagnosis ; Carcinoma, Papillary/pathology ; Carcinoma, Papillary/surgery ; Cell Adhesion Molecules/analysis ; Cytoplasm/chemistry ; Female ; Histocytochemistry ; Humans ; Immunohistochemistry ; Microscopy ; Pancreas/pathology ; Pancreas/surgery ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Vimentin/analysis
    Chemical Substances 12E7 Antigen ; Antigens, CD ; Biomarkers, Tumor ; CD99 protein, human ; Cell Adhesion Molecules ; Vimentin
    Language English
    Publishing date 2015-07
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/0377-4929.162902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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